Patrick B Kyle

Summary

Publications

  1. ncbi request reprint Illicit bath salts: not for bathing
    Patrick B Kyle
    Department of Pathology, University of Mississippi Medical Center, Jackson, MS 39216, USA
    J Miss State Med Assoc 52:375-7. 2011
  2. doi request reprint Mass spectrometric detection of CYP450 adducts following oxidative desulfuration of methyl parathion
    Patrick B Kyle
    Department of Pathology, University of Mississippi Medical Center, Jackson, Mississippi, USA
    J Appl Toxicol 33:644-51. 2013
  3. doi request reprint Aberrant lamellar body counts noted on the Beckman Coulter Unicel DxH 800
    Patrick B Kyle
    Department of Pathology, University of Mississippi Medical Center, Jackson, MS 39216, USA
    Clin Chem Lab Med 50:1631-3. 2012
  4. doi request reprint Reactivity of commercial benzodiazepine immunoassays to phenazepam
    Patrick B Kyle
    Department of Pathology, University of Mississippi Medical Center, Jackson, MS, USA
    J Anal Toxicol 36:207-9. 2012
  5. ncbi request reprint Drugs detected in suspected pediatric ingestions: a three-year review
    Patrick B Kyle
    Analytical Toxicology Laboratory, Department of Pharmacology and Toxicology, University of Mississippi Medical Center, USA
    J Miss State Med Assoc 45:35-40. 2004
  6. pmc Decreased expression of Freud-1/CC2D1A, a transcriptional repressor of the 5-HT1A receptor, in the prefrontal cortex of subjects with major depression
    Bernadeta Szewczyk
    Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS 39216 4505, USA
    Int J Neuropsychopharmacol 13:1089-101. 2010
  7. ncbi request reprint Pharmacokinetics of intranasal and intratracheal pentoxifylline in rabbits
    Kim G Adcock
    Department of Pharmacy Practice, School of Pharmacy, University of Mississippi, Jackson, Mississippi 39216, USA
    Pharmacotherapy 27:200-6. 2007
  8. ncbi request reprint Use of liquid chromatography-tandem mass spectrometry for the analysis of pentoxifylline and lisofylline in plasma
    Patrick B Kyle
    Department of Pharmacology and Toxicology University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA
    Biomed Chromatogr 19:231-6. 2005
  9. ncbi request reprint Domestic abuse of the European rave drug prolintane
    Patrick B Kyle
    Department of Pathology, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA
    J Anal Toxicol 31:415-8. 2007
  10. pmc Elevated level of metabotropic glutamate receptor 2/3 in the prefrontal cortex in major depression
    Anteneh M Feyissa
    Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS, USA
    Prog Neuropsychopharmacol Biol Psychiatry 34:279-83. 2010

Collaborators

  • William L Woolverton
  • Craig A Stockmeier
  • Zhixia Wang
  • Bernadeta Szewczyk
  • Jose J Miguel-Hidalgo
  • Anteneh M Feyissa
  • Kim G Adcock
  • Meng Yang Zhu
  • Warren L May
  • Heidi Fitzgibbon
  • Paul R Albert
  • Gregor Hasler
  • Anastasia Rogaeva
  • Abiye H Iyo
  • Grazyna Rajkowska
  • Mark C Austin
  • Beata Karolewicz
  • Jake H Olivier
  • Jennifer S Deaton
  • Shirley M Hogan
  • Arthur S Hume
  • Gregory A Ordway

Detail Information

Publications12

  1. ncbi request reprint Illicit bath salts: not for bathing
    Patrick B Kyle
    Department of Pathology, University of Mississippi Medical Center, Jackson, MS 39216, USA
    J Miss State Med Assoc 52:375-7. 2011
    ..Although recently outlawed, abuse of these products continues to occur in Mississippi...
  2. doi request reprint Mass spectrometric detection of CYP450 adducts following oxidative desulfuration of methyl parathion
    Patrick B Kyle
    Department of Pathology, University of Mississippi Medical Center, Jackson, Mississippi, USA
    J Appl Toxicol 33:644-51. 2013
    ..Alteration of these residues might modulate substrate entry to the binding pocket of the enzyme...
  3. doi request reprint Aberrant lamellar body counts noted on the Beckman Coulter Unicel DxH 800
    Patrick B Kyle
    Department of Pathology, University of Mississippi Medical Center, Jackson, MS 39216, USA
    Clin Chem Lab Med 50:1631-3. 2012
    ..Recently, significant imprecision was noted during LBC validation on the Beckman Coulter Unicel DxH 800...
  4. doi request reprint Reactivity of commercial benzodiazepine immunoassays to phenazepam
    Patrick B Kyle
    Department of Pathology, University of Mississippi Medical Center, Jackson, MS, USA
    J Anal Toxicol 36:207-9. 2012
    ..Laboratorians and clinicians should be confident that phenazepam will be detected via most commercial drugs of abuse screens in patients after significant ingestion...
  5. ncbi request reprint Drugs detected in suspected pediatric ingestions: a three-year review
    Patrick B Kyle
    Analytical Toxicology Laboratory, Department of Pharmacology and Toxicology, University of Mississippi Medical Center, USA
    J Miss State Med Assoc 45:35-40. 2004
    ..This review shows that comprehensive toxicology testing provides the clinician significantly more information regarding the exposure of the pediatric patient presenting with an unknown chemical ingestion...
  6. pmc Decreased expression of Freud-1/CC2D1A, a transcriptional repressor of the 5-HT1A receptor, in the prefrontal cortex of subjects with major depression
    Bernadeta Szewczyk
    Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS 39216 4505, USA
    Int J Neuropsychopharmacol 13:1089-101. 2010
    ..These data may also suggest that reductions in Freud-1 protein expression in the PFC may be associated with early onset of MDD...
  7. ncbi request reprint Pharmacokinetics of intranasal and intratracheal pentoxifylline in rabbits
    Kim G Adcock
    Department of Pharmacy Practice, School of Pharmacy, University of Mississippi, Jackson, Mississippi 39216, USA
    Pharmacotherapy 27:200-6. 2007
    ..To evaluate the disposition of pentoxifylline and its metabolite, lisofylline, in New Zealand rabbits after two alternative routes of administration, intranasal and intratracheal...
  8. ncbi request reprint Use of liquid chromatography-tandem mass spectrometry for the analysis of pentoxifylline and lisofylline in plasma
    Patrick B Kyle
    Department of Pharmacology and Toxicology University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA
    Biomed Chromatogr 19:231-6. 2005
    ..Calibration curves were generated using peak area and were linear from 1 to 1000 ng/mL (R(2) > 0.99). The small sample volume, ease of extraction, and sensitivity provide advantages over more conventional methods of quantitation...
  9. ncbi request reprint Domestic abuse of the European rave drug prolintane
    Patrick B Kyle
    Department of Pathology, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA
    J Anal Toxicol 31:415-8. 2007
    ..The medical and scientific communities should be aware of the potential for prolintane abuse because it may cause symptoms similar to those of the amphetamines but is not likely to be detected by a routine urine drug screen...
  10. pmc Elevated level of metabotropic glutamate receptor 2/3 in the prefrontal cortex in major depression
    Anteneh M Feyissa
    Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS, USA
    Prog Neuropsychopharmacol Biol Psychiatry 34:279-83. 2010
    ..This observation is consistent with reports showing that mGluR2/3 antagonists exhibit antidepressant-like activity in animal models and demonstrates that these receptors are promising targets for the discovery of novel antidepressants...
  11. ncbi request reprint The persistent membrane retention of desipramine causes lasting inhibition of norepinephrine transporter function
    Meng Yang Zhu
    Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA
    Neurochem Res 29:419-27. 2004
    ..The retention and slow diffusion of DMI and nisoxetine from membranes may contribute to their pharmacological and modulatory action on NET...
  12. ncbi request reprint Suspected pediatric ingestions: effectiveness of immunoassay screens vs. gas chromatography/mass spectroscopy in the detection of drugs and chemicals
    Patrick B Kyle
    Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA
    J Toxicol Clin Toxicol 41:919-25. 2003
    ..This study shows that analysis by GC/MS offers the clinician a more comprehensive view into the exposure of the pediatric patient presenting with an unknown chemical ingestion...