Ava Kwong

Summary

Publications

  1. pmc MicroRNAs as New Players for Diagnosis, Prognosis, and Therapeutic Targets in Breast Cancer
    Enders K O Ng
    Department of Surgery, The University of Hong Kong, Hong Kong
    J Oncol 2009:305420. 2009
  2. pmc Quantitative analysis and diagnostic significance of methylated SLC19A3 DNA in the plasma of breast and gastric cancer patients
    Enders K O Ng
    Department of Surgery, The University of Hong Kong, Hong Kong, Special Administrative Region, People s Republic of China
    PLoS ONE 6:e22233. 2011
  3. ncbi request reprint Male breast cancer: a population-based comparison with female breast cancer in Hong Kong, Southern China: 1997-2006
    Ava Kwong
    Division of Breast Surgery, Department of Surgery, The University of Hong Kong, Hong Kong, Hong Kong
    Ann Surg Oncol 21:1246-53. 2014
  4. doi request reprint Work-life balance of female versus male surgeons in Hong Kong based on findings of a questionnaire designed by a Japanese surgeon
    Ava Kwong
    Division of Breast Surgery, Department of Surgery, The University of Hong Kong, Hong Kong, Hong Kong
    Surg Today 44:62-72. 2014
  5. pmc Common variants at 12p11, 12q24, 9p21, 9q31.2 and in ZNF365 are associated with breast cancer risk for BRCA1 and/or BRCA2 mutation carriers
    Antonis C Antoniou
    Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Worts Causeway, Cambridge CB1 8RN, UK
    Breast Cancer Res 14:R33. 2012
  6. pmc Identification of BRCA1/2 founder mutations in Southern Chinese breast cancer patients using gene sequencing and high resolution DNA melting analysis
    Ava Kwong
    Department of Surgery, The University of Hong Kong, Hong Kong SAR
    PLoS ONE 7:e43994. 2012
  7. pmc Accuracy of BRCA1/2 mutation prediction models for different ethnicities and genders: experience in a southern Chinese cohort
    Ava Kwong
    Division of Breast Surgery, Department of Surgery, The University of Hong Kong, Hong Kong, China
    World J Surg 36:702-13. 2012
  8. doi request reprint Choice of management of southern Chinese BRCA mutation carriers
    Ava Kwong
    Division of Breast Surgery, The University of Hong Kong Li Ka Shing Faculty of Medicine, Hong Kong, Hong Kong, China
    World J Surg 34:1416-26. 2010
  9. doi request reprint Breast cancer in Chinese women younger than age 40: are they different from their older counterparts?
    Ava Kwong
    Breast Care Center, Hong Kong Sanatorium and Hospital, Happy Valley, Hong Kong, China
    World J Surg 32:2554-61. 2008
  10. pmc A novel de novo BRCA1 mutation in a Chinese woman with early onset breast cancer
    Ava Kwong
    Division of Breast Surgery, Queen Mary and Tung Wah Hospital, The University of Hong Kong, Pokfulam, Hong Kong
    Fam Cancer 10:233-7. 2011

Collaborators

  • Dacita Suen
  • Richard Fielding
  • Edmond S K Ma
  • Vivian Y Shin
  • Yiu Fai Cheung
  • Alice W Y Ng
  • Sharon W W Chan
  • Tsz Kok Yau
  • Wai Lun Law
  • Charles Swanton
  • Afaf Girgis
  • Allison W Kurian
  • Vivian Chan
  • I S Soong
  • M S Wong
  • Kenneth S H Chok
  • T Y Ng
  • K K L Chan
  • Ilona Juraskova
  • Enders K O Ng
  • Wendy W T Lam
  • Wylie W Y Li
  • Janice Tsang
  • Angel H Y Au
  • Ka Yan Wong
  • Joyce Suen
  • Wing Kin Sze
  • Rufina Li
  • Winnie Yeo
  • Clare T M Lai
  • Angel Au
  • Miranda Chan
  • Amy Or
  • Antonis C Antoniou
  • Hong Chuan Jin
  • K K Ma
  • Candy P H Leung
  • Kent Man Chu
  • Hilda Wong
  • Chris L P Wong
  • Tanfo T Cheung
  • Tsz Ting Law
  • T T Law
  • Wing Ming Ho
  • Jennifer M Siu
  • Wing M Ho
  • Simon Y K Law
  • Wendy Lam
  • Roberta Pang
  • Ronnie T P Poon
  • Pak Cheong Chow
  • Jensen Poon
  • Daniel Chua
  • Michelle Ye
  • Melissa Southey
  • Saundra Buys
  • Hilmi Ozcelik
  • Marjolijn J Ligtenberg
  • Xiaoqing Chen
  • Claude Houdayer
  • Bernard Peissel
  • Mary U Terry
  • Jan C Oosterwijk
  • Norbert Arnold
  • Julian Adlard
  • Encarna B Gomez Garcia
  • James Fiorica
  • Betsy Bove
  • Rita K Schmutzler
  • Simone Heidemann
  • Jackie Cook
  • Siranoush Manoukian
  • Isabelle Mortemousque
  • Bruno Buecher
  • Mark T Rogers
  • J Margriet Collee
  • Fiona Douglas
  • Christian F Singer
  • Beth Y Karlan
  • Fiona Lalloo
  • Rosa B Barkardottir
  • D Gareth Evans
  • Frans B Hogervorst
  • Patricia A Ganz
  • Christoph Engel
  • Maria A Caligo
  • Antoine de Pauw
  • Susan Domchek
  • Kerry Wong
  • Anneliese Fink-Retter

Detail Information

Publications32

  1. pmc MicroRNAs as New Players for Diagnosis, Prognosis, and Therapeutic Targets in Breast Cancer
    Enders K O Ng
    Department of Surgery, The University of Hong Kong, Hong Kong
    J Oncol 2009:305420. 2009
    ..Here we describe and discuss lines of evidence supporting the important relationship between miRNAs and breast cancer, and its therapeutic strategies...
  2. pmc Quantitative analysis and diagnostic significance of methylated SLC19A3 DNA in the plasma of breast and gastric cancer patients
    Enders K O Ng
    Department of Surgery, The University of Hong Kong, Hong Kong, Special Administrative Region, People s Republic of China
    PLoS ONE 6:e22233. 2011
    ..Here, we aim to develop a new biomarker for cancer diagnosis using methylated SLC19A3 DNA in plasma...
  3. ncbi request reprint Male breast cancer: a population-based comparison with female breast cancer in Hong Kong, Southern China: 1997-2006
    Ava Kwong
    Division of Breast Surgery, Department of Surgery, The University of Hong Kong, Hong Kong, Hong Kong
    Ann Surg Oncol 21:1246-53. 2014
    ..This is the largest population-based study to compare Chinese MBC patients with female patients during a 10-year period in Hong Kong, Southern China...
  4. doi request reprint Work-life balance of female versus male surgeons in Hong Kong based on findings of a questionnaire designed by a Japanese surgeon
    Ava Kwong
    Division of Breast Surgery, Department of Surgery, The University of Hong Kong, Hong Kong, Hong Kong
    Surg Today 44:62-72. 2014
    ..We evaluated the attitudes of female and male surgeons in Hong Kong to work, personal life, and work-life balance, through a questionnaire survey...
  5. pmc Common variants at 12p11, 12q24, 9p21, 9q31.2 and in ZNF365 are associated with breast cancer risk for BRCA1 and/or BRCA2 mutation carriers
    Antonis C Antoniou
    Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Worts Causeway, Cambridge CB1 8RN, UK
    Breast Cancer Res 14:R33. 2012
    ..2)...
  6. pmc Identification of BRCA1/2 founder mutations in Southern Chinese breast cancer patients using gene sequencing and high resolution DNA melting analysis
    Ava Kwong
    Department of Surgery, The University of Hong Kong, Hong Kong SAR
    PLoS ONE 7:e43994. 2012
    ..Knowledge of BRCA mutations in Chinese populations is still largely unknown. We conducted a multi-center study to characterize the spectra of BRCA mutations in Chinese breast and ovarian cancer patients from Southern China...
  7. pmc Accuracy of BRCA1/2 mutation prediction models for different ethnicities and genders: experience in a southern Chinese cohort
    Ava Kwong
    Division of Breast Surgery, Department of Surgery, The University of Hong Kong, Hong Kong, China
    World J Surg 36:702-13. 2012
    ..Results are conflicting in Asian populations. Most studies did not account for gender-specific prediction. We evaluated the performance of these models in a Chinese cohort, including males, before BRCA1/2 mutation testing...
  8. doi request reprint Choice of management of southern Chinese BRCA mutation carriers
    Ava Kwong
    Division of Breast Surgery, The University of Hong Kong Li Ka Shing Faculty of Medicine, Hong Kong, Hong Kong, China
    World J Surg 34:1416-26. 2010
    ..Families carrying the mutation can have intensive surveillance and take preventative measures. This is the first report on the uptake of such interventions in Chinese mutation carriers residing in Asia...
  9. doi request reprint Breast cancer in Chinese women younger than age 40: are they different from their older counterparts?
    Ava Kwong
    Breast Care Center, Hong Kong Sanatorium and Hospital, Happy Valley, Hong Kong, China
    World J Surg 32:2554-61. 2008
    ..This study is the first to report the tumor characteristics and management of breast cancer in Chinese women younger than age 40 and a comparison with their older counterparts...
  10. pmc A novel de novo BRCA1 mutation in a Chinese woman with early onset breast cancer
    Ava Kwong
    Division of Breast Surgery, Queen Mary and Tung Wah Hospital, The University of Hong Kong, Pokfulam, Hong Kong
    Fam Cancer 10:233-7. 2011
    ..None of her parents carried the mutation and molecular analysis showed that this novel de novo germline mutation resulted in down-regulation of BRCA1 gene expression...
  11. pmc Breast cancer in Hong Kong, Southern China: the first population-based analysis of epidemiological characteristics, stage-specific, cancer-specific, and disease-free survival in breast cancer patients: 1997-2001
    Ava Kwong
    Division of Breast Surgery, Department of Surgery, Queen Mary and Tung Wah Hospital, The University of Hong Kong, Hong Kong, China
    Ann Surg Oncol 18:3072-8. 2011
    ..This is the first comprehensive population-based breast cancer study performed using population database of the Hong Kong Cancer Registry...
  12. ncbi request reprint The evolution of supportive care needs trajectories in women with advanced breast cancer during the 12 months following diagnosis
    Wendy W T Lam
    Centre for Psycho Oncology Research and Training, Division of Behavioural Health, School of Public Health, The University of Hong Kong, 5 F, WMW Mong Block, Faculty of Medicine Building, 21 Sassoon Road, Pokulam, Hong Kong
    Support Care Cancer 22:635-44. 2014
    ..This longitudinal study examined if the evolution of supportive care needs differed over the first year following the diagnosis of advanced breast cancer and examined factors differentiating these trajectories...
  13. ncbi request reprint What made her give up her breasts: a qualitative study on decisional considerations for contralateral prophylactic mastectomy among breast cancer survivors undergoing BRCA1/2 genetic testing
    Ava Kwong
    Division of Breast Surgery, The University of Hong Kong, Hong Kong
    Asian Pac J Cancer Prev 13:2241-7. 2012
    ..Limited knowledge is available on this topic especially among Asians; therefore, the aim of this study was to acquire insight from Chinese females' subjective perspectives...
  14. ncbi request reprint Triple negative status is a poor prognostic indicator in Chinese women with breast cancer: a ten year review
    K K Ma
    Division of Breast Surgery, Department of Surgery, Queen Mary and Tung Wah Hospital, Happy Valley, Hong Kong, China
    Asian Pac J Cancer Prev 13:2109-14. 2012
    ..We studied the tumor characteristics and factors which may influence the presentation and prognosis of triple negative breast cancers (TNC) in a cohort of Chinese women...
  15. doi request reprint Interpreting differences in patterns of supportive care needs between patients with breast cancer and patients with colorectal cancer
    Wylie W Y Li
    Centre for Psycho Oncology Research and Training, School of Public Health, The University of Hong Kong, Hong Kong, China
    Psychooncology 22:792-8. 2013
    ..We therefore examined the prevalence of supportive care needs in Chinese breast (BC) and colorectal cancer (CRC) patients to identify prevalence and correlates of unmet needs...
  16. doi request reprint Reducing treatment decision conflict difficulties in breast cancer surgery: a randomized controlled trial
    Wendy W T Lam
    Centre for Psycho oncological Research and Training, Department of Community Medicine and Unit for Behavioural Sciences, School of Public Health, The University of Hong Kong, 5 F, WMW Mong Block, Faculty of Medicine Building, 21 Sassoon Rd, Pokfulam, Hong Kong Special Administrative Region, People s Republic of China
    J Clin Oncol 31:2879-85. 2013
    ..We developed a DA administered after consultation for Chinese women deciding on BC surgery and, where relevant, immediate breast reconstruction, which was evaluated in this randomized controlled trial (RCT)...
  17. pmc Circulating microRNAs as specific biomarkers for breast cancer detection
    Enders K O Ng
    Department of Surgery, The University of Hong Kong, Hong Kong, China
    PLoS ONE 8:e53141. 2013
    ..We previously showed microRNAs (miRNAs) in plasma are potential biomarkers for colorectal cancer detection. Here, we aimed to develop specific blood-based miRNA assay for breast cancer detection...
  18. doi request reprint Is sentinel lymph node biopsy after neoadjuvant chemotherapy feasible in Chinese patients with invasive breast cancers?
    Tanfo T Cheung
    Department of Surgery, The University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong SAR, China
    ANZ J Surg 79:719-23. 2009
    ..This study aimed to be the first to evaluate the feasibility and accuracy of SLNB after neoadjuvant chemotherapy in Chinese patients with breast cancer...
  19. ncbi request reprint MicroRNA-143 is downregulated in breast cancer and regulates DNA methyltransferases 3A in breast cancer cells
    Enders K O Ng
    Department of Surgery, The University of Hong Kong, Hong Kong SAR, Hong Kong
    Tumour Biol 35:2591-8. 2014
    ..These findings elucidated a tumor-suppressive role of miR-143 in epigenetic aberration of breast cancer, providing a potential development of miRNA-based treatment for breast cancer...
  20. doi request reprint Waiting to see the doctor: understanding appraisal and utilization components of consultation delay for new breast symptoms in Chinese women
    Wylie W Y Li
    Centre for Psycho oncological Research and Training, School of Public Health, The University of Hong Kong, Hong Kong
    Psychooncology 21:1316-23. 2012
    ..Delayed consultation for potential cancer symptoms influences treatment outcomes and remains problematic. Delay components (Appraisal versus Utilization) and respective associations are poorly understood...
  21. doi request reprint Breast-conserving surgery in Hong Kong Chinese women
    Dacita Suen
    Department of Surgery, The University of Hong Kong, 102 Pokfulam Road, Hong Kong, Hong Kong
    World J Surg 32:2549-53. 2008
    ..This study aimed to review the rate of BCS in Hong Kong Chinese breast cancer patients and the possible clinicopathologic and psychosocial factors that may have affected the choice of surgery...
  22. ncbi request reprint Factors affecting false-negative breast sentinel node biopsy in Chinese patients
    Kenneth S H Chok
    Division of Breast Surgery, Department of Surgery, The University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong SAR, China
    ANZ J Surg 77:866-9. 2007
    ..The objective of the research was to validate our results on sentinel lymph node biopsy (SLNB) and to determine factors affecting false-negative (FN) rates of SLNB in Chinese patients with invasive breast cancers...
  23. doi request reprint Development and pilot-testing of a Decision Aid for use among Chinese women facing breast cancer surgery
    Angel H Y Au
    Centre for Psycho oncological Research and Training, School of Public Health, The University of Hong Kong, Hong Kong, China
    Health Expect 14:405-16. 2011
    ..Decision Aids (DAs) may facilitate TDM, but there are no DAs designed for Chinese populations. We developed a DA for Chinese women newly diagnosed with breast cancer, for use during the initial surgical consultation...
  24. ncbi request reprint The acceptance and feasibility of breast cancer screening in the East
    Ava Kwong
    Breast Care Centre, Hong Kong Sanatorium and Hospital, Hong Kong, China
    Breast 17:42-50. 2008
    ..3 per 1000 screens and a recall rate of 9.2% were found. Despite culture differences and differences in breast characteristics (denser and smaller breasts), breast screening is feasible and acceptable in the East...
  25. pmc Circulating microRNA expression profile and systemic right ventricular function in adults after atrial switch operation for complete transposition of the great arteries
    Clare T M Lai
    Division of Paediatric Cardiology, Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Hongkong, China
    BMC Cardiovasc Disord 13:73. 2013
    ....
  26. pmc Integrating molecular mechanisms and clinical evidence in the management of trastuzumab resistant or refractory HER-2⁺ metastatic breast cancer
    Hilda Wong
    Division of Hematology and Medical Oncology, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China
    Oncologist 16:1535-46. 2011
    ..The identification of predictive biomarkers is of paramount importance to optimize health economic costs and enhance stratification of anti-HER-2 targeted therapies...
  27. doi request reprint Surgical margins in breast conservation therapy: how much should we excise?
    Tsz Ting Law
    Division of Breast Surgery, Department of Surgery, The University of Hong Kong Li Ka Shing Faculty of Medicine, Queen Mary Hospital, Hong Kong SAR
    South Med J 102:1234-7. 2009
    ..This review looks at the safe margin for BCT in early stage invasive breast cancer and ductal carcinoma in situ (DCIS)...
  28. pmc Localization of hRad9 in breast cancer
    Vivian Chan
    University Department of Medicine, Queen Mary Hospital, Hong Kong, China
    BMC Cancer 8:196. 2008
    ..We have previously shown that the mRNA up-regulation correlated with tumor size and local recurrence. Immunohistochemical studies were made to better define the role of hRad9 in breast carcinogenesis...
  29. ncbi request reprint Telephone pre-anaesthesia assessment for ambulatory breast surgery
    T T Law
    Division of Breast Surgery, Department of Surgery, The University of Hong Kong Li Ka Shing Faculty of Medicine, Tung Wah Hospital, Sheung Wan, Hong Kong
    Hong Kong Med J 15:179-82. 2009
    ..To review the efficacy of telephone preoperative anaesthesia assessment in patients undergoing ambulatory breast surgery...
  30. doi request reprint Supportive care needs in Hong Kong Chinese women confronting advanced breast cancer
    Angel Au
    Centre for Psycho Oncology Research and Training, Department of Community Medicine and Unit for Behavioural Sciences, School of Public Health, The University of Hong Kong, Hong Kong
    Psychooncology 22:1144-51. 2013
    ..This cross-sectional study investigated the type and extent of unmet supportive care needs in Hong Kong Chinese women with advanced breast cancer...