S B Kombian

Summary

Affiliation: Kuwait University
Country: Kuwait

Publications

  1. ncbi Seizures induced by intracerebral administration of pyridoxal-5'-phosphate: effect of GABAergic drugs and glutamate receptor antagonists
    P Salazar
    Departamento de Neurociencias, Instituto de Fisiologia Celular, Universidad Nacional Autonoma de Mexico, AP 70 253, 04510, Mexico, DF, Mexico
    Neuropharmacology 41:546-53. 2001
  2. ncbi GABA(B) receptors modulate short-term potentiation of spontaneous excitatory postsynaptic currents in the rat supraoptic nucleus in vitro
    S B Kombian
    Faculty of Pharmacy, Kuwait University, PO Box 24923, 13110, Safat, Kuwait
    Neuropharmacology 41:554-64. 2001
  3. ncbi Modulation of synaptic transmission by oxytocin and vasopressin in the supraoptic nucleus
    S B Kombian
    Faculty of Pharmacy, Kuwait University, Kuwait
    Prog Brain Res 139:235-46. 2002
  4. ncbi Substance P depresses excitatory synaptic transmission in the nucleus accumbens through dopaminergic and purinergic mechanisms
    Samuel B Kombian
    Department of Applied Therapeutics, Faculty of Pharmacy, Health Science Center, Kuwait University, Safat 13110, Kuwait
    J Neurophysiol 89:728-37. 2003
  5. ncbi Dopamine and adenosine mediate substance P-induced depression of evoked IPSCs in the rat nucleus accumbens in vitro
    Samuel B Kombian
    Department of Applied Therapeutics, Faculty of Pharmacy, Health Science Center, Kuwait University, PO Box 24923, Safat 13110, Kuwait
    Eur J Neurosci 18:303-11. 2003
  6. ncbi Cholecystokinin activates CCKB receptors to excite cells and depress EPSCs in the rat rostral nucleus accumbens in vitro
    Samuel B Kombian
    Department of Applied Therapeutics, Faculty of Pharmacy, Health Science Centre, Kuwait University, PO Box 24923, Safat 13110, Kuwait
    J Physiol 555:71-84. 2004
  7. ncbi Role of protein kinase C in substance P-induced synaptic depression in the nucleus accumbens in vitro
    W C Matowe
    Department of Pharmacy Practice, Faculty of Pharmacy, Health Sciences Center, Kuwait University, Kuwait
    Med Princ Pract 16:90-9. 2007
  8. ncbi TH-9 (a theophylline derivative) induces long-lasting enhancement in excitatory synaptic transmission in the rat hippocampus that is occluded by frequency-dependent plasticity in vitro
    H Nashawi
    Department of Pharmacology and Therapeutics, Faculty of Pharmacy, Kuwait University, Kuwait
    Neuroscience 220:70-84. 2012
  9. ncbi In vitro electrophysiological investigations of the acute effects of linezolid and novel oxazolidinones on central nervous system neurons
    S B Kombian
    Department of Applied Therapeutics, Faculty of Pharmacy, Kuwait University, P O Box 24923, Safat 13110, Kuwait
    Neuroscience 180:53-63. 2011
  10. ncbi Concentration-dependent effects of anticonvulsant enaminone methyl 4-(4'-bromophenyl)aminocyclohex-3-en-6-methyl-2-oxo-1-oate on neuronal excitability in vitro
    K V V Ananthalakshmi
    Department of Applied Therapeutics, Faculty of Pharmacy, Kuwait University, P.O. Box 24923, Safat 13110, Kuwait
    Neuroscience 141:345-56. 2006

Collaborators

Detail Information

Publications23

  1. ncbi Seizures induced by intracerebral administration of pyridoxal-5'-phosphate: effect of GABAergic drugs and glutamate receptor antagonists
    P Salazar
    Departamento de Neurociencias, Instituto de Fisiologia Celular, Universidad Nacional Autonoma de Mexico, AP 70 253, 04510, Mexico, DF, Mexico
    Neuropharmacology 41:546-53. 2001
    ..This decrease might be due to the formation of a Schiff base between the carbonyl group of PLP and the epsilon-amino group of a functionally crucial lysine residue located in one extracellular loop of the GABA(A) receptor...
  2. ncbi GABA(B) receptors modulate short-term potentiation of spontaneous excitatory postsynaptic currents in the rat supraoptic nucleus in vitro
    S B Kombian
    Faculty of Pharmacy, Kuwait University, PO Box 24923, 13110, Safat, Kuwait
    Neuropharmacology 41:554-64. 2001
    ..By contrast, picrotoxin, a GABA(A) chloride channel blocker, had no effect on STP.These findings indicate that GABA is tonically present in the SON and its action at the GABA(B) receptor may determine the magnitude and duration of STP...
  3. ncbi Modulation of synaptic transmission by oxytocin and vasopressin in the supraoptic nucleus
    S B Kombian
    Faculty of Pharmacy, Kuwait University, Kuwait
    Prog Brain Res 139:235-46. 2002
    ....
  4. ncbi Substance P depresses excitatory synaptic transmission in the nucleus accumbens through dopaminergic and purinergic mechanisms
    Samuel B Kombian
    Department of Applied Therapeutics, Faculty of Pharmacy, Health Science Center, Kuwait University, Safat 13110, Kuwait
    J Neurophysiol 89:728-37. 2003
    ..Since the cellular and synaptic effects of SP resemble those of cocaine and amphetamine, it may serve as an endogenous psychogenic peptide...
  5. ncbi Dopamine and adenosine mediate substance P-induced depression of evoked IPSCs in the rat nucleus accumbens in vitro
    Samuel B Kombian
    Department of Applied Therapeutics, Faculty of Pharmacy, Health Science Center, Kuwait University, PO Box 24923, Safat 13110, Kuwait
    Eur J Neurosci 18:303-11. 2003
    ..SP therefore acts in the NAc to modulate both excitatory and inhibitory afferent inputs using the same mechanism(s)...
  6. ncbi Cholecystokinin activates CCKB receptors to excite cells and depress EPSCs in the rat rostral nucleus accumbens in vitro
    Samuel B Kombian
    Department of Applied Therapeutics, Faculty of Pharmacy, Health Science Centre, Kuwait University, PO Box 24923, Safat 13110, Kuwait
    J Physiol 555:71-84. 2004
    ..By contrast, it was completely blocked by CGP55845, a potent GABA(B) receptor-selective antagonist. These results indicate that CCK excites NAc cells directly while depressing evoked EPSCs indirectly, mainly through the release of GABA...
  7. ncbi Role of protein kinase C in substance P-induced synaptic depression in the nucleus accumbens in vitro
    W C Matowe
    Department of Pharmacy Practice, Faculty of Pharmacy, Health Sciences Center, Kuwait University, Kuwait
    Med Princ Pract 16:90-9. 2007
    ..This study set out to determine the roles of protein kinase A (PKA) and protein kinase C (PKC) signalling cascades in substance P- (SP-) mediated synaptic depression in the nucleus accumbens...
  8. ncbi TH-9 (a theophylline derivative) induces long-lasting enhancement in excitatory synaptic transmission in the rat hippocampus that is occluded by frequency-dependent plasticity in vitro
    H Nashawi
    Department of Pharmacology and Therapeutics, Faculty of Pharmacy, Kuwait University, Kuwait
    Neuroscience 220:70-84. 2012
    ..TH-9 may therefore employ similar or convergent mechanisms with frequency-dependent synaptic plasticities to produce the observed long-lasting enhancement in synaptic transmission and may thus, have potential for use in improving memory...
  9. ncbi In vitro electrophysiological investigations of the acute effects of linezolid and novel oxazolidinones on central nervous system neurons
    S B Kombian
    Department of Applied Therapeutics, Faculty of Pharmacy, Kuwait University, P O Box 24923, Safat 13110, Kuwait
    Neuroscience 180:53-63. 2011
    ....
  10. ncbi Concentration-dependent effects of anticonvulsant enaminone methyl 4-(4'-bromophenyl)aminocyclohex-3-en-6-methyl-2-oxo-1-oate on neuronal excitability in vitro
    K V V Ananthalakshmi
    Department of Applied Therapeutics, Faculty of Pharmacy, Kuwait University, P.O. Box 24923, Safat 13110, Kuwait
    Neuroscience 141:345-56. 2006
    ..These two actions of methyl 4-(4'-bromophenyl)aminocyclohex-3-en-6-methyl-2-oxo-1-oate on neuronal excitability would have therapeutic implications in future clinical use of enaminones as anticonvulsants in seizure disorders...
  11. ncbi Ultraviolet spectroscopy of anticonvulsant enaminones
    Ivan O Edafiogho
    Faculty of Pharmacy, Kuwait University, PO Box 24923, Safat 13110, Kuwait
    Bioorg Med Chem 10:593-7. 2002
    ..These results indicate that the anticonvulsant activity of enaminones is not due to electronic effect alone, but is probably due to a combination of factors including electronic and steric effects, lipophilicity, and hydrogen bonding...
  12. ncbi Selenium as a chemoprotective anti-cancer agent: reality or wishful thinking?
    L Novotny
    Faculty of Pharmacy, Kuwait University, Kuwait
    Neoplasma 57:383-91. 2010
    ..Information regarding Se, its effectiveness in various experimental models and in clinical tests, including combinations with other bioactive agents and anticancer drugs, is evaluated and summarized...
  13. ncbi Dopamine-induced synaptic depression in the parabrachial nucleus is independent of CTX- and PTX-sensitive G-proteins, PKA and PLC signalling pathways
    Xihua Chen
    Division of Basic Medical Sciences, Memorial University of Newfoundland, 300 Prince Philip Drive, St John s, Newfoundland, Canada A1B 3V6
    Brain Res 995:236-46. 2004
    ..Furthermore, it does not employ the adenylyl cyclase-cAMP-PKA cascade, the phospholipase C signalling pathway and NMDA receptor-coupled mechanisms to depress excitatory synaptic transmission in the PBN...
  14. ncbi Enaminones: Exploring additional therapeutic activities
    Ivan O Edafiogho
    Department of Pharmacy Practice, Faculty of Pharmacy, Kuwait University, P O Box 24923, Safat 13110, Kuwait
    J Pharm Sci 96:2509-31. 2007
    ..This review provides the background and current research in this area with emphasis of these agents as potential anticonvulsants, their proposed mechanisms of action, and as potential modulators of multidrug resistance (MDR)...
  15. ncbi Enaminones and norepinephrine employ convergent mechanisms to depress excitatory synaptic transmission in the rat nucleus accumbens in vitro
    Samuel B Kombian
    Department of Applied Therapeutics, Faculty of Pharmacy, Health Sciences Centre, Kuwait University, PO Box 24923, Safat 13110, Kuwait
    Eur J Neurosci 24:2781-8. 2006
    ....
  16. ncbi Cholecystokinin-2 receptors couple to cAMP-protein kinase A to depress excitatory synaptic currents in rat nucleus accumbens in vitro
    Samuel B Kombian
    Department of Applied Therapeutics, Kuwait University, Box 24923, Safat 13110, Kuwait
    Can J Physiol Pharmacol 84:203-11. 2006
    ..These findings indicate that cholecystokinin-2, but not GABA(B), receptors are coupled to the adenylyl cyclase-cAMP-protein kinase A signaling pathway in the NAc to induce inward currents and cause synaptic depression...
  17. ncbi 17beta-estradiol attenuates excitatory neurotransmission and enhances the excitability of rat parabrachial neurons in vitro
    Mohammad Fatehi
    Department of Biomedical Sciences, Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, Canada
    J Neurosci Res 84:666-74. 2006
    ..These observations are consistent with our previous findings and support a role for estrogen in modulating neurotransmission in this nucleus...
  18. ncbi Vasopressin differentially modulates non-NMDA receptors in vasopressin and oxytocin neurons in the supraoptic nucleus
    Michiru Hirasawa
    Neuroscience Research Group, Department of Physiology and Biophysics, University of Calgary, Calgary, Alberta, T2N 4N1 Canada
    J Neurosci 23:4270-7. 2003
    ..Thus, we conclude that vasopressin inhibits EPSCs in vasopressin neurons via postsynaptic V1a receptors, whereas it facilitates EPSCs in oxytocin neurons through oxytocin receptors...
  19. ncbi Anticonvulsant enaminones depress excitatory synaptic transmission in the rat brain by enhancing extracellular GABA levels
    Samuel B Kombian
    Department of Applied Therapeutics, Faculty of Pharmacy, Kuwait University, PO Box 24923, Safat 13110, Kuwait
    Br J Pharmacol 145:945-53. 2005
    ..Our data suggest that anticonvulsant enaminones cause EPSC depression by enhancing extracellular GABA levels possibly through the inhibition of either GABA reuptake or GABA-T enzyme, or both...
  20. ncbi Cholecystokinin inhibits evoked inhibitory postsynaptic currents in the rat nucleus accumbens indirectly through gamma-aminobutyric acid and gamma-aminobutyric acid type B receptors
    Samuel B Kombian
    Department of Applied Therapeutics, Faculty of Pharmacy, Kuwait University, Safat, Kuwait
    J Neurosci Res 79:412-20. 2005
    ..9% +/- 3.9%; n=4), a protein kinase A (PKA) inhibitor. These results indicate that CCK acts on CCKB receptors to increase extracellular levels of GABA, which then acts on GABAB receptors to decrease IPSC amplitude...
  21. ncbi Anticonvulsant evaluation and mechanism of action of benzylamino enaminones
    Ivan O Edafiogho
    Faculty of Pharmacy, Kuwait University, PO Box 24923, Safat 13110, Kuwait
    Bioorg Med Chem 14:5266-72. 2006
    ....
  22. ncbi Anticonvulsant enaminone E139 suppresses epileptiform activity in rat hippocampal slices
    Kethireddy V V Ananthalakshmi
    Department of Applied Therapeutics, Faculty of Pharmacy, Kuwait University, PO Box 24923, Safat 13110, Kuwait
    Epilepsy Res 76:85-92. 2007
    ..We conclude that E139 suppresses in vitro seizures in the hippocampus by synaptic and non-synaptic mechanisms. These actions on network activity may underlie their reported in vivo anticonvulsant effects...
  23. ncbi Synthesis and structure-activity relationship studies of theophylline analogs on population responses in the rat hippocampus in vitro
    Kethireddy V V Ananthalakshmi
    Department of Applied Therapeutics, Faculty of Pharmacy, Kuwait University, P O Box 24923, Safat 13110, Kuwait
    Bioorg Med Chem 16:8142-50. 2008
    ..Our results suggest that hexahydroazepin-2-one analogs have potential for further development as cognitive enhancers...