Research Topics


Narayana Kilarkaje


Affiliation: Kuwait University
Country: Kuwait


  1. Narayana K, Raghupathy R. DNA damage in lead-exposed hepatocytes: coexistence of apoptosis and necrosis?. Drug Chem Toxicol. 2012;35:208-17 pubmed publisher
    ..In conclusion, both apoptosis- and necrosis-related DNA damage coexist without significant oxidative DNA damage. Hepatocytes display changes related to necrosis, but not those related to apoptosis. ..
  2. Kilarkaje N, Al Hussaini H. Type 1 diabetes upregulates metastasis-associated protein 1- phosphorylated histone 2AX signaling in the testis. Eur J Pharmacol. 2019;846:30-37 pubmed publisher
    ..We conclude that diabetes upregulates MTA1-Ɣ-H2AX signaling in diabetic rat testis as a response to time-dependent increases in DNA double-strand breaks. ..
  3. Kilarkaje N. Effects of combined treatment of α-tocopherol, L-ascorbic acid, selenium and zinc on bleomycin, etoposide and cisplatin-induced alterations in testosterone synthesis pathway in rats. Cancer Chemother Pharmacol. 2014;74:1175-89 pubmed publisher
    ..The three cycles of BEP treatment inhibit the testosterone synthesis pathway even after the recovery time. The AC recovers the effects of BEP chemotherapy on a few steroidogenic enzymes. ..
  4. Al Hussaini H, Kilarkaje N. Effects of diabetes on retinal pigment epithelial cell proliferation and mitogen-activated protein kinase signaling in dark Agouti rats. Exp Toxicol Pathol. 2015;67:117-24 pubmed publisher
    ..Thus, modulation of mitogen-activated protein kinases signaling may be a putative therapeutic option to alleviate the genesis of diabetes-induced retinal disruptions including retinopathy. ..
  5. Al Bader M, Kilarkaje N. Effects of bleomycin, etoposide and cisplatin treatment on Leydig cell structure and transcription of steroidogenic enzymes in rat testis. Eur J Pharmacol. 2015;747:150-9 pubmed publisher
    ..The BEP chemotherapy inhibits the transcription of steroidogenic enzymes and that these effects sustain over an extended period of time without returning to normal levels. ..
  6. Al Hussaini H, Kilarkaje N. Effects of trans-resveratrol on type 1 diabetes-induced inhibition of retinoic acid metabolism pathway in retinal pigment epithelium of Dark Agouti rats. Eur J Pharmacol. 2018;834:142-151 pubmed publisher
    ..Trans-resveratrol supplementation is beneficial to normalize long-term effects, but not short-term effects, of diabetes on retinoic acid metabolism pathway in the RPE. ..
  7. Faid I, Al Hussaini H, Kilarkaje N. Resveratrol alleviates diabetes-induced testicular dysfunction by inhibiting oxidative stress and c-Jun N-terminal kinase signaling in rats. Toxicol Appl Pharmacol. 2015;289:482-94 pubmed publisher
    ..These results suggest that Resveratrol supplementation may be a useful strategy to treat diabetes-induced testicular dysfunction. ..
  8. Abdelali A, Al Bader M, Kilarkaje N. Effects of Trans-Resveratrol on hyperglycemia-induced abnormal spermatogenesis, DNA damage and alterations in poly (ADP-ribose) polymerase signaling in rat testis. Toxicol Appl Pharmacol. 2016;311:61-73 pubmed publisher
    ..In conclusion, Trans-Resveratrol mitigates T1DM-induced sperm abnormality and DNA damage, but does not significantly modulate PARP signaling pathway, except the SirT1 expression, in the rat testis. ..
  9. Al Bader M, Jasem S, Kilarkaje N. Carbenoxolone exposure during late gestation in rats alters placental expressions of p53 and estrogen receptors. Eur J Pharmacol. 2016;791:675-685 pubmed publisher
    ..In conclusion, carbenoxolone exposure changes placental p53, ER?, ER? expression in favor of cell death but these changes do not induce IUGR in rats. ..

More Information


  1. Kilarkaje N, Al Bader M. Diabetes-induced oxidative DNA damage alters p53-p21CIP1/Waf1 signaling in the rat testis. Reprod Sci. 2015;22:102-12 pubmed publisher
    ..Diabetes upregulates p21(CIP1/Waf1) signaling in testicular germ cells in association with alteration in p-p53ser315 expression, probably to counteract DNA damage-induced cell death. ..
  2. Kilarkaje N, Al Bader M. Effects of antioxidants on drugs used against testicular cancer-induced alterations in metastasis-associated protein 1 signaling in the rat testis. Toxicol Ind Health. 2016;32:89-97 pubmed publisher
    ..However, upregulation of MTA1 protein expression may be related to induced DNA damage. Modulation of MTA1 signaling is a novel mechanism of action of BEP and AO, which may be useful in developing newer anticancer drugs. ..
  3. Al Hussaini H, Kilarkaje N. Trans-resveratrol mitigates type 1 diabetes-induced oxidative DNA damage and accumulation of advanced glycation end products in glomeruli and tubules of rat kidneys. Toxicol Appl Pharmacol. 2018;339:97-109 pubmed publisher
    ..Resveratrol supplementation may be useful to hinder the onset and progression of diabetic kidney diseases. ..