Fahd Al Mulla
Affiliation: Faculty of Medicine
Ali H, Al Mulla F, Hussain N, Naim M, Asbeutah A, AlSahow A, et al
. PKD1 Duplicated regions limit clinical Utility of Whole Exome Sequencing for Genetic Diagnosis of Autosomal Dominant Polycystic Kidney Disease. Sci Rep. 2019;9:4141 pubmed publisher
..Enhancing reading depth, quality and sensitivity of WES in the PKD1 duplicated regions (exons 1-32) is crucial for its potential diagnostic or research applications. ..
Al Mulla F, MacKenzie E. Differences in in vitro invasive capacity induced by differences in Ki-Ras protein mutations. J Pathol. 2001;195:549-56 pubmed
..The precise mechanisms behind these biological differences in vivo and in vitro should now be investigated. ..
Al Mulla F, Abdulrahman M, Varadharaj G, Akhter N, Anim J. BRCA1 gene expression in breast cancer: a correlative study between real-time RT-PCR and immunohistochemistry. J Histochem Cytochem. 2005;53:621-9 pubmed
..Antibody 8F7 had the highest sensitivity of 100%, but its specificity was 30.4% if mRNA levels were considered as the reference standard. ..
Ali R, Marafie M, Bitar M, Al Dousari F, Ismael S, Bin Haider H, et al
. Gender-associated genomic differences in colorectal cancer: clinical insight from feminization of male cancer cells. Int J Mol Sci. 2014;15:17344-65 pubmed publisher
..In summary, our data show that some CNAs in CRC may be gender specific and that male cancers characterized by feminization may constitute a specific subset of CRCs that warrants further investigation. ..
Ali H, Hussain N, Naim M, Zayed M, Al Mulla F, Kehinde E, et al
. A novel PKD1 variant demonstrates a disease-modifying role in trans with a truncating PKD1 mutation in patients with autosomal dominant polycystic kidney disease. BMC Nephrol. 2015;16:26 pubmed publisher
..Understanding the molecular mechanism through which the gene exerts its disease modifying role may aid our understanding of the pathogenesis of ADPKD. ..
Jalkh N, Chouery E, Haidar Z, Khater C, Atallah D, Ali H, et al
. Next-generation sequencing in familial breast cancer patients from Lebanon. BMC Med Genomics. 2017;10:8 pubmed publisher
..Importantly, the overall mutation prevalence was equal to 40%, justifying the urgent need to deploy WES for the identification of genetic variants responsible for familial BC in the Lebanese population. ..
Al Mulla F, Bland J, Serratt D, Miller J, Chu C, Taylor G. Age-dependent penetrance of different germline mutations in the BRCA1 gene. J Clin Pathol. 2009;62:350-6 pubmed publisher
..The data have important ramifications on screening, genetic counselling and prophylactic treatment of BRCA1 gene mutation carriers. ..
Al Temaimi R, Tan T, Marafie M, Thiery J, Quirke P, Al Mulla F. Identification of 42 Genes Linked to Stage II Colorectal Cancer Metastatic Relapse. Int J Mol Sci. 2016;17: pubmed publisher
..The identified 42 genes may be useful for predicting metastatic relapse in stage II CRC. Further studies are necessary to validate these findings. ..
Al Mulla F, Hagan S, Al Ali W, Jacob S, Behbehani A, Bitar M, et al
. Raf kinase inhibitor protein: mechanism of loss of expression and association with genomic instability. J Clin Pathol. 2008;61:524-9 pubmed publisher
..RKIP loss by hypermethylation of its promoter could have a significant influence on colorectal cancer aneuploidy, which might explain its association with metastatic progression. ..