Fahd Al-Mulla

Summary

Affiliation: Faculty of Medicine
Country: Kuwait

Publications

  1. doi request reprint RKIP: much more than Raf kinase inhibitory protein
    Fahd Al-Mulla
    Faculty of Medicine, Department of Pathology, Kuwait University Health Sciences Centre, Safat, Kuwait
    J Cell Physiol 228:1688-702. 2013
  2. pmc A new model for raf kinase inhibitory protein induced chemotherapeutic resistance
    Fahd Al-Mulla
    Department of Pathology, Health Sciences Center, Kuwait University, Faculty of Medicine, Safat, Kuwait
    PLoS ONE 7:e29532. 2012
  3. ncbi request reprint Differences in in vitro invasive capacity induced by differences in Ki-Ras protein mutations
    F Al-Mulla
    Kuwait University, Faculty of Medicine, Department of Pathology Molecular Pathology Laboratory, P O Box 24923, Safat, Kuwait 13110
    J Pathol 195:549-56. 2001
  4. pmc Age-dependent penetrance of different germline mutations in the BRCA1 gene
    F Al-Mulla
    Department of Pathology, Safat, Kuwait
    J Clin Pathol 62:350-6. 2009
  5. pmc Metastatic recurrence of early-stage colorectal cancer is linked to loss of heterozygosity on chromosomes 4 and 14q
    F Al-Mulla
    Department of Pathology, Faculty of Medicine, Molecular Pathology Unit, Kuwait University, Kuwait
    J Clin Pathol 59:624-30. 2006
  6. doi request reprint RAF kinase inhibitory protein (RKIP) modulates cell cycle kinetics and motility
    Fahd Al-Mulla
    Department of Pathology, University of Kuwait, Faculty of Medicine, Health Sciences Center, 13110, Kuwait
    Mol Biosyst 7:928-41. 2011
  7. doi request reprint Raf kinase inhibitor protein RKIP enhances signaling by glycogen synthase kinase-3β
    Fahd Al-Mulla
    Department of Pathology, Faculty of Medicine, Health Sciences Center, Kuwait University, Safat, Kuwait, UK
    Cancer Res 71:1334-43. 2011
  8. ncbi request reprint BRCA1 gene expression in breast cancer: a correlative study between real-time RT-PCR and immunohistochemistry
    Fahd Al-Mulla
    Department of Pathology, Molecular Pathology Laboratory, Faculty of Medicine, Kuwait University, PO Box 24923, Safat 13110, Kuwait
    J Histochem Cytochem 53:621-9. 2005
  9. doi request reprint Microarray-based CGH and copy number analysis of FFPE samples
    Fahd Al-Mulla
    Molecular Pathology Unit, Health Sciences Center, Safat, Kuwait
    Methods Mol Biol 724:131-45. 2011
  10. doi request reprint Impaired TGF-β signaling and a defect in resolution of inflammation contribute to delayed wound healing in a female rat model of type 2 diabetes
    Fahd Al-Mulla
    Department of Pathology, University of Kuwait, Faculty of Medicine, Health Sciences Center, 13110, Kuwait
    Mol Biosyst 7:3006-20. 2011

Collaborators

Detail Information

Publications36

  1. doi request reprint RKIP: much more than Raf kinase inhibitory protein
    Fahd Al-Mulla
    Faculty of Medicine, Department of Pathology, Kuwait University Health Sciences Centre, Safat, Kuwait
    J Cell Physiol 228:1688-702. 2013
    ..Specific biological and functional niches are highlighted to focus future research towards an enhanced understanding of the multiple roles of RKIP in health and disease...
  2. pmc A new model for raf kinase inhibitory protein induced chemotherapeutic resistance
    Fahd Al-Mulla
    Department of Pathology, Health Sciences Center, Kuwait University, Faculty of Medicine, Safat, Kuwait
    PLoS ONE 7:e29532. 2012
    ..Our data illuminate, for the first time, the NRF2-KEAP 1 pathway as a possible target for personalized therapeutic intervention in RKIP depleted cancers...
  3. ncbi request reprint Differences in in vitro invasive capacity induced by differences in Ki-Ras protein mutations
    F Al-Mulla
    Kuwait University, Faculty of Medicine, Department of Pathology Molecular Pathology Laboratory, P O Box 24923, Safat, Kuwait 13110
    J Pathol 195:549-56. 2001
    ..The precise mechanisms behind these biological differences in vivo and in vitro should now be investigated...
  4. pmc Age-dependent penetrance of different germline mutations in the BRCA1 gene
    F Al-Mulla
    Department of Pathology, Safat, Kuwait
    J Clin Pathol 62:350-6. 2009
    ..This study addresses whether different exon mutations have variable expressivity especially in relation to the age of onset of breast cancer...
  5. pmc Metastatic recurrence of early-stage colorectal cancer is linked to loss of heterozygosity on chromosomes 4 and 14q
    F Al-Mulla
    Department of Pathology, Faculty of Medicine, Molecular Pathology Unit, Kuwait University, Kuwait
    J Clin Pathol 59:624-30. 2006
    ..To investigate the prognostic value for loss of heterozygosity (LOH) of chromosomes 4 and 14q in early-stage colorectal cancer (CRC)...
  6. doi request reprint RAF kinase inhibitory protein (RKIP) modulates cell cycle kinetics and motility
    Fahd Al-Mulla
    Department of Pathology, University of Kuwait, Faculty of Medicine, Health Sciences Center, 13110, Kuwait
    Mol Biosyst 7:928-41. 2011
    ....
  7. doi request reprint Raf kinase inhibitor protein RKIP enhances signaling by glycogen synthase kinase-3β
    Fahd Al-Mulla
    Department of Pathology, Faculty of Medicine, Health Sciences Center, Kuwait University, Safat, Kuwait, UK
    Cancer Res 71:1334-43. 2011
    ..RKIP levels in human colorectal cancer positively correlate with GSK3β expression. These findings reveal the RKIP/GSK3 axis as both a potential therapeutic target and a prognosis-based predictor of cancer progression...
  8. ncbi request reprint BRCA1 gene expression in breast cancer: a correlative study between real-time RT-PCR and immunohistochemistry
    Fahd Al-Mulla
    Department of Pathology, Molecular Pathology Laboratory, Faculty of Medicine, Kuwait University, PO Box 24923, Safat 13110, Kuwait
    J Histochem Cytochem 53:621-9. 2005
    ..Antibody 8F7 had the highest sensitivity of 100%, but its specificity was 30.4% if mRNA levels were considered as the reference standard...
  9. doi request reprint Microarray-based CGH and copy number analysis of FFPE samples
    Fahd Al-Mulla
    Molecular Pathology Unit, Health Sciences Center, Safat, Kuwait
    Methods Mol Biol 724:131-45. 2011
    ..This chapter gives a description of the several CGH-microarray platforms currently available and offers practical steps that guide you through optimal handling and superior aCGH data acquisition of DNA extracted from FFPE tissues...
  10. doi request reprint Impaired TGF-β signaling and a defect in resolution of inflammation contribute to delayed wound healing in a female rat model of type 2 diabetes
    Fahd Al-Mulla
    Department of Pathology, University of Kuwait, Faculty of Medicine, Health Sciences Center, 13110, Kuwait
    Mol Biosyst 7:3006-20. 2011
    ....
  11. ncbi request reprint Comparison of two probe preparation methods using long oligonucleotide microarrays
    Fahd Al-Mulla
    Kuwait University, Faculty of Medicine, Department of Pathology, Safat, Kuwait
    Biotechniques 37:827-33. 2004
    ..Overall, the microarray results generated by the poly(T) priming methodology should be viewed cautiously even when high reproducibility is evident...
  12. doi request reprint Raf kinase inhibitor protein: mechanism of loss of expression and association with genomic instability
    F Al-Mulla
    Department of Pathology, Molecular Pathology Unit, Faculty of Medicine, Kuwait University, Kuwait
    J Clin Pathol 61:524-9. 2008
    ..This study aims at correlating RKIP expression with chromosomal instability in colorectal cancer samples and identifies possible mechanisms of RKIP loss...
  13. ncbi request reprint Genetic profiling of stage I and II colorectal cancer may predict metastatic relapse
    Fahd Al-Mulla
    Molecular Pathology Laboratory, Department of Pathology, Faculty of Medicine, Kuwait University, Safat, Kuwait
    Mod Pathol 19:648-58. 2006
    ..Accordingly, the molecular genetic features of primary tumours should be considered in the mainstream management of patients with this specific stage of the disease...
  14. ncbi request reprint Raf kinase inhibitor protein expression in a survival analysis of colorectal cancer patients
    Fahd Al-Mulla
    Kuwait University, Faculty of Medicine, Safat, Kuwait
    J Clin Oncol 24:5672-9. 2006
    ..We examined whether RKIP expression in primary colorectal cancers (CRCs) correlates with the risk of metastasis and overall survival...
  15. doi request reprint Inflammation and apoptosis in aortic tissues of aged type II diabetes: amelioration with alpha-lipoic acid through phosphatidylinositol 3-kinase/Akt- dependent mechanism
    Milad S Bitar
    Department of Pharmacology and Toxicology, School of Medicine, Kuwait University, Kuwait
    Life Sci 86:844-53. 2010
    ....
  16. doi request reprint Caveolin-1/PTRF upregulation constitutes a mechanism for mediating p53-induced cellular senescence: implications for evidence-based therapy of delayed wound healing in diabetes
    Milad S Bitar
    Department of Pharmacology and Toxicology, Kuwait University, Safat, Kuwait
    Am J Physiol Endocrinol Metab 305:E951-63. 2013
    ..Overall, our data illuminate Cav-1/PTRF-1 as a key player of a novel signaling pathway that may link a heightened state of oxidative stress to cellular senescence and impaired wound healing in diabetes. ..
  17. doi request reprint Utilization of microarray platforms in clinical practice: an insight on the preparation and amplification of nucleic acids from frozen and fixed tissues
    Fahd Al-Mulla
    Department of Pathology, Faculty of Medicine, Kuwait University, Safat
    Methods Mol Biol 382:115-36. 2007
    ..This chapter decribes the methods used for nucleic acids preparation from frozen and formalin-fixed paraffin-embedded human tissues using macro-and microdissection and show their suitability for use in microarray experiments...
  18. doi request reprint Whole genome amplification of DNA extracted from FFPE tissues
    Mira Bosso
    Faculty of Medicine, Department of Pathology, Kuwait University, Safat, Kuwait
    Methods Mol Biol 724:161-80. 2011
    ..GenomePlex(®) is a registered trademark of Rubicon Genomics Incorporation...
  19. pmc ROS constitute a convergence nexus in the development of IGF1 resistance and impaired wound healing in a rat model of type 2 diabetes
    Milad S Bitar
    Department of Pharmacology and Toxicology, School of Medicine, PO Box 24923, Safat 13110, Kuwait
    Dis Model Mech 5:375-88. 2012
    ....
  20. pmc Reduced FHIT expression is associated with mismatch repair deficient and high CpG island methylator phenotype colorectal cancer
    Rabeah Abbas Al-Temaimi
    Human Genetics Unit, Pathology Department, Faculty of Medicine, Health Sciences Center, Kuwait University, State of Kuwait
    J Histochem Cytochem 61:627-38. 2013
    ..009) and loss of PMS2 protein expression (p=0.017). We conclude that FHIT expression may be a valuable marker for CRC subtyping, and its diagnostic, prognostic, and therapeutic potential should be perused. ..
  21. doi request reprint Immunocytochemical detection of raf kinase inhibitor protein and human papillomavirus profiling of normal and abnormal cervical ThinPrep samples
    Rana Al-Awadhi
    Department of Medical Laboratory Sciences, Faculty of Allied Health Sciences, Kuwait University, Kuwait City, Kuwait
    Acta Cytol 57:259-65. 2013
    ..RKIP was evaluated for its ability to distinguish between normal and abnormal cervical samples in the context of human papillomavirus (HPV) infections...
  22. pmc Genotypic and phenotypic differences between nodal and extranodal diffuse large B-Cell lymphomas
    Salah A Al-Humood
    Department of Pathology, Faculty of Medicine, Kuwait University, Safat, Kuwait
    J Histochem Cytochem 59:918-31. 2011
    ..The authors demonstrated for the first time a novel genome and proteome-based signatures that may differentiate the two lymphoma types...
  23. doi request reprint Uses of microarray platforms in cancer: a correlative study between genomic copy number changes and their expression at mRNA and protein levels
    Fahd Al-Mulla
    Department of Pathology, Faculty of Medicine, Kuwait University, Safat
    Methods Mol Biol 382:77-95. 2007
    ..The protocols described therein can be assimilated for the study of other human tissues including cancerous ones...
  24. doi request reprint The effect of prostate tissue inflammation in benign prostatic hyperplasia on enhancer of zeste homolog 2 ribonucleic acid expression
    May Al-Maghrebi
    Department of Biochemistry, Kuwait University, Safat, Kuwait
    Ann Saudi Med 32:262-8. 2012
    ....
  25. ncbi request reprint Nitric oxide dynamics and endothelial dysfunction in type II model of genetic diabetes
    Milad S Bitar
    Department of Pharmacology, Kuwait University, School of Medicine, Kuwait
    Eur J Pharmacol 511:53-64. 2005
    ..This phenomenon could play a potentially important role in the pathogenesis of diabetic endothelial dysfunction...
  26. doi request reprint A defect in Nrf2 signaling constitutes a mechanism for cellular stress hypersensitivity in a genetic rat model of type 2 diabetes
    Milad S Bitar
    Department of Pharmacology, Faculty of Medicine, Health Sciences Center, University of Kuwait, Safat, Kuwait
    Am J Physiol Endocrinol Metab 301:E1119-29. 2011
    ..Moreover, they may also offer a new perspective in the understanding and treatment of nonhealing diabetic wounds...
  27. ncbi request reprint Expression of estrogen receptor alpha and estrogen receptor beta in fine needle aspirates of breast carcinoma
    Kusum Kapila
    Cytology Unit and Cytology Laboratory, Department of Pathology, Faculty of Medicine, Kuwait University, Safat, Kuwait
    Acta Cytol 54:25-30. 2010
    ..To evaluate the expression of estrogen receptor beta (ERbeta) in fine needle aspirates (FNAs) and correlate the findings with its expression in tissue sections...
  28. ncbi request reprint BRCA1 gene expression in breast cancer in Kuwait: correlation with prognostic parameters
    M Amirrad
    Department of Pathology, Faculty of Medicine, Kuwait University, Kuwait
    Med Princ Pract 14:67-72. 2005
    ..This study assessed the BRCA1 gene expression in breast cancer in Kuwait, and compared it with other known prognostic factors for the disease...
  29. ncbi request reprint Glycolaldehyde induces apoptosis in a human breast cancer cell line
    May A Al-Maghrebi
    The Department of Biochemistry, Faculty of Medicine, Kuwait University, P O Box 24923, Safat 13110, Kuwait
    Arch Biochem Biophys 417:123-7. 2003
    ..These results suggest that glycolaldehyde might be an important mediator of neutrophil anti-tumor activity...
  30. ncbi request reprint Oxidative stress--mediated alterations in glucose dynamics in a genetic animal model of type II diabetes
    Milad S Bitar
    Department of Pharmacology and Toxicology, Faculty of Medicine, Kuwait University, P O Box 24923, Safat, Kuwait, 13110
    Life Sci 77:2552-73. 2005
    ....
  31. doi request reprint Comparison of the sensitivity and specificity of urine cytology, urinary nuclear matrix protein-22 and multitarget fluorescence in situ hybridization assay in the detection of bladder cancer
    Elijah O Kehinde
    Division of Urology, Department of Surgery, Faculty of Medicine, Kuwait University, Kuwait
    Scand J Urol Nephrol 45:113-21. 2011
    ....
  32. doi request reprint Evaluation of the PrimerDesign™ genesig real-time reverse transcription-polymerase chain reaction assay and the INFINITI® Respiratory Viral Panel Plus assay for the detection of human metapneumovirus in Kuwait
    Mariam Al-Turab
    Department of Microbiology, Faculty of Medicine, Kuwait University, Jabriya, Kuwait
    Diagn Microbiol Infect Dis 72:358-62. 2012
    ..hMPV types A and B could be identified in this study; however, discordant genotyping results were found between the direct sequencing method and the INFINITI(®) RVP-Plus assay in 33% of hMPV-positive patients...
  33. pmc Expressive genomic hybridisation: gene expression profiling at the cytogenetic level
    F Al-Mulla
    Department of Pathology, Molecular Pathology Unit, Kuwait University, Faculty of Medicine, PO Box 24923, Safat, Kuwait 13110
    Mol Pathol 56:210-7. 2003
    ....
  34. ncbi request reprint Reduction of Raf-1 kinase inhibitor protein expression correlates with breast cancer metastasis
    Suzanne Hagan
    Beatson Institute for Cancer Research, Signaling and Proteomics Laboratory, Glasgow, UK
    Clin Cancer Res 11:7392-7. 2005
    ..Therefore, we investigated whether RKIP expression is altered in clinical specimens of human primary breast cancers and their lymph node metastases...
  35. ncbi request reprint Clofibric acid, a peroxisome proliferator-activated receptor alpha ligand, inhibits growth of human ovarian cancer
    Yoshihito Yokoyama
    Department of Obstetrics and Gynecology, Hirosaki University School of Medicine, Hirosaki, Amori, Japan
    Mol Cancer Ther 6:1379-86. 2007
    ..We conclude that CA could be an effective agent in ovarian cancer and should be tested alone and in combination with other anticancer drugs...
  36. doi request reprint Methods for microarray data analysis
    Veronique De Bruyne
    Applied Maths BVBA, Sint Martens Latem
    Methods Mol Biol 382:373-91. 2007
    ....