Fahd Al-Mulla

Summary

Affiliation: Faculty of Medicine
Country: Kuwait

Publications

  1. ncbi A new model for raf kinase inhibitory protein induced chemotherapeutic resistance
    Fahd Al-Mulla
    Department of Pathology, Health Sciences Center, Kuwait University, Faculty of Medicine, Safat, Kuwait
    PLoS ONE 7:e29532. 2012
  2. ncbi Differences in in vitro invasive capacity induced by differences in Ki-Ras protein mutations
    F Al-Mulla
    Kuwait University, Faculty of Medicine, Department of Pathology Molecular Pathology Laboratory, P O Box 24923, Safat, Kuwait 13110
    J Pathol 195:549-56. 2001
  3. ncbi Impaired TGF-β signaling and a defect in resolution of inflammation contribute to delayed wound healing in a female rat model of type 2 diabetes
    Fahd Al-Mulla
    Department of Pathology, University of Kuwait, Faculty of Medicine, Health Sciences Center, 13110, Kuwait
    Mol Biosyst 7:3006-20. 2011
  4. ncbi Microarray-based CGH and copy number analysis of FFPE samples
    Fahd Al-Mulla
    Molecular Pathology Unit, Health Sciences Center, Safat, Kuwait
    Methods Mol Biol 724:131-45. 2011
  5. ncbi Raf kinase inhibitor protein RKIP enhances signaling by glycogen synthase kinase-3β
    Fahd Al-Mulla
    Department of Pathology, Faculty of Medicine, Health Sciences Center, Kuwait University, Safat, Kuwait, UK
    Cancer Res 71:1334-43. 2011
  6. ncbi RAF kinase inhibitory protein (RKIP) modulates cell cycle kinetics and motility
    Fahd Al-Mulla
    Department of Pathology, University of Kuwait, Faculty of Medicine, Health Sciences Center, 13110, Kuwait
    Mol Biosyst 7:928-41. 2011
  7. ncbi Age-dependent penetrance of different germline mutations in the BRCA1 gene
    F Al-Mulla
    Department of Pathology, Safat, Kuwait
    J Clin Pathol 62:350-6. 2009
  8. ncbi Raf kinase inhibitor protein: mechanism of loss of expression and association with genomic instability
    F Al-Mulla
    Department of Pathology, Molecular Pathology Unit, Faculty of Medicine, Kuwait University, Kuwait
    J Clin Pathol 61:524-9. 2008
  9. ncbi Metastatic recurrence of early-stage colorectal cancer is linked to loss of heterozygosity on chromosomes 4 and 14q
    F Al-Mulla
    Department of Pathology, Faculty of Medicine, Molecular Pathology Unit, Kuwait University, Kuwait
    J Clin Pathol 59:624-30. 2006
  10. ncbi BRCA1 gene expression in breast cancer: a correlative study between real-time RT-PCR and immunohistochemistry
    Fahd Al-Mulla
    Department of Pathology, Molecular Pathology Laboratory, Faculty of Medicine, Kuwait University, PO Box 24923, Safat 13110, Kuwait
    J Histochem Cytochem 53:621-9. 2005

Collaborators

Detail Information

Publications32

  1. ncbi A new model for raf kinase inhibitory protein induced chemotherapeutic resistance
    Fahd Al-Mulla
    Department of Pathology, Health Sciences Center, Kuwait University, Faculty of Medicine, Safat, Kuwait
    PLoS ONE 7:e29532. 2012
    ..Our data illuminate, for the first time, the NRF2-KEAP 1 pathway as a possible target for personalized therapeutic intervention in RKIP depleted cancers...
  2. ncbi Differences in in vitro invasive capacity induced by differences in Ki-Ras protein mutations
    F Al-Mulla
    Kuwait University, Faculty of Medicine, Department of Pathology Molecular Pathology Laboratory, P O Box 24923, Safat, Kuwait 13110
    J Pathol 195:549-56. 2001
    ..The precise mechanisms behind these biological differences in vivo and in vitro should now be investigated...
  3. ncbi Impaired TGF-β signaling and a defect in resolution of inflammation contribute to delayed wound healing in a female rat model of type 2 diabetes
    Fahd Al-Mulla
    Department of Pathology, University of Kuwait, Faculty of Medicine, Health Sciences Center, 13110, Kuwait
    Mol Biosyst 7:3006-20. 2011
    ....
  4. ncbi Microarray-based CGH and copy number analysis of FFPE samples
    Fahd Al-Mulla
    Molecular Pathology Unit, Health Sciences Center, Safat, Kuwait
    Methods Mol Biol 724:131-45. 2011
    ..This chapter gives a description of the several CGH-microarray platforms currently available and offers practical steps that guide you through optimal handling and superior aCGH data acquisition of DNA extracted from FFPE tissues...
  5. ncbi Raf kinase inhibitor protein RKIP enhances signaling by glycogen synthase kinase-3β
    Fahd Al-Mulla
    Department of Pathology, Faculty of Medicine, Health Sciences Center, Kuwait University, Safat, Kuwait, UK
    Cancer Res 71:1334-43. 2011
    ..RKIP levels in human colorectal cancer positively correlate with GSK3β expression. These findings reveal the RKIP/GSK3 axis as both a potential therapeutic target and a prognosis-based predictor of cancer progression...
  6. ncbi RAF kinase inhibitory protein (RKIP) modulates cell cycle kinetics and motility
    Fahd Al-Mulla
    Department of Pathology, University of Kuwait, Faculty of Medicine, Health Sciences Center, 13110, Kuwait
    Mol Biosyst 7:928-41. 2011
    ....
  7. ncbi Age-dependent penetrance of different germline mutations in the BRCA1 gene
    F Al-Mulla
    Department of Pathology, Safat, Kuwait
    J Clin Pathol 62:350-6. 2009
    ..This study addresses whether different exon mutations have variable expressivity especially in relation to the age of onset of breast cancer...
  8. ncbi Raf kinase inhibitor protein: mechanism of loss of expression and association with genomic instability
    F Al-Mulla
    Department of Pathology, Molecular Pathology Unit, Faculty of Medicine, Kuwait University, Kuwait
    J Clin Pathol 61:524-9. 2008
    ..This study aims at correlating RKIP expression with chromosomal instability in colorectal cancer samples and identifies possible mechanisms of RKIP loss...
  9. ncbi Metastatic recurrence of early-stage colorectal cancer is linked to loss of heterozygosity on chromosomes 4 and 14q
    F Al-Mulla
    Department of Pathology, Faculty of Medicine, Molecular Pathology Unit, Kuwait University, Kuwait
    J Clin Pathol 59:624-30. 2006
    ..To investigate the prognostic value for loss of heterozygosity (LOH) of chromosomes 4 and 14q in early-stage colorectal cancer (CRC)...
  10. ncbi BRCA1 gene expression in breast cancer: a correlative study between real-time RT-PCR and immunohistochemistry
    Fahd Al-Mulla
    Department of Pathology, Molecular Pathology Laboratory, Faculty of Medicine, Kuwait University, PO Box 24923, Safat 13110, Kuwait
    J Histochem Cytochem 53:621-9. 2005
    ..Antibody 8F7 had the highest sensitivity of 100%, but its specificity was 30.4% if mRNA levels were considered as the reference standard...
  11. ncbi Comparison of two probe preparation methods using long oligonucleotide microarrays
    Fahd Al-Mulla
    Kuwait University, Faculty of Medicine, Department of Pathology, Safat, Kuwait
    Biotechniques 37:827-33. 2004
    ..Overall, the microarray results generated by the poly(T) priming methodology should be viewed cautiously even when high reproducibility is evident...
  12. ncbi Genetic profiling of stage I and II colorectal cancer may predict metastatic relapse
    Fahd Al-Mulla
    Molecular Pathology Laboratory, Department of Pathology, Faculty of Medicine, Kuwait University, Safat, Kuwait
    Mod Pathol 19:648-58. 2006
    ..Accordingly, the molecular genetic features of primary tumours should be considered in the mainstream management of patients with this specific stage of the disease...
  13. ncbi Raf kinase inhibitor protein expression in a survival analysis of colorectal cancer patients
    Fahd Al-Mulla
    Kuwait University, Faculty of Medicine, Safat, Kuwait
    J Clin Oncol 24:5672-9. 2006
    ..We examined whether RKIP expression in primary colorectal cancers (CRCs) correlates with the risk of metastasis and overall survival...
  14. ncbi Inflammation and apoptosis in aortic tissues of aged type II diabetes: amelioration with alpha-lipoic acid through phosphatidylinositol 3-kinase/Akt- dependent mechanism
    Milad S Bitar
    Department of Pharmacology and Toxicology, School of Medicine, Kuwait University, Kuwait
    Life Sci 86:844-53. 2010
    ....
  15. ncbi Utilization of microarray platforms in clinical practice: an insight on the preparation and amplification of nucleic acids from frozen and fixed tissues
    Fahd Al Mulla
    Department of Pathology, Faculty of Medicine, Kuwait University, Safat
    Methods Mol Biol 382:115-36. 2007
    ..This chapter decribes the methods used for nucleic acids preparation from frozen and formalin-fixed paraffin-embedded human tissues using macro-and microdissection and show their suitability for use in microarray experiments...
  16. ncbi Whole genome amplification of DNA extracted from FFPE tissues
    Mira Bosso
    Faculty of Medicine, Department of Pathology, Kuwait University, Safat, Kuwait
    Methods Mol Biol 724:161-80. 2011
    ..GenomePlex(®) is a registered trademark of Rubicon Genomics Incorporation...
  17. ncbi ROS constitute a convergence nexus in the development of IGF1 resistance and impaired wound healing in a rat model of type 2 diabetes
    Milad S Bitar
    Department of Pharmacology and Toxicology, School of Medicine, PO Box 24923, Safat 13110, Kuwait
    Dis Model Mech 5:375-88. 2012
    ....
  18. ncbi Uses of microarray platforms in cancer: a correlative study between genomic copy number changes and their expression at mRNA and protein levels
    Fahd Al Mulla
    Department of Pathology, Faculty of Medicine, Kuwait University, Safat
    Methods Mol Biol 382:77-95. 2007
    ..The protocols described therein can be assimilated for the study of other human tissues including cancerous ones...
  19. ncbi Genotypic and phenotypic differences between nodal and extranodal diffuse large B-Cell lymphomas
    Salah A Al-Humood
    Department of Pathology, Faculty of Medicine, Kuwait University, Safat, Kuwait
    J Histochem Cytochem 59:918-31. 2011
    ..The authors demonstrated for the first time a novel genome and proteome-based signatures that may differentiate the two lymphoma types...
  20. ncbi The effect of prostate tissue inflammation in benign prostatic hyperplasia on enhancer of zeste homolog 2 ribonucleic acid expression
    May Al-Maghrebi
    Department of Biochemistry, Kuwait University, Safat, Kuwait
    Ann Saudi Med 32:262-8. 2012
    ....
  21. ncbi Nitric oxide dynamics and endothelial dysfunction in type II model of genetic diabetes
    Milad S Bitar
    Department of Pharmacology, Kuwait University, School of Medicine, Kuwait
    Eur J Pharmacol 511:53-64. 2005
    ..This phenomenon could play a potentially important role in the pathogenesis of diabetic endothelial dysfunction...
  22. ncbi A defect in Nrf2 signaling constitutes a mechanism for cellular stress hypersensitivity in a genetic rat model of type 2 diabetes
    Milad S Bitar
    Department of Pharmacology, Faculty of Medicine, Health Sciences Center, University of Kuwait, Safat, Kuwait
    Am J Physiol Endocrinol Metab 301:E1119-29. 2011
    ..Moreover, they may also offer a new perspective in the understanding and treatment of nonhealing diabetic wounds...
  23. ncbi Expression of estrogen receptor alpha and estrogen receptor beta in fine needle aspirates of breast carcinoma
    Kusum Kapila
    Cytology Unit and Cytology Laboratory, Department of Pathology, Faculty of Medicine, Kuwait University, Safat, Kuwait
    Acta Cytol 54:25-30. 2010
    ..To evaluate the expression of estrogen receptor beta (ERbeta) in fine needle aspirates (FNAs) and correlate the findings with its expression in tissue sections...
  24. ncbi BRCA1 gene expression in breast cancer in Kuwait: correlation with prognostic parameters
    M Amirrad
    Department of Pathology, Faculty of Medicine, Kuwait University, Kuwait
    Med Princ Pract 14:67-72. 2005
    ..This study assessed the BRCA1 gene expression in breast cancer in Kuwait, and compared it with other known prognostic factors for the disease...
  25. ncbi Glycolaldehyde induces apoptosis in a human breast cancer cell line
    May A Al-Maghrebi
    The Department of Biochemistry, Faculty of Medicine, Kuwait University, P O Box 24923, Safat 13110, Kuwait
    Arch Biochem Biophys 417:123-7. 2003
    ..These results suggest that glycolaldehyde might be an important mediator of neutrophil anti-tumor activity...
  26. ncbi Oxidative stress--mediated alterations in glucose dynamics in a genetic animal model of type II diabetes
    Milad S Bitar
    Department of Pharmacology and Toxicology, Faculty of Medicine, Kuwait University, P O Box 24923, Safat, Kuwait, 13110
    Life Sci 77:2552-73. 2005
    ....
  27. ncbi Comparison of the sensitivity and specificity of urine cytology, urinary nuclear matrix protein-22 and multitarget fluorescence in situ hybridization assay in the detection of bladder cancer
    Elijah O Kehinde
    Division of Urology, Department of Surgery, Faculty of Medicine, Kuwait University, Kuwait
    Scand J Urol Nephrol 45:113-21. 2011
    ....
  28. ncbi Evaluation of the PrimerDesign™ genesig real-time reverse transcription-polymerase chain reaction assay and the INFINITI® Respiratory Viral Panel Plus assay for the detection of human metapneumovirus in Kuwait
    Mariam Al-Turab
    Department of Microbiology, Faculty of Medicine, Kuwait University, Jabriya, Kuwait
    Diagn Microbiol Infect Dis 72:358-62. 2012
    ..hMPV types A and B could be identified in this study; however, discordant genotyping results were found between the direct sequencing method and the INFINITI(®) RVP-Plus assay in 33% of hMPV-positive patients...
  29. ncbi Expressive genomic hybridisation: gene expression profiling at the cytogenetic level
    F Al-Mulla
    Department of Pathology, Molecular Pathology Unit, Kuwait University, Faculty of Medicine, PO Box 24923, Safat, Kuwait 13110
    Mol Pathol 56:210-7. 2003
    ....
  30. ncbi Reduction of Raf-1 kinase inhibitor protein expression correlates with breast cancer metastasis
    Suzanne Hagan
    Beatson Institute for Cancer Research, Signaling and Proteomics Laboratory, Glasgow, UK
    Clin Cancer Res 11:7392-7. 2005
    ..Therefore, we investigated whether RKIP expression is altered in clinical specimens of human primary breast cancers and their lymph node metastases...
  31. ncbi Clofibric acid, a peroxisome proliferator-activated receptor alpha ligand, inhibits growth of human ovarian cancer
    Yoshihito Yokoyama
    Department of Obstetrics and Gynecology, Hirosaki University School of Medicine, Hirosaki, Amori, Japan
    Mol Cancer Ther 6:1379-86. 2007
    ..We conclude that CA could be an effective agent in ovarian cancer and should be tested alone and in combination with other anticancer drugs...
  32. ncbi Methods for microarray data analysis
    Veronique De Bruyne
    Applied Maths BVBA, Sint Martens Latem
    Methods Mol Biol 382:373-91. 2007
    ....