Michio Kuwahara

Summary

Publications

  1. doi request reprint Effects of three kinds of erythropoiesis-stimulating agents on renal anemia in Japanese non-dialysis chronic kidney disease patients
    Michio Kuwahara
    Department of Nephrology, Shuuwa General Hospital, 1200 Yahara Shinden, Kasukabe, Saitama, 344 0035, Japan
    Clin Exp Nephrol 18:755-62. 2014
  2. doi request reprint Type II diabetes mellitus is a risk factor for heart failure in pre-dialysis patients
    Michio Kuwahara
    Division of Nephrology, Shuuwa General Hospital, Kasukabe, Saitama, Japan
    Ther Apher Dial 16:541-7. 2012
  3. doi request reprint Effects of sevelamer hydrochloride on mortality, lipid abnormality and arterial stiffness in hemodialyzed patients: a propensity-matched observational study
    Soichiro Iimori
    Department of Nephrology, Shuwa General Hospital, Saitama, Japan
    Clin Exp Nephrol 16:930-7. 2012
  4. doi request reprint Diagnostic usefulness of bone mineral density and biochemical markers of bone turnover in predicting fracture in CKD stage 5D patients--a single-center cohort study
    Soichiro Iimori
    Department of Nephrology, Shuwa General Hospital, Saitama, Japan
    Nephrol Dial Transplant 27:345-51. 2012
  5. doi request reprint The impact of hyporesponsiveness to erythropoietin-stimulating agents on time-dependent mortality risk among CKD stage 5D patients: a single-center cohort study
    Junichi Ishigami
    Department of Nephrology, Shuwa General Hospital, 1200 Yahara Shinden Kasukabe shi, Saitama 344 0035, Japan
    Clin Exp Nephrol 17:106-14. 2013
  6. doi request reprint Effect of anemia on cardiac disorders in pre-dialysis patients immediately before starting hemodialysis
    Michio Kuwahara
    Division of Nephrology, Shuwa General Hospital, 1200 Yahara Shinden, Kasukabe, Saitama 344 0035, Japan
    Clin Exp Nephrol 15:121-5. 2011
  7. pmc Lower serum sodium level predicts higher risk of infection-related hospitalization in maintenance hemodialysis patients: an observational cohort study
    Shintaro Mandai
    Department of Nephrology, Shuuwa General Hospital, 1200 Yaharashinden, Kasukabe, Saitama 344 0035, Japan
    BMC Nephrol 14:276. 2013
  8. doi request reprint Rate of ankle-brachial index decline predicts cardiovascular mortality in hemodialysis patients
    Michio Kuwahara
    Department of Nephrology, Shuuwa General Hospital, Kasukabe, Japan
    Ther Apher Dial 18:9-18. 2014
  9. ncbi request reprint The C-terminal tail of aquaporin-2 determines apical trafficking
    Michio Kuwahara
    Department of Nephrology, Tokyo Medical and Dental University Graduate School, Japan
    Kidney Int 68:1999-2009. 2005
  10. pmc Baseline characteristics and prevalence of cardiovascular disease in newly visiting or referred chronic kidney disease patients to nephrology centers in Japan: a prospective cohort study
    Soichiro Iimori
    Department of Nephrology, Tokyo Medical and Dental University, 1 5 45 Yushima Bunkyo ku, Tokyo 113 8519, Japan
    BMC Nephrol 14:152. 2013

Collaborators

Detail Information

Publications20

  1. doi request reprint Effects of three kinds of erythropoiesis-stimulating agents on renal anemia in Japanese non-dialysis chronic kidney disease patients
    Michio Kuwahara
    Department of Nephrology, Shuuwa General Hospital, 1200 Yahara Shinden, Kasukabe, Saitama, 344 0035, Japan
    Clin Exp Nephrol 18:755-62. 2014
    ..Erythropoiesis-stimulating agents (ESAs) are standard therapy for chronic kidney disease (CKD) patients with renal anemia. However, few studies have compared the effects of different ESAs on anemia in identical pre-dialysis CKD patients...
  2. doi request reprint Type II diabetes mellitus is a risk factor for heart failure in pre-dialysis patients
    Michio Kuwahara
    Division of Nephrology, Shuuwa General Hospital, Kasukabe, Saitama, Japan
    Ther Apher Dial 16:541-7. 2012
    ..Our findings suggest that not only CKD, but also type II DM, is a potent risk for left ventricular dysfunction, which causes HF and IHD in pre-dialysis patients with CKD...
  3. doi request reprint Effects of sevelamer hydrochloride on mortality, lipid abnormality and arterial stiffness in hemodialyzed patients: a propensity-matched observational study
    Soichiro Iimori
    Department of Nephrology, Shuwa General Hospital, Saitama, Japan
    Clin Exp Nephrol 16:930-7. 2012
    ..The effects of sevelamer HCl on mortality, lipid abnormality and arterial stiffness were examined in patients with chronic kidney disease stage 5D...
  4. doi request reprint Diagnostic usefulness of bone mineral density and biochemical markers of bone turnover in predicting fracture in CKD stage 5D patients--a single-center cohort study
    Soichiro Iimori
    Department of Nephrology, Shuwa General Hospital, Saitama, Japan
    Nephrol Dial Transplant 27:345-51. 2012
    ..The reason for this may be the heterogeneity of underlying pathogenesis of the fracture...
  5. doi request reprint The impact of hyporesponsiveness to erythropoietin-stimulating agents on time-dependent mortality risk among CKD stage 5D patients: a single-center cohort study
    Junichi Ishigami
    Department of Nephrology, Shuwa General Hospital, 1200 Yahara Shinden Kasukabe shi, Saitama 344 0035, Japan
    Clin Exp Nephrol 17:106-14. 2013
    ..This study aimed to assess a safe dose of ESA and the impact of hyporesponsiveness to ESA on mortality risk among hemodialyzed patients...
  6. doi request reprint Effect of anemia on cardiac disorders in pre-dialysis patients immediately before starting hemodialysis
    Michio Kuwahara
    Division of Nephrology, Shuwa General Hospital, 1200 Yahara Shinden, Kasukabe, Saitama 344 0035, Japan
    Clin Exp Nephrol 15:121-5. 2011
    ....
  7. pmc Lower serum sodium level predicts higher risk of infection-related hospitalization in maintenance hemodialysis patients: an observational cohort study
    Shintaro Mandai
    Department of Nephrology, Shuuwa General Hospital, 1200 Yaharashinden, Kasukabe, Saitama 344 0035, Japan
    BMC Nephrol 14:276. 2013
    ..However, specific pathogenesis or diseases contributing to mortality in the hyponatremic population are unknown. This study aimed to clarify the relationship between serum sodium level (sNa) and infection risk in ESRD patients...
  8. doi request reprint Rate of ankle-brachial index decline predicts cardiovascular mortality in hemodialysis patients
    Michio Kuwahara
    Department of Nephrology, Shuuwa General Hospital, Kasukabe, Japan
    Ther Apher Dial 18:9-18. 2014
    ..03) and PAD (HR, 0.595; P < 0.0001) events. Our findings suggested that the rate of a decline in ABI and the baseline ABI value are potent correlation factors for survival and CVE morbidity among patients on hemodialysis in Japan...
  9. ncbi request reprint The C-terminal tail of aquaporin-2 determines apical trafficking
    Michio Kuwahara
    Department of Nephrology, Tokyo Medical and Dental University Graduate School, Japan
    Kidney Int 68:1999-2009. 2005
    ..When one of these mutant AQP-2s was expressed in Madin-Darby canine kidney (MDCK) cells, it was mistargeted to the basolateral membrane, suggesting a critical role of the C-terminal tail in the apical trafficking of AQP-2...
  10. pmc Baseline characteristics and prevalence of cardiovascular disease in newly visiting or referred chronic kidney disease patients to nephrology centers in Japan: a prospective cohort study
    Soichiro Iimori
    Department of Nephrology, Tokyo Medical and Dental University, 1 5 45 Yushima Bunkyo ku, Tokyo 113 8519, Japan
    BMC Nephrol 14:152. 2013
    ..In this report, we describe the baseline characteristics and risk factors for cardiovascular disease (CVD) prevalence among this cohort...
  11. ncbi request reprint Role of the E2F1-p19-p53 pathway in ischemic acute renal failure
    Hiroyuki Tanaka
    Department of Nephrology, Tokyo Medical and Dental University, Tokyo, Japan
    Nephron Physiol 101:p27-34. 2005
    ..The p16(INK4a)/p19(ARF) (alternative reading frame) locus encodes two proteins involved in cell cycle regulation. We investigated the transcriptional regulation and tissue distribution of p19(ARF) in ischemic acute renal failure (ARF)...
  12. pmc Reciprocal interaction with G-actin and tropomyosin is essential for aquaporin-2 trafficking
    Yumi Noda
    Department of Nephrology, Graduate School of Medicine, Tokyo Medical and Dental University, Bunkyo ku, Tokyo 113 8519, Japan
    J Cell Biol 182:587-601. 2008
    ..These findings indicate a novel mechanism of channel protein trafficking, in which the channel protein itself critically regulates local actin reorganization to initiate its movement...
  13. doi request reprint Helicobacter cinaedi kidney cyst infection and bacteremia in a patient with autosomal dominant polycystic kidney disease
    Shintaro Mandai
    Department of Nephrology, Shuuwa General Hospital, 1200 Yaharashinden, Kasukabe, Saitama 344 0035, Japan Electronic address
    J Infect Chemother 20:732-4. 2014
    ..Consideration of this bacterium as a possible pathogen and sufficient duration of incubation with molecular testing are necessary in treating ADPKD patients with cyst infection. ..
  14. doi request reprint Diagnostic value of B-type natriuretic peptide for estimating left atrial size and its usefulness for predicting all-cause mortality and cardiovascular events among chronic haemodialysis patients
    Junichi Ishigami
    Department of Nephrology, Shuuwa General Hospital, Saitama, Japan Department of Nephrology, Tokyo Medical and Dental University, Tokyo, Japan
    Nephrology (Carlton) 19:777-83. 2014
    ..B-type natriuretic peptide (BNP) is a useful surrogate marker in patients with congestive heart failure (CHF), but whether its validity could be generalized to haemodialysis patients has not been studied well...
  15. doi request reprint Effect of sevelamer hydrochloride on bone in experimental uremic rats
    Michio Kuwahara
    Department of Nephrology, Shuwa General Hospital, Kasukabe, Japan
    Ther Apher Dial 13:42-8. 2009
    ..Sevelamer inhibited the elevation of PoAr/CtAr, OS/Es, and Es BFR. Our findings suggest that the decrease in PTH by sevelamer may be beneficial in the treatment of high PTH-induced bone disease...
  16. ncbi request reprint [Case of immune complex crescentic glomerulonephritis with consistently high titers of MPO-ANCA for 6 years]
    Mikiko Ayada
    Division of Nephrology, Shuwa General Hospital, Saitama, Japan
    Nihon Jinzo Gakkai Shi 49:511-6. 2007
    ..When judging relapse and remission in ANCA-associated glomerulonephritis, it is important to evaluate the overall clinical findings and histopathological findings in addition to the serial ANCA titers...
  17. ncbi request reprint Expression of bone type 1 PTH receptor in rats with chronic renal failure
    Michio Kuwahara
    Division of Nephrology, Shuwa General Hospital, 1200 Yahara Shinden, Kasukabe, Saitama 344 0035, Japan
    Clin Exp Nephrol 11:34-40. 2007
    ..05). Our findings suggested that osteoblast PTH1R expression is down-regulated at both the protein and mRNA levels in the steady state of CRF...
  18. doi request reprint Mineral metabolism management in hemodialysis patients with secondary hyperparathyroidism in Japan: baseline data from the MBD-5D
    Masafumi Fukagawa
    Division of Nephrology, Endocrinology, and Metabolism, Tokai University School of Medicine, Isehara, Japan
    Am J Nephrol 33:427-37. 2011
    ..4-10.0 mg/dl), phosphorus (3.5-6.0 mg/dl), and intact parathyroid hormone (PTH) (60-180 pg/ml)...
  19. ncbi request reprint Aldosterone stimulates proliferation of mesangial cells by activating mitogen-activated protein kinase 1/2, cyclin D1, and cyclin A
    Yoshio Terada
    Department of Nephrology, Tokyo Medical and Dental University, 1 5 45, Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    J Am Soc Nephrol 16:2296-305. 2005
    ..MR antagonists may serve as a potential therapeutic approach to mesangial proliferative disease...
  20. ncbi request reprint Identification of a novel aquaporin, AQP12, expressed in pancreatic acinar cells
    Tomohiro Itoh
    Department of Nephrology, Graduate School of Medicine, Tokyo Medical and Dental University, 1 5 45 Yushima Bunkyo, Tokyo 113 8519, Japan
    Biochem Biophys Res Commun 330:832-8. 2005
    ..The selective localization of AQP12 in pancreatic acinar cells and possibly in the intracellular organelles suggests a role of AQP12 in digestive enzyme secretion such as maturation and exocytosis of secretory granules...