Ramadasan Kuttan

Summary

Publications

  1. pmc An evaluation of antioxidant, anti-inflammatory, and antinociceptive activities of essential oil from Curcuma longa. L
    Vijayastelter B Liju
    Department of Biochemistry, Amala Cancer Research Centre, Amala Nagar, Thrissur 680 555, Kerala, India
    Indian J Pharmacol 43:526-31. 2011
  2. doi request reprint Carotenoid lutein protects rats from gastric ulcer induced by ethanol
    Edakkadath R Sindhu
    Amala Cancer Research Center, Kerala, India
    J Basic Clin Physiol Pharmacol 23:33-7. 2012
  3. doi request reprint Antiangiogenic activity of ursolic acid
    Manu Kanjoormana
    Department of Immunology, Amala Cancer Research Centre, Amala Nagar, Thrissur, Kerala, India
    Integr Cancer Ther 9:224-35. 2010
  4. ncbi request reprint Punarnavine induces apoptosis in B16F-10 melanoma cells by inhibiting NF-kappaB signaling
    Kanjoormana Aryan Manu
    Department of Immunology, Amala Cancer Research Centre, Thrissur, Kerala, India
    Asian Pac J Cancer Prev 10:1031-7. 2009
  5. pmc Beneficial effects of green tea: A literature review
    Sabu M Chacko
    NPO International Laboratory of Biochemistry, 1 166 Uchide, Nakagawa Ku, Nagoya, 454 0926, Japan
    Chin Med 5:13. 2010
  6. ncbi request reprint Carotenoid lutein protects rats from paracetamol-, carbon tetrachloride- and ethanol-induced hepatic damage
    Edakkadath R Sindhu
    Amala Cancer Research Centre, Amala Nagar, Thrissur, Kerala, India
    J Pharm Pharmacol 62:1054-60. 2010
  7. ncbi request reprint Inhibition of viral carcinogenesis by Phyllanthus amarus
    Kuzhuvelil B Harikumar
    Amala Cancer Research Centre, Amala Nagar, Thrissur, Kerala, India
    Integr Cancer Ther 8:254-60. 2009
  8. ncbi request reprint Hepato-protective potential of carotenoid meso-zeaxanthin against paracetamol, CCl4 and ethanol induced toxicity
    Alikunjhi P Firdous
    Amala Cancer Research Centre, Amala Nagar P O, Thrissur 680 555, India
    Indian J Exp Biol 49:44-9. 2011
  9. ncbi request reprint Antidiabetic and antioxidant activity of Terminalia belerica. Roxb
    M C Sabu
    Amala Cancer Research Centre, Amala Nagar, Thrissur, India, 680 553
    Indian J Exp Biol 47:270-5. 2009
  10. ncbi request reprint Hypoglycemic effect of methanol extract of Phyllanthus amarus Schum & Thonn on alloxan induced diabetes mellitus in rats and its relation with antioxidant potential
    K Regi Raphael
    Amala Cancer Research Center, Amalanagar, Thrissur 680 553, India
    Indian J Exp Biol 40:905-9. 2002

Collaborators

  • Korangath C Preethi
  • Girija Kuttan
  • Edakkadath R Sindhu
  • M C Sabu
  • Kuzhuvelil B Harikumar
  • Kanjoormana Aryan Manu
  • Kottarapat Jeena
  • Alikunjhi P Firdous
  • K Regi Raphael
  • Sheeja T Tharakan
  • Vijayastelter B Liju
  • Vijayasteltar B Liju
  • Viswanathan Ramnath
  • K B Hari Kumar
  • N V Rajeshkumar
  • Alikkunjhi P Firdous
  • Alikkunjhi Pararikkal Firdous
  • A P Firdous
  • Sabu M Chacko
  • Manu Kanjoormana
  • Ellanzhiyil Surendran Sunila
  • K Rajagopalan
  • M Kesavan
  • Sunila Es
  • Kuzhuvelil Bhaskarannair Hari Kumar
  • V Ramnath
  • Kavitha Sivaraman Sreekanth
  • Ramanath Viswanathan
  • Ikuo Nishigaki
  • Priya T Thambi
  • - Austin
  • S Austin
  • C Nimita Venugopal
  • Preethi Kc
  • E S Sunila
  • Kb Hari Kumar
  • P S Lima
  • Leyon Varghese
  • Chittezhath Manesh
  • Muraleedharan G Nair
  • K L Joy
  • T A Ajith
  • Swarnam Joseph
  • R S Ramsewak

Detail Information

Publications55

  1. pmc An evaluation of antioxidant, anti-inflammatory, and antinociceptive activities of essential oil from Curcuma longa. L
    Vijayastelter B Liju
    Department of Biochemistry, Amala Cancer Research Centre, Amala Nagar, Thrissur 680 555, Kerala, India
    Indian J Pharmacol 43:526-31. 2011
    ..This study was aimed to evaluate the chemical composition, antioxidant potential in vitro and in vivo, anti-inflammatory, and antinociceptive activity of turmeric oil...
  2. doi request reprint Carotenoid lutein protects rats from gastric ulcer induced by ethanol
    Edakkadath R Sindhu
    Amala Cancer Research Center, Kerala, India
    J Basic Clin Physiol Pharmacol 23:33-7. 2012
    ..Carotenoid lutein was evaluated for antiulcerogenic activity in rats...
  3. doi request reprint Antiangiogenic activity of ursolic acid
    Manu Kanjoormana
    Department of Immunology, Amala Cancer Research Centre, Amala Nagar, Thrissur, Kerala, India
    Integr Cancer Ther 9:224-35. 2010
    ..Gelatin zymographic analysis showed the inhibitory effect of ursolic acid on the protein expression of matrix metalloproteinases MMP-2 and MMP-9. The above observation shows the antiangiogenic activity of ursolic acid...
  4. ncbi request reprint Punarnavine induces apoptosis in B16F-10 melanoma cells by inhibiting NF-kappaB signaling
    Kanjoormana Aryan Manu
    Department of Immunology, Amala Cancer Research Centre, Thrissur, Kerala, India
    Asian Pac J Cancer Prev 10:1031-7. 2009
    ..All these results demonstrate that Punarnavine induces apoptosis via activation of p53 induced caspase-3 mediated pro-apoptotic signaling and suppression of NF-kappaB induced Bcl-2 mediated survival signaling...
  5. pmc Beneficial effects of green tea: A literature review
    Sabu M Chacko
    NPO International Laboratory of Biochemistry, 1 166 Uchide, Nakagawa Ku, Nagoya, 454 0926, Japan
    Chin Med 5:13. 2010
    ..Further research that conforms to international standards should be performed to monitor the pharmacological and clinical effects of green tea and to elucidate its mechanisms of action...
  6. ncbi request reprint Carotenoid lutein protects rats from paracetamol-, carbon tetrachloride- and ethanol-induced hepatic damage
    Edakkadath R Sindhu
    Amala Cancer Research Centre, Amala Nagar, Thrissur, Kerala, India
    J Pharm Pharmacol 62:1054-60. 2010
    ..In the present study the carotenoid lutein (3,3'-dihydroxy-beta,epsilon-carotene) was evaluated for its hepatoprotective activity in rats...
  7. ncbi request reprint Inhibition of viral carcinogenesis by Phyllanthus amarus
    Kuzhuvelil B Harikumar
    Amala Cancer Research Centre, Amala Nagar, Thrissur, Kerala, India
    Integr Cancer Ther 8:254-60. 2009
    ..P.amarus is known to inhibit chemically induced neoplasm in different rodent models.The current results indicate that P.amarus has the ability to suppress virally induced cancers as well...
  8. ncbi request reprint Hepato-protective potential of carotenoid meso-zeaxanthin against paracetamol, CCl4 and ethanol induced toxicity
    Alikunjhi P Firdous
    Amala Cancer Research Centre, Amala Nagar P O, Thrissur 680 555, India
    Indian J Exp Biol 49:44-9. 2011
    ..Histopathological analysis of liver tissue showed the hepatoprotective potential of meso-zeaxanthin...
  9. ncbi request reprint Antidiabetic and antioxidant activity of Terminalia belerica. Roxb
    M C Sabu
    Amala Cancer Research Centre, Amala Nagar, Thrissur, India, 680 553
    Indian J Exp Biol 47:270-5. 2009
    ..Glutathione reductase also was found to be increased in blood and liver. These results suggested that T. belerica fruit extract possessed anti-diabetic and anti-oxidant activity and these activities may be interrelated...
  10. ncbi request reprint Hypoglycemic effect of methanol extract of Phyllanthus amarus Schum & Thonn on alloxan induced diabetes mellitus in rats and its relation with antioxidant potential
    K Regi Raphael
    Amala Cancer Research Center, Amalanagar, Thrissur 680 553, India
    Indian J Exp Biol 40:905-9. 2002
    ..Continued administration of the extract for 15 days produced significant (P < 0.001) reduction in blood sugar. On 18th day after alloxan administration values were almost similar to normal in the group taking 1000 mg/kg body wt...
  11. doi request reprint Amelioration of cisplatin-induced toxicity in mice by carotenoid meso-zeaxanthin
    A P Firdous
    Amala Cancer Research Centre, Amala Nagar, Thrissur, Kerala, India
    Hum Exp Toxicol 31:710-7. 2012
    ..The results of histopathological analysis supported the protective potential of MZ against cisplatin-induced toxicity...
  12. ncbi request reprint Antidiabetic activity of Aegle marmelos and its relationship with its antioxidant properties
    M C Sabu
    Amala Cancer Research Centre, Amala Nagar, Thrissur 680 553
    Indian J Physiol Pharmacol 48:81-8. 2004
    ..These results indicate that Aegle marmelos extract effectively reduced the oxidative stress induced by alloxan and produced a reduction in blood sugar...
  13. ncbi request reprint Antioxidant activity of carotenoid lutein in vitro and in vivo
    Edakkadath R Sindhu
    Amala Cancer Research Centre, Amala Nagar, Thrissur 680 555, India
    Indian J Exp Biol 48:843-8. 2010
    ..Implication of these results in terms of its role in reducing degenerative diseases is discussed...
  14. ncbi request reprint Carotenoid lutein protects the kidney against cisplatin-induced acute renal failure
    Edakkadath R Sindhu
    Amala Cancer Research Centre, Amala Nagar, Thrissur, Kerala 680 555, India
    J Environ Pathol Toxicol Oncol 32:21-8. 2013
    ..001). The results of the study show that lutein effectively protected the kidneys of mice treated with cisplatin; these results are also supported by the histopathologies of the kidney tissues of treated mice...
  15. ncbi request reprint Immunostimulatory action of AC II--an ayurvedic formulation useful in HIV
    Sheeja T Tharakan
    Amala Cancer Research Centre, Amala Nagar, Thrissur 680 555, India
    Indian J Exp Biol 46:47-51. 2008
    ..Administration of AC II was also found to increase the cytotoxic T lymphocyte production in EL4 treated mice. These studies support the use of this immune stimulatory preparation in HIV patients...
  16. ncbi request reprint Anti-diabetic activity of green tea polyphenols and their role in reducing oxidative stress in experimental diabetes
    M C Sabu
    Amala Cancer Research Centre, Amala Nagar, Trichur 680 553, Kerala, India
    J Ethnopharmacol 83:109-16. 2002
    ..These results indicate that alterations in the glucose utilizing system and oxidation status in rats increased by alloxan were partially reversed by the administration of the glutamate pyruvate transaminase...
  17. ncbi request reprint Inhibition of experimental gastric lesion and inflammation by Phyllanthus amarus extract
    K Regi Raphael
    Amala Cancer Research Centre, Thrissur, Kerala 680 553, India
    J Ethnopharmacol 87:193-7. 2003
    ..Anti-oxidant activity of the extract as well as presence of tannins in the extract may be responsible for these observed activities...
  18. ncbi request reprint Anti-tumour activity of Ruta graveolens extract
    K C Preethi
    Amala Cancer Research Centre, Amala Nagar, Thrissur, Kerala 680555, India
    Asian Pac J Cancer Prev 7:439-43. 2006
    ..These data indicates that the prooxidant activity of Ruta graveolens may be responsible for the cytocidal action of the extract and its ability to produce tumour reduction...
  19. ncbi request reprint Inhibition of metastasis of B16F-10 melanoma cells in C57BL/6 mice by an extract of Calendula officinalis L flowers
    Korangath C Preethi
    Department of Biochemistry, Amala Cancer Research Centre, Amala Nagar, Thrissur, Kerala, India
    Asian Pac J Cancer Prev 11:1773-9. 2010
    ..To determine the effect of a Calendula officinalis flower extract on lung metastasis by B16F-10 melanoma cells in C57BL/6 mice...
  20. doi request reprint Acute and subchronic toxicity as well as mutagenic evaluation of essential oil from turmeric (Curcuma longa L)
    Vijayasteltar B Liju
    Department of Biochemistry, Amala Cancer Research Centre, Amala Nagar 680555, Thrissur, Kerala, India
    Food Chem Toxicol 53:52-61. 2013
    ..Administration of TEO to rats (1 g/kg b.wt.) for 14 days did not produce any chromosome aberration or micronuclei in rat bone marrow cells and did not produce any DNA damage as seen by comet assay confirming the non toxicity of TEO...
  21. doi request reprint Amelioration of radiation-induced damages in mice by carotenoid meso-zeaxanthin
    Alikkunjhi P Firdous
    Amala Cancer Research Centre, Amala Nagar, Kerala
    Int J Radiat Biol 89:171-81. 2013
    ..The present study was undertaken to evaluate the radioprotective effect of meso-zeaxanthin, a xanthophyll carotenoid with profound antioxidant activity...
  22. doi request reprint Induction of apoptosis of tumor cells by some potentiated homeopathic drugs: implications on mechanism of action
    Korengath Preethi
    Amala Cancer Research Centre, Thrissur, Kerala, India
    Integr Cancer Ther 11:172-82. 2012
    ..Earlier studies indicated that homoeopathic medicines are cytotoxic to tumor cells and reduced animal tumors. However, the mechanism of homoeopathic medicines at the cellular level is not known...
  23. doi request reprint Phyllanthus amarus inhibits cell growth and induces apoptosis in Dalton's lymphoma ascites cells through activation of caspase-3 and downregulation of Bcl-2
    Kuzhuvelil B Harikumar
    Amala Cancer Research Centre, Amala Nagar, Thrissur, Kerala, India com
    Integr Cancer Ther 8:190-4. 2009
    ..So the present study provides some insights into the possible mechanism by which P. amarus brings about apoptosis and growth inhibition in DLA cells...
  24. ncbi request reprint Hepato and reno protective action of Calendula officinalis L. flower extract
    Korengath Chandran Preethi
    Department of Biochemistry Amala Cancer Research Centre, Amala Nagar, Thrissur, India, 680 555
    Indian J Exp Biol 47:163-8. 2009
    ..Extract has been found to contain several carotenoids of which lutein, zeaxanthin and lycopene predominates. Possible mechanism of action of the flower extract may be due to its antioxidant activity and reduction of oxygen radicals...
  25. ncbi request reprint Clastogenic potential of Ruta graveolens extract and a homeopathic preparation in mouse bone marrow cells
    Korengath C Preethi
    Department of Biochemistry, Amala Cancer Research Centre, Kerala, India
    Asian Pac J Cancer Prev 9:763-9. 2008
    ..5 to 50.2 after the extract treatment. Administration of Ruta 200C for 5 consecutive days increased the tail moment to 11.7. These results indicate that Ruta graveolens and Ruta 200C may induce genotoxicity in animals...
  26. ncbi request reprint Antimutagenic activity of Lutein--an oxycarotenoid present in the macula and its inhibition of cytochrome P 450 enzymes in vitro
    Edakkadath R Sindhu
    Amala Cancer Research Centre, Amala Nagar, Thrissur, Kerala 680 555, India
    Drug Metab Lett 6:213-20. 2012
    ..Results indicated that strong antioxidant activity of lutein as well as inhibition of carcinogen metabolisom enzymes are the major reason for the inhibition of mutagenicity by this oxycarotenoid...
  27. doi request reprint Effect of carotenoid lutein on N-nitrosodiethylamine-induced hepatocellular carcinoma and its mechanism of action
    Edakkadath R Sindhu
    Department of Biochemistry, Amala Cancer Research Centre, College of Veterinary and Animal Sciences, Thrissur, Kerala, India
    Eur J Cancer Prev 22:320-7. 2013
    ..Lutein is nontoxic and is one of the prime compounds in the chemoprevention trials of the future...
  28. ncbi request reprint Chemo protective activity of carotenoid meso-zeaxanthin against doxorubicin-induced cardio toxicity
    Alikunjhi P Firdous
    Amala Cancer Research Centre, India
    J Exp Ther Oncol 10:101-6. 2012
    ..Histopathological analysis further confirmed cardio-protective potential of this carotenoid...
  29. doi request reprint Toxicity profile of lutein and lutein ester isolated from marigold flowers (Tagetes erecta)
    Kuzhuvelil Bhaskarannair Harikumar
    Amala Cancer Research Centre, Amala Nagar, Thrissur, Kerala, India
    Int J Toxicol 27:1-9. 2008
    ..Histopathological analysis of the organs supported the nontoxicity of lutein and its ester form...
  30. ncbi request reprint Inhibition of progression of erythroleukemia induced by Friend virus in BALB/c mice by natural products--berberine, curcumin and picroliv
    Kuzhuvelil B Harikumar
    Amala Cancer Research Centre, Amala Nagar, Thrissur, Kerala, India
    J Exp Ther Oncol 7:275-84. 2008
    ..Overall, our results suggest that berberine, curcumin and picroliv were able to suppress the progression of leukemia induced by FMuLv and further support their chemopreventive potential against virally induced cancers...
  31. ncbi request reprint Effect of homeopathic medicines on transplanted tumors in mice
    Sunila Es
    Amala Cancer Research Centre, Amala Nagar, Thrissur, Kerala State, India 680555
    Asian Pac J Cancer Prev 8:390-4. 2007
    ..These findings support that homeopathic preparations of Ruta and Hydrastis have significant antitumour activity. The mechanism of action of these medicines is not known at present...
  32. ncbi request reprint Effect of AC II, an herbal formulation in cyclophosphamide-induced immunosuppression in BALB/c mice--Implication in HIV treatment
    Sheeja T Tharakan
    Amala Cancer Research Centre, Amala Nagar, Thrissur, Kerala, India
    Immunol Invest 36:147-57. 2007
    ..Results indicate the usefulness of AC II to combat immunosuppression induced by chemical and biological agents...
  33. ncbi request reprint Modulation of haematopoetic system and antioxidant enzymes by Emblica officinalis gaertn and its protective role against gamma-radiation induced damages in mice
    K B Hari Kumar
    Amala Cancer Research Centre, Thrissur, Kerala State, India
    J Radiat Res 45:549-55. 2004
    ..The data clearly indicated that the extract significantly reduced the bioeffects of radiation. Emblica extract may be useful in reducing the side effects produced during therapeutic radiation...
  34. doi request reprint Anticarcinogenic activity of meso-zeaxanthin in rodents and its possible mechanism of action
    Alikkunjhi Pararikkal Firdous
    Amala Cancer Research Centre, Kerala, India
    Nutr Cancer 65:850-6. 2013
    ..Results indicated that mode of action of MZ may be through inhibition of carcinogen activation coupled with enhancement of detoxification process. MZ may also inhibit promotion phases of carcinogenesis by its antioxidant activity...
  35. ncbi request reprint Effect of AC II, a herbal formulation on radiation-induced immunosuppression in mice
    Sheeja T Tharakan
    Amala Ayurvedic Hospital, Amala Nagar, Thrissur, India
    Indian J Exp Biol 44:719-25. 2006
    ..Similarly bone marrow cellularity and alpha-esterase positive cells, which were lowered by radiation, were partly restored in AC II treated groups. The data indicate that AC II can overcome the immunosuppression produced by irradiation...
  36. ncbi request reprint Anti-inflammatory activity of flower extract of Calendula officinalis Linn. and its possible mechanism of action
    Korengath Chandran Preethi
    Department of Biochemistry, Amala Cancer Research Centre, Amala Nagar, Thrissur 680 555, India
    Indian J Exp Biol 47:113-20. 2009
    ..The results showed that potent anti-inflammatory response of C. officinalis extract may be mediated by the inhibition of proinflammatory cytokines and Cox-2 and subsequent prostaglandin synthesis...
  37. ncbi request reprint Inhibition of N-Methyl N'-nitro-N-nitrosoguanidine (MNNG) induced gastric carcinogenesis by Phyllanthus amarus extract
    K Regi Raphael
    Amala Cancer Research Centre, Thrissur, Kerala 680 555, India
    Asian Pac J Cancer Prev 7:299-302. 2006
    ..6+/- 0.9 to 8.5+/-1.4 n mol/min/mg protein. AgNOR dots and clusters, indicators of cellular proliferation, which were increased by MNNG treatment, became near to normal in P. amarus treated animals...
  38. ncbi request reprint Antioxidant, anti-inflammatory and antinociceptive activities of essential oil from ginger
    Kottarapat Jeena
    Amala Cancer Research Centre, Amala Nagar, Thrissur 680 555, Kerala, India
    Indian J Physiol Pharmacol 57:51-62. 2013
    ..001). The present report revealed that ginger oil possesses antioxidant activity as well as significant anti-inflammatory and antinociceptive property...
  39. ncbi request reprint Modulation of carcinogenic response and antioxidant enzymes of rats administered with 1,2-dimethylhydrazine by Picroliv
    N V Rajeshkumar
    Amala Cancer Research Centre, Thrissur, Kerala 680 553, India
    Cancer Lett 191:137-43. 2003
    ..Picroliv treated liver resembled normal liver except the presence of a few degenerating cells. Renal anatomy was not altered by DMH administration...
  40. doi request reprint Inhibition of tumor progression by naturally occurring terpenoids
    Girija Kuttan
    Department of Immunology, Amala Cancer Research Centre, Amala Nagar, Thrissur, Kerala, India
    Pharm Biol 49:995-1007. 2011
    ..Effective ingredients in several plant-derived medicinal extracts are terpenoid compounds and many terpenes have biological activities and are used for the treatment of human diseases...
  41. ncbi request reprint Anti-mutagenic and anti-carcinogenic potential of the carotenoid meso-zeaxanthin
    Alikunjhi P Firdous
    Amala Cancer Research Centre, Amala Nagar P O, Kerala, India
    Asian Pac J Cancer Prev 11:1795-800. 2010
    ....
  42. ncbi request reprint Antioxidant activity of Smoke Shield in-vitro and in-vivo
    Kavitha Sivaraman Sreekanth
    Amala Cancer Research Centre, Amala Nagar, Thrissur 680 553, Kerala, India
    J Pharm Pharmacol 55:847-53. 2003
    ..These results indicate that Smoke Shield has potent antioxidant activity, could inhibit phase I enzymes and increase detoxifying enzymes, which makes it an effective chemoprotective herbal formulation...
  43. ncbi request reprint Inhibition of chemically induced carcinogenesis by drugs used in homeopathic medicine
    K B Hari Kumar
    Amala Cancer Research Centre, Amala Nagar, Thrissur, Kerala State, India
    Asian Pac J Cancer Prev 8:98-102. 2007
    ..These studies demonstrate that homeopathic drugs, at ultra low doses, may be able to decrease tumor induction by carcinogen administration. At present we do not know the mechanisms of action of these drugs useful against carcinogenesis...
  44. ncbi request reprint Wound healing activity of flower extract of Calendula officinalis
    Korengath C Preethi
    Department of Biochemistry, Amala Cancer Research Centre Amala Nagar, Thrissur 680555, Kerala, India
    J Basic Clin Physiol Pharmacol 20:73-9. 2009
    ..A significant increase was observed in the hydroxy proline and hexosamine content in the extract-treated group compared with the untreated animals. The data indicate potent wound healing activity ofC. officinalis extract...
  45. ncbi request reprint A preliminary assessment of the acute and subchronic toxicity profile of phase2: an alpha-amylase inhibitor
    Kuzhuvelil B Harikumar
    Amala Cancer Research Centre, Amala Nagar, Department of Animal Production and Aquatic Environment, Thrissur, India
    Int J Toxicol 24:95-102. 2005
    ..0 g/kg body weight). These data indicate that acute and subchronic administration of Phase2 did not produce any toxicity to rats as evident from weight change, mortality, and limited biochemical and histopathological analyses...
  46. ncbi request reprint Inhibition of drug metabolizing enzymes (cytochrome P450) in vitro as well as in vivo by Phyllanthus amarus SCHUM & THONN
    Kuzhuvelil Bhaskarannair Hari Kumar
    Amala Cancer Research Centre, Thrissur, India
    Biol Pharm Bull 29:1310-3. 2006
    ..The implication of these results on the inhibition of carcinogenesis produced by the extract is discussed...
  47. ncbi request reprint Effect of abrin on cell-mediated immune responses in mice
    V Ramnath
    Department of Physiology, College of Veterinary and Animal Sciences, Mannuthy, Kerala, India
    Immunopharmacol Immunotoxicol 28:259-68. 2006
    ..An early antibody dependent complement mediated cytotoxicity was observed in the abrin treated group on day 15 (27.6% cell lysis). Results of our present study suggest the immunomodulatory property of abrin...
  48. ncbi request reprint Anti-diabetic activity of medicinal plants and its relationship with their antioxidant property
    M C Sabu
    Amala Cancer Research Centre, Amala Nagar, Kerala Trichur 680 553, India
    J Ethnopharmacol 81:155-60. 2002
    ..Continued, daily administration of the drug produced a sustained effect...
  49. ncbi request reprint An extract of Phyllanthus amarus protects mouse chromosomes and intestine from radiation induced damages
    Kuzhuvelil Bhaskaran Nair Harikumar
    Amala Cancer Research Centre, Amala Nagar, Thrissur, India
    J Radiat Res (Tokyo) 48:469-76. 2007
    ..The administration of P.amarus was also found to decrease the percentage of chromosomal aberrations. Based on our present and previous reports it could be concluded that P.amarus extract has significant radioprotective activity...
  50. ncbi request reprint Anti-mutagenic activity of Phyllanthus amarus Schum & Thonn in vitro as well as in vivo
    K Regi Raphael
    Amala Cancer Research Centre, Thrissur, Kerala, India
    Teratog Carcinog Mutagen 22:285-91. 2002
    ..These results indicate significant anti-mutagenicity of the extract in vitro as well as in vivo...
  51. doi request reprint A preliminary 13-week oral toxicity study of ginger oil in male and female Wistar rats
    Kottarapat Jeena
    Amala Cancer Research Centre, Amala Nagar, Thrissur, Kerala, India
    Int J Toxicol 30:662-70. 2011
    ..These results confirmed that ginger oil is not toxic to male and female rats following subchronic oral administrations of up to 500 mg/kg per day (no observed adverse effect level [NOAEL])...
  52. ncbi request reprint Antimutagenic potential and modulation of carcinogen-metabolizing enzymes by ginger essential oil
    Kottarapat Jeena
    Amala Cancer Research Centre, Thrissur, Kerala, India
    Phytother Res 28:849-55. 2014
    ..Copyright © 2013 John Wiley & Sons, Ltd. ..
  53. ncbi request reprint Antitumor, anti-invasion, and antimetastatic effects of curcumin
    Girija Kuttan
    Department of Immunology, Amala Cancer Research Centre, Thrissur Kerala, India
    Adv Exp Med Biol 595:173-84. 2007
    ..These results indicate that curcumin acts at various stages of tumor cell progression...
  54. pmc Dynamized preparations in cell culture
    Ellanzhiyil Surendran Sunila
    Research Director, Amala Cancer Research Centre, Amala Nagar, Thrissur, Kerala 680 555, India
    Evid Based Complement Alternat Med 6:257-63. 2009
    ..These results indicate that dynamized medicines possess cytotoxic as well as apoptosis-inducing properties...
  55. ncbi request reprint Antitumour and anticarcinogenic activity of Phyllanthus amarus extract
    N V Rajeshkumar
    Amala Cancer Research Centre, Thrissur, Kerala, 680 553, India
    J Ethnopharmacol 81:17-22. 2002
    ..Antitumour and anticancer activity of P. amarus may be related with the inhibition of metabolic activation of carcinogen as well as the inhibition of cell cycle regulators and DNA repair...