Methanol extract of Desmodium gangeticum roots preserves mitochondrial respiratory enzymes, protecting rat heart against oxidative stress induced by reperfusion injuryGino A Kurian
MMM Academy of Medical Sciences, Institute of Cardiovascular Diseases, Madras Medical Mission, 4A Jayalalithanagar, Mogappair, Chennai 37, India
J Pharm Pharmacol 60:523-30. 2008
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Energy status determines the distinct biochemical and physiological behavior of interfibrillar and sub-sarcolemmal mitochondriaGino A Kurian
Department of Cellular Biochemistry and Human Genetics, The Hebrew University Hadassah Schools of Medicine and Dental Medicine, Ein Kerem, Jerusalem, Israel
Biochem Biophys Res Commun 428:376-82. 2012
..The distinct physiological-biochemical functions of the mitochondrial sub-populations during ischemia and reperfusion depend on the overall energy status of the mitochondrial sub-population...
Rat cardiac mitochondrial sub-populations show distinct features of oxidative phosphorylation during ischemia, reperfusion and ischemic preconditioningGino A Kurian
Department of Cellular Biochemistry and Human Genetics, The Hebrew University Hadassah Schools of Medicine and Dental Medicine, Jerusalem, Israel
Cell Physiol Biochem 30:83-94. 2012
..This study was undertaken to compare functional oxidative phosphorylation (OXPHOS) in IFM and SSM during ischemia, reperfusion and ischemic preconditioning...
Methanol extract of Desmodium gangeticum DC root mimetic post-conditioning effect in isolated perfused rat heart by stimulating muscarinic receptorsGino A Kurian
Medical Biochemistry, School of Chemical and Biotechnology, SASTRA University, Thanjavur, Tamil Nadu, India
Asian Pac J Trop Med 5:448-54. 2012
..To evaluate pharmacological mimetic action of herbal extract Desmodium gangeticum (DG) roots on ischemia reperfusion injury...
Effect of aqueous extract of the Desmodium gangeticum DC root in the severity of myocardial infarctionGino A Kurian
BITS Training Center, Institute of Cardiovascular Diseases, Madras Medical Mission, 4A Jayalalithanagar, Mogappair, Chennai 50, India
J Ethnopharmacol 97:457-61. 2005
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Administration of aqueous extract of Desmodium gangeticum (L) root protects rat heart against ischemic reperfusion injury induced oxidative stressGino A Kurian
MMM Academy of Medical Sciences, Institute of Cardiovascular Diseases, Madras Medical Mission, 4A Jayalalithanagar, Mogappair, Chennai 600 037, India
Indian J Exp Biol 47:129-35. 2009
..These results indicate that DG improves the antioxidant capacity of heart and attenuate the degree of lipid peroxidation after IR...
Antioxidant effects of ethyl acetate extract of Desmodium gangeticum root on myocardial ischemia reperfusion injury in rat heartsGino A Kurian
School of Chemical and Biotechnology, SASTRA University, Thirumalaisamudram, Thanjavur, Tamil Nadu, India
Chin Med 5:3. 2010
..CONCLUSION: The ethyl acetate extract of Desmodium gangeticum root protects the myocardium against ischemia-reperfusion-induced damage in rats. The effects of the extract may be related to the inhibition of lipid peroxidation...
N-acetylcysteine and magnesium improve biochemical abnormalities associated with myocardial ischaemic reperfusion in South Indian patients undergoing coronary artery bypass grafting: a comparative analysisG A Kurian
MMM Academy of Medical Sciences, Institute of Cardiovascular Diseases, Madras Medical Mission, 4A Jayalalithanagar, Mogappair, Chennai 600037, India
Singapore Med J 51:381-8. 2010
..The limited clinical success of anti-ischaemic reperfusion agents has prompted a comparison of the efficacy of N-acetylcysteine (NAC) and magnesium (Mg) in South Indian patients undergoing coronary artery bypass grafting (CABG)...
Antioxidant status of South Indian patients undergoing coronary artery bypass graft surgery: a role of intra operative magnesium supplementationGino A Kurian
Int J Cardiol 128:139-41. 2008
..However, the extensive treatment of the patients with magnesium influences the cellular response to ischemia and thus induces cardio-protection against oxidative stress...