Charles Kunos

Summary

Publications

  1. doi request reprint Role of stereotactic radiosurgery in gynecologic cancer
    Charles A Kunos
    Department of Radiation Oncology, Summa Comprehensive Cancer Institute, Akron, OH 44304, USA
    Curr Opin Oncol 25:532-8. 2013
  2. doi request reprint Radiochemotherapy plus 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP, NSC #663249) in advanced-stage cervical and vaginal cancers
    Charles A Kunos
    Department of Radiation Oncology, Case Comprehensive Cancer Center, University Hospitals Case Medical Center and Case Western Reserve University School of Medicine, Cleveland, OH 44106, United States
    Gynecol Oncol 130:75-80. 2013
  3. pmc Ribonucleotide reductase expression in cervical cancer: a radiation therapy oncology group translational science analysis
    Charles A Kunos
    University Hospitals of Cleveland, Cleveland, OH, USA
    Int J Gynecol Cancer 23:615-21. 2013
  4. pmc Inhibition of Poly(ADP-Ribose) Polymerase Enhances Radiochemosensitivity in Cancers Proficient in DNA Double-Strand Break Repair
    Lauren Shunkwiler
    Department of Radiation Oncology, Case Comprehensive Cancer Center, University Hospitals Case Medical Center and Case Western Reserve School of Medicine, Cleveland, OH 44106, USA
    Int J Mol Sci 14:3773-85. 2013
  5. doi request reprint Retrospective analysis of concomitant Cisplatin during radiation in patients aged 55 years or older for treatment of advanced cervical cancer: a gynecologic oncology group study
    Charles Kunos
    Department of Radiation Oncology, Case Comprehensive Cancer Center and University Hospitals of Cleveland Case Medical Center, Cleveland, Ohio, USA
    Int J Gynecol Cancer 19:1258-63. 2009
  6. pmc Posttherapy residual disease associates with long-term survival after chemoradiation for bulky stage 1B cervical carcinoma: a Gynecologic Oncology Group study
    Charles Kunos
    Department of Radiation Oncology, University Hospitals of Cleveland, Cleveland, OH 44106 5000, USA
    Am J Obstet Gynecol 203:351.e1-8. 2010
  7. doi request reprint 18F-fluoro-2-deoxy-D-glucose positron emission tomography standard uptake value ratio as an indicator of cervical cancer chemoradiation therapeutic response
    Charles Kunos
    Department of Radiation Oncology, Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA
    Int J Gynecol Cancer 21:1117-23. 2011
  8. doi request reprint Patterns of recurrence in stage I endometrioid endometrial adenocarcinoma with lymphovascular space invasion
    Fiona Simpkins
    Division of Gynecology Oncology, Department of Obstetrics and Gynecology, Cleveland Clinic Foundation, Cleveland, OH, USA
    Int J Gynecol Cancer 23:98-104. 2013
  9. ncbi request reprint Stereotactic body radiosurgery for pelvic relapse of gynecologic malignancies
    Charles Kunos
    Department of Radiation Oncology, Hospital of Cleveland MAILSTOP LTR 6068 Case Medical Center and Case Western Reserve University Cleveland, OH 44106, USA
    Technol Cancer Res Treat 8:393-400. 2009
  10. doi request reprint Concurrent cisplatin-based chemoradiation International Federation of Gynecology and Obstetrics stage IB2 cervical carcinoma
    Behiye P C Goksedef
    Section of Gynecologic Oncology, Department of Obstetrics and Gynecology, Cleveland Clinic, Cleveland, OH 44195, USA
    Am J Obstet Gynecol 200:175.e1-5. 2009

Collaborators

Detail Information

Publications17

  1. doi request reprint Role of stereotactic radiosurgery in gynecologic cancer
    Charles A Kunos
    Department of Radiation Oncology, Summa Comprehensive Cancer Institute, Akron, OH 44304, USA
    Curr Opin Oncol 25:532-8. 2013
    ..This current work offers an opinion on the evidence accumulated in humans regarding stereotactic ablative radiation (SABR) therapy, a favorable option for the treatment of persistent or recurrent metastatic gynecologic cancers...
  2. doi request reprint Radiochemotherapy plus 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP, NSC #663249) in advanced-stage cervical and vaginal cancers
    Charles A Kunos
    Department of Radiation Oncology, Case Comprehensive Cancer Center, University Hospitals Case Medical Center and Case Western Reserve University School of Medicine, Cleveland, OH 44106, United States
    Gynecol Oncol 130:75-80. 2013
    ..Cervical and vaginal cancers have virally-mediated or mutated defects in DNA damage repair responses, making these cancers sensible targets for ribonucleotide reductase inhibition during radiochemotherapy...
  3. pmc Ribonucleotide reductase expression in cervical cancer: a radiation therapy oncology group translational science analysis
    Charles A Kunos
    University Hospitals of Cleveland, Cleveland, OH, USA
    Int J Gynecol Cancer 23:615-21. 2013
    ..To evaluate pretherapy ribonucleotide reductase (RNR) expression and its effect on radiochemotherapeutic outcome in women with cervical cancer...
  4. pmc Inhibition of Poly(ADP-Ribose) Polymerase Enhances Radiochemosensitivity in Cancers Proficient in DNA Double-Strand Break Repair
    Lauren Shunkwiler
    Department of Radiation Oncology, Case Comprehensive Cancer Center, University Hospitals Case Medical Center and Case Western Reserve School of Medicine, Cleveland, OH 44106, USA
    Int J Mol Sci 14:3773-85. 2013
    ..Overall, our findings support enhanced radiochemotherapy toxicity in cancers proficient in DNA double-strand break repair when PARP is inhibited by ABT-888...
  5. doi request reprint Retrospective analysis of concomitant Cisplatin during radiation in patients aged 55 years or older for treatment of advanced cervical cancer: a gynecologic oncology group study
    Charles Kunos
    Department of Radiation Oncology, Case Comprehensive Cancer Center and University Hospitals of Cleveland Case Medical Center, Cleveland, Ohio, USA
    Int J Gynecol Cancer 19:1258-63. 2009
    ....
  6. pmc Posttherapy residual disease associates with long-term survival after chemoradiation for bulky stage 1B cervical carcinoma: a Gynecologic Oncology Group study
    Charles Kunos
    Department of Radiation Oncology, University Hospitals of Cleveland, Cleveland, OH 44106 5000, USA
    Am J Obstet Gynecol 203:351.e1-8. 2010
    ..The objective of the study was to study posttherapy chemoradiation hysterectomy histology with long-term survival in bulky stage 1(B) cervical cancer patients...
  7. doi request reprint 18F-fluoro-2-deoxy-D-glucose positron emission tomography standard uptake value ratio as an indicator of cervical cancer chemoradiation therapeutic response
    Charles Kunos
    Department of Radiation Oncology, Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA
    Int J Gynecol Cancer 21:1117-23. 2011
    ....
  8. doi request reprint Patterns of recurrence in stage I endometrioid endometrial adenocarcinoma with lymphovascular space invasion
    Fiona Simpkins
    Division of Gynecology Oncology, Department of Obstetrics and Gynecology, Cleveland Clinic Foundation, Cleveland, OH, USA
    Int J Gynecol Cancer 23:98-104. 2013
    ..The objective of this study was to determine the patterns of recurrence of stage IB-IIA endometrioid endometrial adenocarcinoma (EMCA) with lymphovascular invasion (LVSI)...
  9. ncbi request reprint Stereotactic body radiosurgery for pelvic relapse of gynecologic malignancies
    Charles Kunos
    Department of Radiation Oncology, Hospital of Cleveland MAILSTOP LTR 6068 Case Medical Center and Case Western Reserve University Cleveland, OH 44106, USA
    Technol Cancer Res Treat 8:393-400. 2009
    ..This study details our clinical experience with stereotactic body radiosurgery for treatment of patients with pelvic relapses of gynecologic malignancies after prior pelvic radiation...
  10. doi request reprint Concurrent cisplatin-based chemoradiation International Federation of Gynecology and Obstetrics stage IB2 cervical carcinoma
    Behiye P C Goksedef
    Section of Gynecologic Oncology, Department of Obstetrics and Gynecology, Cleveland Clinic, Cleveland, OH 44195, USA
    Am J Obstet Gynecol 200:175.e1-5. 2009
    ..The objective of the study was to assess the effectiveness of primary chemoradiation for stage IB(2) cervical carcinoma...
  11. pmc Ribonucleotide reductase inhibition restores platinum-sensitivity in platinum-resistant ovarian cancer: a Gynecologic Oncology Group Study
    Charles Kunos
    Department of Radiation Oncology, University Hospitals of Cleveland, Cleveland, OH 44106, USA
    J Transl Med 10:79. 2012
    ..The potent ribonucleotide reductase (RNR) inhibitor 3-aminopyridine-2-carboxyaldehyde-thiosemicarbazone (3-AP) was tested as a chemosensitizer for restored cisplatin-mediated cytotoxicity in platinum-resistant ovarian cancer...
  12. doi request reprint Stereotactic body radiation therapy for nonresectable tumors of the pancreas
    Kush Goyal
    Department of Surgery, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Surg Res 174:319-25. 2012
    ..We report on our experience with SBRT in patients with pancreatic adenocarcinoma who were found not to be candidates for surgical resection...
  13. doi request reprint Radiation therapy compared with pelvic node resection for node-positive vulvar cancer: a randomized controlled trial
    Charles Kunos
    Department of Radiation Oncology, University Hospitals of Cleveland, 11100 Euclid Avenue, Cleveland, OH 44106, USA
    Obstet Gynecol 114:537-46. 2009
    ..To report long-term survival and toxicity of radiation compared with pelvic node resection for patients with groin node-positive vulvar cancer...
  14. doi request reprint Stage I, grade 3 endometrioid adenocarcinoma of the endometrium: an analysis of clinical outcomes and patterns of recurrence
    Nabila Rasool
    Department of Obstetrics and Gynecology, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Gynecol Oncol 116:10-4. 2010
    ..To study patterns of recurrence and survival outcomes in patients with surgical stage I, grade 3 endometrioid adenocarcinoma of the endometrium (EA) treated with various treatment modalities...
  15. doi request reprint Emerging application of stereotactic body radiation therapy for gynecologic malignancies
    Nina A Mayr
    Arthur G James Cancer Hospital and Solove Research Institute Ohio State University, OH, USA
    Expert Rev Anticancer Ther 11:1069-75. 2011
    ..This article will consider indications for SBRT application in gynecological cancer management, will reflect on outcomes from key SBRT clinical trials and will discuss new therapeutic roles of SBRT for gynecological cancers...
  16. pmc Chemotherapy Administration during Pelvic Radiation for Cervical Cancer Patients Aged >/=55 Years in the SEER-Medicare Population
    Charles Kunos
    Department of Radiation Oncology, Case Comprehensive Cancer Center and University Hospitals of Cleveland Case Medical Center, Cleveland, OH 44106, USA
    J Oncol 2008:931532. 2008
    ..04). While SEER-Medicare data indicated an increasing trend for chemoradiation after the 1999 NCI clinical alert, chemoradiation was less frequent in elderly women with cervical cancer...
  17. ncbi request reprint Cyberknife radiosurgery for squamous cell carcinoma of vulva after prior pelvic radiation therapy
    Charles Kunos
    Department of Radiation Oncology, University Hospitals of Cleveland Case Medical Center and Case Western Reserve University, Cleveland, OH 44106, USA
    Technol Cancer Res Treat 7:375-80. 2008
    ..This study describes the first reported use of cyberknife radiosurgery for the treatment of recurrent vulvar cancer in three women...