Mei Ping Kung

Summary

Publications

  1. ncbi request reprint Amyloid plaque imaging from IMPY/SPECT to AV-45/PET
    Mei Ping Kung
    Department of Medical Imaging and Radiological Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan
    Chang Gung Med J 35:211-8. 2012
  2. ncbi request reprint Characterization of radioiodinated ligand binding to amyloid beta plaques
    Mei Ping Kung
    Department of Radiology, University of Pennsylvania, Philadelphia, PA 19014, USA
    J Mol Neurosci 20:249-54. 2003
  3. ncbi request reprint 2-(2-(dimethylaminomethyl)phenoxy)-5-iodophenylamine: an improved serotonin transporter imaging agent
    Hank F Kung
    Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Med Chem 47:5258-64. 2004
  4. ncbi request reprint IMPY: an improved thioflavin-T derivative for in vivo labeling of beta-amyloid plaques
    Mei Ping Kung
    Department of Radiology, University of Pennsylvania, 3700 Market Street, Room 305, Philadelphia, PA 19104, USA
    Brain Res 956:202-10. 2002
  5. ncbi request reprint Characterization of IMPY as a potential imaging agent for beta-amyloid plaques in double transgenic PSAPP mice
    Mei Ping Kung
    Department of Radiology, University of Pennsylvania, 3700 Market Street, Room 305, Philadelphia, PA 19104, USA
    Eur J Nucl Med Mol Imaging 31:1136-45. 2004
  6. ncbi request reprint 18F-labeled styrylpyridines as PET agents for amyloid plaque imaging
    Wei Zhang
    Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Nucl Med Biol 34:89-97. 2007
  7. ncbi request reprint Development and evaluation of iodinated tracers targeting amyloid plaques for SPECT imaging
    Mei Ping Kung
    Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Mol Neurosci 24:49-53. 2004
  8. pmc Brain imaging of vesicular monoamine transporter type 2 in healthy aging subjects by 18F-FP-(+)-DTBZ PET
    Kun Ju Lin
    Department of Medical Imaging and Radiological Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan Healthy Aging Research Center, Chang Gung University, Taoyuan, Taiwan Department of Nuclear Medicine and Molecular Imaging Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan
    PLoS ONE 8:e75952. 2013
  9. doi request reprint In vivo detection of monoaminergic degeneration in early Parkinson disease by (18)F-9-fluoropropyl-(+)-dihydrotetrabenzazine PET
    Shao Cheng Lin
    Department of Neurology, Chang Gung Memorial Hospital, Taoyuan, Taiwan
    J Nucl Med 55:73-9. 2014
  10. doi request reprint Perfusion-like template and standardized normalization-based brain image analysis using 18F-florbetapir (AV-45/Amyvid) PET
    Ing Tsung Hsiao
    Department of Medical Imaging and Radiological Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan
    Eur J Nucl Med Mol Imaging 40:908-20. 2013

Collaborators

Detail Information

Publications28

  1. ncbi request reprint Amyloid plaque imaging from IMPY/SPECT to AV-45/PET
    Mei Ping Kung
    Department of Medical Imaging and Radiological Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan
    Chang Gung Med J 35:211-8. 2012
    ..This review presents recent experience with Aβ-targeting radiotracers at Chang Gung University and Chang Gung Memorial Hospital...
  2. ncbi request reprint Characterization of radioiodinated ligand binding to amyloid beta plaques
    Mei Ping Kung
    Department of Radiology, University of Pennsylvania, Philadelphia, PA 19014, USA
    J Mol Neurosci 20:249-54. 2003
    ....
  3. ncbi request reprint 2-(2-(dimethylaminomethyl)phenoxy)-5-iodophenylamine: an improved serotonin transporter imaging agent
    Hank F Kung
    Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Med Chem 47:5258-64. 2004
    ..These data suggest that [(123)I]4 may be useful for imaging SERT binding sites in the brain by single photon emission computed tomography (SPECT)...
  4. ncbi request reprint IMPY: an improved thioflavin-T derivative for in vivo labeling of beta-amyloid plaques
    Mei Ping Kung
    Department of Radiology, University of Pennsylvania, 3700 Market Street, Room 305, Philadelphia, PA 19104, USA
    Brain Res 956:202-10. 2002
    ....
  5. ncbi request reprint Characterization of IMPY as a potential imaging agent for beta-amyloid plaques in double transgenic PSAPP mice
    Mei Ping Kung
    Department of Radiology, University of Pennsylvania, 3700 Market Street, Room 305, Philadelphia, PA 19104, USA
    Eur J Nucl Med Mol Imaging 31:1136-45. 2004
    ..Taken together, these data indicate that [123I]IMPY is a potentially useful SPECT imaging agent for in vivo labeling of Abeta plaques in the living brain...
  6. ncbi request reprint 18F-labeled styrylpyridines as PET agents for amyloid plaque imaging
    Wei Zhang
    Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Nucl Med Biol 34:89-97. 2007
    ..These preliminary results suggest that novel PET tracers may be potentially useful for the imaging of Abeta plaques in the living human brain...
  7. ncbi request reprint Development and evaluation of iodinated tracers targeting amyloid plaques for SPECT imaging
    Mei Ping Kung
    Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Mol Neurosci 24:49-53. 2004
    ..Only ligands with the promising in vitro and in vivo characteristics such as IMPY will likely warrant their success to be potential imaging agents mapping amyloid plaques in living human brain...
  8. pmc Brain imaging of vesicular monoamine transporter type 2 in healthy aging subjects by 18F-FP-(+)-DTBZ PET
    Kun Ju Lin
    Department of Medical Imaging and Radiological Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan Healthy Aging Research Center, Chang Gung University, Taoyuan, Taiwan Department of Nuclear Medicine and Molecular Imaging Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan
    PLoS ONE 8:e75952. 2013
    ..The goal was to explore the image features in normal human brains with (18)F-FP-(+)-DTBZ as a reference of molecular landmark for clinical diagnosis in Parkinson's disease (PD) and related disorders...
  9. doi request reprint In vivo detection of monoaminergic degeneration in early Parkinson disease by (18)F-9-fluoropropyl-(+)-dihydrotetrabenzazine PET
    Shao Cheng Lin
    Department of Neurology, Chang Gung Memorial Hospital, Taoyuan, Taiwan
    J Nucl Med 55:73-9. 2014
    ..PET with (18)F-9-fluoropropyl-(+)-dihydrotetrabenzazine ((18)F-DTBZ), a novel radiotracer targeting vesicular monoamine transporter type 2 (VMAT2), has been proven as a useful imaging marker to measure dopaminergic integrity...
  10. doi request reprint Perfusion-like template and standardized normalization-based brain image analysis using 18F-florbetapir (AV-45/Amyvid) PET
    Ing Tsung Hsiao
    Department of Medical Imaging and Radiological Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan
    Eur J Nucl Med Mol Imaging 40:908-20. 2013
    ..This work proposed and evaluated the performance of new MR-free spatial normalization methods using a perfusion-like template for amyloid PET imaging...
  11. ncbi request reprint Binding of two potential imaging agents targeting amyloid plaques in postmortem brain tissues of patients with Alzheimer's disease
    Mei Ping Kung
    Department of Radiology, University of Pennsylvania, 3700 Market Street, Room 305 Philadelphia, PA 19104, United States
    Brain Res 1025:98-105. 2004
    ..These properties suggest that when labeled with I-123 or C-11, these two ligands may be useful to quantitate amyloid plaque burdens in the living AD patients...
  12. ncbi request reprint New diphenylacetylenes as probes for positron emission tomographic imaging of amyloid plaques
    Rajesh Chandra
    Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Med Chem 50:2415-23. 2007
    ..These preliminary results suggest that the novel diphenylacetylenes may be potentially useful for imaging of Abeta plaques in the brain of patients with Alzheimer's disease...
  13. doi request reprint Quantitative analysis of binding sites for 9-fluoropropyl-(+)-dihydrotetrabenazine ([¹⁸F]AV-133) in a MPTP-lesioned PD mouse model
    Ko Ting Chao
    Department of Nuclear Medicine, Molecular Imaging Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan
    Synapse 66:823-31. 2012
    ..The aim of this study is to characterize and quantify the loss of monoamine neurons with [¹⁸F]AV-133 in the MPTP-lesioned PD mouse model using animal PET imaging and ex vivo quantitative autoradiography (QARG)...
  14. doi request reprint Optimal scanning time window for 18F-FP-(+)-DTBZ (18F-AV-133) summed uptake measurements
    Kun Ju Lin
    Department of Nuclear Medicine and Molecular Imaging Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan
    Nucl Med Biol 38:1149-55. 2011
    ..Studies were performed to optimize the imaging time window for calculating standardized uptake value ratio (SUVR) with correlation to distribution volume ratio (DVR) and in differentiating PD from normal controls (NCs)...
  15. doi request reprint Comparison of 99mTc-TRODAT-1 SPECT and 18 F-AV-133 PET imaging in healthy controls and Parkinson's disease patients
    Ing Tsung Hsiao
    Healthy Aging Research Center, and Department of Medical Imaging and Radiological Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan Molecular Imaging Center and Department of Nuclear Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan
    Nucl Med Biol 41:322-9. 2014
    ..The aim of this study is to compare both images in the same health control (HC) and PD subjects...
  16. ncbi request reprint Correlation of Parkinson Disease Severity and 18F-DTBZ Positron Emission Tomography
    Ing Tsung Hsiao
    Department of Medical Imaging and Radiological Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan2Healthy Aging Research Center, Chang Gung University, Taoyuan, Taiwan3Department of Nuclear Medicine and Molecular Imaging Center, Chang G
    JAMA Neurol 71:758-66. 2014
    ..CONCLUSIONS AND RELEVANCE In PD, 18F-DTBZ PET is a potential imaging biomarker for measuring dopaminergic degeneration in vivo and monitoring the severity of disease. ..
  17. doi request reprint Whole-body biodistribution and radiation dosimetry of 18F-FP-(+)-DTBZ (18F-AV-133): a novel vesicular monoamine transporter 2 imaging agent
    Kun Ju Lin
    Department of Nuclear Medicine and Molecular Imaging Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan
    J Nucl Med 51:1480-5. 2010
    ....
  18. pmc Characterization of optically resolved 9-fluoropropyl-dihydrotetrabenazine as a potential PET imaging agent targeting vesicular monoamine transporters
    Mei Ping Kung
    Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Nucl Med Biol 34:239-46. 2007
    ..From these findings, we conclude that [(18)F]FP-(+)-DTBZ is a sensitive and selective tracer for VMAT2 binding sites and it may be useful for in vivo evaluation of diseases relating to changes of monoamine neuronal integrity...
  19. pmc Fluoro-pegylated (FPEG) imaging agents targeting Abeta aggregates
    Karin A Stephenson
    Department of Radiology, University of Pennsylvania, 3700 Market Street, Room 305, Philadelphia, Pennsylvania 19104, USA
    Bioconjug Chem 18:238-46. 2007
    ..This approach appears to be effective in some core structures, but it cannot be uniformly applied to all structures...
  20. pmc 5-Chloro-2-(2'-((dimethylamino)methyl)-4'-iodophenylthio)benzenamine: a new serotonin transporter ligand
    Shunichi Oya
    Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Nucl Med Biol 34:129-39. 2007
    ..The excellent selective uptake and retention in the hypothalamus region suggest that [(123)I]7 is a potential lead compound for developing new imaging agents targeting SERT-binding sites with single-photon emission computed tomography...
  21. ncbi request reprint Occupancy of dopamine D2 receptors in the mouse brain measured using ultra-high-resolution single-photon emission tomography and [123]IBF
    Paul D Acton
    Department of Radiology, University of Pennsylvania, 3700 Market Street, Room 305, Philadelphia 19104, USA
    Eur J Nucl Med Mol Imaging 29:1507-15. 2002
    ..03 mg/kg using a single receptor site saturation model. This study has demonstrated clearly that ultra-high-resolution SPET of small animals is capable of measuring displacement and occupancy of dopamine D2 receptors by competing ligands...
  22. doi request reprint Validation of an (18)F-labeled biphenylalkyne as a positron emission tomography imaging agent for beta-amyloid plaques
    Shiaw Pyng Wey
    Department of Medical Imaging and Radiological Sciences, Graduate Institute of Medical Physics and Imaging Science, Chang Gung University, Taoyuan, 333 Taiwan
    Nucl Med Biol 36:411-7. 2009
    ..We report herein the preclinical validation of a potential (18)F-labeled biphenylalkyne, AV-138, as a preliminary step toward developing the imaging agent for patients suspected of having Alzheimer's disease...
  23. pmc Radioiodinated aza-diphenylacetylenes as potential SPECT imaging agents for beta-amyloid plaque detection
    Wenchao Qu
    Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Bioorg Med Chem Lett 17:3581-4. 2007
    ..Taken together, these preliminary results strongly suggest that these novel iodinated aza-diphenylacetylenes may be potentially useful for imaging Abeta plaques in the living human brain...
  24. pmc Regional amyloid deposition in amnestic mild cognitive impairment and Alzheimer's disease evaluated by [18F]AV-45 positron emission tomography in Chinese population
    Kuo Lun Huang
    Department of Neurology and Dementia Center, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan
    PLoS ONE 8:e58974. 2013
    ..To compare the neocortical amyloid loads among cognitively normal (CN), amnestic mild cognitive impairment (aMCI), and Alzheimer's disease (AD) subjects with [(18)F]AV-45 positron emission tomography (PET)...
  25. doi request reprint Binding characteristics of 9-fluoropropyl-(+)-dihydrotetrabenzazine (AV-133) to the vesicular monoamine transporter type 2 in rats
    Hsin Hsin Tsao
    Department of Medical Imaging and Radiological Sciences, Chang Gung University, Taoyuan, Taiwan
    Nucl Med Biol 37:413-9. 2010
    ..In the present study, we examined the binding characteristics of 9-fluoropropyl-(+)-dihydrotetrabenzazine ([(18)F]AV-133), a potential PET tracer for BCM imaging, in rat pancreas and rat brain...
  26. ncbi request reprint Safety, biodistribution, and dosimetry of 123I-IMPY: a novel amyloid plaque-imaging agent for the diagnosis of Alzheimer's disease
    Andrew B Newberg
    Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Nucl Med 47:748-54. 2006
    ..The pharmacologic safety profile of the compound was simultaneously assessed...
  27. ncbi request reprint Clinical acceptance of a molecular imaging agent: a long march with [99mTc]TRODAT
    Hank F Kung
    Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Nucl Med Biol 34:787-9. 2007
    ..The trials and tribulations of developing [99mTc]TRODAT for routine clinical use in Taiwan provide an interesting case study in how to (critics may say, how not to) develop a molecular imaging agent...
  28. pmc Quick assembly of 1,4-diphenyltriazoles as probes targeting beta-amyloid aggregates in Alzheimer's disease
    Wenchao Qu
    Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Med Chem 50:3380-7. 2007
    ....