Bioremediation of radionuclides: emerging technologiesRaj Kumar
Division of Radiation Biology and Radiation Protection, Institute of Nuclear Medicine and Allied Sciences, New Delhi 100 054, India
OMICS 11:295-304. 2007
..transcriptomics and proteomics. Studies combining functional transcriptomics and proteomics would create a system-wide approach studying the microbial metabolism in radionuclides detoxification...
Bioconversion of lignocellulosic biomass: biochemical and molecular perspectivesRaj Kumar
Radiation Biotechnology Unit, Division of Radiation Biology and Radiation Protection, Institute of Nuclear Medicine and Allied Sciences, New Delhi, 110054 India
J Ind Microbiol Biotechnol 35:377-91. 2008
....
Antioxidative and radioprotective activities of semiquinone glucoside derivative (SQGD) isolated from Bacillus sp. INM-1Raj Kumar
Institute of Nuclear Medicine and Allied Sciences, Delhi, India
Mol Cell Biochem 349:57-67. 2011
..Therefore, it can be concluded that SQGD is a natural stable o-semiquinone-type radical, possessing strong antioxidant activities and can effectively neutralize radiation induced free radicals in biological system...
Induction of immunostimulatory cytokine genes expression in human PBMCs by a novel semiquinone glucoside derivative (SQGD) isolated from a Bacillus sp. INM-1Raj Kumar
Institute of Nuclear Medicine and Allied Sciences, Delhi, India
Cell Immunol 267:67-75. 2011
..Further studies related to molecular mechanisms offering immunostimulation is underway, will certainly helpful to unravel its mode of action in the biological system...
Radioprotective and antioxidant properties of low-altitude Podophyllum hexandrum (LAPH)Rajesh Arora
Division of Radiopharmaceuticals and Radiation Biology, Institute of Nuclear Medicine and Allied Sciences, Delhi, India
J Environ Pathol Toxicol Oncol 24:299-314. 2005
....
Evaluation of radioprotective activities Rhodiola imbricata Edgew--a high altitude plantRajesh Arora
Division of Radiopharmaceuticals and Radiation Biology, Institute of Nuclear Medicine and Allied Sciences, Delhi, India
Mol Cell Biochem 273:209-23. 2005
..In conclusion, Rhodiola renders in vitro and in vivo radioprotection via multifarious mechanisms that act in a synergistic manner...
Radioprotective and antioxidant activity of fractionated extracts of berries of Hippophae rhamnoidesRaman Chawla
Institute of Nuclear Medicine and Allied Sciences, Defence Research and Development Organization, Jamia Hamdard, Hamdard Nagar, Delhi, India
J Med Food 10:101-9. 2007
..Further, REC-1001 was found to be nontoxic up to 200 mg/kg of body weight. This research suggests that the REC-1001 fraction of H. rhamnoides extract is a safe and effective antioxidant nutraceutical product...
Antioxidant activity of fractionated extracts of rhizomes of high-altitude Podophyllum hexandrum: role in radiation protectionRaman Chawla
Division of Radiopharmaceuticals and Radiation Biology, Institute of Nuclear Medicine and Allied Sciences, New Delhi, India
Mol Cell Biochem 273:193-208. 2005
..The present comparative study indicated that alcoholic (AE) and hydro-alcoholic (HA) fractions are the most promising fractions, which can effectively tackle radiation-induced oxidative stress...
Podophyllum hexandrum fraction (REC-2006) shows higher radioprotective efficacy in the p53-carrying hepatoma cell line: a role of cell cycle regulatory proteinsPankaj Kumar Singh
Institute of Nuclear Medicine and Allied Sciences, Delhi, India
Integr Cancer Ther 8:261-72. 2009
....
Zingiber officinale exhibits behavioral radioprotection against radiation-induced CTA in a gender-specific mannerAnupum Haksar
Division of Radiological Imaging, Bio-informatics and Radiation Biology, Institute of Nuclear Medicine and Allied Sciences, Brig. S. K. Mazumdar Road, Delhi-110054, India
Pharmacol Biochem Behav 84:179-88. 2006
..officinale possesses antioxidant, radioprotective and neuromodulatory properties that can be effectively utilized for behavioral radioprotection and for efficiently mitigating radiation-induced CTA in both males and females species...
Protection of the hemopoietic system by Podophyllum hexandrum against gamma radiation-induced damageRavinder Kumar Sagar
Department of Radiation Biology, Institute of Nuclear Medicine and Allied Sciences, Brig, SK Mazumdar Road, Delhi-110 054, India
Planta Med 72:114-20. 2006
..Further studies investigating the effects of REC-2001 on stem cell modulation are warranted...
3-O-beta-D-Galactopyranoside of quercetin as an active principle from high altitude Podophyllum hexandrum and evaluation of its radioprotective propertiesRaman Chawla
Department of Radiation Biology, Institute of Nuclear Medicine and Allied Sciences, Delhi, India
Z Naturforsch [C] 60:728-38. 2005
..This study implies that 3-O-beta-D-galactoside present in AEE renders radioprotection by protecting lipids, proteins in renal and neural model system against supra-lethal (0.25 kGy) gamma radiation...
Evaluation of silymarin as a promising radioprotectorManish Adhikari
Institute of Nuclear Medicine and Allied Sciences, Brig SK Mazumdar Marg, Delhi 110054, India
Z Naturforsch C 65:337-46. 2010
..The ability of INM-7035 to modulate the levels of NF-kappaB, indicated its inherent potential as a radioprotective bioactive constituent...
Radioprotection to small intestine of the mice against ionizing radiation by semiquinone glucoside derivative (SQGD) isolated from Bacillus sp. INM-1Dev Dutt Patel
Division of Radiation Biosciences, Institute of Nuclear Medicine and Allied Sciences, DRDO, Delhi, India
Mol Cell Biochem 370:115-25. 2012
....
Mint oil (Mentha spicata Linn.) offers behavioral radioprotection: a radiation-induced conditioned taste aversion studyA Haksar
Division of Radiation Biology and Radioprotection, Institute of Nuclear Medicine and Allied Sciences, Brig S K Mazumdar Road, Delhi 110 054, India
Phytother Res 23:293-6. 2009
..This finding clearly demonstrates that gastroprotective and calcium channel antagonizing properties of Mentha spicata can be effectively utilized in preventing radiation-induced behavioral changes...
Zingiber officinale Rosc. modulates gamma radiation-induced conditioned taste aversionAshok Sharma
Division of Radiopharmaceuticals and Radiation Biology, Institute of Nuclear Medicine and Allied Sciences, Brig. SK Mazumdar Road, Delhi 110 054, India
Pharmacol Biochem Behav 81:864-70. 2005
..Ginger extract has tremendous potential for clinical applications in mitigation of radiation-induced emesis in humans...
Radioprotection by plant products: present status and future prospectsRajesh Arora
Division of Radiopharmaceuticals and Radiation Biology, Institute of Nuclear Medicine and Allied Sciences, Defence Research and Development Organization, Brig. SK Mazumdar Road, Delhi-110 054, India
Phytother Res 19:1-22. 2005
....
Role of Apoptotic Proteins in REC-2006 Mediated Radiation Protection in Hepatoma Cell LinesPankaj Kumar Singh
Institute of Nuclear Medicine and Allied Sciences, Delhi, India
Evid Based Complement Alternat Med 2011:758326. 2011
....
In vitro studies on radioprotective efficacy of silymarin against γ-irradiationManish Adhikari
Department of Radiation Biotechnology, Radiation Biosciences Division and Division of CBRN Defence, Institute of Nuclear Medicine and Allied Sciences, Brig SK Mazumdar Marg, Delhi, India
Int J Radiat Biol 89:200-11. 2013
..In vitro experiments on HEK cells explicitly prove that silymarin is a promising, effective and safe radiation countermeasure agent...
Proteomic analysis of global changes in protein expression during exposure of gamma radiation in Bacillus sp. HKG 112 isolated from saline soilAnil Kumar Gupta
Division of Comparative Genomics, Institute of Genomics and Integrative Biology, Mall Road, New Delhi, India
J Microbiol Biotechnol 21:574-81. 2011
....
Electron paramagnetic resonance spectroscopy in radiation research: Current status and perspectivesSudha Rana
Division of CBRN Defence, Institute of Nuclear Medicine and Allied Sciences, Brig S K Mazumdar Marg, Timarpur Delhi 110054, India
J Pharm Bioallied Sci 2:80-7. 2010
..Various applications of EPR in radiation research studies are discussed in this review...
Salvage application of secondary blood cardioplegia in intractable ventricular fibrillationRajiv Lakhotia
Department of Cardiac Sciences, Sri Sathya Sai Institute of Higher Medical Sciences, Bangalore, India
J Cardiothorac Vasc Anesth 18:641-4. 2004
Determination of stature from cephalo-facial dimensions in a North Indian populationKewal Krishan
Department of Anthropology, Panjab University, Chandigarh 160 014, India
Leg Med (Tokyo) 9:128-33. 2007
....
Comparison of the impaired fasting blood glucose in young healthy individuals with diabetic and non-diabetic first degree relativesMumtaz Ali Shaikh
Department of Medicine, Liaquat University of Medical and Health Sciences, Jamshoro
J Coll Physicians Surg Pak 20:499-501. 2010
..To compare the fasting blood glucose (FBG) level in the healthy young individuals with diabetic first degree relatives considered as high risk and non-diabetic first degree relative considered as low risk...
Whole body protection to lethally irradiated mice by oral administration of semipurified fraction of Podophyllum hexandrum and post irradiation treatment of Picrorhiza kurroaManju Lata Gupta
Division of Radiation Biology and Radioprotection Institute of nuclear Medicine and Allied Sciences Brig SK Mazumdar Marg, Timarpur, Delhi 110054, India
Tokai J Exp Clin Med 33:6-12. 2008
..to evaluate the radioprotective potential of alcoholic fraction of Podophyllum hexandrum rhizomes (REC-2001) individually as well as in combination with Picrorhiza kurroa administered orally in lethally irradiated Swiss albino mice...
Radiation-induced biomarkers for the detection and assessment of absorbed radiation dosesSudha Rana
Division of CBRN Defence, Institute of Nuclear Medicine and Allied Sciences, Brig S K Mazumdar Marg, Delhi 110 054, India
J Pharm Bioallied Sci 2:189-96. 2010
..Serum enzymes such as serum amylase and diamine oxidase are the most promising biodosimeters. The level of gene expression and protein are also good biomarkers of radiation...
Himalayan Bioresource Rhodiola imbricata as a promising radioprotector for nuclear and radiological emergenciesRaman Chawla
Division of CBRN Defence, Institute of Nuclear Medicine and Allied Sciences, Brig SK Mazumdar Marg, Delhi 110 054, India
J Pharm Bioallied Sci 2:213-9. 2010
..In conclusion, solvent extraction and dose are crucial in bioactivity modulation and R. imbricata could be developed as a potential prophylactic radiation countermeasure for use in nuclear and radiological emergencies...
Breath carbon monoxide level of non-smokers exposed to environmental tobacco smokeRaj Kumar
Department of Respiratory Medicine, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi, India
Indian J Chest Dis Allied Sci 53:215-9. 2011
..Environmental tobacco smoke (ETS) exposure is a health hazard for non-smokers...
Podophyllum hexandrum (Himalayan mayapple) extract provides radioprotection by modulating the expression of proteins associated with apoptosisRaj Kumar
Division of Radiopharmaceuticals and Radiation Biology, Institute of Nuclear Medicine and Allied Sciences, Brigadier S.K. Mazumdar Road, Delhi-110054, India
Biotechnol Appl Biochem 42:81-92. 2005
..The present study thus clearly demonstrated that P. hexandrum extract provides protection from gamma-radiation by the modulation of expression of proteins associated with cell death...
Breath carbon monoxide concentration in cigarette and bidi smokers in IndiaRaj Kumar
Department of Respiratory Medicine, V P Chest Institute, University of Delhi, Delhi, India
Indian J Chest Dis Allied Sci 52:19-24. 2010
..To measure and compare the breath carbon monoxide (CO) levels in cigarette and bidi smokers in India...
Association of IL4 gene polymorphisms with asthma in North IndiansRana Nagarkatti
Institute of Genomics and Integrative Biology, Delhi University, Delhi, India
Int Arch Allergy Immunol 134:206-12. 2004
..The aim of our case-control study was to determine the association between IL4 and asthma in North Indians...
Identification of cross-reactive proteins amongst different Curvularia speciesRatna Gupta
Centre for Biochemical Technology, University of Delhi South Campus, Delhi, India
Int Arch Allergy Immunol 127:38-46. 2002
..lunata. CONCLUSIONS: A high degree of cross-reactivity was observed between C. lunata and the six other Curvularia species tested. C. lunata and C. senegalensis shared maximum allergenic and antigenic components...
Intraventricular neurocysticercus cyst(s) in Indian childrenRaj Kumar
Department of Neurosurgery, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
Pediatr Neurosurg 44:118-23. 2008
..Thus, we managed 6 of our cases with excision of the cysts obstructing the CSF pathway, and in 4 cases excision of cysts with ventriculoperitoneal shunt was adequate...
Tobacco cessation in IndiaV K Vijayan
Indian J Chest Dis Allied Sci 47:5-8. 2005
Outcome of meningomyelocele/lipomeningomyelocele in children of northern IndiaRaj Kumar
Department of Neurosurgery, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
Pediatr Neurosurg 43:7-14. 2007
..To evaluate the clinical profile, associated anomalies and surgical outcome of children with meningomyelocele (MMC)/lipomeningomyelocele...
Expression and secretion of a prokaryotic protein streptokinase without glycosylation and degradation in Schizosaccharomyces pombeRaj Kumar
Institute of Microbial Technology, Sector 39A, Chandigarh 160036, India
Yeast 21:1343-58. 2004
..We suggest that the unique vector/strain system developed here could be advantageous for large-scale production of prokaryotic proteins without significant modification or degradation in Sz. pombe...
Childhood choroid plexus papillomas: operative complicationsRaj Kumar
Department of Neurosurgery and Anaesthesia, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow 226014, UP, India
Childs Nerv Syst 21:138-43. 2005
..All children presented with features of raised intracranial pressure. Due to gross hydrocephalus with severe manifestations at admission two patients required CSF diversion before definitive surgery...
Spinal dysraphism: trends in northern IndiaRaj Kumar
Department of Neurosurgery, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
Pediatr Neurosurg 38:133-45. 2003
..To evaluate the clinical profiles, image findings and surgical outcome of 155 cases of spinal dysraphism...
Evaluation of allergic bronchopulmonary aspergillosis in patients with and without central bronchiectasisRaj Kumar
Department of Respiratory Medicine, Vallabhbhai Patel Chest Institute, University of Delhi, India
J Asthma 39:473-7. 2002
..This may be due to early recognition and treatment. The present data suggest that ABPA-S represents the early stage of an apparently less aggressive form of ABPA than ABPA-CB...
Comparative study of complex spina bifida and split cord malformationRaj Kumar
Department of Neurosurgery, Sanjay Gandhi Post Graduate Institute of Medical Sciences and King Georges Medical University, Lucknow, India
Indian J Pediatr 72:109-15. 2005
..To see the difference in clinical profiles, radiological findings and surgical outcome of the group 1 split cord malformation and meningomyelocele (SCM with MMC) from group 2 (SCM without MMC)...
Spinal tuberculosis: with reference to the children of northern IndiaRaj Kumar
Department of Neurosurgery, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow 226014, UP, India
Childs Nerv Syst 21:19-26. 2005
..Fifteen of our children made a remarkable recovery. Children with paraplegia also made an excellent recovery of their strength and sensations...
Benign intradural extramedullary masses in children of northern IndiaRaj Kumar
Department of Neurosurgery, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
Pediatr Neurosurg 41:22-8. 2005
....
Mefloquine toxicity presenting with polyneuropathy - a report of two cases in IndiaSanjeev Jha
Department of Neurology, Sanjay Gandhi PGIMS, Raebareli Road, Lucknow 226014, India
Trans R Soc Trop Med Hyg 100:594-6. 2006
..We report two cases of people from different states in India who developed polyneuropathy following intake of mefloquine for treatment of malaria. To the best of our knowledge this has not been reported before...
Intracranial sinonasal undifferentiated carcinoma (SNUC) in a childRaj Kumar
Department of Neurosurgery, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 26014, India
Childs Nerv Syst 22:1208-11. 2006
..Sinonasal undifferentiated carcinoma (SNUC) is a rare and relatively newly described clinicopathological entity of the nasal cavity and paranasal sinuses...
LC and LC-MS study of stress decomposition behaviour of isoniazid and establishment of validated stability-indicating assay methodHemant Bhutani
Department of Pharmaceutical Analysis, National Institute of Pharmaceutical Education and Research, Sector 67, S A S Nagar 160062, Punjab, India
J Pharm Biomed Anal 43:1213-20. 2007
..The same was indicated to be responsible for discolouration of isoniazid bulk drug substance and formulations, which is a familiar problem. The mechanism of formation of the said compound is outlined...
Relevance of serum IgE estimation in allergic bronchial asthma with special reference to food allergyRaj Kumar
Department of Respiratory Medicine, Vallabhbhai Patel Chest Institute, University of Delhi, India
Asian Pac J Allergy Immunol 24:191-9. 2006
..Specific IgE, three times of normal controls correlates well with positive DBPCFC and offers evidence for the cases of food allergy...
Biotechnological production of gluconic acid: future implicationsOm V Singh
Department of Pediatrics, The Johns Hopkins School of Medicine, 600 N Wolfe St, CMSC, 3 106, Baltimore, MD 21287, USA
Appl Microbiol Biotechnol 75:713-22. 2007
..8%, and banana must may assist reducing the overall cost of GA production. These methodologies would open new markets and increase applications of GA...
Association of indoor and outdoor air pollutant level with respiratory problems among children in an industrial area of Delhi, IndiaRaj Kumar
Vallabhbhai Patel Chest Institute, University of Delhi, India
Arch Environ Occup Health 62:75-80. 2007
..Results suggest that both indoor and outdoor particulate exposure may be important risk factors in the development of respiratory illness in children...
Association of IFNG gene polymorphism with asthma in the Indian populationRana Nagarkatti
The Center for Biochemical Technology, Mall Road, Delhi
J Allergy Clin Immunol 110:410-2. 2002
..Furthermore, a previously reported promoter polymorphism at the -333 base pair position was not detected in our population. This is the first report on the association of a candidate gene with asthma from the Indian subcontinent...