Anil Kumar

Summary

Publications

  1. Kumar A, Kaur H, Singh A. Neuropathic Pain models caused by damage to central or peripheral nervous system. Pharmacol Rep. 2017;70:206-216 pubmed publisher
    ..The development of novel, but rational analgesic drugs to alleviate this intractable pain demands elucidation of molecular mechanisms of NP for which different types of animal models have been established. ..
  2. Kumar A, Chanana P. Role of Nitric Oxide in Stress-Induced Anxiety: From Pathophysiology to Therapeutic Target. Vitam Horm. 2017;103:147-167 pubmed publisher
    ....
  3. Kumar A, Kumari B, Kumar P. Protective effects of selective and non-selective cyclooxygenase inhibitors in an animal model of chronic stress. Neurosci Bull. 2010;26:17-27 pubmed publisher
    ..p.) significantly attenuated these behavioral and biochemical (oxidative damage) alterations in chronic-stressed mice. The cyclooxygenase inhibitors could be used in the management of chronic fatigue-like conditions. ..
  4. Kumar A, Aakriti -, Gupta V. A review on animal models of stroke: An update. Brain Res Bull. 2016;122:35-44 pubmed publisher
    ....
  5. Bhardwaj M, Kumar A. Neuroprotective mechanism of Coenzyme Q10 (CoQ10) against PTZ induced kindling and associated cognitive dysfunction: Possible role of microglia inhibition. Pharmacol Rep. 2016;68:1301-1311 pubmed publisher
    ..The present study suggests the involvement of microglia inhibition in the protective effect of CoQ10 in PTZ induced kindling in mice. ..
  6. Kumar A, Aggrawal A, Pottabathini R, Singh A. Possible neuroprotective mechanisms of clove oil against icv-colchicine induced cognitive dysfunction. Pharmacol Rep. 2016;68:764-72 pubmed publisher
    ..The present study highlights that the major neuroprotective effect of clove oil due to its mitochondrial restoring and anti-oxidant properties along with a microglial inhibitory mechanism. ..
  7. Kumar A, Chanana P, Choudhary S. Emerging role of orexin antagonists in insomnia therapeutics: An update on SORAs and DORAs. Pharmacol Rep. 2016;68:231-42 pubmed publisher
    ..The present review focuses on the orexin peptides and receptors signifying their physiological profile as well as the development of orexin receptor antagonists as novel strategies in sleep medicine. ..
  8. Pottabathini R, Kumar A, Bhatnagar A, Garg S, Ekavali E. Ameliorative potential of pioglitazone and ceftriaxone alone and in combination in rat model of neuropathic pain: Targeting PPARγ and GLT-1 pathways. Pharmacol Rep. 2016;68:85-94 pubmed publisher
    ....
  9. Kumar A, Sharma N, Gupta A, Kalonia H, Mishra J. Neuroprotective potential of atorvastatin and simvastatin (HMG-CoA reductase inhibitors) against 6-hydroxydopamine (6-OHDA) induced Parkinson-like symptoms. Brain Res. 2012;1471:13-22 pubmed publisher
    ..The findings of the present study demonstrate the neuroprotective potential of statins in experimental model of 6-OHDA induced Parkinson like symptoms. ..
  10. Kumar A, Garg R, Gaur V, Kumar P. Nitric oxide mechanism in protective effect of imipramine and venlafaxine against acute immobilization stress-induced behavioral and biochemical alteration in mice. Neurosci Lett. 2009;467:72-5 pubmed publisher
    ..Present study highlights the involvement of nitric oxide mechanism in the protective effect of imipramine and venlafaxine against acute immobilization-induced behavioral and biochemical alterations in mice. ..

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Detail Information

Publications23

  1. Kumar A, Kaur H, Singh A. Neuropathic Pain models caused by damage to central or peripheral nervous system. Pharmacol Rep. 2017;70:206-216 pubmed publisher
    ..The development of novel, but rational analgesic drugs to alleviate this intractable pain demands elucidation of molecular mechanisms of NP for which different types of animal models have been established. ..
  2. Kumar A, Chanana P. Role of Nitric Oxide in Stress-Induced Anxiety: From Pathophysiology to Therapeutic Target. Vitam Horm. 2017;103:147-167 pubmed publisher
    ....
  3. Kumar A, Kumari B, Kumar P. Protective effects of selective and non-selective cyclooxygenase inhibitors in an animal model of chronic stress. Neurosci Bull. 2010;26:17-27 pubmed publisher
    ..p.) significantly attenuated these behavioral and biochemical (oxidative damage) alterations in chronic-stressed mice. The cyclooxygenase inhibitors could be used in the management of chronic fatigue-like conditions. ..
  4. Kumar A, Aakriti -, Gupta V. A review on animal models of stroke: An update. Brain Res Bull. 2016;122:35-44 pubmed publisher
    ....
  5. Bhardwaj M, Kumar A. Neuroprotective mechanism of Coenzyme Q10 (CoQ10) against PTZ induced kindling and associated cognitive dysfunction: Possible role of microglia inhibition. Pharmacol Rep. 2016;68:1301-1311 pubmed publisher
    ..The present study suggests the involvement of microglia inhibition in the protective effect of CoQ10 in PTZ induced kindling in mice. ..
  6. Kumar A, Aggrawal A, Pottabathini R, Singh A. Possible neuroprotective mechanisms of clove oil against icv-colchicine induced cognitive dysfunction. Pharmacol Rep. 2016;68:764-72 pubmed publisher
    ..The present study highlights that the major neuroprotective effect of clove oil due to its mitochondrial restoring and anti-oxidant properties along with a microglial inhibitory mechanism. ..
  7. Kumar A, Chanana P, Choudhary S. Emerging role of orexin antagonists in insomnia therapeutics: An update on SORAs and DORAs. Pharmacol Rep. 2016;68:231-42 pubmed publisher
    ..The present review focuses on the orexin peptides and receptors signifying their physiological profile as well as the development of orexin receptor antagonists as novel strategies in sleep medicine. ..
  8. Pottabathini R, Kumar A, Bhatnagar A, Garg S, Ekavali E. Ameliorative potential of pioglitazone and ceftriaxone alone and in combination in rat model of neuropathic pain: Targeting PPARγ and GLT-1 pathways. Pharmacol Rep. 2016;68:85-94 pubmed publisher
    ....
  9. Kumar A, Sharma N, Gupta A, Kalonia H, Mishra J. Neuroprotective potential of atorvastatin and simvastatin (HMG-CoA reductase inhibitors) against 6-hydroxydopamine (6-OHDA) induced Parkinson-like symptoms. Brain Res. 2012;1471:13-22 pubmed publisher
    ..The findings of the present study demonstrate the neuroprotective potential of statins in experimental model of 6-OHDA induced Parkinson like symptoms. ..
  10. Kumar A, Garg R, Gaur V, Kumar P. Nitric oxide mechanism in protective effect of imipramine and venlafaxine against acute immobilization stress-induced behavioral and biochemical alteration in mice. Neurosci Lett. 2009;467:72-5 pubmed publisher
    ..Present study highlights the involvement of nitric oxide mechanism in the protective effect of imipramine and venlafaxine against acute immobilization-induced behavioral and biochemical alterations in mice. ..
  11. Kumar A, Garg R. A role of nitric oxide mechanism involved in the protective effects of venlafaxine in sleep deprivation. Behav Brain Res. 2008;194:169-73 pubmed publisher
    ..Results of present study suggest that nitric oxide mechanism is involved in the protective effect of venlafaxine against sleep-deprivation-induced behavior alteration and oxidative damage in mice...
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    Kumar A, Naidu P, Seghal N, Padi S. Effect of curcumin on intracerebroventricular colchicine-induced cognitive impairment and oxidative stress in rats. J Med Food. 2007;10:486-94 pubmed
    ..The results of the present study indicate that curcumin has a protective role against colchicine-induced cognitive impairment and associated oxidative stress. ..
  13. Kumar A, Prakash A, Dogra S. Protective effect of curcumin (Curcuma longa) against D-galactose-induced senescence in mice. J Asian Nat Prod Res. 2011;13:42-55 pubmed publisher
    ..In conclusion, the present study highlights the therapeutic potential of curcumin against d-galactose induced senescence in mice...
  14. Kumar A, Prakash A, Pahwa D. Galantamine potentiates the protective effect of rofecoxib and caffeic acid against intrahippocampal Kainic acid-induced cognitive dysfunction in rat. Brain Res Bull. 2011;85:158-68 pubmed publisher
    ..The results of the present study suggest that galantamine potentiates the protective effect of rofecoxib and caffeic acid against kainic acid induced cognitive impairment and associated oxidative damage. ..
  15. request reprint
    Kumar A, Naidu P, Seghal N, Padi S. Neuroprotective effects of resveratrol against intracerebroventricular colchicine-induced cognitive impairment and oxidative stress in rats. Pharmacology. 2007;79:17-26 pubmed
    ..Results of the present study indicated that trans-resveratrol has a neuroprotective role against colchicine-induced cognitive impairment and associated oxidative stress. ..
  16. Kumar A, Dogra S, Prakash A. Protective effect of naringin, a citrus flavonoid, against colchicine-induced cognitive dysfunction and oxidative damage in rats. J Med Food. 2010;13:976-84 pubmed publisher
    ..The present study highlights the therapeutic potential of naringin against colchicine-induced cognitive impairment and associated oxidative damage. ..
  17. Kumar A, Garg R, Prakash A. Effect of St. John's Wort (Hypericum perforatum) treatment on restraint stress-induced behavioral and biochemical alteration in mice. BMC Complement Altern Med. 2010;10:18 pubmed publisher
    ..The present study was designed to investigate the effect of St. John's Wort (Hypericum perforatum) in restraint stress-induced behavioral and biochemical alterations in mice...
  18. Kumar A, Dogra S. Neuroprotective effect of carvedilol, an adrenergic antagonist against colchicine induced cognitive impairment and oxidative damage in rat. Pharmacol Biochem Behav. 2009;92:25-31 pubmed publisher
    ..Present study demonstrates a neuroprotective effect of carvedilol against colchicine-induced cognitive impairment and associated oxidative damage...
  19. Kumar A, Goyal R. Quercetin protects against acute immobilization stress-induced behaviors and biochemical alterations in mice. J Med Food. 2008;11:469-73 pubmed publisher
    ..Results suggest that neuroprotective properties of quercetin can be used in the treatment and management of stress and related disorders. ..
  20. Kumar A, Mittal R. Nrf2: a potential therapeutic target for diabetic neuropathy. Inflammopharmacology. 2017;25:393-402 pubmed publisher
    ..Despite involvement of Nrf2 in progression of diabetic neuropathy, targeting Nrf2 activators as a therapeutic potential will provide important new insights into the ways that influence treatment of diabetic neuropathy. ..
  21. Kumar A, Yadav M, Parle M, Dhingra S, Dhull D. Potential drug targets and treatment of schizophrenia. Inflammopharmacology. 2017;25:277-292 pubmed publisher
    ....
  22. Mittal R, Kumar A, Singh D, Bishnoi M, Nag T. Ameliorative potential of rutin in combination with nimesulide in STZ model of diabetic neuropathy: targeting Nrf2/HO-1/NF-kB and COX signalling pathway. Inflammopharmacology. 2017;: pubmed publisher
    ..The present study suggests the involvement of Nrf-2/HO-1 pathway in the protective effect of rutin against streptozotocin-induced diabetic neuropathy...
  23. Dhull D, Kumar A. Tramadol ameliorates behavioural, biochemical, mitochondrial and histological alterations in ICV-STZ-induced sporadic dementia of Alzheimer's type in rats. Inflammopharmacology. 2017;: pubmed publisher
    ..Further, these findings reveal the possibility of MOR agonist as a therapeutic approach for sporadic Alzheimer disease...