Anand Kumar

Summary

Publications

  1. doi request reprint A survival benefit of combination antibiotic therapy for serious infections associated with sepsis and septic shock is contingent only on the risk of death: a meta-analytic/meta-regression study
    Anand Kumar
    Medical Microbiology and Pharmacology Therapeutics, University of Manitoba, Winnipeg, Manitoba, Canada
    Crit Care Med 38:1651-64. 2010
  2. ncbi request reprint Early antimicrobial therapy in severe sepsis and septic shock
    Anand Kumar
    Section of Critical Care Medicine, Section of Infectious Diseases, JJ399d, Health Sciences Centre, 700 William Street, Winnipeg, Manitoba, R3A 1R9, Canada
    Curr Infect Dis Rep 12:336-44. 2010
  3. doi request reprint Initiation of inappropriate antimicrobial therapy results in a fivefold reduction of survival in human septic shock
    Anand Kumar
    Section of Critical Care Medicine, Health Sciences Centre St Boniface Hospital, University of Manitoba, Winnipeg, MB, Canada
    Chest 136:1237-48. 2009
  4. pmc Correlates of severe disease in patients with 2009 pandemic influenza (H1N1) virus infection
    Ryan Zarychanski
    Department of Internal Medicine, University of Manitoba, CancerCare Manitoba, Winnipeg, Manitoba
    CMAJ 182:257-64. 2010
  5. doi request reprint Optimizing antimicrobial therapy in sepsis and septic shock
    Anand Kumar
    Section of Critical Care Medicine, Section of Infectious Diseases, Department of Medicine, Medical Microbiology and Pharmacology Therapeutics, University of Manitoba, Canada
    Crit Care Nurs Clin North Am 23:79-97. 2011
  6. pmc Clinical review: Myocardial depression in sepsis and septic shock
    Olivier Court
    Section of Critical Care Medicine, Health Sciences Center, University of Manitoba, Winnipeg, Canada
    Crit Care 6:500-8. 2002
  7. doi request reprint Early versus late oseltamivir treatment in severely ill patients with 2009 pandemic influenza A (H1N1): speed is life
    Anand Kumar
    Section of Critical Care Medicine and Infectious Diseases, Health Sciences Centre and St Boniface Hospital, University of Manitoba, Winnipeg, Manitoba, Canada
    J Antimicrob Chemother 66:959-63. 2011
  8. ncbi request reprint Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock
    Anand Kumar
    Section of Critical Care Medicine, Health Sciences Centre St Boniface Hospital, University of Manitoba, Winnipeg, MB, Canada
    Crit Care Med 34:1589-96. 2006
  9. pmc Preload-independent mechanisms contribute to increased stroke volume following large volume saline infusion in normal volunteers: a prospective interventional study
    Anand Kumar
    Division of Cardiovascular Diseases and Critical Care Medicine, Cooper Hospital University Medical Center, Robert Wood Johnson Medical School, Camden, New Jersey, USA
    Crit Care 8:R128-36. 2004
  10. doi request reprint Early combination antibiotic therapy yields improved survival compared with monotherapy in septic shock: a propensity-matched analysis
    Anand Kumar
    Section of Critical Care Medicine, Health Sciences Centre St Boniface Hospital, University of Manitoba, Winnipeg, Manitoba, Canada
    Crit Care Med 38:1773-85. 2010

Detail Information

Publications75

  1. doi request reprint A survival benefit of combination antibiotic therapy for serious infections associated with sepsis and septic shock is contingent only on the risk of death: a meta-analytic/meta-regression study
    Anand Kumar
    Medical Microbiology and Pharmacology Therapeutics, University of Manitoba, Winnipeg, Manitoba, Canada
    Crit Care Med 38:1651-64. 2010
    ..To assess whether a potential benefit with combination antibiotic therapy is restricted to the most critically ill subset of patients, particularly those with septic shock...
  2. ncbi request reprint Early antimicrobial therapy in severe sepsis and septic shock
    Anand Kumar
    Section of Critical Care Medicine, Section of Infectious Diseases, JJ399d, Health Sciences Centre, 700 William Street, Winnipeg, Manitoba, R3A 1R9, Canada
    Curr Infect Dis Rep 12:336-44. 2010
    ..Recognizing the role of delays in administration of antimicrobial therapy in the poor outcomes of septic shock is central to this effort...
  3. doi request reprint Initiation of inappropriate antimicrobial therapy results in a fivefold reduction of survival in human septic shock
    Anand Kumar
    Section of Critical Care Medicine, Health Sciences Centre St Boniface Hospital, University of Manitoba, Winnipeg, MB, Canada
    Chest 136:1237-48. 2009
    ..Our goal was to determine the impact of the initiation of inappropriate antimicrobial therapy on survival to hospital discharge of patients with septic shock...
  4. pmc Correlates of severe disease in patients with 2009 pandemic influenza (H1N1) virus infection
    Ryan Zarychanski
    Department of Internal Medicine, University of Manitoba, CancerCare Manitoba, Winnipeg, Manitoba
    CMAJ 182:257-64. 2010
    ..The objective of this study was to identify factors correlated with severity of disease in confirmed cases of pandemic H1N1 influenza...
  5. doi request reprint Optimizing antimicrobial therapy in sepsis and septic shock
    Anand Kumar
    Section of Critical Care Medicine, Section of Infectious Diseases, Department of Medicine, Medical Microbiology and Pharmacology Therapeutics, University of Manitoba, Canada
    Crit Care Nurs Clin North Am 23:79-97. 2011
    ..Antimicrobial therapy should be stopped if infection is not considered the etiologic factor for a shock state...
  6. pmc Clinical review: Myocardial depression in sepsis and septic shock
    Olivier Court
    Section of Critical Care Medicine, Health Sciences Center, University of Manitoba, Winnipeg, Canada
    Crit Care 6:500-8. 2002
    ..The present paper reviews both the clinical manifestations and the molecular/cellular mechanisms of sepsis-induced myocardial depression...
  7. doi request reprint Early versus late oseltamivir treatment in severely ill patients with 2009 pandemic influenza A (H1N1): speed is life
    Anand Kumar
    Section of Critical Care Medicine and Infectious Diseases, Health Sciences Centre and St Boniface Hospital, University of Manitoba, Winnipeg, Manitoba, Canada
    J Antimicrob Chemother 66:959-63. 2011
    ..Optimal survival and minimal disease severity appear to result when antivirals are started as soon as possible after symptom onset...
  8. ncbi request reprint Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock
    Anand Kumar
    Section of Critical Care Medicine, Health Sciences Centre St Boniface Hospital, University of Manitoba, Winnipeg, MB, Canada
    Crit Care Med 34:1589-96. 2006
    ..To determine the prevalence and impact on mortality of delays in initiation of effective antimicrobial therapy from initial onset of recurrent/persistent hypotension of septic shock...
  9. pmc Preload-independent mechanisms contribute to increased stroke volume following large volume saline infusion in normal volunteers: a prospective interventional study
    Anand Kumar
    Division of Cardiovascular Diseases and Critical Care Medicine, Cooper Hospital University Medical Center, Robert Wood Johnson Medical School, Camden, New Jersey, USA
    Crit Care 8:R128-36. 2004
    ..We sought to confirm this to be the mechanism by which high-volume saline administration (comparable to that used in resuscitation of shock) results in improved cardiac output in normal healthy volunteers...
  10. doi request reprint Early combination antibiotic therapy yields improved survival compared with monotherapy in septic shock: a propensity-matched analysis
    Anand Kumar
    Section of Critical Care Medicine, Health Sciences Centre St Boniface Hospital, University of Manitoba, Winnipeg, Manitoba, Canada
    Crit Care Med 38:1773-85. 2010
    ..Current guidelines do not recommend combination therapy except for the express purpose of broadening coverage when resistant pathogens are a concern...
  11. ncbi request reprint Effect of large volume infusion on left ventricular volumes, performance and contractility parameters in normal volunteers
    Anand Kumar
    Division of Cardiovascular Disease and Critical Care Medicine, Rush Presbyterian St Luke s Medical Center, 1653 West Congress Parkway, Chicago, IL 60612 3833, USA
    Intensive Care Med 30:1361-9. 2004
    ..Characterize the normal human cardiovascular response to large volume infusion of normal saline...
  12. ncbi request reprint The duration of hypotension before the initiation of antibiotic treatment is a critical determinant of survival in a murine model of Escherichia coli septic shock: association with serum lactate and inflammatory cytokine levels
    Anand Kumar
    Division of Cardiovascular Diseases and Critical Care Medicine, Cooper Hospital University Medical Center, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Camden, New Jersey
    J Infect Dis 193:251-8. 2006
    ..This study was designed to examine the relationship between the timing of antibiotic treatment and both survival rates and hemodynamic/inflammatory correlates of survival in a murine model of Escherichia coli septic shock...
  13. pmc Cardiovascular response to dobutamine stress predicts outcome in severe sepsis and septic shock
    Anand Kumar
    Section of Critical Care Medicine, Health Sciences Centre St, Boniface Hospital, University of Manitoba, Winnipeg, Manitoba, Canada
    Crit Care 12:R35. 2008
    ..The objective of this study was to assess cardiovascular and metabolic responses to dobutamine as correlates of outcome in patients with severe sepsis or septic shock...
  14. ncbi request reprint Nitric oxide-dependent and -independent mechanisms are involved in TNF-alpha -induced depression of cardiac myocyte contractility
    Anand Kumar
    Section of Critical Care Medicine, Health Sciences Centre, Winnipeg, Manitoba, Canada
    Am J Physiol Regul Integr Comp Physiol 292:R1900-6. 2007
    ..These data suggest that TNF-alpha exposure is associated with a second nitric oxide-independent but calcium-dependent early depressant mechanism that is manifested by reduced contractile and cAMP response to beta-adrenergic stimulation...
  15. doi request reprint Critically ill patients with 2009 influenza A(H1N1) infection in Canada
    Anand Kumar
    Section of Critical Care Medicine, Health Sciences Centre, JJ 399, 700 William Ave, Winnipeg, MB R3E 0Z3 Canada
    JAMA 302:1872-9. 2009
    ..Between March and July 2009, the largest number of confirmed cases of 2009 influenza A(H1N1) infection occurred in North America...
  16. doi request reprint Optimizing antimicrobial therapy in sepsis and septic shock
    Anand Kumar
    Department of Medicine, Medical Microbiology and Pharmacology Therapeutics, University of Manitoba, Winnipeg, Manitoba, Canada
    Crit Care Clin 25:733-51, viii. 2009
    ..Antimicrobial therapy should be stopped if infection is not considered the etiologic factor for a shock state...
  17. ncbi request reprint Experimental human endotoxemia is associated with depression of load-independent contractility indices: prevention by the lipid a analogue E5531
    Anand Kumar
    Section of Critical Care Medicine, Health Sciences Centre, GE706, 820 Sherbrook St, Winnipeg, MB, Canada, R3A 1R9
    Chest 126:860-7. 2004
    ....
  18. doi request reprint Role of the venous return in critical illness and shock: part II-shock and mechanical ventilation
    Duane J Funk
    Section of Critical Care Medicine, Department of Medicine, University of Manitoba, Manitoba, Canada
    Crit Care Med 41:573-9. 2013
    ..To provide a conceptual and clinical review of the physiology of the venous system as it is related to cardiac function in health and disease...
  19. doi request reprint Sepsis and septic shock: a history
    Duane J Funk
    Anesthesiology and Critical Care, University of Manitoba, Manitoba, Canada
    Crit Care Clin 25:83-101, viii. 2009
    ..The early descriptions and theories about the etiology (microbial pathogens), pathogenesis (toxins and mediators), and treatment of sepsis-associated disease are also discussed...
  20. ncbi request reprint Pulmonary artery occlusion pressure and central venous pressure fail to predict ventricular filling volume, cardiac performance, or the response to volume infusion in normal subjects
    Anand Kumar
    Division of Cardiovascular Disease and Critical Care Medicine, Rush Presbyterian St Luke s Medical Center, Chicago, IL, USA
    Crit Care Med 32:691-9. 2004
    ....
  21. ncbi request reprint Interleukin-10 blunts the human inflammatory response to lipopolysaccharide without affecting the cardiovascular response
    Anand Kumar
    Division of Cardiovascular Disease and Critical Care Medicine, Rush Presbyterian St Luke s Medical Center, Chicago, IL, USA
    Crit Care Med 33:331-40. 2005
    ..The objective of this study was to assess the efficacy of variations in dose and timing of administration of recombinant human IL-10 (rhIL-10) on inflammatory and cardiovascular responses in a human endotoxemia model of sepsis...
  22. ncbi request reprint Septic shock, multiple organ failure, and acute respiratory distress syndrome
    Sat Sharma
    Section of Pulmonary Care Medicine, Department of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    Curr Opin Pulm Med 9:199-209. 2003
    ..This review will highlight and discuss recent advances in the pathophysiology and management of sepsis...
  23. ncbi request reprint Bacterial DNA and RNA induce rat cardiac myocyte contraction depression in vitro
    Bhanu Paladugu
    Division of Cardiovascular Disease and Critical Care Medicine, Cooper Hospital, University Medical Center, Robert Wood Johnson Medical School, Camden, New Jersey 08103, USA
    Shock 21:364-9. 2004
    ..These data suggest that bacterial DNA and RNA may contribute to myocardial depression during bacterial sepsis and septic shock...
  24. doi request reprint Vancomycin pharmacodynamics and survival in patients with methicillin-resistant Staphylococcus aureus-associated septic shock
    Sheryl Zelenitsky
    Faculty of Pharmacy, University of Manitoba, 750 McDermot Avenue, Winnipeg, MB R3E 0T5, Canada
    Int J Antimicrob Agents 41:255-60. 2013
    ..Improved survival was observed with the attainment of these pharmacodynamic targets...
  25. doi request reprint Sedation and analgesia usage in severe pandemic H1N1 (2009) infection: a comparison to respiratory failure secondary to other infectious pneumonias
    Kendiss Olafson
    Section of Critical Care, Department of Medicine, University of Manitoba, Winnipeg, MB, Canada
    Ann Pharmacother 46:9-20. 2012
    ..During the 2009 H1N1 pandemic (pH1N1), patients requiring mechanical ventilation for respiratory failure received high doses of sedation and analgesia...
  26. doi request reprint Antimicrobial management of sepsis and septic shock
    Sat Sharma
    Section of Pulmonary Medicine, Department of Internal Medicine, University of Manitoba, 700 William Avenue, Winnipeg, Manitoba, Canada R3E 0Z3
    Clin Chest Med 29:677-87, ix. 2008
    ..Antimicrobial therapy should be stopped if infection is not considered the etiologic factor for a shock state...
  27. doi request reprint Activated protein C and septic shock: a propensity-matched cohort study*
    Emily Rimmer
    Department of Internal Medicine, University of Manitoba, Winnipeg, Canada
    Crit Care Med 40:2974-81. 2012
    ..Further clinical trials, including a recently completed trial in patients with septic shock, failed to reproduce these results...
  28. pmc Enteric absorption and pharmacokinetics of oseltamivir in critically ill patients with pandemic (H1N1) influenza
    Robert E Ariano
    Department of Pharmacy, St Boniface General Hospital, and Department of Internal Medicine, The Faculty of Pharmacy, University of Manitoba, Winnipeg, Manitoba
    CMAJ 182:357-63. 2010
    ..We documented the pharmacokinetic profile of oseltamivir in patients admitted to intensive care units (ICUs) with suspected or confirmed pandemic (H1N1) influenza...
  29. pmc Human endotoxemia and human sepsis: limits to the model
    Ramon Anel
    Section of Critical Care Medicine, University of North Dakota, Grand Forks, North Dakota, USA
    Crit Care 9:151-2. 2005
    ..The current study demonstrates that human experimental endotoxemia fails to generate evidence of increased vascular permeability within the relatively short time frame of the study...
  30. ncbi request reprint Transforming growth factor-beta1 blocks in vitro cardiac myocyte depression induced by tumor necrosis factor-alpha, interleukin-1beta, and human septic shock serum
    Anand Kumar
    Section of Critical Care Medicine, Division of Cardiovascular Diseases and Critical Care Medicine, Cooper Hospital University Medical Center, Robert Wood Johnson Medical School, UMDNJ, Camden, NJ, USA
    Crit Care Med 35:358-64. 2007
    ..Using an in vitro assay, this study sought to determine the effect of TGF-beta1 on myocyte depression induced by TNF-alpha, IL-1beta, and serum with known depressant activity from patients with septic shock...
  31. doi request reprint The role of venous return in critical illness and shock-part I: physiology
    Duane J Funk
    Section of Critical Care Medicine, Department of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    Crit Care Med 41:255-62. 2013
    ..To provide a conceptual and clinical review of the physiology of the venous system as it is relates to cardiac function in health and disease...
  32. doi request reprint Acute kidney injury in critically ill patients infected with 2009 pandemic influenza A(H1N1): report from a Canadian Province
    Manish M Sood
    St Boniface General Hospital, University of Manitoba, Winnipeg, Manitoba, Canada
    Am J Kidney Dis 55:848-55. 2010
    ..2009 pandemic influenza A(H1N1) has led to a global increase in severe respiratory illness. Little is known about kidney outcomes and dialytic requirements in critically ill patients infected with pandemic H1N1...
  33. ncbi request reprint Myocardial dysfunction in the patient with sepsis
    Sreenandh Krishnagopalan
    Section of Critical Care Medicine, Rush Presbyterian St Luke s Medical Center, Chicago, Illinois, USA
    Curr Opin Crit Care 8:376-88. 2002
    ..In addition, septic myocardial depression appears to be mediated in part through combinations of nitric oxide-dependent and -independent alterations of basal and catecholamine-stimulated cardiac myocyte contractility...
  34. doi request reprint Extracorporeal lung support for patients who had severe respiratory failure secondary to influenza A (H1N1) 2009 infection in Canada
    Darren H Freed
    Surgical Heart Failure Program, Cardiac Sciences Program, St Boniface General Hospital, CR3030 Asper Clinical Research Building, 369 Tache Ave, Winnipeg, Manitoba R2H 2A6, Canada
    Can J Anaesth 57:240-7. 2010
    ..In this report, we describe characteristics, treatment, and outcomes of critically ill patients in Canada who had H1N1-2009 infection and were treated with extracorporeal lung support (ECLS)...
  35. ncbi request reprint Perinatal and maternal outcomes in critically ill obstetrics patients with pandemic H1N1 Influenza A
    Titilayo Oluyomi-Obi
    Department of Obstetrics, Gynaecology and Reproductive Sciences, University of Manitoba, Winnipeg MB, Canada
    J Obstet Gynaecol Can 32:443-7, 448-52. 2010
    ..Information about these cases will be useful to help us understand the potential impact of future outbreaks and review critical illness in pregnancy...
  36. doi request reprint Early intravenous unfractionated heparin and mortality in septic shock
    Ryan Zarychanski
    Section of Critical Care Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    Crit Care Med 36:2973-9. 2008
    ..Unfractionated heparin is a known anticoagulant, which also possesses anti-inflammatory properties. Unfractionated heparin has been shown to increase survival in experimental models of septic shock...
  37. doi request reprint The history and evolution of circulatory shock
    Rizwan A Manji
    Cardiac Sciences Program, University of Manitoba, Winnipeg, Manitoba, Canada
    Crit Care Clin 25:1-29, vii. 2009
    ..The most accepted current definition involves an oxygen supply/demand imbalance that can have various causes-hypovolemia, cardiac dysfunction, vascular failure, or obstructive processes...
  38. ncbi request reprint Cytokine modulation in sepsis and septic shock
    Sergio Zanotti
    Section of Critical Care Medicine, Rush Presbyterian St Luke s Medical Center, Room 214 Jones, 1635 west Congress Parkway, Chicago, Illinois 60612, USA
    Expert Opin Investig Drugs 11:1061-75. 2002
    ..Finally, newer developments related to less known cytokines such as macrophage migration inhibitory factor and high mobility group 1 protein will be evaluated...
  39. doi request reprint Antimicrobial therapy for life-threatening infections: speed is life
    Duane J Funk
    Department of Anesthesia, Section of Critical Care Medicine, 2nd Floor Harry Medovy House, University of Manitoba, Winnipeg, Manitoba R3E 1X2, Canada
    Crit Care Clin 27:53-76. 2011
    ..If "Time is tissue" when it comes to thrombolytic therapy for acute myocardial infarction and thrombotic stroke, then an appropriate rule for life-threatening infections, particularly septic shock, is "Speed is life."..
  40. doi request reprint Biodiesel surrogates: achieving performance demands
    Rakesh Sarin
    Indian Oil Corporation Ltd, R and D Centre, Faridabad 121 007, India
    Bioresour Technol 100:3022-8. 2009
    ..The cetane number of synthesized esters is 62-69, which is much better than diesel and biodiesel. The blends of the synthesized esters in diesel at 5% and 10% meet Indian standards of diesel...
  41. ncbi request reprint Ventrally placed craniovertebral junction arachnoid cysts in children: a report of 2 cases and literature review
    Sandeep Mohindra
    Department of Neurosurgery, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India
    Surg Neurol 68:85-8. 2007
    ..Arachnoid cysts at the craniovertebral junction are uncommon, and all the reported cases had location posterior to the brain stem. We describe 2 cases of ventral arachnoid cysts among children...
  42. doi request reprint Evidence of early retinal microvascular changes in patients with type 2 diabetes and depression
    Thanh Tan Nguyen
    Centre for Eye Research Australia, University of Melbourne, 32 Gisborne Street, Victoria 3002, Australia
    Psychosom Med 72:535-8. 2010
    ..To examine retinal vascular caliber, an indicator of early microvascular disease and depression in patients with Type 2 diabetes...
  43. ncbi request reprint Giant dumbbell foramen magnum neurinomas presenting as posterior neck masses: single-stage removal by posterior midline approach
    Sunil K Gupta
    Department of Neurosurgery, Postgraduate Institute of Medical Education and Research, Chandigarh 160 012, India
    Neurol India 55:61-3. 2007
    ..In both patients total surgical removal was achieved by a single-stage posterior midline approach. Both patients had complete neurological recovery...
  44. ncbi request reprint Foreign currency-related translation complexities in cross-border healthcare applications
    Anand Kumar
    Department of Public Health and Medical Informatics, SSPIM CIM 42 Université Jean Monnet, CHU Saint Etienne, 42270 Saint Priest en Jarez, France
    Stud Health Technol Inform 150:96-100. 2009
    ..Such systems would need to come to terms with the complexities involved in such currency-related translations in order to provide the correct data for performance benchmarking...
  45. doi request reprint Practical lessons from the first outbreaks: clinical presentation, obstacles, and management strategies for severe pandemic (pH1N1) 2009 influenza pneumonitis
    Duane J Funk
    Department of Anesthesia, University of Manitoba, Winnipeg, Manitoba, Canada
    Crit Care Med 38:e30-7. 2010
    ..We hope to offer some insight into potential pitfalls and problems that may be experienced by other centers and provide some potential approaches to addressing these issues...
  46. doi request reprint Ventilator management for hypoxemic respiratory failure attributable to H1N1 novel swine origin influenza virus
    Clare D Ramsey
    Department of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    Crit Care Med 38:e58-65. 2010
    ....
  47. doi request reprint Efficacy and safety of a phospholipid emulsion (GR270773) in Gram-negative severe sepsis: results of a phase II multicenter, randomized, placebo-controlled, dose-finding clinical trial
    R Phillip Dellinger
    Cooper University Hospital and University Medicine Dentistry New Jersey PD, Camden, NJ, USA
    Crit Care Med 37:2929-38. 2009
    ..Endotoxin neutralization correlates with the amount of phospholipid in the lipoprotein particles...
  48. doi request reprint The utility of tissue Doppler imaging for the noninvasive determination of left ventricular filling pressures in patients with septic shock
    Negareh Mousavi
    Section of Cardiology, Department of Cardiac Sciences, University of Manitoba, Winnipeg, Manitoba, Canada
    J Intensive Care Med 25:163-7. 2010
    ..Diastolic indices using transthoracic echocardiography (TTE) may provide an accurate estimate of PAWP...
  49. ncbi request reprint Novel therapies for sepsis: antiendotoxin therapies
    Sanjay Manocha
    Section of Critical Care Medicine, Health Sciences Center, University of Manitoba, 820 Sherbrook Street, Winnipeg, Manitoba, Canada, R3A 1R
    Expert Opin Investig Drugs 11:1795-812. 2002
    ..This review discusses current knowledge regarding endotoxin signalling, antiendotoxin therapies currently under development, and future areas for research...
  50. pmc Chemokine receptor 5 △32 allele in patients with severe pandemic (H1N1) 2009
    Yoav Keynan
    Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada
    Emerg Infect Dis 16:1621-2. 2010
    ..We found a large proportion of heterozygosity for the CCR5Δ32 allele among white patients with severe disease...
  51. doi request reprint The occurrence and impact of bacterial organisms complicating critical care illness associated with 2009 influenza A(H1N1) infection
    John Muscedere
    Department of Medicine, Queen s University, Kingston, ON, Canada
    Chest 144:39-47. 2013
    ....
  52. pmc Enrichment of variations in KIR3DL1/S1 and KIR2DL2/L3 among H1N1/09 ICU patients: an exploratory study
    David La
    National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada
    PLoS ONE 6:e29200. 2011
    ..To study factors involved in NK cell dysfunction in overactive immune responses to H1N1 infection, KIR3DL1/S1 and KIR2DL2/L3 allotypes and cognate HLA ligands of H1N1/09 intensive-care unit (ICU) patients were determined...
  53. doi request reprint H1N1: viral pneumonia as a cause of acute respiratory distress syndrome
    Clare Ramsey
    Section of Respiratory Medicine, Department of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    Curr Opin Crit Care 17:64-71. 2011
    ..To review the literature on novel swine origin influenza A (H1N1 2009) as a cause of respiratory failure and acute respiratory distress syndrome (ARDS)...
  54. doi request reprint Antimicrobial therapy of sepsis and septic shock--when are two drugs better than one?
    Cybele L Abad
    Department of Internal Medicine, Section of Infectious Diseases, University of Wisconsin Hospital and Clinics, 1685 Highland Avenue, Madison, WI 53705, USA
    Crit Care Clin 27:e1-27. 2011
    ..In this article, we examine the evidence for, or against, the use of combination drug therapy compared with monotherapy in the management of serious infections, sepsis, and septic shock...
  55. ncbi request reprint Persistent left superior vena cava: an intensivist's experience and review of the literature
    Rajit Pahwa
    Section of Critical Care Medicine, Rush Presbyterian St Luke s Medical Center, Chicago, IL, USA
    South Med J 96:528-9. 2003
    ..This report describes a case of persistent left superior vena cava detected after successful placement of a pulmonary artery catheter...
  56. doi request reprint A systems approach to the early recognition and rapid administration of best practice therapy in sepsis and septic shock
    Duane Funk
    Department of Medicine, Section of Critical Care Medicine, University of Manitoba, Winnipeg, Canada
    Curr Opin Crit Care 15:301-7. 2009
    ..This review focuses on the early diagnosis of sepsis and the implementation of a systems-based approach to help coordinate the identification and treatment of patients with this disease...
  57. pmc Nationwide molecular surveillance of pandemic H1N1 influenza A virus genomes: Canada, 2009
    Morag Graham
    National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada
    PLoS ONE 6:e16087. 2011
    ..Sequencing has since been conducted at an unprecedented rate globally in order to monitor the diversification of this emergent virus and to track mutations that may affect virus behavior...
  58. ncbi request reprint Nitric oxide and inflammatory cytokines in the heart: the presence of positive feedback loops
    Anand Kumar
    Crit Care Med 33:2851-2. 2005
  59. ncbi request reprint Comparison of sevoflurane and isoflurane in OPCAB surgery
    B G Venkatesh
    Department of Anaesthesiology and Critical Care, Escorts Heart Institute and Research Centre, New Delhi
    Ann Card Anaesth 10:46-50. 2007
    ..We conclude that sevoflurane and isoflurane can both be safely used in OPCAB surgery, but the awakening and extubation times are significantly less with sevoflurane...
  60. ncbi request reprint Leukocyte lysozyme: a novel cause of septic myocardial depression?
    Leo Taiberg
    Crit Care Med 32:304-5. 2004
  61. ncbi request reprint Endotoxemic myocardial depression: a novel inducible nitric oxide synthase suppressant effect of albumin
    Anand Kumar
    Crit Care Med 31:324-6. 2003
  62. ncbi request reprint Human serum from patients with septic shock activates transcription factors STAT1, IRF1, and NF-kappaB and induces apoptosis in human cardiac myocytes
    Aseem Kumar
    Department of Chemistry and Biochemistry and the Biomolecular Sciences Programme, Laurentian University, Sudbury, Ontario P3E 2C6, Canada
    J Biol Chem 280:42619-26. 2005
    ..These data suggest that transcription factor activation and early myocyte apoptosis play a mechanistic role in septic myocardial depression and sepsis-induced organ dysfunction...
  63. ncbi request reprint Circulating substances and energy metabolism in septic shock
    Anand Kumar
    Crit Care Med 31:632-3. 2003
  64. ncbi request reprint Prevalence of multiple micronutrient deficiencies amongst pregnant women in a rural area of Haryana
    Priyali Pathak
    Department of Human Nutrition, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110 029, India
    Indian J Pediatr 71:1007-14. 2004
    ..However, no attempt has been made to concurrently assess the prevalence of multiple micronutrient deficiencies and the factors associated with them amongst PW...
  65. ncbi request reprint Color Doppler ultrasound as an objective assessment tool for chemotherapeutic response in advanced breast cancer
    Seema Singh
    Department of General Surgery, Institute of Medical Sciences, B 4 New Medical enclave Banaras Hindu University Varanasi 221005, India
    Breast Cancer 12:45-51. 2005
    ..Magnetic Resonance Imaging (MRI) and Computed Tomography (CT) are expensive. The role of Doppler ultrasonography as an imaging modality for this purpose is therefore being evaluated...
  66. ncbi request reprint Interleukin-1 gene cluster polymorphisms: all in the family
    Aseem Kumar
    Crit Care Med 30:1168-9. 2002
  67. ncbi request reprint The feasibility of nitric oxide delivery with high frequency jet ventilation
    Yaseen Arabi
    Department of Intensive Care, King Abdulaziz Medical City, Riyadh, Kingdom of Saudi Arabia
    Respirology 10:673-7. 2005
    ..In this case we were able to achieve reliable and constant levels of NO. The purpose of this report is to discuss the technical aspects and pitfalls of this method...
  68. doi request reprint Daily functioning and prefrontal brain morphology in healthy and depressed community-dwelling elderly
    Virginia Elderkin-Thompson
    Semel Institute for Neuroscience and Human Behavior, Geriatric Division, UCLA, Los Angeles, CA, USA
    Am J Geriatr Psychiatry 16:633-42. 2008
    ..This study examined relationships between self-reported levels of general functioning and the combined volume of three integrated prefrontal structures associated with self-perception and emotion...
  69. ncbi request reprint Decompressive hemicraniectomy in malignant middle cerebral artery infarction: an analysis of long-term outcome and factors in patient selection
    Ashok Pillai
    Department of Neurosurgery, Amrita Institute of Medical Sciences, Amrita Vishwa Vidyapeetham University, Kochi, Kerala, India
    J Neurosurg 106:59-65. 2007
    ..The present study was undertaken to assess the immediate and long-term outcome of this intervention and to help better define the selection criteria for surgery...
  70. ncbi request reprint Methylphenidate-enhanced antidepressant response to citalopram in the elderly: a double-blind, placebo-controlled pilot trial
    Helen Lavretsky
    Department of Psychiatry and Biobehavioral Sciences, UCLA School of Medicine, Los Angeles, California 90095, USA
    Am J Geriatr Psychiatry 14:181-5. 2006
    ..The authors evaluated the potential of methylphenidate to accelerate and enhance antidepressant response to citalopram in elderly depressed patients...
  71. pmc Application of a plain abdominal radiograph transition zone (PARTZ) in Hirschsprung's disease
    Akshay Pratap
    Division of Pediatric Surgery, B P Koirala Institute of Health Sciences, Dharan, Nepal
    BMC Pediatr 7:5. 2007
    ..The aim of this study was to determine the utility and diagnostic accuracy of a plain abdominal radiograph transition zone (PARTZ) in predicting the level of aganglionosis...
  72. ncbi request reprint Antibiotic management of suspected nosocomial ICU-acquired infection: does prolonged empiric therapy improve outcome?
    Mary Anne W Aarts
    University of Toronto, Interdepartmental Division of Critical Care Medicine and the Department of Surgery, Toronto, Canada
    Intensive Care Med 33:1369-78. 2007
    ..To characterize empiric antibiotic use in patients with suspected nosocomial ICU-acquired infections (NI), and determine the impact of prolonged therapy in the absence of infection...
  73. ncbi request reprint The effects of the dopamine and serotonin transporter polymorphisms on clinical features and treatment response in geriatric depression: a pilot study
    Helen Lavretsky
    UCLA School of Medicine, Department of Psychiatry and Biobehavioral Sciences, Los Angeles, CA 90095, USA
    Int J Geriatr Psychiatry 23:55-9. 2008
    ....
  74. doi request reprint One year of neurosurgery in the eastern region of Nepal
    Amit Agrawal
    Department of Surgery, B P Koirala Institute of Health Sciences, Dharan, Nepal
    Surg Neurol 69:652-6; discussion 656. 2008
    ..This article briefly discusses about the present status, future strategies, and perspectives of neurosurgery in the eastern region of Nepal...
  75. ncbi request reprint Myocardial depressant substances in meningococcal septic shock
    Anand Kumar
    Crit Care Med 30:2379-80. 2002