Elevated [(18)F]FDOPA utilization in the periaqueductal gray and medial nucleus accumbens of patients with early Parkinson's diseaseYoshitaka Kumakura
Centre for Functionally Integrative Neuroscience, Aarhus University, Denmark
Neuroimage 49:2933-9. 2010
..Increased FDOPA trapping in the periaqueductal grey of PD patients seems consistent with recent reports of increased activity of serotonin neurons in a rat model of parkinsonism...
- PET studies of cerebral levodopa metabolism: a review of clinical findings and modeling approaches
Yoshitaka Kumakura
Department of Nuclear Medicine, Graduate School of Medicine, University of Tokyo, and Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan
Neuroscientist 15:635-50. 2009
....
- Age-dependent decline of steady state dopamine storage capacity of human brain: an FDOPA PET study
Yoshitaka Kumakura
Centre for Functionally Integrative Neuroscience, Aarhus University, Aarhus C 8000, Denmark
Neurobiol Aging 31:447-63. 2010
..Consequently, the magnitude of V(d) declined with healthy aging, possibly reflecting impaired vesicular storage capacity, resulting in enhanced exposure of cytosolic [(18)F]fluorodopamine to monoamine oxidase...
Elevated [18F]fluorodopamine turnover in brain of patients with schizophrenia: an [18F]fluorodopa/positron emission tomography studyYoshitaka Kumakura
Centre for Functionally Integrative Neuroscience, Aarhus University, DK 8000 Aarhus C, Denmark
J Neurosci 27:8080-7. 2007
....
- Detection of cerebrospinal fluid leakage in intracranial hypotension with radionuclide cisternography and blood activity monitoring
Miwako Takahashi
Department of Radiology, The University of Tokyo, Graduate School of Medicine, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan
Ann Nucl Med 19:339-43. 2005
..CONCLUSIONS: The combination of radionuclide cisternography, including early time points and blood sampling, may enable accurate diagnosis of SIH...
- PET studies of net blood-brain clearance of FDOPA to human brain: age-dependent decline of [18F]fluorodopamine storage capacity
Yoshitaka Kumakura
PET Centre, Aarhus University Hospitals, Aarhus, Denmark
J Cereb Blood Flow Metab 25:807-19. 2005
..The present results furthermore constitute the first demonstration of an abnormality in the cerebral utilization of FDOPA in caudate and putamen as a function of normal aging, which we attribute to loss of vesicular storage capacity...
- Modulation of [18F]fluorodopa (FDOPA) kinetics in the brain of healthy volunteers after acute haloperidol challenge
Ingo Vernaleken
Department of Psychiatry and Psychotherapy, RWTH Aachen University, Aachen, Germany
Neuroimage 30:1332-9. 2006
..The stimulation of DDC cannot be excluded due to insufficient statistical power in the estimation of k3(D) changes...
- Dopamine storage capacity in caudate and putamen of patients with early Parkinson's disease: correlation with asymmetry of motor symptoms
Yoshitaka Kumakura
PET Centre, Aarhus University Hospital, Denmark
J Cereb Blood Flow Metab 26:358-70. 2006
....
- Fluorodopa F 18 positron emission tomography and the progression of Parkinson disease
Per Borghammer
Arch Neurol 62:1480; author reply 1480-1. 2005
- Baseline [18F]-FDOPA kinetics are predictive of haloperidol-induced changes in dopamine turnover and cognitive performance: A positron emission tomography study in healthy subjects
Ingo Vernaleken
Department of Psychiatry and Psychotherapy, RWTH Aachen University, Pauwelsstrasse 30, 52074 Aachen, Germany
Neuroimage 40:1222-31. 2008
..We hypothesize that these effects may be driven by D(1)-receptor mediated transmission during D(2) blockade...
- Alpha-[11C]methyl-L-tryptophan uptake in patients with periventricular nodular heterotopia and epilepsy
Jun Natsume
Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan
Epilepsia 49:826-31. 2008
..Electrophysiological evidence suggests the involvement of the neocortex in periventricular nodular heterotopia (PVNH)...
- Correlation of alcohol craving with striatal dopamine synthesis capacity and D2/3 receptor availability: a combined [18F]DOPA and [18F]DMFP PET study in detoxified alcoholic patients
Andreas Heinz
Central Institute of Mental Health, Mannheim, Germany
Am J Psychiatry 162:1515-20. 2005
..CONCLUSIONS: Simultaneous assay by PET of pre- and postsynaptic markers of dopamine neurotransmission indicated that a striatal dopamine deficit correlated with alcohol craving, which was associated with a high relapse risk...
- 'Prefrontal' cognitive performance of healthy subjects positively correlates with cerebral FDOPA influx: an exploratory [18F]-fluoro-L-DOPA-PET investigation
Ingo Vernaleken
Department of Psychiatry and Psychotherapy, RWTH Aachen University, Aachen, Germany
Hum Brain Mapp 28:931-9. 2007
..005; putamen: -0.870, P < 0. 001). Thus, the present findings reveal a strong correlation between dopamine synthesis capacity in striatum of healthy volunteers and performance of cognitive tasks linked to the prefrontal cortex...
