Yoshitaka Kumakura

Summary

Publications

  1. ncbi request reprint Elevated [18F]fluorodopamine turnover in brain of patients with schizophrenia: an [18F]fluorodopa/positron emission tomography study
    Yoshitaka Kumakura
    Centre for Functionally Integrative Neuroscience, Aarhus University, DK 8000 Aarhus C, Denmark
    J Neurosci 27:8080-7. 2007
  2. doi request reprint Elevated [(18)F]FDOPA utilization in the periaqueductal gray and medial nucleus accumbens of patients with early Parkinson's disease
    Yoshitaka Kumakura
    Centre for Functionally Integrative Neuroscience, Aarhus University, Denmark
    Neuroimage 49:2933-9. 2010
  3. doi request reprint PET studies of cerebral levodopa metabolism: a review of clinical findings and modeling approaches
    Yoshitaka Kumakura
    Department of Nuclear Medicine, Graduate School of Medicine, University of Tokyo, and Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan
    Neuroscientist 15:635-50. 2009
  4. doi request reprint Age-dependent decline of steady state dopamine storage capacity of human brain: an FDOPA PET study
    Yoshitaka Kumakura
    Centre for Functionally Integrative Neuroscience, Aarhus University, Aarhus C 8000, Denmark
    Neurobiol Aging 31:447-63. 2010
  5. doi request reprint The impact of dopamine on aggression: an [18F]-FDOPA PET Study in healthy males
    Thorben Schlüter
    Department of Psychiatry, Psychotherapy and Psychosomatics, and Department of Nuclear Medicine, RWTH Aachen University, 52074 Aachen, Germany, ABX Chemicals, 01454 Radeberg, Germany, Department of Nuclear Medicine, Graduate School of Medicine, University of Tokyo, Bunkyo ku, 113 8654 Tokyo, Japan, Department of Anesthesiology, University Hospitals of the KU Leuven, 3000 Leuven, Belgium, Jülich Aachen Research Alliance JARA, 52074 Aachen, Germany, Department of Anesthesiology, University Hospital of the RWTH Aachen University, 52074 Aachen, Germany, and Department of Nuclear Medicine, Maastricht University Medical Center, 6229 HX Maastricht, The Netherlands
    J Neurosci 33:16889-96. 2013
  6. pmc Increased turnover of dopamine in caudate nucleus of detoxified alcoholic patients
    Yoshitaka Kumakura
    Department of Neuroscience and Pharmacology, University of Copenhagen, Copenhagen, Denmark Center for Functionally Integrative Neuroscience, Aarhus University, Aarhus C, Denmark Department of Nuclear Medicine, Tokyo University, Tokyo, Japan
    PLoS ONE 8:e73903. 2013
  7. ncbi request reprint Detection of cerebrospinal fluid leakage in intracranial hypotension with radionuclide cisternography and blood activity monitoring
    Miwako Takahashi
    Department of Radiology, The University of Tokyo, Graduate School of Medicine, Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Ann Nucl Med 19:339-43. 2005
  8. ncbi request reprint Dopamine storage capacity in caudate and putamen of patients with early Parkinson's disease: correlation with asymmetry of motor symptoms
    Yoshitaka Kumakura
    PET Centre, Aarhus University Hospital, Denmark
    J Cereb Blood Flow Metab 26:358-70. 2006
  9. ncbi request reprint Modulation of [18F]fluorodopa (FDOPA) kinetics in the brain of healthy volunteers after acute haloperidol challenge
    Ingo Vernaleken
    Department of Psychiatry and Psychotherapy, RWTH Aachen University, Aachen, Germany
    Neuroimage 30:1332-9. 2006
  10. ncbi request reprint PET studies of net blood-brain clearance of FDOPA to human brain: age-dependent decline of [18F]fluorodopamine storage capacity
    Yoshitaka Kumakura
    PET Centre, Aarhus University Hospitals, Aarhus, Denmark
    J Cereb Blood Flow Metab 25:807-19. 2005

Collaborators

Detail Information

Publications15

  1. ncbi request reprint Elevated [18F]fluorodopamine turnover in brain of patients with schizophrenia: an [18F]fluorodopa/positron emission tomography study
    Yoshitaka Kumakura
    Centre for Functionally Integrative Neuroscience, Aarhus University, DK 8000 Aarhus C, Denmark
    J Neurosci 27:8080-7. 2007
    ....
  2. doi request reprint Elevated [(18)F]FDOPA utilization in the periaqueductal gray and medial nucleus accumbens of patients with early Parkinson's disease
    Yoshitaka Kumakura
    Centre for Functionally Integrative Neuroscience, Aarhus University, Denmark
    Neuroimage 49:2933-9. 2010
    ..Increased FDOPA trapping in the periaqueductal grey of PD patients seems consistent with recent reports of increased activity of serotonin neurons in a rat model of parkinsonism...
  3. doi request reprint PET studies of cerebral levodopa metabolism: a review of clinical findings and modeling approaches
    Yoshitaka Kumakura
    Department of Nuclear Medicine, Graduate School of Medicine, University of Tokyo, and Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan
    Neuroscientist 15:635-50. 2009
    ....
  4. doi request reprint Age-dependent decline of steady state dopamine storage capacity of human brain: an FDOPA PET study
    Yoshitaka Kumakura
    Centre for Functionally Integrative Neuroscience, Aarhus University, Aarhus C 8000, Denmark
    Neurobiol Aging 31:447-63. 2010
    ..Consequently, the magnitude of V(d) declined with healthy aging, possibly reflecting impaired vesicular storage capacity, resulting in enhanced exposure of cytosolic [(18)F]fluorodopamine to monoamine oxidase...
  5. doi request reprint The impact of dopamine on aggression: an [18F]-FDOPA PET Study in healthy males
    Thorben Schlüter
    Department of Psychiatry, Psychotherapy and Psychosomatics, and Department of Nuclear Medicine, RWTH Aachen University, 52074 Aachen, Germany, ABX Chemicals, 01454 Radeberg, Germany, Department of Nuclear Medicine, Graduate School of Medicine, University of Tokyo, Bunkyo ku, 113 8654 Tokyo, Japan, Department of Anesthesiology, University Hospitals of the KU Leuven, 3000 Leuven, Belgium, Jülich Aachen Research Alliance JARA, 52074 Aachen, Germany, Department of Anesthesiology, University Hospital of the RWTH Aachen University, 52074 Aachen, Germany, and Department of Nuclear Medicine, Maastricht University Medical Center, 6229 HX Maastricht, The Netherlands
    J Neurosci 33:16889-96. 2013
    ..618, p = 0.003). The results suggest that individuals with low DA transmission capacity are more vulnerable to reactive/impulsive aggression in response to provocation...
  6. pmc Increased turnover of dopamine in caudate nucleus of detoxified alcoholic patients
    Yoshitaka Kumakura
    Department of Neuroscience and Pharmacology, University of Copenhagen, Copenhagen, Denmark Center for Functionally Integrative Neuroscience, Aarhus University, Aarhus C, Denmark Department of Nuclear Medicine, Tokyo University, Tokyo, Japan
    PLoS ONE 8:e73903. 2013
    ....
  7. ncbi request reprint Detection of cerebrospinal fluid leakage in intracranial hypotension with radionuclide cisternography and blood activity monitoring
    Miwako Takahashi
    Department of Radiology, The University of Tokyo, Graduate School of Medicine, Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Ann Nucl Med 19:339-43. 2005
    ..The aim of this work is to improve the diagnostic ability of radionuclide cisternography and to reevaluate the reliability of early bladder visualization as an indirect finding of CSF leakage...
  8. ncbi request reprint Dopamine storage capacity in caudate and putamen of patients with early Parkinson's disease: correlation with asymmetry of motor symptoms
    Yoshitaka Kumakura
    PET Centre, Aarhus University Hospital, Denmark
    J Cereb Blood Flow Metab 26:358-70. 2006
    ....
  9. ncbi request reprint Modulation of [18F]fluorodopa (FDOPA) kinetics in the brain of healthy volunteers after acute haloperidol challenge
    Ingo Vernaleken
    Department of Psychiatry and Psychotherapy, RWTH Aachen University, Aachen, Germany
    Neuroimage 30:1332-9. 2006
    ..The stimulation of DDC cannot be excluded due to insufficient statistical power in the estimation of k3(D) changes...
  10. ncbi request reprint PET studies of net blood-brain clearance of FDOPA to human brain: age-dependent decline of [18F]fluorodopamine storage capacity
    Yoshitaka Kumakura
    PET Centre, Aarhus University Hospitals, Aarhus, Denmark
    J Cereb Blood Flow Metab 25:807-19. 2005
    ..The present results furthermore constitute the first demonstration of an abnormality in the cerebral utilization of FDOPA in caudate and putamen as a function of normal aging, which we attribute to loss of vesicular storage capacity...
  11. doi request reprint Alpha-[11C]methyl-L-tryptophan uptake in patients with periventricular nodular heterotopia and epilepsy
    Jun Natsume
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan
    Epilepsia 49:826-31. 2008
    ..Electrophysiological evidence suggests the involvement of the neocortex in periventricular nodular heterotopia (PVNH)...
  12. doi request reprint Baseline [18F]-FDOPA kinetics are predictive of haloperidol-induced changes in dopamine turnover and cognitive performance: A positron emission tomography study in healthy subjects
    Ingo Vernaleken
    Department of Psychiatry and Psychotherapy, RWTH Aachen University, Pauwelsstrasse 30, 52074 Aachen, Germany
    Neuroimage 40:1222-31. 2008
    ..We hypothesize that these effects may be driven by D(1)-receptor mediated transmission during D(2) blockade...
  13. ncbi request reprint Fluorodopa F 18 positron emission tomography and the progression of Parkinson disease
    Per Borghammer
    Arch Neurol 62:1480; author reply 1480-1. 2005
  14. ncbi request reprint Correlation of alcohol craving with striatal dopamine synthesis capacity and D2/3 receptor availability: a combined [18F]DOPA and [18F]DMFP PET study in detoxified alcoholic patients
    Andreas Heinz
    Central Institute of Mental Health, Mannheim, Germany
    Am J Psychiatry 162:1515-20. 2005
    ..In this study, positron emission tomography (PET) was used to compare dopamine synthesis capacity in the striatum in alcoholic patients and healthy comparison subjects...
  15. ncbi request reprint 'Prefrontal' cognitive performance of healthy subjects positively correlates with cerebral FDOPA influx: an exploratory [18F]-fluoro-L-DOPA-PET investigation
    Ingo Vernaleken
    Department of Psychiatry and Psychotherapy, RWTH Aachen University, Aachen, Germany
    Hum Brain Mapp 28:931-9. 2007
    ..005; putamen: -0.870, P < 0. 001). Thus, the present findings reveal a strong correlation between dopamine synthesis capacity in striatum of healthy volunteers and performance of cognitive tasks linked to the prefrontal cortex...