Shrinivas Kulkarni

Summary

Publications

  1. doi request reprint Evaluation of antidepressant-like activity of novel water-soluble curcumin formulations and St. John's wort in behavioral paradigms of despair
    S K Kulkarni
    Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India
    Pharmacology 89:83-90. 2012
  2. doi request reprint On the mechanism of antidepressant-like action of berberine chloride
    Shrinivas K Kulkarni
    Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India
    Eur J Pharmacol 589:163-72. 2008
  3. ncbi request reprint Effect of Withania somnifera Dunal root extract against pentylenetetrazol seizure threshold in mice: possible involvement of GABAergic system
    S K Kulkarni
    Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160 014, India
    Indian J Exp Biol 46:465-9. 2008
  4. doi request reprint Antidepressant activity of curcumin: involvement of serotonin and dopamine system
    Shrinivas K Kulkarni
    Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India
    Psychopharmacology (Berl) 201:435-42. 2008
  5. ncbi request reprint Comparative behavioural profile of newer antianxiety drugs on different mazes
    Shrinivas K Kulkarni
    Centre with Potential for Excellence in Biomedical Sciences, Panjab University, Chandigarh, 160 014, India
    Indian J Exp Biol 46:633-8. 2008
  6. ncbi request reprint New therapeutic promises in the treatment of depression and schizophrenia
    Ashish Dhir
    Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, India
    Drug News Perspect 21:581-92. 2008
  7. doi request reprint Cyclooxygenase in epilepsy: from perception to application
    S K Kulkarni
    Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India
    Drugs Today (Barc) 45:135-54. 2009
  8. ncbi request reprint In vivo microdialysis studies of striatal level of neurotransmitters after haloperidol and chlorpromazine administration
    Shrinivas K Kulkarni
    Centre with Potential for Excellence in Biomedical Sciences CPEBS, Panjab University, Chandigarh 160 014, India
    Indian J Exp Biol 47:91-7. 2009
  9. ncbi request reprint Current investigational drugs for major depression
    Shrinivas K Kulkarni
    University Institute of Pharmaceutical Sciences, Pharmacology Division, Panjab University, Chandigarh, India
    Expert Opin Investig Drugs 18:767-88. 2009
  10. doi request reprint sigma-1 receptors in major depression and anxiety
    Shrinivas K Kulkarni
    Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, 160 014, India
    Expert Rev Neurother 9:1021-34. 2009

Detail Information

Publications26

  1. doi request reprint Evaluation of antidepressant-like activity of novel water-soluble curcumin formulations and St. John's wort in behavioral paradigms of despair
    S K Kulkarni
    Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India
    Pharmacology 89:83-90. 2012
    ..Further, the study comparatively evaluates St. John's wort (SJW), another herbal preparation...
  2. doi request reprint On the mechanism of antidepressant-like action of berberine chloride
    Shrinivas K Kulkarni
    Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India
    Eur J Pharmacol 589:163-72. 2008
    ..Further, nitric oxide pathway and/or sigma receptors are involved in mediating its antidepressant-like activity in mouse forced swim test...
  3. ncbi request reprint Effect of Withania somnifera Dunal root extract against pentylenetetrazol seizure threshold in mice: possible involvement of GABAergic system
    S K Kulkarni
    Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160 014, India
    Indian J Exp Biol 46:465-9. 2008
    ..5 mg/kg, ip) increased the seizure threshold. The results suggested that the anticonvulsant effect of W. somnifera against PTZ seizure threshold paradigm involved the GABAAergic modulation...
  4. doi request reprint Antidepressant activity of curcumin: involvement of serotonin and dopamine system
    Shrinivas K Kulkarni
    Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India
    Psychopharmacology (Berl) 201:435-42. 2008
    ..Curcumin is a major active principle of Curcuma longa, one of the widely used preparations in the Indian system of medicine. It is known for its diverse biological actions...
  5. ncbi request reprint Comparative behavioural profile of newer antianxiety drugs on different mazes
    Shrinivas K Kulkarni
    Centre with Potential for Excellence in Biomedical Sciences, Panjab University, Chandigarh, 160 014, India
    Indian J Exp Biol 46:633-8. 2008
    ..Present study confirms the antianxiety activity of different newer classes of drugs and found some of them comparable to diazepam in both the elevated zero maze and elevated plus maze paradigm...
  6. ncbi request reprint New therapeutic promises in the treatment of depression and schizophrenia
    Ashish Dhir
    Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, India
    Drug News Perspect 21:581-92. 2008
    ..The conference also brought together scientists involved in basic or clinical research. The present article summarizes the outcome of the deliberations...
  7. doi request reprint Cyclooxygenase in epilepsy: from perception to application
    S K Kulkarni
    Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India
    Drugs Today (Barc) 45:135-54. 2009
    ..It is speculated that COX inhibition will be a useful ameliorative adjunct in the management of epilepsy and related disorders...
  8. ncbi request reprint In vivo microdialysis studies of striatal level of neurotransmitters after haloperidol and chlorpromazine administration
    Shrinivas K Kulkarni
    Centre with Potential for Excellence in Biomedical Sciences CPEBS, Panjab University, Chandigarh 160 014, India
    Indian J Exp Biol 47:91-7. 2009
    ..The results provide evidence for the involvement of striatal adrenergic and serotonergic systems, besides dopaminergic system in neuroleptic-induced acute and chronic extrapyramidal symptoms...
  9. ncbi request reprint Current investigational drugs for major depression
    Shrinivas K Kulkarni
    University Institute of Pharmaceutical Sciences, Pharmacology Division, Panjab University, Chandigarh, India
    Expert Opin Investig Drugs 18:767-88. 2009
    ..The World Health Organization (WHO) report has predicted that major depression will become a key cause of illness-induced disability by the year 2020, second only to ischemic heart diseases...
  10. doi request reprint sigma-1 receptors in major depression and anxiety
    Shrinivas K Kulkarni
    Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, 160 014, India
    Expert Rev Neurother 9:1021-34. 2009
    ..Although, sigma-1 receptor modulators may be future therapeutic options, either as individual agents or adjuvants in the treatment of mental disorders, the topic needs further preclinical and clinical exploration...
  11. doi request reprint Potentials of curcumin as an antidepressant
    Shrinivas Kulkarni
    Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India
    ScientificWorldJournal 9:1233-41. 2009
    ..A need for clinical trials in order to explore the antidepressant efficacy and safety profile of curcumin is emphasized...
  12. doi request reprint Berberine: a plant alkaloid with therapeutic potential for central nervous system disorders
    S K Kulkarni
    Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160 014, India
    Phytother Res 24:317-24. 2010
    ..However, more detailed clinical trials along with a safety assessment of berberine are warranted for positioning the alkaloid in the treatment of neurological disorders...
  13. ncbi request reprint Licofelone: the answer to unmet needs in osteoarthritis therapy?
    Shrinivas K Kulkarni
    Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160 014, India
    Curr Rheumatol Rep 10:43-8. 2008
    ..Last, further evidence suggests that it could be a suitable alternative for the long-term treatment of a wide population of patients with OA. The preset review describes the status of licofelone in the treatment of OA...
  14. doi request reprint Positioning dual inhibitors in the treatment of pain and inflammatory disorders
    S K Kulkarni
    Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, 160 014, India
    Inflammopharmacology 16:1-15. 2008
  15. ncbi request reprint Dopamine D4 receptors and development of newer antipsychotic drugs
    S K Kulkarni
    Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India
    Fundam Clin Pharmacol 14:529-39. 2000
    ..The therapeutic potential of D4 receptors as a target for developing antipsychotics will be known only when selective D4 receptor-antagonists with varying D2/D4 and D4/5-HT2A ratios are developed and tested in psychiatric patients...
  16. ncbi request reprint Pathophysiology and drug therapy of tardive dyskinesia: current concepts and future perspectives
    Shrinivas K Kulkarni
    Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160 014, India
    Drugs Today (Barc) 39:19-49. 2003
    ..e., pharmacogenetic aspect of tardive dyskinesia, is also gaining impetus as a research area, and is discussed in detail in this article...
  17. ncbi request reprint Modulatory effect of diclofenac on antispasmodic effect of pitofenone in cholinergic spasm
    Shrinivas K Kulkarni
    Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160 014, India
    Indian J Exp Biol 42:567-9. 2004
    ....
  18. ncbi request reprint Phosphodiesterase 5 enzyme and its inhibitors: update on pharmacological and therapeutical aspects
    S K Kulkarni
    Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India
    Methods Find Exp Clin Pharmacol 26:789-99. 2004
    ..Research in this field is intense, with a goal of identifying and developing new, selective PDE5 inhibitors that would be beneficial in a number of maladies, as well as angina, hypertension and erectile dysfunction (ED)...
  19. ncbi request reprint Licofelone--a novel analgesic and anti-inflammatory agent
    S K Kulkarni
    Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160 014, India
    Curr Top Med Chem 7:251-63. 2007
    ..It is currently under clinical evaluation in osteoarthritis (OA), the most common form of arthritis. The present review describes pharmacological and clinical development of licofelone as a dual inhibitor...
  20. ncbi request reprint Involvement of adenosinergic receptors in anxiety related behaviours
    Shrinivas K Kulkarni
    Centre with Potential for Excellence in Biomedical Sciences, Panjab University, Chandigarh 160 014, India
    Indian J Exp Biol 45:439-43. 2007
    ..Pretreatment with caffeine (8, 15, 30 mg/kg) and theophylline (30 mg/kg) reversed the anxiolytic effect of adenosine. The study suggested the involvement of adenosinergic receptor system in anxiety related behaviours...
  21. ncbi request reprint Effect of various classes of antidepressants in behavioral paradigms of despair
    S K Kulkarni
    Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160014, India
    Prog Neuropsychopharmacol Biol Psychiatry 31:1248-54. 2007
    ..The present study further validated that both the test procedures are equi-sensitive to antidepressant drugs of different class in the strain of animals used...
  22. ncbi request reprint Possible involvement of L-arginine-nitric oxide (NO)-cyclic guanosine monophosphate (cGMP) signaling pathway in the antidepressant activity of berberine chloride
    Shrinivas K Kulkarni
    Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160014, India
    Eur J Pharmacol 569:77-83. 2007
    ....
  23. ncbi request reprint Elevated zero maze: a paradigm to evaluate antianxiety effects of drugs
    S K Kulkarni
    Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India
    Methods Find Exp Clin Pharmacol 29:343-8. 2007
    ..Results of the present study indicated that elevated zero maze offered a better animal model to study antianxiety activity, when compared with elevated plus maze and mirror chamber...
  24. ncbi request reprint Effect of withdrawal of diazepam or morphine treatment on gastric motility (charcoal meal test) in mice: possible role of different central and peripheral receptors
    S K Kulkarni
    Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160 014, India
    Indian J Exp Biol 45:642-8. 2007
    ..The results suggest the involvement of both central and peripheral receptors of benzodiazepines and opioid (mu) receptors in the withdrawal symptoms of the benzodiazepines and morphine, respectively...
  25. ncbi request reprint Withania somnifera: an Indian ginseng
    S K Kulkarni
    Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160 014, India
    Prog Neuropsychopharmacol Biol Psychiatry 32:1093-105. 2008
    ....
  26. ncbi request reprint Cyclooxygenase isoenzymes and newer therapeutic potential for selective COX-2 inhibitors
    S K Kulkarni
    Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India
    Methods Find Exp Clin Pharmacol 22:291-8. 2000
    ..The present review discusses the biology as well as the role of these COX isoenzymes in various pathophysiological conditions...