Saturated fat, carbohydrates and cardiovascular diseaseR S Kuipers
University Medical Center Groningen, Groningen, The Netherlands
Neth J Med 69:372-8. 2011
..We conclude that avoidance of SAFA accumulation by reducing the intake of CHO with high glycaemic index is more effective in the prevention of CVD than reducing SAFA intake per se...
Differences in preterm and term milk fatty acid compositions may be caused by the different hormonal milieu of early parturitionRemko S Kuipers
Laboratory Medicine, University Medical Center Groningen, The Netherlands
Prostaglandins Leukot Essent Fatty Acids 85:369-79. 2011
..The decrease of insulin sensitivity with compensatory hyperinsulinemia with advancing gestation, causes adipose tissue lipolysis and hepatic de novo lipogenesis (DNL)...
- Postdelivery changes in maternal and infant erythrocyte fatty acids in 3 populations differing in fresh water fish intakes
Remko S Kuipers
Laboratory Medicine, Room Y 3 181, University Medical Center Groningen, P O Box 30 001, 9700 RB Groningen, The Netherlands
Prostaglandins Leukot Essent Fatty Acids 85:387-97. 2011
..Long-chain polyunsaturated (LCP) fatty acids (FA) are important during infant development. Mother-to-infant FA-transport occurs at the expense of the maternal status. Maternal and infant FA-status change rapidly after delivery...
- Gestational age dependent changes of the fetal brain, liver and adipose tissue fatty acid compositions in a population with high fish intakes
Remko S Kuipers
Laboratory Medicine, University Medical Center Groningen, The Netherlands
Prostaglandins Leukot Essent Fatty Acids 86:189-99. 2012
..There are no data on the intrauterine fatty acid (FA) compositions of brain, liver and adipose tissue of infants born to women with high fish intakes...
- Fatty acid compositions of preterm and term colostrum, transitional and mature milks in a sub-Saharan population with high fish intakes
Remko S Kuipers
Laboratory Medicine, University Medical Center Groningen, The Netherlands
Prostaglandins Leukot Essent Fatty Acids 86:201-7. 2012
..However, it is generally acknowledged that our ancestors evolved in sub-Saharan East-Africa, where they inhabited the land-water ecosystems...
- Fetal intrauterine whole body linoleic, arachidonic and docosahexaenoic acid contents and accretion rates
Remko S Kuipers
Laboratory Medicine, University Medical Center Groningen, Groningen, The Netherlands
Prostaglandins Leukot Essent Fatty Acids 86:13-20. 2012
..There is no information on the whole body fatty acid (FA) contents of preterm or term infants, although scattered information on the FA-composition of many organs is available...
- Gestational age dependent content, composition and intrauterine accretion rates of fatty acids in fetal white adipose tissue
Remko S Kuipers
Pathology and Laboratory Medicine, University Medical Center Groningen, Groningen, The Netherlands
Prostaglandins Leukot Essent Fatty Acids 86:39-49. 2012
..Little is known about the gestational age (GA) dependent content, composition and intrauterine accretion rates of fatty acids (FA) in fetal white adipose tissue (WAT)...
- Estimated macronutrient and fatty acid intakes from an East African Paleolithic diet
Remko S Kuipers
Department of Laboratory Medicine, University Medical Center Groningen UMCG, University of Groningen, Groningen, The Netherlands
Br J Nutr 104:1666-87. 2010
..Data on Paleolithic diets and lifestyle, rather than the investigation of single nutrients, might be useful for the rational design of clinical trials...
- Maternal DHA equilibrium during pregnancy and lactation is reached at an erythrocyte DHA content of 8 g/100 g fatty acids
Remko S Kuipers
Laboratory Medicine, University Medical Center Groningen, 9700 RB, Groningen, The Netherlands
J Nutr 141:418-27. 2011
..RBC-AA-relations might support uniform iRBC-AA. A (maternal) RBC-DHA of 8 g% might be optimal for infant neurodevelopment and adult cardiovascular disease incidence...
- Postpartum changes in maternal and infant erythrocyte fatty acids are likely to be driven by restoring insulin sensitivity and DHA status
Remko S Kuipers
Laboratory Medicine, University Medical Center Groningen UMCG, The Netherlands
Med Hypotheses 76:794-801. 2011
..Although other authors described changes in maternal serum and RBC essential-FA (EFA) after delivery, none went into detail about the changes in non-EFA and the mechanisms behind -and/or functions of- the observed changes...
- Intrauterine, postpartum and adult relationships between arachidonic acid (AA) and docosahexaenoic acid (DHA)
Remko S Kuipers
Laboratory Medicine, University Medical Center Groningen UMCG, Room Y 3 181, 9700 RB Groningen, The Netherlands
Prostaglandins Leukot Essent Fatty Acids 85:245-52. 2011
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- The relation between the omega-3 index and arachidonic acid is bell shaped: synergistic at low EPA+DHA status and antagonistic at high EPA+DHA status
Martine F Luxwolda
Laboratory Medicine, University Medical Center Groningen UMCG, 9700 RB Groningen, The Netherlands
Prostaglandins Leukot Essent Fatty Acids 85:171-8. 2011
..The relation between docosahexaenoic (DHA) and eicosapentaenoic (EPA) vs. arachidonic acid (AA) seems characterized by both synergism and antagonism...
A maternal erythrocyte DHA content of approximately 6 g% is the DHA status at which intrauterine DHA biomagnifications turns into bioattenuation and postnatal infant DHA equilibrium is reachedMartine F Luxwolda
Laboratory Medicine, Groningen University Hospital, University Medical Center Groningen UMCG, Groningen, The Netherlands
Eur J Nutr 51:665-75. 2012
..We investigated whether biomagnification persists at lifelong high fish intakes and whether the latter prevents a postpartum decline of infant and/or maternal DHA status...
- Milk in the island of Chole [Tanzania] is high in lauric, myristic, arachidonic and docosahexaenoic acids, and low in linoleic acid reconstructed diet of infants born to our ancestors living in tropical coastal regions
Remko S Kuipers
Pathology and Laboratory Medicine, University Medical Center Groningen, The Netherlands
Prostaglandins Leukot Essent Fatty Acids 76:221-33. 2007
..We need information on the diet on which our genes evolved...
- Higher de novo synthesized fatty acids and lower omega3- and omega6-long-chain polyunsaturated fatty acids in umbilical vessels of women with preeclampsia and high fish intakes
Victor J B Huiskes
Laboratory Center, University Medical Center Groningen, CMC V, Room Y 1 147, P O Box 30 001, 9700 RB Groningen, The Netherlands
Prostaglandins Leukot Essent Fatty Acids 80:101-6. 2009
..An explanation of this might be placental dysfunction, while the similarity of umbilical vessel FA-abnormalities in preeclamptic and diabetic pregnancies suggests insulin resistance as a common denominator...
- Long-chain polyunsaturated fatty acids in maternal and infant nutrition
Frits A J Muskiet
Pathology and Laboratory Medicine, University Medical Center Groningen, The Netherlands
Prostaglandins Leukot Essent Fatty Acids 75:135-44. 2006
..Subtle signs of dysbalanced maternal glucose homeostasis may be important and observations from current Western societies may not provide us with an adequate basis for dietary recommendations...
- High contents of both docosahexaenoic and arachidonic acids in milk of women consuming fish from lake Kitangiri (Tanzania): targets for infant formulae close to our ancient diet?
Remko S Kuipers
Pathology and Laboratory Medicine, Groningen University Hospital, CMC V, Room Y 1 165, P O Box 30 001, 9700 RB Groningen, The Netherlands
Prostaglandins Leukot Essent Fatty Acids 72:279-88. 2005
..We conclude that the milk AA, DHA and EPA contents of Doromoni women might provide us with clues to optimize infant formulae and perhaps the milk of Western women...
- A multidisciplinary reconstruction of Palaeolithic nutrition that holds promise for the prevention and treatment of diseases of civilisation
Remko S Kuipers
Laboratory Medicine, University Medical Center Groningen, Groningen, The Netherlands
Nutr Res Rev 25:96-129. 2012
..The benefits of these diets illustrate that it is time to incorporate this knowledge into dietary recommendations...
- Traditionally living populations in East Africa have a mean serum 25-hydroxyvitamin D concentration of 115 nmol/l
Martine F Luxwolda
Laboratory Medicine, University Medical Center Groningen, Groningen, The Netherlands
Br J Nutr 108:1557-61. 2012
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