M E Kuipers

Summary

Publications

  1. pmc Synergistic fungistatic effects of lactoferrin in combination with antifungal drugs against clinical Candida isolates
    M E Kuipers
    Section of Pharmacokinetics and Drug Delivery, Groningen University Institute for Drug Studies, University Centre for Pharmacy, 9713 AV Groningen, The Netherlands
    Antimicrob Agents Chemother 43:2635-41. 1999
  2. ncbi request reprint Solifenacin demonstrates high absolute bioavailability in healthy men
    Mirjam E Kuipers
    Yamanouchi Europe BV, Leiderdorp, The Netherlands
    Drugs R D 5:73-81. 2004
  3. ncbi request reprint Antiviral effects of milk proteins: acylation results in polyanionic compounds with potent activity against human immunodeficiency virus types 1 and 2 in vitro
    P J Swart
    Department of Pharmaceutical Pharmacology and Clinical Pharmacy, University Centre for Pharmacy, Groningen, The Netherlands
    AIDS Res Hum Retroviruses 12:769-75. 1996
  4. ncbi request reprint Pharmacokinetics and anti-HIV-1 efficacy of negatively charged human serum albumins in mice
    M E Kuipers
    Groningen Utrecht Institute for Drug Studies GIDS, University Centre for Pharmacy, Groningen, The Netherlands
    Antiviral Res 33:99-108. 1997
  5. ncbi request reprint The in vitro anti-HIV efficacy of negatively charged human serum albumin is antagonized by heparin
    P J Swart
    Groningen Institute for Drug Studies, University Centre for Pharmacy, Section Pharmacokinetics and Drug Delivery, The Netherlands
    AIDS Res Hum Retroviruses 13:677-83. 1997
  6. ncbi request reprint Anti-HIV-1 activity of combinations and covalent conjugates of negatively charged human serum albumins (NCAs) and AZT
    M E Kuipers
    Groningen Institute for Drug Studies, Section of Pharmacokinetics and Drug Delivery, University Centre for Pharmacy, The Netherlands
    J Drug Target 6:323-35. 1999
  7. ncbi request reprint Plasma lactoferrin levels are decreased in end-stage AIDS patients
    B W van der Strate
    Department of Pharmacokinetics and Drug Delivery, Groningen University Institute for Drug Exploration, University Centre for Pharmacy, The Netherlands
    Viral Immunol 12:197-203. 1999
  8. ncbi request reprint Charge modification of plasma and milk proteins results in antiviral active compounds
    P J Swart
    Groningen University Institute for Drug Exploration, Department of Pharmacokinetics and Drug Delivery, University Centre for Pharmacy, The Netherlands
    J Pept Sci 5:563-76. 1999
  9. ncbi request reprint Targeting of superoxide dismutase to the liver results in anti-inflammatory effects in rats with fibrotic livers
    P J Swart
    Groningen Utrecht Institute of Drug Exploration, Department of Pharmacokinetics and Drug Delivery, University Centre for Pharmacy, The Netherlands
    J Hepatol 31:1034-43. 1999
  10. ncbi request reprint Homing of negatively charged albumins to the lymphatic system: general implications for drug targeting to peripheral tissues and viral reservoirs
    P J Swart
    Groningen University Institute for Drug Expoloration, Department of Pharmacokinetics and Drug Delivery, University Centre for Pharmacy, The Netherlands
    Biochem Pharmacol 58:1425-35. 1999

Collaborators

Detail Information

Publications14

  1. pmc Synergistic fungistatic effects of lactoferrin in combination with antifungal drugs against clinical Candida isolates
    M E Kuipers
    Section of Pharmacokinetics and Drug Delivery, Groningen University Institute for Drug Studies, University Centre for Pharmacy, 9713 AV Groningen, The Netherlands
    Antimicrob Agents Chemother 43:2635-41. 1999
    ..Clinical studies to further elucidate the potential utility of this combination therapy have been initiated...
  2. ncbi request reprint Solifenacin demonstrates high absolute bioavailability in healthy men
    Mirjam E Kuipers
    Yamanouchi Europe BV, Leiderdorp, The Netherlands
    Drugs R D 5:73-81. 2004
    ..This study was designed to assess the absolute bioavailability of a single oral dose of solifenacin 10 mg, which is twice the suggested starting dose...
  3. ncbi request reprint Antiviral effects of milk proteins: acylation results in polyanionic compounds with potent activity against human immunodeficiency virus types 1 and 2 in vitro
    P J Swart
    Department of Pharmaceutical Pharmacology and Clinical Pharmacy, University Centre for Pharmacy, Groningen, The Netherlands
    AIDS Res Hum Retroviruses 12:769-75. 1996
    ..Therefore, shielding of this domain, resulting in inhibition of virus-cell fusion and entry of the virus into MT4 cells, may be the likely underlying mechanism of antiviral action...
  4. ncbi request reprint Pharmacokinetics and anti-HIV-1 efficacy of negatively charged human serum albumins in mice
    M E Kuipers
    Groningen Utrecht Institute for Drug Studies GIDS, University Centre for Pharmacy, Groningen, The Netherlands
    Antiviral Res 33:99-108. 1997
    ..Intraperitoneal injections of 300 and 3 mg/kg Suc-HSA, given 15-30 min before the mice were challenged with the virus, sufficed to protect these mice against infection with the HIV-1 IIIB strain...
  5. ncbi request reprint The in vitro anti-HIV efficacy of negatively charged human serum albumin is antagonized by heparin
    P J Swart
    Groningen Institute for Drug Studies, University Centre for Pharmacy, Section Pharmacokinetics and Drug Delivery, The Netherlands
    AIDS Res Hum Retroviruses 13:677-83. 1997
    ..The fact that heparin and heparin degradation products antagonize Suc-HSA without having a significant anti-HIV-1 effect indicates that the anticoagulant acts as a relatively weak partial inhibitor...
  6. ncbi request reprint Anti-HIV-1 activity of combinations and covalent conjugates of negatively charged human serum albumins (NCAs) and AZT
    M E Kuipers
    Groningen Institute for Drug Studies, Section of Pharmacokinetics and Drug Delivery, University Centre for Pharmacy, The Netherlands
    J Drug Target 6:323-35. 1999
    ....
  7. ncbi request reprint Plasma lactoferrin levels are decreased in end-stage AIDS patients
    B W van der Strate
    Department of Pharmacokinetics and Drug Delivery, Groningen University Institute for Drug Exploration, University Centre for Pharmacy, The Netherlands
    Viral Immunol 12:197-203. 1999
    ..We conclude that Lf, as part of the nonspecific immune system, might play an important role in the first line of defense against opportunistic microbial infections in AIDS patients...
  8. ncbi request reprint Charge modification of plasma and milk proteins results in antiviral active compounds
    P J Swart
    Groningen University Institute for Drug Exploration, Department of Pharmacokinetics and Drug Delivery, University Centre for Pharmacy, The Netherlands
    J Pept Sci 5:563-76. 1999
    ....
  9. ncbi request reprint Targeting of superoxide dismutase to the liver results in anti-inflammatory effects in rats with fibrotic livers
    P J Swart
    Groningen Utrecht Institute of Drug Exploration, Department of Pharmacokinetics and Drug Delivery, University Centre for Pharmacy, The Netherlands
    J Hepatol 31:1034-43. 1999
    ..We therefore compared the pharmacokinetics and in vivo efficacy of SOD with two modified forms of this protein: SOD coupled to the copolymer DIVEMA and mannosylated-SOD...
  10. ncbi request reprint Homing of negatively charged albumins to the lymphatic system: general implications for drug targeting to peripheral tissues and viral reservoirs
    P J Swart
    Groningen University Institute for Drug Expoloration, Department of Pharmacokinetics and Drug Delivery, University Centre for Pharmacy, The Netherlands
    Biochem Pharmacol 58:1425-35. 1999
    ....
  11. pmc Multiple doses of the antimuscarinic agent solifenacin do not affect the pharmacodynamics or pharmacokinetics of warfarin or the steady-state pharmacokinetics of digoxin in healthy subjects
    R A Smulders
    Astellas Pharma Europe B V, Leiderdorp, The Netherlands
    Br J Clin Pharmacol 62:210-7. 2006
    ..Solifenacin succinate is used for the treatment of overactive bladder (OAB). The potential for pharmacokinetic and/or pharmacodynamic interactions between solifenacin and warfarin or digoxin was investigated...
  12. ncbi request reprint Mechanism of anti-HIV activity of negatively charged albumins: biomolecular interaction with the HIV-1 envelope protein gp120
    M E Kuipers
    Section of Pharmacokinetics and Drug Delivery, University Center for Pharmacy, Groningen Institute for Drug Studies GIDS, The Netherlands
    J Acquir Immune Defic Syndr Hum Retrovirol 11:419-29. 1996
    ....
  13. ncbi request reprint Pharmacokinetic interaction of solifenacin with an oral contraceptive containing ethinyl estradiol and levonorgestrel in healthy women: a double-blind, placebo-controlled study
    Miriam E J Taekema-Roelvink
    Exploratory Development Department, Astellas Pharma Europe BV, Leiderdorp, The Netherlands
    Clin Ther 27:1403-10. 2005
    ..Solifenacin succinate (YM905; Vesicare, Astellas Pharma Inc., Tokyo, Japan) is a new once-daily, orally administered muscarinic receptor antagonist under investigation for the treatment of overactive bladder...
  14. ncbi request reprint Design and fungicidal activity of mucoadhesive lactoferrin tablets for the treatment of oropharyngeal candidosis
    Mirjam E Kuipers
    Department of Pharmacokinetics and Drug Delivery, University of Groningen, Groningen, The Netherlands
    Drug Deliv 9:31-8. 2002
    ..We concluded that the developed mucoadhesive tablet can improve the therapeutic efficacy of Lf and that it is suitable for further clinical research...