Krzystanek M, Pałasz A. NMDA Receptor Model of Antipsychotic Drug-Induced Hypofrontality. Int J Mol Sci. 2019;20: pubmed publisher
..We discuss our findings within the literature of the subject. ..
Krzystanek M, Bogus K, PaÅ‚asz A, Krzystanek E, Worthington J, Wiaderkiewicz R. Effects of long-term treatment with the neuroleptics haloperidol, clozapine and olanzapine on immunoexpression of NMDA receptor subunits NR1, NR2A and NR2B in the rat hippocampus. Pharmacol Rep. 2015;67:965-9 pubmed publisher
..A decrease in hippocampal glutamatergic signalling after long-term neuroleptic administration may cautiously explain the incomplete effectiveness of these drugs in the therapy of schizophrenia-related cognitive disturbances. ..
Krzystanek M, Krzeszowski D, Jagoda K, Krysta K. Long term telemedicine study of compliance in paranoid schizophrenia. Psychiatr Danub. 2015;27 Suppl 1:S266-8 pubmed
..3% to 10.3% (p<0.0001). The compliance in the group of schizophrenic patients in remission is very low. The telemedicine system improves the compliance in the patients with the worst compliance. ..
Krzystanek M, Krzystanek E, Trzeciak H, MaÅ‚ecki A, Krupka Matuszczyk I, Janas Kozik M, et al
. Effects of olanzapine and paroxetine on phospholipase D activity in the rat brain. Pharmacol Rep. 2013;65:724-9 pubmed
..6%; 20 mmol/kg - by 31.5%, and long-term (21 days) administration of PX - by 39.5%. The study indicates that the 5-HT2 receptor-mediated inhibition of oleate-activated PLD may be a common part of the mechanisms of action of OLZ and PX. ..
Krzystanek M, Bogus K, Pałasz A, Wiaderkiewicz A, Filipczyk Ł, Rojczyk E, et al
. Extended neuroleptic administration modulates NMDA-R subunit immunoexpression in the rat neocortex and diencephalon. Pharmacol Rep. 2016;68:990-5 pubmed publisher
..A decrease in NMDA signaling in this region after long-term neuroleptic administration may also cautiously explain the incomplete effectiveness of these drugs in the therapy of schizophrenia-related cognitive disturbances. ..