Gout and the risk of acute myocardial infarctionEswar Krishnan
University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
Arthritis Rheum 54:2688-96. 2006
....
- Primary knee and hip arthroplasty among nonagenarians and centenarians in the United States
Eswar Krishnan
University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
Arthritis Rheum 57:1038-42. 2007
..This report focuses on the poorly studied epidemiology and mortality outcomes of arthroplasty among these individuals...
- Hyperuricemia and incidence of hypertension among men without metabolic syndrome
Eswar Krishnan
School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
Hypertension 49:298-303. 2007
..09; 95% CI: 1.02 to 1.17). We conclude that the hyperuricemia-hypertension risk relationship is present among normotensive middle-aged men without diabetes/glucose intolerance or metabolic syndrome...
- Gout in ambulatory care settings in the United States
Eswar Krishnan
Division of Rheumatology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
J Rheumatol 35:498-501. 2008
..To describe the ambulatory care utilization by patients with gouty arthritis (gout) in the United States using a nationally representative sample...
Ethnicity and mortality from systemic lupus erythematosus in the USE Krishnan
Division of Rheumatology, Department of Medicine, University of Pittsburgh, S709 BST South, 3500 Terrace St, Pittsburgh, PA 15261, USA
Ann Rheum Dis 65:1500-5. 2006
..To study ethnic differences in mortality from systemic lupus erythematosus (lupus) in two large, population-based datasets...
- Gout and coronary artery disease: epidemiologic clues
Eswar Krishnan
S709 BST South, 3500 Terrace Street, Pittsburgh, PA 15215, USA
Curr Rheumatol Rep 10:249-55. 2008
..Although there are gaps in evidence pointing to a causative pathway, overall, evidence exists for a relationship between gouty arthritis and coronary artery disease independent of traditional risk factors...
- Hospitalization and mortality of patients with systemic lupus erythematosus
Eswar Krishnan
Division of Rheumatology, Department of Medicine, University of Pittsburgh, Pennsylvania 15261, USA
J Rheumatol 33:1770-4. 2006
..To describe hospitalization and mortality outcomes of patients with systemic lupus erythematosus (SLE) in the general population...
Disability in rheumatoid arthritis in the era of biological treatmentsEswar Krishnan
Division of Rheumatology and Immunology, Stanford University Department of Medicine, Palo Alto, CA 94304, USA
Ann Rheum Dis 71:213-8. 2012
..Rheumatoid arthritis (RA) is a disabling disease. The authors studied the impact of new, expensive and occasionally toxic biological treatments on disability outcomes in real-world populations of patients with RA...
- Hyperuricemia in young adults and risk of insulin resistance, prediabetes, and diabetes: a 15-year follow-up study
Eswar Krishnan
Department of Medicine, School of Medicine, Stanford University, Palo Alto, California, USA
Am J Epidemiol 176:108-16. 2012
..This observation was generally consistent across subgroups. The authors conclude that hyperuricemia in the midtwenties is an independent marker for predicting diabetes and prediabetes among young adults in the subsequent 15 years...
- Hyperuricemia and untreated gout are poor prognostic markers among those with a recent acute myocardial infarction
Eswar Krishnan
Department of Medicine, Stanford University School of Medicine, 1000 Welch Rd, Suite 203, Palo Alto, CA 94304, USA
Arthritis Res Ther 14:R10. 2012
..The purpose of this study was to assess hyperuricemia as a biomarker of CHD outcomes in such patients...
- Declines in mortality from acute myocardial infarction in successive incidence and birth cohorts of patients with rheumatoid arthritis
Eswar Krishnan
Stanford University, Division of Immunology, Department of Medicine, 1000 Welch Rd, Suite 203, Palo Alto, Calif, USA
Circulation 110:1774-9. 2004
..The impact of this on atherosclerotic cardiovascular diseases is not known...
- Low-level lead exposure and the prevalence of gout: an observational study
Eswar Krishnan
Stanford University School of Medicine, 1000 Welch Road, Suite 203, Palo Alto, CA 94304, USA
Ann Intern Med 157:233-41. 2012
..Lead toxicity can lead to gouty arthritis (gout), but whether the low lead exposure in the contemporary general population confers risk for gout is not known...
- Muscle strength, mass, and quality in older men and women with knee osteoarthritis
Molly B Conroy
University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Arthritis Care Res (Hoboken) 64:15-21. 2012
..To examine the relationship between knee osteoarthritis (OA) and muscle parameters in a biracial cohort of older adults...
- Serum uric acid level and risk for peripheral arterial disease: analysis of data from the multiple risk factor intervention trial
Joshua F Baker
Department of Medicine, University of Pennsylvania, USA
Angiology 58:450-7. 2007
..A history of gouty arthritis is an independent and statistically significant predictor of incidence of PAD even after adjustment for the effect of underlying hyperuricemia...
- Hyperuricemia and the echocardiographic measures of myocardial dysfunction
Eswar Krishnan
Stanford University School of Medicine, Palo Alto, CA 94304, USA
Congest Heart Fail 18:138-43. 2012
..604) for abnormal LV ejection fraction and 4.584 (95% confidence interval, 1.951-10.768) for LV systolic dysfunction compared with those in the lowest quartile. Hyperuricemia in young adults can be a marker for subsequent heart failure...
- Percentile benchmarks in patients with rheumatoid arthritis: Health Assessment Questionnaire as a quality indicator (QI)
Eswar Krishnan
Clinical Research Center of Reading, West Reading, PA, USA
Arthritis Res Ther 6:R505-13. 2004
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- Hyperuricemia and incident heart failure
Eswar Krishnan
Department of Medicine, Stanford University School of Medicine, Stanford, California, USA
Circ Heart Fail 2:556-62. 2009
..However, the relationship between hyperuricemia and the risk for incidence of heart failure in a community-based population has not been studied...
- Improved responsiveness and reduced sample size requirements of PROMIS physical function scales with item response theory
James F Fries
Department of Medicine, Stanford University School of Medicine, 1000 Welch Road, Suite 203, Palo Alto, CA 04304, USA
Arthritis Res Ther 13:R147. 2011
..We compared the ability to detect change in physical function using original (Legacy) instruments with Item-Improved and PROMIS IRT-based instruments...
- Inflammation, oxidative stress and lipids: the risk triad for atherosclerosis in gout
Eswar Krishnan
Division of Immunology and Rheumatology, Stanford University School of Medicine, Palo Alto, CA, USA
Rheumatology (Oxford) 49:1229-38. 2010
..It is hoped that the introduction of newer urate-lowering agents may help to clarify this picture and improve treatment options for both gout and atherosclerosis...
- Stroke subtypes among young patients with systemic lupus erythematosus
Eswar Krishnan
Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
Am J Med 118:1415. 2005
..Little is known about subtypes of stroke in lupus...
- Attrition bias in rheumatoid arthritis databanks: a case study of 6346 patients in 11 databanks and 65,649 administrations of the Health Assessment Questionnaire
Eswar Krishnan
Division of Rheumatology, Department of Medicine, Stanford University, Palo Alto, California, USA
J Rheumatol 31:1320-6. 2004
..Patient dropout (attrition) can bias and threaten validity of databank-based studies. Although there are several databanks of rheumatoid arthritis (RA) in operation, this phenomenon has not been well studied...
- Patient questionnaires and formal education level as prospective predictors of mortality over 10 years in 97% of 1416 patients with rheumatoid arthritis from 15 United States private practices
Theodore Pincus
Division of Rheumatology and Immunology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232-4500, USA
J Rheumatol 31:229-34. 2004
..This study shows that it is possible to account for more than 95% of patients over 10 years using mailed questionnaires to monitor patient status...
- Hyperuricemia and the risk for subclinical coronary atherosclerosis--data from a prospective observational cohort study
Eswar Krishnan
Department of Medicine, Stanford University School of Medicine, 1000 Welch Road, Suite 203, Palo Alto, CA 94304, USA
Arthritis Res Ther 13:R66. 2011
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- Progress in assessing physical function in arthritis: PROMIS short forms and computerized adaptive testing
James F Fries
Department of Medicine, Stanford University School of Medicine, Palo Alto, CA 94304, USA
J Rheumatol 36:2061-6. 2009
..IRT-based instruments can improve measurement precision substantially over a wider range of disease severity. These modern methods were applied and the magnitude of improvement was estimated...
- The PROMIS of better outcome assessment: responsiveness, floor and ceiling effects, and Internet administration
James Fries
Department of Medicine, Stanford University School of Medicine, Palo Alto, California, USA
J Rheumatol 38:1759-64. 2011
..We present data on current progress in 3 crucial areas: floor and ceiling effects, responsiveness to change, and interactive computer-based administration over the Internet...
- Measuring effectiveness of drugs in observational databanks: promises and perils
Eswar Krishnan
Division of Immunology, Department of Medicine, Stanford University, Palo Alto, CA, USA
Arthritis Res Ther 6:41-4. 2004
..An international metaRegister and a formal mechanism for standardizing and sharing drug data could help improve the utility of databanks. Medical journals have a vital role in enforcing a quality checklist that improves reporting...
- Reduction in long-term functional disability in rheumatoid arthritis from 1977 to 1998:a longitudinal study of 3035 patients
Eswar Krishnan
Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, California 94304, USA
Am J Med 115:371-6. 2003
..This decline is consistent with a beneficial effect of the associated changes in treatment strategies...
- Smoking-gender interaction and risk for rheumatoid arthritis
Eswar Krishnan
Department of Medicine, Stanford University, Palo Alto, California, USA
Arthritis Res Ther 5:R158-62. 2003
..We conclude that sex is a biologic effect modifier in the association between smoking and rheumatoid arthritis. The role of menopause in the etiology of rheumatoid arthritis merits further research...
- Systemic lupus erythematosus, rheumatoid arthritis, and postarthroplasty mortality: a cross-sectional analysis from the nationwide inpatient sample
Robyn T Domsic
Stanford University School of Medicine, Palo Alto, CA 94304, USA
J Rheumatol 37:1467-72. 2010
..Systemic lupus erythematosus (SLE) is a disease of considerable morbidity, and this may place patients at greater risk for poor in-hospital postoperative outcomes for procedures such as arthroplasty. Our aim was to test this hypothesis...
- Long-term cardiovascular mortality among middle-aged men with gout
Eswar Krishnan
Division of Rheumatology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Arch Intern Med 168:1104-10. 2008
..There are limited data available on the association of gouty arthritis (gout) in middle age with long-term cardiovascular disease (CVD) mortality...
- National databases and rheumatology research II: the National Health and Nutrition Examination Surveys
Tuulikki Sokka
Division of Rheumatology and Immunology, Department of Medicine, Vanderbilt University, 203 Oxford House, Nashville, TN 37232 4500, USA
Rheum Dis Clin North Am 30:869-78, viii. 2004
..This article describes features of the surveys and provides examples of research on musculoskeletal disorders that used the survey data...
- Normative values for the Health Assessment Questionnaire disability index: benchmarking disability in the general population
Eswar Krishnan
Stanford University, Palo Alto, California, USA
Arthritis Rheum 50:953-60. 2004
..This study was undertaken to establish normative values for the HAQ DI in a general population and to analyze its correlates...
- Nature versus nurture in gout: a twin study
Eswar Krishnan
Division of Immunology and Rheumatology, Stanford University School of Medicine, Palo Alto, CA, USA
Am J Med 125:499-504. 2012
..Some rare forms of gout have a known genetic basis, but the relative importance of genetic factors on the risk for the lifetime prevalence of gout is not clear...
- What constitutes progress in assessing patient outcomes?
James F Fries
Stanford University School of Medicine, Palo Alto, CA 94304, USA
J Clin Epidemiol 62:779-80. 2009
..Another limitation is the degree of measurement error, the signal-to-noise ratio. These two issues drive down the statistical power of clinical trials and increase their expense...
- An analysis of connective tissue disease-associated interstitial lung disease at a US Tertiary Care Center: better survival in patients with systemic sclerosis
Robert Su
Department of Medicine, Division of Immunology and Rheumatology, Division of Pulmonary and Critical Care, Stanford University School of Medicine, Palo Alto, CA, USA
J Rheumatol 38:693-701. 2011
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- Equipoise, design bias, and randomized controlled trials: the elusive ethics of new drug development
James F Fries
Stanford University School of Medicine, Palo Alto, California, USA
Arthritis Res Ther 6:R250-5. 2004
..We propose a principle of 'positive expected outcomes', which informs the assessment that a trial is ethical, together with a restatement of the priority of personal autonomy...
- Systemic sclerosis mortality in the United States: 1979-1998
Eswar Krishnan
Department of Medicine, Division of Rheumatology and Clinical Immmunology, University of Pittsburgh, Pittsburgh, PA, USA
Eur J Epidemiol 20:855-61. 2005
..This rise occurred during a period in which post-diagnosis survival of SSc is known to have increased, suggesting an increasing incidence of this disease...
- Factors associated with patients who leave acute-care hospitals against medical advice
Said A Ibrahim
Center for Health Equity Research and Promotion, Veterans Administration Pittsburgh Healthcare System, Pittsburgh, PA 15240, USA
Am J Public Health 97:2204-8. 2007
..We examined hospital- and patient-related factors associated with discharge against medical advice (termed self-discharge) after emergency admission to acute-care hospitals...
- Decline in miR-181a expression with age impairs T cell receptor sensitivity by increasing DUSP6 activity
Guangjin Li
Department of Medicine, Stanford University School of Medicine, Stanford, California, USA
Nat Med 18:1518-24. 2012
..DUSP6 is a potential intervention target for restoring T cell responses in the elderly, which may augment the effectiveness of vaccination...
- Obstetric hospitalizations in the United States for women with systemic lupus erythematosus and rheumatoid arthritis
Eliza F Chakravarty
Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, California, USA
Arthritis Rheum 54:899-907. 2006
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- Disease-related and all-cause health care costs of elderly patients with gout
Eric Q Wu
Analysis Group, 111 Huntington Ave, 10th Fl, Boston, MA 02199, USA
J Manag Care Pharm 14:164-75. 2008
..Older adults with gout are of particular interest because they tend to experience higher rates of tophi, an advanced stage of gout, than do younger patients...
- Serum uric acid and cardiovascular disease: recent developments, and where do they leave us?
Joshua F Baker
University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
Am J Med 118:816-26. 2005
..Trials of SUA-lowering therapy in hyperuricemic patients evaluating the effect on cardiovascular outcomes are justified in high-risk patients...
- Functional disability in rheumatoid arthritis patients compared with a community population in Finland
Tuulikki Sokka
Jyvaskyla Central Hospital, Jyvaskyla, Finland
Arthritis Rheum 48:59-63. 2003
..To compare Health Assessment Questionnaire (HAQ) scores of patients with rheumatoid arthritis (RA) with HAQ scores from a sex- and age-adjusted population...
- Smoking, gender and rheumatoid arthritis-epidemiological clues to etiology. Results from the behavioral risk factor surveillance system
Eswar Krishnan
Clinical Research Center of Reading, 401 Buttonwood St, West Reading, PA 19611, USA
Joint Bone Spine 70:496-502. 2003
..This study was undertaken to confirm and extend our earlier observation that gender is a biological effect modifier of smoking-rheumatoid arthritis (RA) relationship in a diverse national survey sample in the United States...
