Factors of influence on acute skin toxicity of breast cancer patients treated with standard three-dimensional conformal radiotherapy (3D-CRT) after breast conserving surgery (BCS)Uta Kraus-Tiefenbacher
Department of Radiation Oncology, University Medical Center Mannheim, University of Heidelberg, 68167, Mannheim, Germany
Radiat Oncol 7:217. 2012
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Postoperative seroma formation after intraoperative radiotherapy using low-kilovoltage X-rays given during breast-conserving surgeryUta Kraus-Tiefenbacher
Department of Radiation Oncology, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany
Int J Radiat Oncol Biol Phys 77:1140-5. 2010
..To determine the frequency and volume of seroma after breast-conserving surgery (BCS) with or without intraoperative radiotherapy (IORT)...
- Intraoperative radiotherapy as a boost during breast-conserving surgery using low-kilovoltage X-rays: the first 5 years of experience with a novel approach
Frederik Wenz
Department of Radiation Oncology, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany
Int J Radiat Oncol Biol Phys 77:1309-14. 2010
..We report the first 5 years of a single-center experience after introduction of a novel approach to deliver IORT as a tumor bed boost during BCS for breast cancer...
Intraoperative radiotherapy (IORT) for breast cancer using the Intrabeam systemUta Kraus-Tiefenbacher
Department of Radiation Oncology, Mannheim Medical Center, University of Heidelberg, Germany
Tumori 91:339-45. 2005
..This report will focus on the feasibility and technical aspects of the Intrabeam device and will summarize our experience with side effects and local control...
- Long-term toxicity of an intraoperative radiotherapy boost using low energy X-rays during breast-conserving surgery
Uta Kraus-Tiefenbacher
Department of Radiation Oncology, Mannheim Medical Center, University of Heidelberg, Mannheim, Germany
Int J Radiat Oncol Biol Phys 66:377-81. 2006
..To date there are only limited data available on breast cancer patients treated with IORT using low energy X-rays. We analyzed toxicity and cosmesis after IORT as a boost with a minimum follow-up of 18 months...
- Intraoperative radiotherapy (IORT) as a boost in patients with early-stage breast cancer -- acute toxicity
Uta Kraus-Tiefenbacher
Department of Radiation Oncology, Universitatsklinikum Mannheim, Germany
Onkologie 29:77-82. 2006
..We report on acute toxicities as well as the early cosmetic outcome of patients receiving intraoperative radiotherapy (IORT) followed by whole-breast radiotherapy (WBRT) compared to patients treated with standard WBRT alone...
- Health-related quality of life after breast-conserving surgery and intraoperative radiotherapy for breast cancer using low-kilovoltage X-rays
Grit Welzel
Department of Radiation Oncology, University Medical Center Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, Mannheim, Germany
Ann Surg Oncol 17:359-67. 2010
..In a matched-pair study, we assessed quality of life (QoL) in 69 patients with early breast cancer treated with BCS and/or IORT and/or EBRT...
- Late radiation toxicity after intraoperative radiotherapy (IORT) for breast cancer: results from the randomized phase III trial TARGIT A
Elena Sperk
Department of Radiation Oncology, University Medical Center Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
Breast Cancer Res Treat 135:253-60. 2012
..With its very low chronic skin toxicity rates and outstanding long-term results regarding toxicity and local control, IORT with 50 kV X-rays is a safe and effective method for treatment of selected breast cancer patients...
- Intraoperative radiotherapy during breast-conserving surgery using a miniature x-ray generator (Intrabeam®): theoretical and experimental background and clinical experience
Frederik Wenz
Department of Radiation Oncology, University Medical Centre Mannheim, University of Heidelberg, 68167 Mannheim, Germany
Womens Health (Lond Engl) 8:39-47. 2012
..Experimental and clinical experience is presented based on in vitro experiments and more than 300 treated patients in a single department with mature follow-up...
- Single-center long-term follow-up after intraoperative radiotherapy as a boost during breast-conserving surgery using low-kilovoltage x-rays
Elena Blank
Department of Radiation Oncology, University Medical Centre Mannheim, University of Heidelberg, Mannheim, Germany
Ann Surg Oncol 17:352-8. 2010
..Intraoperative radiotherapy (IORT) during breast-conserving surgery as a boost followed by whole-breast radiotherapy is increasingly used...
- Acute neurocognitive impairment during cranial radiation therapy in patients with intracranial tumors
Grit Welzel
Department of Radiation Oncology, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany
Strahlenther Onkol 184:647-54. 2008
..8, 2, 3, >or=20 Gy) on cognitive function with special emphasis on memory. We assessed patients with and without intracranial tumors to distinguish between direct and indirect radiation effects on brain tissue...
- Early initiation of external beam radiotherapy (EBRT) may increase the risk of long-term toxicity in patients undergoing intraoperative radiotherapy (IORT) as a boost for breast cancer
Frederik Wenz
Department of Radiation Oncology, University of Heidelberg, University Medical Center Mannheim, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
Breast 17:617-22. 2008
..Intraoperative radiotherapy (IORT) during breast-conserving surgery is increasingly used. We analyzed the influence of the interval between an IORT boost and external beam radiotherapy (EBRT) on late toxicity...
- Radiobiological aspects of intraoperative radiotherapy (IORT) with isotropic low-energy X rays for early-stage breast cancer
Carsten Herskind
Department of Radiation Oncology, Inst of Clinical Radiology, Mannheim Medical Center, University of Heidelberg, Germany
Radiat Res 163:208-15. 2005
..The RBE for tumor cells was higher than for late-reacting tissue. The applicator diameter is an important parameter in determining the range of tumor cell control in the irradiated tumor bed...
- Sphere of equivalence--a novel target volume concept for intraoperative radiotherapy using low-energy X rays
Carsten Herskind
Department of Radiation Oncology, University of Heidelberg, Mannheim Medical Center, Mannheim, Germany
Int J Radiat Oncol Biol Phys 72:1575-81. 2008
..The purpose was to compare the expected risk of local recurrence in this nonuniform radiation field with that after conventional external beam radiotherapy...
- Kypho-IORT--a novel approach of intraoperative radiotherapy during kyphoplasty for vertebral metastases
Frederik Wenz
Department of Radiation Oncology, University Medical Centre Mannheim, Heidelberg University, Mannheim, Germany
Radiat Oncol 5:11. 2010
..We developed a novel approach to deliver intraoperative radiotherapy (IORT) during kyphoplasty and report the first treated case...
- Intraoperative radiotherapy (IORT) is an option for patients with localized breast recurrences after previous external-beam radiotherapy
Uta Kraus-Tiefenbacher
Department of Radiation Oncology, Mannheim Medical Center, University of Heidelberg, Theodor Kutzer Ufer 1 3, D 68167 Mannheim, Germany
BMC Cancer 7:178. 2007
..The following report presents a single center experience with intraoperative radiotherapy (IORT) during excision of recurrent breast cancer in the previously irradiated breast...
- Potential effect of robust and simple IMRT approach for left-sided breast cancer on cardiac mortality
Frank Lohr
Department of Radiation Oncology, Mannheim University Medical Center, University of Heidelberg, Mannheim, Germany
Int J Radiat Oncol Biol Phys 74:73-80. 2009
..We compared aperture-based multifield intensity-modulated radiotherapy (IMRT) plans to 3D-planned tangent fields using dose-volume histograms, cardiac toxicity risk, and the robustness to positioning errors...
- Memory function before and after whole brain radiotherapy in patients with and without brain metastases
Grit Welzel
Department of Radiation Oncology, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany
Int J Radiat Oncol Biol Phys 72:1311-8. 2008
..To prospectively compare the effect of prophylactic and therapeutic whole brain radiotherapy (WBRT) on memory function in patients with and without brain metastases...
- First description of MR mammographic findings in the tumor bed after intraoperative radiotherapy (IORT) of breast cancer
Klaus Wasser
Institute of Clinical Radiology and Nuclear Medicine, University Medical Center, Mannheim, Medical Faculty Mannheim, Heidelberg University, Germany
Clin Imaging 36:176-84. 2012
..It normally presented as rim enhancement and did not cause any diagnostic uncertainty if viewed together with other tissue characteristics. We do not expect a limited diagnostic value of MRM after IORT...
- Phase I trial of cetuximab in combination with capecitabine, weekly irinotecan, and radiotherapy as neoadjuvant therapy for rectal cancer
Ralf Dieter Hofheinz
Onkologisches Zentrum, III, Medizinische Klinik, Fakultät für Klinische Medizin Mannheim der Universität Heidelberg, Mannheim, Germany
Int J Radiat Oncol Biol Phys 66:1384-90. 2006
..To establish the feasibility and efficacy of chemotherapy with capecitabine, weekly irinotecan, cetuximab, and pelvic radiotherapy for patients with locally advanced rectal cancer...
- A novel device for intravaginal electronic brachytherapy
Frank Schneider
Department of Radiation Oncology, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany
Int J Radiat Oncol Biol Phys 74:1298-305. 2009
..The aim of this study was to create and evaluate a homogeneous cylindrical energy deposition around a newly designed vaginal applicator...
