Aleksander Krag

Summary

Publications

  1. ncbi request reprint Terlipressin improves renal function in patients with cirrhosis and ascites without hepatorenal syndrome
    Aleksander Krag
    Department of Gastroenterology, Hvidovre Hospital, Denmark
    Hepatology 46:1863-71. 2007
  2. doi request reprint The cardiorenal link in advanced cirrhosis
    Aleksander Krag
    Department of Medical Gastroenterology, Hvidovre Hospital, Faculty of Health Sciences, University of Copenhagen, Denmark
    Med Hypotheses 79:53-5. 2012
  3. pmc Safety and efficacy of Profermin® to induce remission in ulcerative colitis
    Aleksander Krag
    Gastrounit, Medical Devision 360, Copenhagen University Hospital Hvidovre, Faculty of Health Sciences, Copenhagen University, DK 2650 Hvidovre, Denmark
    World J Gastroenterol 18:1773-80. 2012
  4. ncbi request reprint [Treatment with infliximab of peristomal pyoderma gangrenosum in ulcerative colitis]
    Aleksander Ahm Krag
    H S Hvidovre Hospital, Gastroenheden, Medicinsk Sektion
    Ugeskr Laeger 167:1968-9. 2005
  5. ncbi request reprint Effects of a single terlipressin administration on cardiac function and perfusion in cirrhosis
    Aleksander Krag
    Departments of aClinical Physiology bGastroenterology, Copenhagen University Hospital Hvidovre, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Eur J Gastroenterol Hepatol 22:1085-92. 2010
  6. doi request reprint Impaired free water excretion in child C cirrhosis and ascites: relations to distal tubular function and the vasopressin system
    Aleksander Krag
    Department of Gastroenterology, Copenhagen University Hospital Hvidovre, Faculty of Health Sciences, University of Copenhagen, Hvidovre, Denmark
    Liver Int 30:1364-70. 2010
  7. doi request reprint Effects of the vasopressin agonist terlipressin on plasma cAMP and ENaC excretion in the urine in patients with cirrhosis and water retention
    Aleksander Krag
    Department of Gastroenterology, Hvidovre University Hospital, Faculty of Health Sciences, University of Copenhagen, Denmark
    Scand J Clin Lab Invest 71:112-6. 2011
  8. doi request reprint Effects of terlipressin on the aquaretic system: evidence of antidiuretic effects
    Aleksander Krag
    Department of Gastroenterology, Hvidovre University Hospital, DK 2650 Hvidovre, Denmark
    Am J Physiol Renal Physiol 295:F1295-300. 2008
  9. ncbi request reprint Pulmonary dysfunction and hepatopulmonary syndrome in cirrhosis and portal hypertension
    Søren Møller
    Department of Clinical Physiology and Nuclear Medicine, Hvidovre Hospital, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Liver Int 29:1528-37. 2009
  10. ncbi request reprint Reduced baroreflex sensitivity and pulmonary dysfunction in alcoholic cirrhosis: effect of hyperoxia
    Søren Møller
    Dept of Clinical Physiology, Hvidovre Hospital, Denmark
    Am J Physiol Gastrointest Liver Physiol 299:G784-90. 2010

Detail Information

Publications26

  1. ncbi request reprint Terlipressin improves renal function in patients with cirrhosis and ascites without hepatorenal syndrome
    Aleksander Krag
    Department of Gastroenterology, Hvidovre Hospital, Denmark
    Hepatology 46:1863-71. 2007
    ..55 mL/min, P < 0.05). U(Na) increased in both groups after terlipressin (P < 0.005). Plasma norepinephrine (P < 0.05) and renin (P < 0.05) decreased after terlipressin. All parameters remained unchanged after the placebo...
  2. doi request reprint The cardiorenal link in advanced cirrhosis
    Aleksander Krag
    Department of Medical Gastroenterology, Hvidovre Hospital, Faculty of Health Sciences, University of Copenhagen, Denmark
    Med Hypotheses 79:53-5. 2012
    ..Thus, the relation between cardiac dysfunction and renal insufficiency should be target for future studies and development of new treatments should focus on ameliorating the cardiac dysfunction...
  3. pmc Safety and efficacy of Profermin® to induce remission in ulcerative colitis
    Aleksander Krag
    Gastrounit, Medical Devision 360, Copenhagen University Hospital Hvidovre, Faculty of Health Sciences, Copenhagen University, DK 2650 Hvidovre, Denmark
    World J Gastroenterol 18:1773-80. 2012
    ..To test the efficacy and safety of Profermin(®) in inducing remission in patients with active ulcerative colitis (UC)...
  4. ncbi request reprint [Treatment with infliximab of peristomal pyoderma gangrenosum in ulcerative colitis]
    Aleksander Ahm Krag
    H S Hvidovre Hospital, Gastroenheden, Medicinsk Sektion
    Ugeskr Laeger 167:1968-9. 2005
  5. ncbi request reprint Effects of a single terlipressin administration on cardiac function and perfusion in cirrhosis
    Aleksander Krag
    Departments of aClinical Physiology bGastroenterology, Copenhagen University Hospital Hvidovre, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Eur J Gastroenterol Hepatol 22:1085-92. 2010
    ..The vasoconstrictor terlipressin is widely used in the treatment of the hepatorenal syndrome and variceal bleeding. However, terlipressin may compromise cardiac function and induce ischemia...
  6. doi request reprint Impaired free water excretion in child C cirrhosis and ascites: relations to distal tubular function and the vasopressin system
    Aleksander Krag
    Department of Gastroenterology, Copenhagen University Hospital Hvidovre, Faculty of Health Sciences, University of Copenhagen, Hvidovre, Denmark
    Liver Int 30:1364-70. 2010
    ..Water retention in advanced cirrhosis and ascites may involve disturbances in renal distal tubular function and in the vasopressin system...
  7. doi request reprint Effects of the vasopressin agonist terlipressin on plasma cAMP and ENaC excretion in the urine in patients with cirrhosis and water retention
    Aleksander Krag
    Department of Gastroenterology, Hvidovre University Hospital, Faculty of Health Sciences, University of Copenhagen, Denmark
    Scand J Clin Lab Invest 71:112-6. 2011
    ..Stimulation of renal V2 receptors may also affect sodium transport via the Epithelial Sodium Channel (ENaC). Furthermore, endothelial V2 receptors may indirectly affect proximal sodium handling by increasing plasma cAMP...
  8. doi request reprint Effects of terlipressin on the aquaretic system: evidence of antidiuretic effects
    Aleksander Krag
    Department of Gastroenterology, Hvidovre University Hospital, DK 2650 Hvidovre, Denmark
    Am J Physiol Renal Physiol 295:F1295-300. 2008
    ..1 mmol/l (P < 0.01). An increase in AQP2 excretion and a decrease in C(H2O) and distal water excretion after terlipressin despite water loading is a clear indication of activation of the antidiuretic system (V2 receptor effect)...
  9. ncbi request reprint Pulmonary dysfunction and hepatopulmonary syndrome in cirrhosis and portal hypertension
    Søren Møller
    Department of Clinical Physiology and Nuclear Medicine, Hvidovre Hospital, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Liver Int 29:1528-37. 2009
    ..Pulmonary dysfunction including the hepatopulmonary syndrome (HPS) is an important complication to cirrhosis and portal hypertension. However, the precise relation to liver dysfunction and the prevalence of HPS are unclear...
  10. ncbi request reprint Reduced baroreflex sensitivity and pulmonary dysfunction in alcoholic cirrhosis: effect of hyperoxia
    Søren Møller
    Dept of Clinical Physiology, Hvidovre Hospital, Denmark
    Am J Physiol Gastrointest Liver Physiol 299:G784-90. 2010
    ..Acute hyperoxia does not significantly revert the low BRS or the prolonged QT interval in cirrhosis...
  11. doi request reprint Effects of treatment with β-blocker and aldosterone antagonist on central and peripheral haemodynamics and oxygenation in cirrhosis
    Christine Winkler
    Department of Clinical Physiology and Nuclear Medicine, Faculty of Health Sciences, Hvidovre Hospital, University of Copenhagen, Copenhagen, Denmark
    Eur J Gastroenterol Hepatol 23:334-42. 2011
    ..We therefore investigated systemic haemodynamics and oxygenation in patients with cirrhosis before and after 3 weeks of treatment with propranolol or spironolactone...
  12. ncbi request reprint Adherence to guidelines in bleeding oesophageal varices and effects on outcome: comparison between a specialized unit and a community hospital
    Lise Hobolth
    Department of Gastroenterology, Hvidovre Hospital, University of Copenhagen, Hvidovre, Denmark
    Eur J Gastroenterol Hepatol 22:1221-7. 2010
    ..Our aims were to compare adherence to evidence-based guidelines in BOV between a specialized unit and a community hospital, and to investigate whether differences in adherence affected the outcome...
  13. ncbi request reprint Profermin is efficacious in patients with active ulcerative colitis--a randomized controlled trial
    Aleksander Krag
    Department of Gastroenterology, Odense University Hospital, Odense, Denmark Gastroenterology Unit, Medical Section, Herlev University Hospital, Copenhagen, Denmark Nordisk Rebalance, Allerød, Denmark Statistics, Bioinformatics and Registry, Danish Cancer Society Research Center, Copenhagen, Denmark and Gastrounit, Medical Division, Hvidovre University Hospital, Denmark
    Inflamm Bowel Dis 19:2584-92. 2013
    ..It consists of water, fermented oats, barley malt, lecithin, and Lactobacillus plantarum 299v. The aim of this study was to assess the clinical efficacy of Profermin...
  14. doi request reprint High-sensitivity C-reactive protein levels predict survival and are related to haemodynamics in alcoholic cirrhosis
    Christian Mortensen
    Department of Gastroenterology, Hvidovre Hospital and Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Eur J Gastroenterol Hepatol 24:619-26. 2012
    ..We investigated a possible association between markers of inflammation and splanchnic and systemic haemodynamics, complications and survival in patients with cirrhosis...
  15. doi request reprint Efficacy and safety of terlipressin in cirrhotic patients with variceal bleeding or hepatorenal syndrome
    Aleksander Krag
    Department of Gastroenterology, Hvidovre University Hospital, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Adv Ther 25:1105-40. 2008
    ..At present, treatment with terlipressin and albumin is considered the most efficient therapy and should therefore be recommended for the treatment of type 1 HRS-1...
  16. ncbi request reprint Pathophysiological aspects of pulmonary complications of cirrhosis
    Søren Møller
    Department of Clinical Physiology 239, Hvidovre Hospital, DK 2650 Hvidovre, Denmark
    Scand J Gastroenterol 42:419-27. 2007
  17. doi request reprint Effects of a single dose of terlipressin on transcutaneous oxygen pressures
    Aleksander Krag
    Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital, Hvidovre, Faculty of Health Sciences, Copenhagen, Denmark
    Scand J Gastroenterol 45:953-8. 2010
    ..Side effects to TP are often related to skin hypoxaemia. The aim of the study was to investigate the transcutaneous oxygen pressures (TcPO(2) mmHg) after administration of 2 mg of TP...
  18. ncbi request reprint The recent reduction in mortality from bleeding oesophageal varices is primarily observed from Days 1 to 5
    Lise Hobolth
    Department of Gastroenterology, Hvidovre University Hospital, Faculty of Health Science, Copenhagen University, Hvidovre, Denmark
    Liver Int 30:455-62. 2010
    ..Several new treatments of bleeding oesophageal varices (BOV) have been introduced during the last 25 years; among these are vasoactive drugs, improved endoscopic techniques and prophylactic antibiotics...
  19. doi request reprint The heart and the liver
    Søren Møller
    Department of Clinical Physiology and Nuclear Medicine, 239, Hvidovre Hospital, Kettegaard Alle 30, DK 2650 Hvidovre, Denmark
    Expert Rev Gastroenterol Hepatol 3:51-64. 2009
    ..Future research should focus on beneficial effects of treatment on cardiac function and mortality...
  20. ncbi request reprint Kidney injury in cirrhosis: pathophysiological and therapeutic aspects of hepatorenal syndromes
    Søren Møller
    Department of Clinical Physiology 239, Center of Functional and Diagnostic Imaging and Research, Hvidovre Hospital, University of Copenhagen, Hvidovre, Denmark
    Liver Int 34:1153-63. 2014
    ..Patients with cirrhosis mainly develop hypervolaemic hyponatraemia. Current evidence does not support routine use of vaptans in the management of hyponatraemia in cirrhosis. ..
  21. doi request reprint Targeting the gut-liver axis in cirrhosis: antibiotics and non-selective β-blockers
    Bjørn S Madsen
    Department of Medical Gastroenterology, Odense University Hospital, Sdr Boulevard 29, 5000 Odense C, Denmark
    Adv Ther 30:659-70. 2013
    ..We discuss their mechanism of action and suggest that combining the two treatment modalities could potentially reduce the risk of complications. ..
  22. doi request reprint Diastolic and autonomic dysfunction in early cirrhosis: a dobutamine stress study
    Emilie Kristine Dahl
    Department of Gastroenterology, Odense University Hospital, Odense, Denmark
    Scand J Gastroenterol 49:362-72. 2014
    ..However, the cardiac chronotropic and inotropic responses to dobutamine stress were normal. The dynamics of ventricular repolarization appears normal in patients with early stage cirrhosis...
  23. doi request reprint The effect of anti-tumor necrosis factor alpha agents on postoperative anastomotic complications in Crohn's disease: a systematic review
    Alaa El-Hussuna
    1Department of Surgery, Slagelse Hospital, Slagelse, Denmark 2Department of Medical Gastroenterology, Odense University Hospital, Odense, Denmark 3Department of Surgery, Holbaek Hospital, University of Copenhagen, Copenhagen, Denmark 4Gastrounit, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark
    Dis Colon Rectum 56:1423-33. 2013
    ..Patients with Crohn's disease treated with anti-tumor necrosis factor alpha agents may have an increased risk of surgical complications...
  24. ncbi request reprint Effect of meal and propranolol on whole body and splanchnic oxygen consumption in patients with cirrhosis
    Aleksander Krag
    Department of Gastroenterology, Hvidovre Hospital, Kettegaard Alle 30, 2650 Hvidovre, Denmark
    Am J Physiol Gastrointest Liver Physiol 291:G8-15. 2006
    ..The splanchnic reduction in oxygen consumption can explain almost the entire reduction in whole body oxygen consumption...
  25. pmc Soluble TNF-Alpha-Receptors I Are Prognostic Markers in TIPS-Treated Patients with Cirrhosis and Portal Hypertension
    Jonel Trebicka
    Department of Internal Medicine I, University of Bonn, Bonn, Germany Gastrounit, Medical Division, Hvidovre Hospital, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 8:e83341. 2013
    ..The aims were to investigate the circulating levels of soluble TNFR-I and -II in cirrhotic patients receiving TIPS...
  26. doi request reprint Endotoxin and tumor necrosis factor-receptor levels in portal and hepatic vein of patients with alcoholic liver cirrhosis receiving elective transjugular intrahepatic portosystemic shunt
    Jonel Trebicka
    Department of Internal Medicine I, University of Bonn, Germany
    Eur J Gastroenterol Hepatol 23:1218-25. 2011
    ..However, the hepatic elimination of endotoxin in cirrhotic patients with severe portal hypertension, in the absence of acute complications, has not been investigated so far...