Uriel Koziol



  1. Preza M, Montagne J, Costábile A, Iriarte A, Castillo E, Koziol U. Analysis of classical neurotransmitter markers in tapeworms: Evidence for extensive loss of neurotransmitter pathways. Int J Parasitol. 2018;48:979-992 pubmed publisher
    ..This gene showed the widest expression in the nervous system, but was also expressed in other tissues, suggesting additional roles of peptidergic signaling in tapeworm development and reproduction. ..
  2. Koziol U. Precursors of neuropeptides and peptide hormones in the genomes of tardigrades. Gen Comp Endocrinol. 2018;267:116-127 pubmed publisher
  3. Koziol U, Radio S, Smircich P, Zarowiecki M, Fernández C, Brehm K. A Novel Terminal-Repeat Retrotransposon in Miniature (TRIM) Is Massively Expressed in Echinococcus multilocularis Stem Cells. Genome Biol Evol. 2015;7:2136-53 pubmed publisher
    ..Future studies of active and inactive ta-TRIM elements could give the first clues on MGE silencing mechanisms in cestodes. ..
  4. Koziol U. Evolutionary developmental biology (evo-devo) of cestodes. Exp Parasitol. 2017;180:84-100 pubmed publisher
    ..Together with the availability of powerful models for related free-living flatworms, these developments should encourage the incorporation of these fascinating parasites into the first-line of evo-devo research. ..
  5. Koziol U, Jarero F, Olson P, Brehm K. Comparative analysis of Wnt expression identifies a highly conserved developmental transition in flatworms. BMC Biol. 2016;14:10 pubmed publisher
    ..Furthermore, the up-regulation of Wnt inhibitors during the specification of multiple anterior poles suggests a mechanism for the unique asexual reproduction of E. multilocularis larvae. ..
  6. Koziol U, Costábile A, Domínguez M, Iriarte A, Alvite G, Kun A, et al. Developmental expression of high molecular weight tropomyosin isoforms in Mesocestoides corti. Mol Biochem Parasitol. 2011;175:181-91 pubmed publisher
    ..Therefore, HMW tropomyosins are markers for the development of muscles during the final differentiation of genital primordia...
  7. Del Puerto L, Rovetta R, Navatta M, Fontana C, Lin G, Moyna G, et al. Negligible elongation of mucin glycans with Gal β1-3 units distinguishes the laminated layer of Echinococcus multilocularis from that of Echinococcus granulosus. Int J Parasitol. 2016;46:311-21 pubmed publisher
    ..The candidate gene was experimentally verified to be transcribed at much higher levels in the larva of E. granulosus than that of E. multilocularis. ..
  8. Koziol U, Koziol M, Preza M, Costábile A, Brehm K, Castillo E. De novo discovery of neuropeptides in the genomes of parasitic flatworms using a novel comparative approach. Int J Parasitol. 2016;46:709-21 pubmed publisher
    ..All genes were expressed in the nervous system with different patterns, indicating a hidden complexity of peptidergic signalling in cestodes. ..
  9. Hemer S, Konrad C, Spiliotis M, Koziol U, Schaack D, Förster S, et al. Host insulin stimulates Echinococcus multilocularis insulin signalling pathways and larval development. BMC Biol. 2014;12:5 pubmed publisher
    ..Furthermore, our data show that Echinococcus insulin signalling pathways are promising targets for the development of novel drugs. ..