KovÃ¡Äik J, Klejdus B, Babula P, Soares M, Hedbavny J, de Lourdes Bastos M. Chromium speciation and biochemical changes vary in relation to plant ploidy. J Inorg Biochem. 2015;145:70-8 pubmed publisher
..Subsequent comparison of Cr(III)-chloride and Cr(III)-nitrate showed similar influence on Cr accumulation and majority of biochemical responses while different impact on phytochelatin 2 amount was the most distinct feature. ..
Kováčik J, Klejdus B. Induction of phenolic metabolites and physiological changes in chamomile plants in relation to nitrogen nutrition. Food Chem. 2014;142:334-41 pubmed publisher
..These data indicate a negative impact of NH4(+) as the only source of N on physiology, but also a higher stimulation of some valuable phenols. Nitrogen-induced changes in comparison with other food/crop plants are discussed. ..
Kováčik J, Backor M. Oxidative status of Matricaria chamomilla plants related to cadmium and copper uptake. Ecotoxicology. 2008;17:471-9 pubmed publisher
..Cd had substantially lower influences and stimulated GR activity more than Cu. Activities of hydrogen peroxide-scavenging enzymes in relation to its accumulation are also discussed. ..
Kováčik J, Klejdus B, Stork F, Hedbavny J. Nitrate deficiency reduces cadmium and nickel accumulation in chamomile plants. J Agric Food Chem. 2011;59:5139-49 pubmed publisher
..On the contrary, ammonium-fed plants exposed to N deficiency did not show similar changes in Cd and Ni contents. The present findings are discussed with respect to the role of phenols and mineral nutrition in metal uptake. ..
KovÃ¡Äik J, GrÃºz J, Biba O, Hedbavny J. Content of metals and metabolites in honey originated from the vicinity of industrial town KoÅ¡ice (eastern Slovakia). Environ Sci Pollut Res Int. 2016;23:4531-40 pubmed publisher
..We conclude that black locust (acacia) honey is the most suitable for daily use and that central European monofloral honeys contain lower amounts of toxic metals in comparison with other geographical regions. ..
Kováčik J, Klejdus B, Hedbavny J, Zon J. Significance of phenols in cadmium and nickel uptake. J Plant Physiol. 2011;168:576-84 pubmed publisher
..Our results indicate that phenols have important roles in the uptake of Cd and Ni. The present findings are discussed in the context of available data regarding AIP's effect on phenols. ..
Kováčik J, Dresler S, Peterková V, Babula P. Metal-induced oxidative stress in terrestrial macrolichens. Chemosphere. 2018;203:402-409 pubmed publisher
..These data suggest close relations between thiols, NO and appearance of oxidative stress (ROS generation) under metallic stress also in lichens. ..
Kováčik J, Gruz J, Hedbavny J, Klejdus B, Strnad M. Cadmium and nickel uptake are differentially modulated by salicylic acid in Matricaria chamomilla plants. J Agric Food Chem. 2009;57:9848-55 pubmed publisher
..The effects of SA on phenolic metabolism, and the signaling role of ROS in the accumulation of phenols, are discussed. ..
Kováčik J, Klejdus B, Backor M. Nitric oxide signals ROS scavenger-mediated enhancement of PAL activity in nitrogen-deficient Matricaria chamomilla roots: side effects of scavengers. Free Radic Biol Med. 2009;46:1686-93 pubmed publisher
..The anomalous effect of PTIO on NO content and possible mechanism of ROS scavenger-evoked NO increases in light of the current knowledge are also discussed. ..
Babula P, Klejdus B, Kováčik J, Hedbavny J, Hlavna M. Lanthanum rather than cadmium induces oxidative stress and metabolite changes in Hypericum perforatum. J Hazard Mater. 2015;286:334-42 pubmed publisher
..Clear differences in the stem and root anatomy in response to Cd or La were also found. Overall, H. perforatum is La-sensitive species and rather Cd ameliorated negative impact of La. ..
Kováčik J, Gruz J, Backor M, Strnad M, Repcák M. Salicylic acid-induced changes to growth and phenolic metabolism in Matricaria chamomilla plants. Plant Cell Rep. 2009;28:135-43 pubmed publisher
..Free SA content in the rosettes increased significantly only in the 250 microM SA treatment, with levels tending to decrease towards the end of the experiment and the opposite trend was observed in the roots. ..
Kováčik J, Klejdus B. Dynamics of phenolic acids and lignin accumulation in metal-treated Matricaria chamomilla roots. Plant Cell Rep. 2008;27:605-15 pubmed
..Taken together, different forms of phenolic metabolites play an important role in chamomile tolerance to metal excess and participate in active antioxidative protection. ..
KovÃ¡Äik J, AntoÅ¡ V, Micalizzi G, Dresler S, HrabÃ¡k P, Mondello L. Accumulation and toxicity of organochlorines in green microalgae. J Hazard Mater. 2018;347:168-175 pubmed publisher
..Accumulation of organochlorines and metabolic responses in algae are reported here for the first time. ..
Kováčik J, Bujdos M, Babula P. Impact of humic acid on the accumulation of metals by microalgae. Environ Sci Pollut Res Int. 2018;25:10792-10798 pubmed publisher
..Present study for the first time showed that humic acid may indirectly affect accumulation of metals and that solid HA-enriched medium used for pre-culture is more suitable to increase accumulation of metals by algae. ..
KovÃ¡Äik J, Klejdus B, Babula P, Hedbavny J. Age affects not only metabolome but also metal toxicity in Scenedesmus quadricauda cultures. J Hazard Mater. 2016;306:58-66 pubmed publisher
..and Parachlorella sp.) and the impact of age on metal uptake may be useful for bioremediation purposes. ..
Kováčik J, Dudáš M, Hedbavny J, Mártonfi P. Dandelion Taraxacum linearisquameum does not reflect soil metal content in urban localities. Environ Pollut. 2016;218:160-167 pubmed publisher
..Overall, our data indicate low pollution of urban soil by Cd (5.53-113.8 ng g-1) and partially by Cr and the suitability of above-ground organs of dandelion species for the monitoring of air pollution mainly by Cd. ..
Kováčik J, Klejdus B, Backor M, Stork F, Hedbavny J. Physiological responses of root-less epiphytic plants to acid rain. Ecotoxicology. 2011;20:348-57 pubmed publisher
..Macronutrients (K, Ca, Mg) decreased more pronouncedly in comparison with micronutrients in all species. Xanthoria showed higher tolerance in comparison with Hypogymnia, suggesting that could be useful for long-term biomonitoring...
Kováčik J, Stork F, Klejdus B, Gruz J, Hedbavny J. Effect of metabolic regulators on aluminium uptake and toxicity in Matricaria chamomilla plants. Plant Physiol Biochem. 2012;54:140-8 pubmed publisher
..These data, to our knowledge for the first time, exactly confirm that phenolic metabolites may affect shoot Al uptake and this relation is rather positive in terms of simple phenols (and negative in terms of coumarin-related compounds). ..
Kováčik J, Rotková G, Bujdos M, Babula P, Peterková V, Matús P. Ascorbic acid protects Coccomyxa subellipsoidea against metal toxicity through modulation of ROS/NO balance and metal uptake. J Hazard Mater. 2017;339:200-207 pubmed publisher
..Our data suggest that given Coccomyxa species is suitable candidate for remediation of Hg or Pb and that ascorbic acid effectively ameliorates metal-induced toxicity without side effects. ..
Kováčik J, Klejdus B, Backor M. Physiological responses of Scenedesmus quadricauda (Chlorophyceae) to UV-A and UV-C light. Photochem Photobiol. 2010;86:612-6 pubmed publisher
..Present findings in the context of available data and with emphasis on phenolics in algae are discussed...
KovÃ¡Äik J, Dresler S. Calcium availability but not its content modulates metal toxicity in Scenedesmus quadricauda. Ecotoxicol Environ Saf. 2018;147:664-669 pubmed publisher
..These data confirm that Ca nutrition affects accumulation of metals in algae and metabolic parameters as observed in vascular plants but, unlike them, rather Ca/Na ratio than absolute Ca content seems to regulate the uptake of metals. ..
Kováčik J, Babula P, Hedbavny J. Comparison of vascular and non-vascular aquatic plant as indicators of cadmium toxicity. Chemosphere. 2017;180:86-92 pubmed publisher
..It was also proven that sensitive microscopic techniques allow the visualization of Cd-induced changes in aquatic plants even after short-term exposure when no morphological signs of damage are visible. ..
Kováčik J, Klejdus B, Stork F, Hedbavny J. Prey-induced changes in the accumulation of amino acids and phenolic metabolites in the leaves of Drosera capensis L. Amino Acids. 2012;42:1277-85 pubmed publisher
..The prey also showed to be an important source of other nutrients besides N, and a stimulation of root uptake of some mineral nutrients is assumed (Mg, Cu, Zn). Accumulation of Ca and Na was not affected by feeding...
Kováčik J, Babula P, Klejdus B, Hedbavny J. Chromium uptake and consequences for metabolism and oxidative stress in chamomile plants. J Agric Food Chem. 2013;61:7864-73 pubmed publisher
..These data indicate that Cr-induced oxidative stress is not simply a function of exposure time and applied concentration. Microscopic observations in terms of oxidative stress and chromium uptake are presented here for the first time. ..
Kováčik J, Klejdus B, Stork F, Hedbavny J. Physiological responses of Tillandsia albida (Bromeliaceae) to long-term foliar metal application. J Hazard Mater. 2012;239-240:175-82 pubmed publisher
..50% of total Cd was absorbed while almost all Ni was absorbed). These data indicate tolerance of T. albida to foliar metal application and together with strong xerophytic morphology, use for environmental studies is recommended...
Kováčik J, Klejdus B, Repčáková K. Phenolic metabolites in carnivorous plants: Inter-specific comparison and physiological studies. Plant Physiol Biochem. 2012;52:21-7 pubmed publisher
..Possible explanations in physiological, biochemical and ecological context are discussed...