K Koss

Summary

Publications

  1. ncbi request reprint Interleukin-10 gene promoter polymorphism in English and Polish healthy controls. Polymerase chain reaction haplotyping using 3' mismatches in forward and reverse primers
    K Koss
    Gastroenterology Unit, Radcliffe Infirmary, Oxford, UK
    Genes Immun 1:321-4. 2000
  2. ncbi request reprint Cytokine (TNF alpha, LT alpha and IL-10) polymorphisms in inflammatory bowel diseases and normal controls: differential effects on production and allele frequencies
    K Koss
    Gastroenterology Unit, Radcliffe Infirmary, Oxford, UK
    Genes Immun 1:185-90. 2000
  3. ncbi request reprint Is interleukin-6 important in inflammatory bowel disease?
    K Koss
    Gastroenterology Unit, Radcliffe Infirmary, Oxford, UK
    Genes Immun 1:207-12. 2000
  4. pmc The metabolic marker tumour pyruvate kinase type M2 (tumour M2-PK) shows increased expression along the metaplasia-dysplasia-adenocarcinoma sequence in Barrett's oesophagus
    K Koss
    Department of Gastroenterology, University Hospital Birmingham, Edgbaston, Birmingham B15 2TH, UK
    J Clin Pathol 57:1156-9. 2004
  5. ncbi request reprint Faecal dimeric M2 pyruvate kinase in colorectal cancer and polyps correlates with tumour staging and surgical intervention
    K Koss
    Gastroenterology Department, Macclesfield District General Hospital, Maccelsfield, UK
    Colorectal Dis 10:244-8. 2008
  6. ncbi request reprint The outcome of surgery in fulminant Clostridium difficile colitis
    K Koss
    Gastrointestinal Unit, Queen Elizabeth Hospital, University Hospital Birmingham NHS Trust, Birmingham, UK
    Colorectal Dis 8:149-54. 2006

Detail Information

Publications6

  1. ncbi request reprint Interleukin-10 gene promoter polymorphism in English and Polish healthy controls. Polymerase chain reaction haplotyping using 3' mismatches in forward and reverse primers
    K Koss
    Gastroenterology Unit, Radcliffe Infirmary, Oxford, UK
    Genes Immun 1:321-4. 2000
    ..Population frequencies of IL-10 genotypes show, in contrast to HLA, that UK and Polish frequencies are remarkably similar...
  2. ncbi request reprint Cytokine (TNF alpha, LT alpha and IL-10) polymorphisms in inflammatory bowel diseases and normal controls: differential effects on production and allele frequencies
    K Koss
    Gastroenterology Unit, Radcliffe Infirmary, Oxford, UK
    Genes Immun 1:185-90. 2000
    ..005, P = 0.015 respectively). These data provide evidence that the effect of TNF alpha, LT alpha and IL-10 gene polymorphisms on cytokine production differ in CD, UC patients and controls...
  3. ncbi request reprint Is interleukin-6 important in inflammatory bowel disease?
    K Koss
    Gastroenterology Unit, Radcliffe Infirmary, Oxford, UK
    Genes Immun 1:207-12. 2000
    ..We postulate that the IL-6 polymorphisms investigated here may be in linkage disequilibrium with a susceptibility gene and that they may be utilised as genetic markers...
  4. pmc The metabolic marker tumour pyruvate kinase type M2 (tumour M2-PK) shows increased expression along the metaplasia-dysplasia-adenocarcinoma sequence in Barrett's oesophagus
    K Koss
    Department of Gastroenterology, University Hospital Birmingham, Edgbaston, Birmingham B15 2TH, UK
    J Clin Pathol 57:1156-9. 2004
    ..In tumours cells, M2-PK usually exists in dimeric form (tumour M2-PK), causing the accumulation of glycolytic phosphometabolites, which allows cells to invade areas with low oxygen and glucose concentrations...
  5. ncbi request reprint Faecal dimeric M2 pyruvate kinase in colorectal cancer and polyps correlates with tumour staging and surgical intervention
    K Koss
    Gastroenterology Department, Macclesfield District General Hospital, Maccelsfield, UK
    Colorectal Dis 10:244-8. 2008
    ..Sandwich ELISA with monoclonal antibodies against dimeric (tumour) M2-PK was used to measure faecal tumour M2-PK in; 13 controls, 10 patients with colonic polyps and 32 patients with colorectal cancer...
  6. ncbi request reprint The outcome of surgery in fulminant Clostridium difficile colitis
    K Koss
    Gastrointestinal Unit, Queen Elizabeth Hospital, University Hospital Birmingham NHS Trust, Birmingham, UK
    Colorectal Dis 8:149-54. 2006
    ..Although not common, fulminant C. difficile colitis can result in bowel perforation and peritonitis with a high mortality rate. Colectomy is often indicated in these cases...