Effects of ezetimibe on the pharmacodynamics and pharmacokinetics of lovastatinTeddy Kosoglou
Department of Early Clinical Research and Experimental Medicine, Schering Plough Research Institute, Kenilworth, NJ 07033 1300, USA
Curr Med Res Opin 20:955-65. 2004
..This study investigated the potential for pharmacodynamic and/or pharmacokinetic interactions between ezetimibe and lovastatin...
Pharmacodynamic interaction between the new selective cholesterol absorption inhibitor ezetimibe and simvastatinTeddy Kosoglou
Schering Plough Research Institute, Kenilworth, NJ
Br J Clin Pharmacol 54:309-19. 2002
..Evaluation of the tolerance of the coadministration of ezetimibe and simvastatin was a secondary objective...
- Pharmacokinetic interaction between ezetimibe and lovastatin in healthy volunteers
Larisa Reyderman
Department of Drug Metabolism and Pharmacokinetics, Schering Plough Research Institute, Kenilworth, NJ 07033 1300, USA
Curr Med Res Opin 20:1493-500. 2004
..The current study was designed to further investigate the potential for pharmacokinetic interaction between ezetimibe and lovastatin...
- Pharmacodynamic and pharmacokinetic interaction between fenofibrate and ezetimibe
Teddy Kosoglou
Department of Early Clinical Research and Experimental Medicine, Schering Plough Research Institute, Kenilworth, NJ 07033, USA
Curr Med Res Opin 20:1197-207. 2004
..The pharmacodynamic, pharmacokinetic, and safety profiles of ezetimibe and fenofibrate were evaluated alone and after co-administration in 32 subjects with primary hypercholesterolemia...
- Pharmacodynamic interaction between ezetimibe and rosuvastatin
Teddy Kosoglou
Department of Early Clinical Research and Experimental Medicine, Schering Plough Research Institute, Kenilworth, NJ 07033, USA
Curr Med Res Opin 20:1185-95. 2004
..A secondary objective was to examine the potential for a pharmacokinetic interaction between ezetimibe and rosuvastatin...
- The effect of fluvastatin on the pharmacokinetics and pharmacodynamics of ezetimibe
Larisa Reyderman
Drug Metabolism and Pharmacokinetics, Schering Plough Research Institute, Kenilworth, NJ 07033 1300, USA
Curr Med Res Opin 21:1171-9. 2005
....
- Ezetimibe: a review of its metabolism, pharmacokinetics and drug interactions
Teddy Kosoglou
Department of Early Clinical Research and Experimental Medicine, Schering Plough Research Institute, Kenilworth, New Jersey, USA
Clin Pharmacokinet 44:467-94. 2005
..Because treatment experience in patients receiving ciclosporin is limited, physicians are advised to exercise caution when initiating ezetimibe in the setting of ciclosporin coadministration, and to carefully monitor ciclosporin levels...
- Disposition of the selective cholesterol absorption inhibitor ezetimibe in healthy male subjects
James E Patrick
Schering Plough Research Institute, Kenilworth, New Jersey 07033 1300, USA
Drug Metab Dispos 30:430-7. 2002
..The pharmacokinetics of ezetimibe are consistent with extensive glucuronidation and enterohepatic recirculation. The primary metabolic pathway for ezetimibe is by glucuronidation of the 4-hydroxyphenyl group...
Once-daily evening dosing of mometasone furoate administered via a dry powder inhaler does not adversely affect the hypothalamic-pituitary-adrenal axisTeddy Kosoglou
Early Clinical Research and Experimental Medicine, Schering Plough Research Institute, 2015 Galloping Hill Road K 15 4, 4455, Kenilworth, NJ 07033, USA
Chest 137:115-21. 2010
..This study reports the effects of moderate-dose (400 microg) mometasone furoate administered via dry powder inhaler (MF-DPI) once daily in the evening on the HPA axis in adults with mild to moderate asthma...
- Effects of ezetimibe on cyclosporine pharmacokinetics in healthy subjects
Arthur J Bergman
Merck Research Laboratories, West Point, PA 19486, USA
J Clin Pharmacol 46:321-7. 2006
..CyA concentrations should be monitored in patients receiving EZE and CyA...
- Interaction of single-dose ezetimibe and steady-state cyclosporine in renal transplant patients
Arthur J Bergman
Clinical Drug Metabolism, Merck Research Laboratories, WP 75-100, Sumneytown Pike, PO Box 4, West Point, PA 19486, USA
J Clin Pharmacol 46:328-36. 2006
..Because the long-term safety implications of both higher EZE exposures and undetermined effect on CyA are not yet understood, the clinical significance of this interaction is unknown...
