Richard S Kornbluth

Summary

Publications

  1. doi request reprint Design of CD40 agonists and their use in growing B cells for cancer immunotherapy
    Richard S Kornbluth
    Multimeric Biotherapeutics, Inc, La Jolla, CA, USA
    Int Rev Immunol 31:279-88. 2012
  2. ncbi request reprint In this issue: Harnessing Immunity against Difficult Targets, through the CD40-CD40L Pathway
    Richard S Kornbluth
    1Richard S Kornbluth, M D, Ph D, Guest Editor, President and Chief Scientific Officer, Multimeric Biotherapeutics, Inc 5580 La Jolla Blvd, Ste 76, La Jolla, CA 92037 7651 E mail
    Int Rev Immunol 31:243-5. 2012
  3. pmc Latent Membrane Protein 1 as a molecular adjuvant for single-cycle lentiviral vaccines
    Sachin Gupta
    Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL, USA
    Retrovirology 8:39. 2011
  4. pmc Macaque multimeric soluble CD40 ligand and GITR ligand constructs are immunostimulatory molecules in vitro
    Geoffrey W Stone
    Department of Medicine, University of California, San Diego, La Jolla, California 92093 0679, USA
    Clin Vaccine Immunol 13:1223-30. 2006
  5. doi request reprint Regression of established AB1 murine mesothelioma induced by peritumoral injections of CpG oligodeoxynucleotide either alone or in combination with poly(I:C) and CD40 ligand plasmid DNA
    Geoffrey W Stone
    Department of Medicine, University of California San Diego, La Jolla, California 92093 0679, USA
    J Thorac Oncol 4:802-8. 2009
  6. ncbi request reprint Immunostimulatory combinations: designing the next generation of vaccine adjuvants
    Richard S Kornbluth
    Department of Medicine, University of California San Diego, 9500 Gilman Dr, 0679, La Jolla, CA 92093 0679, USA
    J Leukoc Biol 80:1084-102. 2006
  7. pmc Multimeric soluble CD40 ligand and GITR ligand as adjuvants for human immunodeficiency virus DNA vaccines
    Geoffrey W Stone
    Department of Medicine 0679, Stein Clinical Sciences Bldg, Room 304, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0679, USA
    J Virol 80:1762-72. 2006
  8. pmc Mutations in the E9L polymerase gene of cidofovir-resistant vaccinia virus strain WR are associated with the drug resistance phenotype
    Richard S Kornbluth
    Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0676, USA
    Antimicrob Agents Chemother 50:4038-43. 2006

Collaborators

Detail Information

Publications8

  1. doi request reprint Design of CD40 agonists and their use in growing B cells for cancer immunotherapy
    Richard S Kornbluth
    Multimeric Biotherapeutics, Inc, La Jolla, CA, USA
    Int Rev Immunol 31:279-88. 2012
    ..As a result, the use of CD40-B cells as antigen-presenting cells (APCs) promises to streamline the generation of anti-tumor CD8(+) T cells for the adoptive cell therapy (ACT) of cancer...
  2. ncbi request reprint In this issue: Harnessing Immunity against Difficult Targets, through the CD40-CD40L Pathway
    Richard S Kornbluth
    1Richard S Kornbluth, M D, Ph D, Guest Editor, President and Chief Scientific Officer, Multimeric Biotherapeutics, Inc 5580 La Jolla Blvd, Ste 76, La Jolla, CA 92037 7651 E mail
    Int Rev Immunol 31:243-5. 2012
    ....
  3. pmc Latent Membrane Protein 1 as a molecular adjuvant for single-cycle lentiviral vaccines
    Sachin Gupta
    Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL, USA
    Retrovirology 8:39. 2011
    ..Here we explore the incorporation of two CD40 mimics, Epstein Barr Virus gene LMP1 or an LMP1-CD40 chimera, into a strain of SIV that was engineered to be limited to a single cycle of infection...
  4. pmc Macaque multimeric soluble CD40 ligand and GITR ligand constructs are immunostimulatory molecules in vitro
    Geoffrey W Stone
    Department of Medicine, University of California, San Diego, La Jolla, California 92093 0679, USA
    Clin Vaccine Immunol 13:1223-30. 2006
    ..These molecular adjuvants provide new tools for vaccine development in the simian immunodeficiency virus system and other macaque models...
  5. doi request reprint Regression of established AB1 murine mesothelioma induced by peritumoral injections of CpG oligodeoxynucleotide either alone or in combination with poly(I:C) and CD40 ligand plasmid DNA
    Geoffrey W Stone
    Department of Medicine, University of California San Diego, La Jolla, California 92093 0679, USA
    J Thorac Oncol 4:802-8. 2009
    ..The synergistic effects of these combinations have been tested in other tumor types but not in mesothelioma...
  6. ncbi request reprint Immunostimulatory combinations: designing the next generation of vaccine adjuvants
    Richard S Kornbluth
    Department of Medicine, University of California San Diego, 9500 Gilman Dr, 0679, La Jolla, CA 92093 0679, USA
    J Leukoc Biol 80:1084-102. 2006
    ..Taken together, these new approaches provide significant incremental progress in the development of vaccines to elicit cell-mediated immunity against HIV and other pathogens...
  7. pmc Multimeric soluble CD40 ligand and GITR ligand as adjuvants for human immunodeficiency virus DNA vaccines
    Geoffrey W Stone
    Department of Medicine 0679, Stein Clinical Sciences Bldg, Room 304, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0679, USA
    J Virol 80:1762-72. 2006
    ..In summary, multimeric CD40L and GITRL are new adjuvants for DNA vaccines. Plasmids for expressing multimeric TNFSF fusion proteins permit the rapid testing of TNFSF molecules in vivo...
  8. pmc Mutations in the E9L polymerase gene of cidofovir-resistant vaccinia virus strain WR are associated with the drug resistance phenotype
    Richard S Kornbluth
    Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0676, USA
    Antimicrob Agents Chemother 50:4038-43. 2006
    ..These findings suggest that drug therapy for poxviruses may be complicated by drug resistance but that treatment of the infection with currently known compounds is possible...