Ahmet Korkmaz

Summary

Publications

  1. ncbi request reprint The use of melatonin to combat mustard toxicity. REVIEW
    Ahmet Korkmaz
    Department of Physiology, School of Medicine, Gulhane Military Medical Academy, Ankara, Turkey
    Neuro Endocrinol Lett 29:614-9. 2008
  2. ncbi request reprint Melatonin alleviates lung damage induced by the chemical warfare agent nitrogen mustard
    Muharrem Ucar
    Department of Public Health, Gulhane Military Medical Academy, Ankara, Turkey
    Toxicol Lett 173:124-31. 2007
  3. doi request reprint The protective effects of ozone therapy in a rat model of acetaminophen-induced liver injury
    Husamettin Gul
    Department of Toxicology, Gulhane Military Medical Academy, Etlik, Ankara, Turkey
    Environ Toxicol Pharmacol 34:81-6. 2012
  4. doi request reprint Melatonin and 1400 W ameliorate both intestinal and remote organ injury following mesenteric ischemia/reperfusion
    Vural Kesik
    Department of Pediatrics, Gulhane Military Medical Academy, Etlik, Ankara, Turkey
    J Surg Res 157:e97-e105. 2009
  5. doi request reprint Poly(ADP-ribose) polymerase inhibition modulates experimental acute necrotizing pancreatitis-induced oxidative stress, bacterial translocation and neopterin concentrations in rats
    Mehmet Yasar
    Noncommissioned Officer Health College, Gulhane Military Medical Academy, Etlik, Ankara 06018, Turkey
    Exp Biol Med (Maywood) 235:1126-33. 2010
  6. doi request reprint Comparison of the efficacy of melatonin and 1400W on renal ischemia/reperfusion injury: a role for inhibiting iNOS
    Nail Ersoz
    Gulhane Military Medical Academy, Department of Surgery, 06018 Etlik, Ankara, Turkey
    Ren Fail 31:704-10. 2009
  7. doi request reprint Evaluation of effects of s-methyl isothiourea and melatonin on intestinal ischemia/reperfusion injury in rats
    Turan Tunc
    Department of Pediatrics, School of Medicine, Gulhane Military Medical Academy, Ankara, Turkey
    Fetal Pediatr Pathol 29:212-23. 2010
  8. doi request reprint Effect of 3-amino benzamide, a poly(adenosine diphosphate-ribose) polymerase inhibitor, in experimental caustic esophageal burn
    Ahmet Guven
    Department of Pediatric Surgery, Gulhane Military Medical Academy, Etlik, 06017 Ankara, Turkey
    J Pediatr Surg 43:1474-9. 2008
  9. ncbi request reprint Oxidative stress levels in rats following exposure to oxygen at 3 atm for 0-120 min
    Sukru Oter
    Department of Physiology, Gulhane Military Medical Academy, Ankara, Turkey
    Aviat Space Environ Med 78:1108-13. 2007
  10. doi request reprint Effect of preconditioned hyperbaric oxygen and ozone on ischemia-reperfusion induced tourniquet in skeletal bone of rats
    Kenan Koca
    Department of Orthopaedic Surgery, Gulhane Military Medical Academy, Etlik Ankara, Turkey
    J Surg Res 164:e83-9. 2010

Collaborators

Detail Information

Publications69

  1. ncbi request reprint The use of melatonin to combat mustard toxicity. REVIEW
    Ahmet Korkmaz
    Department of Physiology, School of Medicine, Gulhane Military Medical Academy, Ankara, Turkey
    Neuro Endocrinol Lett 29:614-9. 2008
    ..We propose that epigenetic aberrations may be responsible for delayed detrimental effects of mustard poisoning. Therefore, as a putative epigenetic modulator, melatonin may also be beneficial to subjects with delayed toxicity of SM...
  2. ncbi request reprint Melatonin alleviates lung damage induced by the chemical warfare agent nitrogen mustard
    Muharrem Ucar
    Department of Public Health, Gulhane Military Medical Academy, Ankara, Turkey
    Toxicol Lett 173:124-31. 2007
    ..In conclusion, the results of study provide evidence that melatonin may have the ability to reduce mustard-induced toxicity in the lungs...
  3. doi request reprint The protective effects of ozone therapy in a rat model of acetaminophen-induced liver injury
    Husamettin Gul
    Department of Toxicology, Gulhane Military Medical Academy, Etlik, Ankara, Turkey
    Environ Toxicol Pharmacol 34:81-6. 2012
    ..Ozone therapy (OT) is shown to reduce inflammation and necrosis in several entities. Thus, we have designed this study to evaluate the efficacy of OT in a rat model of APAP-induced liver injury...
  4. doi request reprint Melatonin and 1400 W ameliorate both intestinal and remote organ injury following mesenteric ischemia/reperfusion
    Vural Kesik
    Department of Pediatrics, Gulhane Military Medical Academy, Etlik, Ankara, Turkey
    J Surg Res 157:e97-e105. 2009
    ....
  5. doi request reprint Poly(ADP-ribose) polymerase inhibition modulates experimental acute necrotizing pancreatitis-induced oxidative stress, bacterial translocation and neopterin concentrations in rats
    Mehmet Yasar
    Noncommissioned Officer Health College, Gulhane Military Medical Academy, Etlik, Ankara 06018, Turkey
    Exp Biol Med (Maywood) 235:1126-33. 2010
    ..These findings suggest that it may be possible to improve the outcome of ANP by using PARP inhibitors...
  6. doi request reprint Comparison of the efficacy of melatonin and 1400W on renal ischemia/reperfusion injury: a role for inhibiting iNOS
    Nail Ersoz
    Gulhane Military Medical Academy, Department of Surgery, 06018 Etlik, Ankara, Turkey
    Ren Fail 31:704-10. 2009
    ....
  7. doi request reprint Evaluation of effects of s-methyl isothiourea and melatonin on intestinal ischemia/reperfusion injury in rats
    Turan Tunc
    Department of Pediatrics, School of Medicine, Gulhane Military Medical Academy, Ankara, Turkey
    Fetal Pediatr Pathol 29:212-23. 2010
    ..It was shown; combination of SMT and melatonin may exert more promised results...
  8. doi request reprint Effect of 3-amino benzamide, a poly(adenosine diphosphate-ribose) polymerase inhibitor, in experimental caustic esophageal burn
    Ahmet Guven
    Department of Pediatric Surgery, Gulhane Military Medical Academy, Etlik, 06017 Ankara, Turkey
    J Pediatr Surg 43:1474-9. 2008
    ....
  9. ncbi request reprint Oxidative stress levels in rats following exposure to oxygen at 3 atm for 0-120 min
    Sukru Oter
    Department of Physiology, Gulhane Military Medical Academy, Ankara, Turkey
    Aviat Space Environ Med 78:1108-13. 2007
    ..We previously defined the pressure-related oxidative effects of HBO in several tissues of rats. This study was performed to elucidate the relationship of HBO exposure time to its oxidative effects...
  10. doi request reprint Effect of preconditioned hyperbaric oxygen and ozone on ischemia-reperfusion induced tourniquet in skeletal bone of rats
    Kenan Koca
    Department of Orthopaedic Surgery, Gulhane Military Medical Academy, Etlik Ankara, Turkey
    J Surg Res 164:e83-9. 2010
    ..The aim of the study was to investigate effect of I/R injury on bone tissue and protective role of hyperbaric oxygen precondition (HBO-PC) and ozone precondition (O(3)-PC) on I/R injury by using biochemical analysis...
  11. doi request reprint Efficacy of hyperbaric oxygen therapy and medical ozone therapy in experimental acute necrotizing pancreatitis
    Bulent Uysal
    Department of Physiology, Gulhane Military Medical Academy, Ankara, Turkey
    Pancreas 39:9-15. 2010
    ..Our aims were to evaluate the efficacy of ozone therapy (OT) in an experimental rat model of acute necrotizing pancreatitis (ANP) and to compare its effects with hyperbaric oxygen (HBO) therapy in this entity...
  12. ncbi request reprint Time-dependent course of hyperbaric oxygen-induced oxidative effects in rat lung and erythrocytes
    Hakan Ay
    Department of Undersea and Hyperbaric Medicine, Gulhane Military Medical Academy, Ankara, Turkey
    Clin Exp Pharmacol Physiol 34:787-91. 2007
    ..Further studies should focus on the molecular mechanisms that can be activated during this time interval...
  13. doi request reprint Long-term exposure to repetitive hyperbaric oxygen results in cumulative oxidative stress in rat lung tissue
    Kemal Simsek
    Gulhane Military Medical Academy, Department of Undersea and Hyperbaric Medicine, Ankara, Turkey
    Inhal Toxicol 23:166-72. 2011
    ..Nevertheless, these studies were usually performed with single-session HBO exposure but its clinical use commonly depends on long-term exposure periods...
  14. ncbi request reprint Persistence of hyperbaric oxygen-induced oxidative effects after exposure in rat brain cortex tissue
    Hakan Ay
    Department of Undersea and Hyperbaric Medicine, Gulhane Military Medical Academy, 06018 Etlik Ankara, Turkey
    Life Sci 80:2025-9. 2007
    ..In conclusion, the oxidative effect of HBO was shown to persist only for 1 h. Further studies should be performed to elucidate the possible molecular interactions during this period...
  15. ncbi request reprint 3-aminobenzamide, a poly ADP ribose polymerase inhibitor, attenuates renal ischemia/reperfusion injury
    Emin Oztas
    Gulhane Military Medical Academy, Department of Medical Histology and Embrology, Etlik, Ankara, Turkey
    Ren Fail 31:393-9. 2009
    ....
  16. doi request reprint Medical ozone therapy decreases postoperative uterine adhesion formation in rats
    Bulent Uysal
    Department of Physiology, Gulhane Military Medical Academy, Ankara, Turkey
    Arch Gynecol Obstet 286:1201-7. 2012
    ..Ozone therapy (OT) is shown to reduce inflammation in several pathological conditions. Therefore, we aimed to evaluate the efficacy of OT in a rat model of experimental uterine adhesion (EUA)...
  17. doi request reprint Inhibition of iNOS reduces the therapeutic effects of ozone in acute necrotizing pancreatitis: an in vivo animal study
    Yesim Oztas
    Department of Medical Biochemistry, Hacettepe University Faculty of Medicine, Sihhiye, Ankara, Turkey
    Scand J Clin Lab Invest 71:370-7. 2011
    ..It is possible that the combination of ozone and SMT may be more effective than either therapy. Therefore, we investigated the efficacy of combination therapy with ozone and SMT in an experimental rat model of ANP...
  18. doi request reprint Protective effects of melatonin and S-methylisothiourea on mechlorethamine induced nephrotoxicity
    Zeki Ilker Kunak
    Department of CBRN Defense, Gulhane Military Medical Academy, Ankara, Turkey
    J Surg Res 175:e17-23. 2012
    ..In this study, we aimed to investigate the protective effects of melatonin (MEL) and S-methylisothiourea (SMT) on mechlorethamine (MEC) induced nephrotoxicity...
  19. doi request reprint Effects of medical ozone therapy on acetaminophen-induced nephrotoxicity in rats
    Suzi Demirbag
    Department of Pediatric Surgery, Gulhane Military Medical Academy, Etlik 06018, Ankara, Turkey
    Ren Fail 32:493-7. 2010
    ..In conclusion, our study results are consistent with encouraging data for ozone therapy on APAP-induced nephrotoxicity in rats by improving antioxidant mechanism and oxidative stress...
  20. doi request reprint Effect of hyperbaric oxygen and ozone preconditioning on oxidative/nitrosative stress induced by tourniquet ischemia/reperfusion in rat skeletal muscle
    Kenan Koca
    GATA, Department of Orthopedics, Ankara, Turkey
    Acta Orthop Traumatol Turc 44:476-83. 2010
    ..The aim of the study was to investigate the effect of hyperbaric oxygen-preconditioning (HBO-PC) and ozone-preconditioning (O3-PC) on oxidative/nitrosative stress induced by tourniquet ischemia/reperfusion (I/R) in rat skeletal muscle...
  21. doi request reprint Ameliorative effects of proanthocyanidin on renal ischemia/reperfusion injury
    Omer Yanarates
    Department of Anesthesiology and Reanimation, Gulhane Military Medical Academy, Ankara, Turkey
    Ren Fail 30:931-8. 2008
    ..Therefore, this study was designed to investigate the efficiency of proanthocyanidin (PA), a natural product derived from grape seed, on renal dysfunction and injury induced by I/R of rat kidney...
  22. doi request reprint Ozone therapy prevents renal inflammation and fibrosis in a rat model of acute pyelonephritis
    Bahadir Caliskan
    Department of Pediatric Surgery, Gulhane Military Medical Faculty, Etlik, Ankara, Turkey
    Scand J Clin Lab Invest 71:473-80. 2011
    ..This study was conducted to evaluate the effect of ozone therapy (OT), as an immunomodulator and antioxidant, on the renal function, morphology and biochemical parameters of oxidative stress in an experimental model of APN in rats...
  23. doi request reprint Alpha-lipoic acid and ebselen prevent ischemia/reperfusion injury in the rat intestine
    Ahmet Guven
    Department of Pediatric Surgery, Gulhane Military Medical Academy, Etlik, Ankara, 06018, Turkey
    Surg Today 38:1029-35. 2008
    ..We conducted this study to evaluate the protective effect of alpha-lipoic acid (alpha-LA) and ebselen against intestinal I/R injury...
  24. doi request reprint Medical ozone therapy reduces oxidative stress and intestinal damage in an experimental model of necrotizing enterocolitis in neonatal rats
    Ahmet Guven
    Department of Pediatric Surgery, Gulhane Military Medical Academy, Etlik, Ankara, Turkey
    J Pediatr Surg 44:1730-5. 2009
    ..Ozone has been proposed as an antioxidant enzyme activator, immunomodulator, and cellular metabolic activator. Therefore, this study was designed to investigate whether medical ozone therapy is effective on neonatal rat model of NEC...
  25. ncbi request reprint Effects of hyperbaric oxygen treatment on liver functions, oxidative status and histology in septic rats
    Sukru Oter
    Department of Physiology, Gulhane Military Medical Academy, Etlik, 06018 Ankara, Turkey
    Intensive Care Med 31:1262-8. 2005
    ..Hyperbaric oxygen (HBO) therapy provides more oxygenation in the whole body. This study examined the effect of HBO alone or in combination with cefepime (CEF) on the liver in septic rats...
  26. doi request reprint The effects of medical ozone therapy on renal ischemia/reperfusion injury
    Muzaffer Oztosun
    Health Services Command, Turkish Armed Forces, Ankara, Turkey
    Ren Fail 34:921-5. 2012
    ....
  27. pmc Evaluation of the oxidative effect of long-term repetitive hyperbaric oxygen exposures on different brain regions of rats
    Kemal Simsek
    Department of Undersea and Hyperbaric Medicine, Gulhane Military Medical Academy, 06010 Etlik, Ankara, Turkey
    ScientificWorldJournal 2012:849183. 2012
    ..These comparable results provide evidence for the safety of HBO treatments and/or successful adaptive mechanisms at least in the brain tissue of rats, even when administered for longer periods...
  28. ncbi request reprint Lung toxicity of nitrogen mustard may be mediated by nitric oxide and peroxynitrite in rats
    Hakan Yaren
    Gulhane Military Medical Academy, Department of Nuclear, Biologic and Chemical Warfare, Ankara, Turkey
    Res Vet Sci 83:116-22. 2007
    ..In conclusion, the ability of ebselen to prevent against lung damage without blocking NO synthesis suggests that peroxynitrites may have an important role in the pathogenesis of NM toxicity in addition to NO...
  29. ncbi request reprint Antioxidant effects of melatonin in rats during chronic exposure to hyperbaric oxygen
    Hakan Mollaoglu
    Department of Physiology, Afyon Kocatepe University School of Medicine, Afyon, Turkey
    J Pineal Res 42:50-4. 2007
    ..Both exogenously injected and physiologically secreted melatonin has this potential. The effects of HBO-exposure and melatonin on the activities of the antioxidative enzymes are less clear...
  30. pmc Ozone therapy and hyperbaric oxygen treatment in lung injury in septic rats
    Levent Yamanel
    Department of Emergency Medicine, Gulhane Military Medical Academy, Ankara, Turkey
    Int J Med Sci 8:48-55. 2011
    ..These findings indicated that OT tended to be more effective than HBO, in particular regarding serum IL-1β, lung GSH-Px and histologic outcome...
  31. ncbi request reprint Protective effects of exogenously administered or endogenously produced melatonin on hyperbaric oxygen-induced oxidative stress in the rat brain
    Kadir Dundar
    Department of Undersea and Hyperbaric Medicine, Gulhane Military Medical Academy, Ankara, Turkey
    Clin Exp Pharmacol Physiol 32:926-30. 2005
    ..5. In conclusion, HBO caused oxidative stress and melatonin exhibited protective effects. Both endogenously produced and exogenously administered melatonin were found to be effective...
  32. ncbi request reprint Melatonin ameliorates bladder damage induced by cyclophosphamide in rats
    Turgut Topal
    Department of Physiology, Gulhane Military Medical Academy, Ankara, Turkey
    J Pineal Res 38:272-7. 2005
    ..Oxidants may have a major role in the pathogenesis of CP-induced cystitis and iNOS is an important mediator leading to peroxynitrite production. Melatonin ameliorates bladder damage induced by CP...
  33. doi request reprint Efficacy of melatonin, mercaptoethylguanidine and 1400W in doxorubicin- and trastuzumab-induced cardiotoxicity
    Mustafa Ozturk
    Department of Medical Oncology, Gulhane Military Medical Academy, Ankara, Turkey
    J Pineal Res 50:89-96. 2011
    ..These results suggested that MEL, MEG, as well as 1400 W are effective in preventing DOX- or DOX+TRAST-induced cardiotoxicity...
  34. doi request reprint Establishing the use of melatonin as an adjuvant therapeutic against paraquat-induced lung toxicity in rats
    Ercan Gocgeldi
    Department of Public Health, Gulhane Military Medical Academy, Ankara, Turkey
    Exp Biol Med (Maywood) 233:1133-41. 2008
    ..This difference was also apparent when tissues were histologically compared. In conclusion, Mel exhibited strong additive beneficial effects with Dex and can be considered as a safe treatment modality against PQ toxicity...
  35. doi request reprint Protective effect of sulfhydryl-containing antioxidants against ischemia/reperfusion injury of prepubertal rat intestine
    Turan Tunc
    Department of Pediatrics, Gulhane Military Medical Academy, Ankara, Turkey
    J Gastroenterol Hepatol 24:681-7. 2009
    ..The aim of this study was to investigate and compare the protective effects of three sulfide-based antioxidants, N-acetylcysteine (NAC), erdosteine (ERD), and alpha-lipoic acid (LA), on I/R injury of the small intestine tissue...
  36. doi request reprint Proanthocyanidin protects intestine and remote organs against mesenteric ischemia/reperfusion injury
    Ali Sizlan
    Department of Anesthesiology and Reanimation, Gulhane Military Medical Academy, Etlik, Ankara, Turkey
    World J Surg 33:1384-91. 2009
    ..We conducted this study to find out if proanthocyanidins (PA) has protective effects against mesenteric IR injury and mesenteric IR-induced intestinal and distant organ injury...
  37. doi request reprint Effects of poly(ADP-ribose) polymerase inhibition in bladder damage caused by cyclophosphamide in rats
    Ahmet Korkmaz
    Department of Physiology, Gulhane Military Medical Academy, 06018, Ankara, Turkey
    Exp Biol Med (Maywood) 233:338-43. 2008
    ..Furthermore, PARP is not only important for ulceration but also for bladder edema, hemorrhage, and inflammation because of broken uroepithelial cellular integrity...
  38. ncbi request reprint Molecular targets against mustard toxicity: implication of cell surface receptors, peroxynitrite production, and PARP activation
    Ahmet Korkmaz
    Department of Physiology, Gulhane Military Medical Academy, 06018 Etlik Ankara, Turkey
    Arch Toxicol 80:662-70. 2006
    ..Therefore, variations of combination of cell membrane receptor blockers, antioxidants, nitric oxide synthase inhibitors, ONOO(-) scavengers, and PARP inhibitors should be investigated...
  39. doi request reprint Mercaptoethylguanidine attenuates caustic esophageal injury in rats: a role for scavenging of peroxynitrite
    Ahmet Guven
    Department of Pediatric Surgery, Gulhane Military Medical Academy, 06170 Etlik, Ankara, Turkey
    J Pediatr Surg 46:1746-52. 2011
    ..Mercaptoethylguanidine (MEG) is a well-known scavenger of peroxynitrite. This study was designed to determine whether MEG has a beneficial effect on caustic esophageal injury...
  40. doi request reprint Melatonin prevents peritoneal adhesions in rats
    Nail Ersoz
    Department of General Surgery, Gulhane Military Medical Faculty, Ankara, Turkey
    J Gastroenterol Hepatol 24:1763-7. 2009
    ..The aim of this study was to evaluate the effects of melatonin on peritoneal adhesions created in rats...
  41. ncbi request reprint The effect of alpha-lipoic acid in the prevention of peritoneal adhesions
    Mehmet Ozler
    Gulhane Military Medical Academy, Department of Physiology, Ankara, Turkey
    Turk J Gastroenterol 22:190-4. 2011
    ..In the present study, the probable preventive role of alpha-lipoic acid, a strong antioxidant, in the development of peritoneal adhesions was investigated...
  42. doi request reprint Scavenging of peroxynitrite reduces renal ischemia/reperfusion injury
    Ahmet Guven
    Department of Pediatric Surgery, Gulhane Military Medical Academy, Ankara, Turkey
    Ren Fail 30:747-54. 2008
    ....
  43. pmc Melatonin: an established antioxidant worthy of use in clinical trials
    Ahmet Korkmaz
    Department of Physiology, School of Medicine, Gulhane Military Medical Academy, Ankara, Turkey
    Mol Med 15:43-50. 2009
    ..Accumulating evidence suggests that this nontoxic indolamine may be useful either as a sole treatment or in conjunction with other treatments for inhibiting the biohazardous actions of nitrooxidative stress...
  44. ncbi request reprint Exposure time related oxidative action of hyperbaric oxygen in rat brain
    Ahmet Korkmaz
    Department of Physiology, Gulhane Askeri Tip Akademisi, Fizyoloji Anabilim Dali, 06018 Ankara, Turkey
    Neurochem Res 33:160-6. 2008
    ..GSH-Px activity reflected an inconsistent course. NOX levels were found to be increased only in the 120 min exposed group. The results of this study suggests that HBO induced oxidative effects are strongly related with exposure time...
  45. ncbi request reprint Peroxynitrite may be involved in bladder damage caused by cyclophosphamide in rats
    Ahmet Korkmaz
    Department of Physiology, Gulhane Military Medical Academy, Ankara, Turkey
    J Urol 173:1793-6. 2005
    ..In this study we evaluated whether peroxynitrite is also responsible for CP induced bladder damage in rats...
  46. doi request reprint Comparison of the effect of topical and systemic melatonin administration on delayed wound healing in rats that underwent pinealectomy
    Mehmet Ozler
    Department of Physiology, Gulhane Military Medical Academy, Gulhane, Ankara, Turkey
    Scand J Clin Lab Invest 70:447-52. 2010
    ..The aim of the present study was to investigate the difference between sytemic and topical administration of melatonin by forming a chronic wound model in rats whose release of basal melatonin was supressed by pinealectomy...
  47. ncbi request reprint Contribution of flavonoid antioxidants to the preventive effect of mesna in cyclophosphamide-induced cystitis in rats
    Ayhan Ozcan
    Department of Pathology, Gulhane Military Medical Academy, Ankara, Turkey
    Arch Toxicol 79:461-5. 2005
    ..It was concluded that oxidants might be important in the pathogenesis of CP-induced cystitis, and that flavonoid antioxidants, used in addition to mesna, may help to ameliorate bladder damage...
  48. doi request reprint Similarities and differences of hyperbaric oxygen and medical ozone applications
    Mehmet Ozler
    Department of Physiology, Gulhane Military Medical Academy, Ankara, Turkey
    Free Radic Res 45:1267-78. 2011
    ..We will try to emphasize the similarities and differences of HBO and medical ozone applications in this article...
  49. ncbi request reprint Contribution of antioxidants to preventive effect of mesna in cyclophosphamide-induced hemorrhagic cystitis in rats
    Ibrahim Yildirim
    Department of Urology, Gulhane Military Medical Academy, Ankara, Turkey
    Cancer Chemother Pharmacol 54:469-73. 2004
    ..The aim of this study was to evaluate whether combination of antioxidants and mesna may prevent cystitis induced by cyclophosphamide better than mesna alone...
  50. ncbi request reprint Correlation between hyperbaric oxygen exposure pressures and oxidative parameters in rat lung, brain, and erythrocytes
    Sukru Oter
    Gulhane Military Medical Academy, Department of Physiology, GATA Fizyoloji Anabilim Dali, 06018 Etlik Ankara, Turkey
    Clin Biochem 38:706-11. 2005
    ..The purpose of this study was to determine the effects of various HBO pressure modalities on the oxidative values of rat lung, brain, and erythrocytes...
  51. doi request reprint Glucose: a vital toxin and potential utility of melatonin in protecting against the diabetic state
    Ahmet Korkmaz
    Department of Physiology, School of Medicine, Gulhane Military Medical Academy, Ankara, Turkey
    Mol Cell Endocrinol 349:128-37. 2012
    ....
  52. ncbi request reprint Alpha-tocopherol, beta-carotene and melatonin administration protects cyclophosphamide-induced oxidative damage to bladder tissue in rats
    Serdar Sadir
    Department of Physiology, Gulhane Military Medical Academy, Ankara, Turkey
    Cell Biochem Funct 25:521-6. 2007
    ..In conclusion, there is no doubt that oxidants have a role in the pathogenesis of CP-cystitis. Antioxidants, especially melatonin and alpha-tocopherol, may help to ameliorate bladder damage induced by CP...
  53. doi request reprint The efficacy of ozone therapy in experimental caustic esophageal burn
    Ahmet Guven
    Department of Pediatric Surgery, Gulhane Military Medical Academy, Etlik, Ankara 06017, Turkey
    J Pediatr Surg 43:1679-84. 2008
    ..This study was designed to investigate the efficacy of ozone therapy in the prevention of esophageal damage and stricture formation developed after esophageal caustic injuries in the rat...
  54. doi request reprint Role of melatonin in metabolic regulation
    Ahmet Korkmaz
    Department of Physiology, School of Medicine, Gulhane Military Medical Academy, Ankara, Turkey
    Rev Endocr Metab Disord 10:261-70. 2009
    ..This paper provides a brief outline about metabolic dysregulation in conjunction with a disrupted melatonin rhythm...
  55. ncbi request reprint Pressure-related increase of asymmetric dimethylarginine caused by hyperbaric oxygen in the rat brain: a possible neuroprotective mechanism
    Emin Ozgur Akgul
    Department of Biochemistry, Gulhane Military Medical Academy, Ankara, Turkey
    Neurochem Res 32:1586-91. 2007
    ..The simultaneously decreased NOx values suggest that ADMA elevation resulted in NOS inhibition and therefore may be responsible for the early phase hyperoxic vasoconstriction...
  56. ncbi request reprint Synergistic effects of hyperbaric oxygen and granulocytecolony stimulating factor on postoperative adhesion formation in a rat cecal abrasion model
    Can Kece
    Gulhane Military Medical Academy, General Surgery, Ankara, Turkey
    Bratisl Lek Listy 111:115-20. 2010
    ..We investigated the synergistic effect of hyperbaric oxygen (HBO) and granulocyte-colony stimulating factor (G-CSF) on adhesion formation in rats...
  57. ncbi request reprint An evaluation of the effectiveness of pre-ischemic hyperbaric oxygen and post-ischemic aminoguanidine in experimental cerebral ischemia
    Ferhat Harman
    Department of Neurosurgery, Gulhane Military Medical Academy, Ankara, Turkey
    Neurosciences (Riyadh) 17:121-6. 2012
    ..To study the effects of pre-ischemic hyperbaric oxygen (HBO) and post-ischemic aminoguanidine (AG) on the infarct volume in permanent middle cerebral artery occlusion...
  58. ncbi request reprint The effect of hyperbaric oxygen treatment on the renal functions in septic rats: relation to oxidative damage
    Mustafa Edremitlioglu
    Department of Physiology, Kirikkale University School of Medicine, 71100 Kirikkale, Turkey
    Surg Today 35:653-61. 2005
    ..To investigate the effects of hyperbaric oxygen (HBO) treatment on renal functions and damage in septic rats...
  59. pmc Epigenetic perturbations in the pathogenesis of mustard toxicity; hypothesis and preliminary results
    Ahmet Korkmaz
    Department of Physiology, School of Medicine, Gulhane Military Medical Academy, Ankara, Turkey
    Interdiscip Toxicol 1:236-41. 2008
    ..Under light of preliminary results, the current hypothesis will focus on epigenetic regulations to clarify mustard toxicity and the use of drugs to correct possible epigenetic defects...
  60. doi request reprint The effect of iNOS inhibitors and hyperbaric oxygen treatment in a rat model of experimental colitis
    Cemal Nuri Ercin
    Division of Internal Medicine, Department of Gastroenterology, Gulhane School of Medicine, Etlik, Ankara, Turkey
    Dig Dis Sci 54:75-9. 2009
    ..Our aim was to investigate the effectiveness of aminoguanidine (AMG), an inducible nitric oxide synthase inhibitor, and hyperbaric oxygen (HBO) treatment in an experimental colitis model...
  61. ncbi request reprint Could rice be used as an anticaking agent in table salt?
    Cemal Akay
    Department of Pharmaceutical Toxicology, Gulhane Medical School, Ankara, Turkey
    Int J Food Sci Nutr 60:95-9. 2009
    ..001). Adding powdered rice to salt as an anticaking agent during salt manufacturing at a concentration of 1% could take the place of other anticaking food additives used in table salt production...
  62. doi request reprint Effects of hyperbaric oxygen on energy production and xanthine oxidase levels in striated muscle tissue of healthy rats
    Bulent Kurt
    Department of Pathology, Gulhane Military Medical Academy and Medical School, Etlik, Ankara, Turkey
    J Clin Neurosci 15:445-50. 2008
    ..Thus, HBO might have some beneficial effects in the treatment of heteroplasmic mitochondrial disease, where normal and defective mitochondria coexist...
  63. doi request reprint Role of melatonin in the epigenetic regulation of breast cancer
    Ahmet Korkmaz
    Department of Physiology, School of Medicine, Gulhane Military Medical Academy, Ankara, Turkey
    Breast Cancer Res Treat 115:13-27. 2009
    ..e., light at night) with the subsequent deregulation of PER2 which acts as a tumor suppressor gene...
  64. doi request reprint Retroperitoneal lymph node mapping with intratesticular injected patent blue dye in rats
    Seref Basal
    Department of Urology, Gulhane Military Medical Academy, Ankara, Turkey
    Urol Oncol 26:286-90. 2008
    ..The aim of this experimental study was to investigate whether intratesticular patent blue dye injection is feasible and is an accurate method for retroperitoneal lymph node mapping in rats...
  65. doi request reprint Does hypothermic treatment provide an advantage after spinal cord injury until surgery? An experimental study
    Bulent Duz
    Department of Neurosurgery, School of Medicine, Gulhane Military Medical Academia, Etlik, 06018 Ankara, Turkey
    Neurochem Res 34:407-10. 2009
    ..05). Short-term systemic hypothermia reduces lipid peroxidation in the early stages after spinal cord injury. This beneficial effect disappears 24 h following systemic hypothermic treatment...
  66. ncbi request reprint Inducible nitric oxide synthase inhibition in cyclophosphamide induced hemorrhagic cystitis in rats
    Sukru Oter
    Gulhane Military Medical Academy, Department of Physiology, Ankara, Turkey
    Urol Res 32:185-9. 2004
    ..CP injection resulted in severe cystitis. SMT but not L-arginine produced marked inhibition of CP induced bladder damage. We concluded that NO produced by iNOS, is an important mediator in the pathogenesis of CP induced cystitis...
  67. doi request reprint Melatonin as an antibiotic: new insights into the actions of this ubiquitous molecule
    Omer Faruk Tekbas
    Department of Public Health, Gulhane School of Medicine, Ankara, Turkey
    J Pineal Res 44:222-6. 2008
    ..Also, it was determined that melatonin has a more potent antimicrobial effect on gram-negative microorganism. Among possible mechanisms, it is concluded that melatonin showed antibacterial effects by reducing intracellular substrates...
  68. ncbi request reprint Epigenetic regulation: a new research area for melatonin?
    Ahmet Korkmaz
    Department of Physiology, School of Medicine, Gulhane Military Medical Academy, Ankara, Turkey
    J Pineal Res 44:41-4. 2008
    ..In this review, the potential role of melatonin in inhibiting DNA methyltransferase and epigenetic regulation is discussed...
  69. pmc Acute and delayed sulfur mustard toxicity; novel mechanisms and future studies
    Ahmet Korkmaz
    Department of Physiology, School of Medicine, Gulhane Military Medical Academy, Ankara, Turkey
    Interdiscip Toxicol 1:22-6. 2008
    ..Future studies are warranted to clarify whether epigenetic mechanisms are involved in pathogenesis of delayed sulfur mustard toxicity and melatonin alleviates delayed toxicity of this warfare agent...