Gideon Koren

Summary

Publications

  1. doi request reprint A pilot study of paternal drug exposure: the Motherisk experience
    Candace Y W Lee
    Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada
    Reprod Toxicol 29:353-60. 2010
  2. pmc Folate Intake, MTHFR Polymorphisms, and the Risk of Colorectal Cancer: A Systematic Review and Meta-Analysis
    Deborah A Kennedy
    The Motherisk Program, Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, 555 University Avenue, Toronto, ON, Canada M5G 1X8 Leslie Dan Faculty of Pharmacy, University of Toronto, 144 College Street, Toronto, ON, Canada M5S 3M2
    J Cancer Epidemiol 2012:952508. 2012
  3. ncbi request reprint Gender differences in drug bioequivalence: time to rethink practices
    G Koren
    Motherisk Program, Division of Clinical Pharmacology Toxicology, SickKids Hospital, University of Toronto, Toronto, Ontario, Canada
    Clin Pharmacol Ther 93:260-2. 2013
  4. doi request reprint Safety assessment in pediatric studies
    Gideon Koren
    The Motherisk Program, Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, Toronto, M5G 1X8, ON, Canada
    Handb Exp Pharmacol 205:169-80. 2011
  5. pmc Methamphetamine detection in maternal and neonatal hair: implications for fetal safety
    F Garcia-Bournissen
    G Koren, The Motherisk Program, Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, University of Toronto, 555 University Avenue, 8th Floor, Black Wing, Toronto, Canada ON, USA
    Arch Dis Child Fetal Neonatal Ed 92:F351-5. 2007
  6. doi request reprint Fetal risks of maternal pharmacotherapy: identifying signals
    Gideon Koren
    The Motherisk Program, Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, Toronto M5G 1X8, ON, Canada
    Handb Exp Pharmacol 205:285-94. 2011
  7. ncbi request reprint Preconception counseling: rational, practice and challenges
    A Walfisch
    Hospital for Sick Children, Department of Pharmacology, University of Toronto, Ontario, Canada
    Minerva Ginecol 63:411-9. 2011
  8. ncbi request reprint Exposure to mirtazapine during pregnancy: a prospective, comparative study of birth outcomes
    Josephine Djulus
    Motherisk Program, Division of Clinical Pharmacology, The Hospital for Sick Children, Toronto, Ontario, Canada
    J Clin Psychiatry 67:1280-4. 2006
  9. doi request reprint CYP2D6 polymorphisms and codeine analgesia in postpartum pain management: a pilot study
    Sondra vanderVaart
    Department of Pharmaceutical Sciences, University of Toronto, Ontario, Canada
    Ther Drug Monit 33:425-32. 2011
  10. ncbi request reprint Long-term neurodevelopment of children exposed to maternal nausea and vomiting of pregnancy and diclectin
    Irena Nulman
    Department of Clinical Pharmacology, Hospital for Sick Children, Toronto, Ontario, Canada
    J Pediatr 155:45-50, 50.e1-2. 2009

Detail Information

Publications129 found, 100 shown here

  1. doi request reprint A pilot study of paternal drug exposure: the Motherisk experience
    Candace Y W Lee
    Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada
    Reprod Toxicol 29:353-60. 2010
    ..Here, we reviewed for the first time our experience with PEx...
  2. pmc Folate Intake, MTHFR Polymorphisms, and the Risk of Colorectal Cancer: A Systematic Review and Meta-Analysis
    Deborah A Kennedy
    The Motherisk Program, Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, 555 University Avenue, Toronto, ON, Canada M5G 1X8 Leslie Dan Faculty of Pharmacy, University of Toronto, 144 College Street, Toronto, ON, Canada M5S 3M2
    J Cancer Epidemiol 2012:952508. 2012
    ..Conclusion. These results suggest that the 677TT genotype is associated with a reduced risk of developing CRC, under conditions of high total folate intake, and this associated risk remains reduced for both MTHFR 677 CC and TT genotypes...
  3. ncbi request reprint Gender differences in drug bioequivalence: time to rethink practices
    G Koren
    Motherisk Program, Division of Clinical Pharmacology Toxicology, SickKids Hospital, University of Toronto, Toronto, Ontario, Canada
    Clin Pharmacol Ther 93:260-2. 2013
    ..This article challenges this hypothesis on the basis of available evidence and urges that studies of BE of sufficient power be undertaken in women also for all generic drugs aimed at women...
  4. doi request reprint Safety assessment in pediatric studies
    Gideon Koren
    The Motherisk Program, Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, Toronto, M5G 1X8, ON, Canada
    Handb Exp Pharmacol 205:169-80. 2011
    ..In this chapter, several novel methods, both clinically based pharmacoepidemiological approaches and laboratory-based methods, are described...
  5. pmc Methamphetamine detection in maternal and neonatal hair: implications for fetal safety
    F Garcia-Bournissen
    G Koren, The Motherisk Program, Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, University of Toronto, 555 University Avenue, 8th Floor, Black Wing, Toronto, Canada ON, USA
    Arch Dis Child Fetal Neonatal Ed 92:F351-5. 2007
    ..Methamphetamine misuse is a serious health problem of epidemic proportions. Use of this drug, particularly during pregnancy, is difficult to ascertain. Sparse information is available on gestational exposure...
  6. doi request reprint Fetal risks of maternal pharmacotherapy: identifying signals
    Gideon Koren
    The Motherisk Program, Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, Toronto M5G 1X8, ON, Canada
    Handb Exp Pharmacol 205:285-94. 2011
    ..This chapter will review the principles of teratology and the pharmacoepidemiological evidence for drug safety/risk in human gestation...
  7. ncbi request reprint Preconception counseling: rational, practice and challenges
    A Walfisch
    Hospital for Sick Children, Department of Pharmacology, University of Toronto, Ontario, Canada
    Minerva Ginecol 63:411-9. 2011
    ..In addition, specific topics are reviewed in depth including folic acid supplementation, obesity, depression, seizure disorders, and drug therapy during pregnancy...
  8. ncbi request reprint Exposure to mirtazapine during pregnancy: a prospective, comparative study of birth outcomes
    Josephine Djulus
    Motherisk Program, Division of Clinical Pharmacology, The Hospital for Sick Children, Toronto, Ontario, Canada
    J Clin Psychiatry 67:1280-4. 2006
    ..Currently, apart from a few case reports and case series in the literature, there are no studies evaluating the safety of this drug during pregnancy...
  9. doi request reprint CYP2D6 polymorphisms and codeine analgesia in postpartum pain management: a pilot study
    Sondra vanderVaart
    Department of Pharmaceutical Sciences, University of Toronto, Ontario, Canada
    Ther Drug Monit 33:425-32. 2011
    ..In contrast, poor metabolizers (PMs), individuals who have no active CYP2D6 genes, convert almost no codeine into morphine and as a result may take multiple doses of codeine without attaining analgesia...
  10. ncbi request reprint Long-term neurodevelopment of children exposed to maternal nausea and vomiting of pregnancy and diclectin
    Irena Nulman
    Department of Clinical Pharmacology, Hospital for Sick Children, Toronto, Ontario, Canada
    J Pediatr 155:45-50, 50.e1-2. 2009
    ..To determine the effects of nausea and vomiting of pregnancy (NVP) and its treatment with diclectin on child neurodevelopment...
  11. doi request reprint Long-term neurodevelopment of children exposed in utero to ciclosporin after maternal renal transplant
    Irena Nulman
    The Motherisk Program, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    Paediatr Drugs 12:113-22. 2010
    ..Immunosuppressant therapy is essential in the prevention of organ transplant rejection...
  12. doi request reprint Prenatal exposure to antidepressants and persistent pulmonary hypertension of the newborn: systematic review and meta-analysis
    Sophie Grigoriadis
    Department of Psychiatry, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, Ontario, Canada, M4N 3M5
    BMJ 348:f6932. 2014
    ..To examine the risk for persistent pulmonary hypertension of the newborn associated with antenatal exposure to antidepressants...
  13. doi request reprint Neonatal screening for prenatal alcohol exposure: assessment of voluntary maternal participation in an open meconium screening program
    Irene Zelner
    Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, Toronto, Ontario, Canada
    Alcohol 46:269-76. 2012
    ....
  14. ncbi request reprint Development of Canadian screening tools for fetal alcohol spectrum disorder
    Y Ingrid Goh
    The Motherisk Program, Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, Toronto, Ontario
    Can J Clin Pharmacol 15:e344-66. 2008
    ..Screening for FASD may facilitate diagnosis and hence management of these children. We present a variety of screening tools for the identification of children at risk for FASD...
  15. pmc Use of hypoglycemic drugs during lactation
    Miguel Marcelo Glatstein
    Hospital for Sick Children, Toronto, Ontario
    Can Fam Physician 55:371-3. 2009
    ..Can sulfonylureas cross into human milk and, if so, is it safe for her to breastfeed her infant?..
  16. ncbi request reprint Opioid detection in maternal and neonatal hair and meconium: characterization of an at-risk population and implications to fetal toxicology
    Monique Moller
    Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, Toronto, Ontario, Canada
    Ther Drug Monit 32:318-23. 2010
    ..657, P = 0.03). Understanding the addiction profiles of these women may lead to better clinical and social management and may largely benefit an at-risk population...
  17. ncbi request reprint Chronic prenatal ethanol exposure and increased concentration of fatty acid ethyl esters in meconium of term fetal Guinea pig
    James F Brien
    Department of Pharmacology and Toxicology, Faculty of Health Sciences, Queen s University, Kingston, ON, Canada
    Ther Drug Monit 28:345-50. 2006
    ....
  18. doi request reprint Putative association of ABCB1 2677G>T/A with oxycodone-induced central nervous system depression in breastfeeding mothers
    Jessica Lam
    Department of Pharmacology and Toxicology, University of Toronto, Toronto, Canada
    Ther Drug Monit 35:466-72. 2013
    ..To assess the effect of maternal CYP2D6, CYP3A5, ABCB1, and OPRM1 polymorphisms in predicting both neonatal and maternal central nervous system depression after oxycodone use during lactation...
  19. ncbi request reprint Pregnancy outcome of women using atypical antipsychotic drugs: a prospective comparative study
    Kate McKenna
    Motherisk Program, The Hospital for Sick Children, Toronto, Ontario, Canada
    J Clin Psychiatry 66:444-9; quiz 546. 2005
    ..Atypical antipsychotics have been on the market since the mid-1990s, and to date there are no prospective comparative studies regarding use during pregnancy...
  20. ncbi request reprint Universal screening for prenatal alcohol exposure: a progress report of a pilot study in the region of Grey Bruce, Ontario
    Irene Zelner
    Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, Toronto, Ontario, Canada
    Ther Drug Monit 32:305-10. 2010
    ....
  21. ncbi request reprint Recent developments in meconium and hair testing methods for the confirmation of gestational exposures to alcohol and tobacco smoke
    Daphne Chan
    The Hospital for Sick Children, Toronto, Ontario, Canada
    Clin Biochem 37:429-38. 2004
    ..The latest developments and novel applications of meconium and hair testing for the confirmation of prenatal alcohol and tobacco exposure are discussed in this review...
  22. ncbi request reprint Child neurodevelopmental outcome and maternal occupational exposure to solvents
    Dionne Laslo-Baker
    Motherisk Program and Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, Toronto, Ontario, Canada
    Arch Pediatr Adolesc Med 158:956-61. 2004
    ..Animal toxicological studies and human case reports demonstrate that high exposure to solvents causes neurodevelopmental toxicity in exposed offspring. Data from occupationally exposed women and their children are few...
  23. ncbi request reprint Fetal exposure to isotretinoin-an international problem
    Facundo Garcia-Bournissen
    Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, University of Toronto, Toronto, Canada
    Reprod Toxicol 25:124-8. 2008
    ..Isotretinoin is a known teratogen. Pregnancy prevention programs aimed at minimizing isotretinoin exposure in pregnancy have been implemented in North America with limited success...
  24. doi request reprint Neurodevelopment of children following prenatal exposure to venlafaxine, selective serotonin reuptake inhibitors, or untreated maternal depression
    Irena Nulman
    Motherisk Program, Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, University of Toronto, Canada
    Am J Psychiatry 169:1165-74. 2012
    ..The authors compared the effects of prenatal exposure to venlafaxine (serotonin-norepinephrine reuptake inhibitor), selective serotonin reuptake inhibitors (SSRIs), and maternal depression...
  25. doi request reprint Pregnancy outcomes following use of escitalopram: a prospective comparative cohort study
    Chagit Klieger-Grossmann
    Motherisk Program, The Hospital for Sick Children, Toronto, Ontario, Canada
    J Clin Pharmacol 52:766-70. 2012
    ..In addition, the higher rates of spontaneous abortions in both antidepressant groups confirmed previous findings...
  26. ncbi request reprint Prospective comparative study of the safety and effectiveness of ginger for the treatment of nausea and vomiting in pregnancy
    Galina Portnoi
    The Motherisk Program, The Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
    Am J Obstet Gynecol 189:1374-7. 2003
    ..The primary objective of our study was to examine the safety and the secondary objective was to examine the effectiveness of ginger for nausea and vomiting of pregnancy (NVP)...
  27. doi request reprint Correlation between drugs of abuse and alcohol by hair analysis: parents at risk for having children with fetal alcohol spectrum disorder
    Vivian Kulaga
    Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, Toronto, Ontario, Canada M5G 1X8
    Alcohol 44:615-21. 2010
    ..26, 1.1-9.7). Our results suggest that parents abusing stimulants are at risk of high alcohol exposure, which put their unborn children at risk for FASD...
  28. doi request reprint Is morphine exposure associated with acute chest syndrome in children with vaso-occlusive crisis of sickle cell disease? A 6-year case-crossover study
    Yaron Finkelstein
    Department of Pediatrics, The Hospital for Sick Children, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
    Clin Ther 29:2738-43. 2007
    ..However, the belief that these drugs can promote development of the acute chest syndrome (ACS) may lead to undertreatment of pain...
  29. ncbi request reprint Reference values for hair cotinine as a biomarker of active and passive smoking in women of reproductive age, pregnant women, children, and neonates: systematic review and meta-analysis
    Ana Florescu
    Public Health Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Ontario, Canada
    Ther Drug Monit 29:437-46. 2007
    ..These new values should facilitate clinical diagnosis of active and passive exposure to tobacco smoke. Such diagnosis is critical in pregnancy and in a large number of tobacco-induced medical conditions...
  30. doi request reprint MotherNature: establishing a Canadian research network for natural health products (NHPs) during pregnancy and lactation
    Gideon Koren
    Motherisk Program, Hospital for Sick Children, Toronto, Ontario, Canada
    J Altern Complement Med 14:369-72. 2008
    ....
  31. ncbi request reprint Safety and efficacy of chastetree (Vitex agnus-castus) during pregnancy and lactation
    Jean Jacques Dugoua
    Graduate Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University ofToronto, Toronto, Canada
    Can J Clin Pharmacol 15:e74-9. 2008
    ..This is one article in a series that systematically reviews the evidence for herbs commonly used during pregnancy and lactation...
  32. doi request reprint The impact of maternal depression during pregnancy on perinatal outcomes: a systematic review and meta-analysis
    Sophie Grigoriadis
    Women s Mood and Anxiety Clinic Reproductive Transitions, Department of Psychiatry, FG 29, Sunnybrook Health Sciences Centre, 2075 Bayview Ave, Toronto, ON M4N 3M5, Canada
    J Clin Psychiatry 74:e321-41. 2013
    ..Our systematic review and meta-analysis was conducted to determine whether maternal depression during pregnancy is associated with adverse perinatal and infant outcomes...
  33. doi request reprint Selected pregnancy and delivery outcomes after exposure to antidepressant medication: a systematic review and meta-analysis
    Lori E Ross
    Social and Epidemiological Research Department, Centre for Addiction and Mental Health, University of Toronto, ON, Canada
    JAMA Psychiatry 70:436-43. 2013
    ..Untreated depression during pregnancy has been associated with increased morbidity and mortality for both mother and child and, as such, optimal treatment strategies are required for this population...
  34. doi request reprint Rates of fetal alcohol exposure among newborns in a high-risk obstetric unit
    Y Ingrid Goh
    Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, Toronto, Ontario, Canada M5G 1X8
    Alcohol 44:629-34. 2010
    ..04, 95% confidence interval=6.40-22.65, P<.0001). These results suggest that the high-risk pregnancies should be screened for PAE and followed-up for potential diagnosis of fetal alcohol spectrum disorder...
  35. ncbi request reprint Agreement between the fatty acid ethyl ester hair test for alcohol and social workers' reports
    Vivian Kulaga
    The Hospital for Sick Children, Toronto, Canada
    Ther Drug Monit 32:294-9. 2010
    ..Reported factors directly related to alcohol use were significantly associated with testing positive for excessive alcohol use, whereas factors not directly related to alcohol use were negatively associated with testing positive...
  36. ncbi request reprint Sulfonylurea intoxication at a tertiary care paediatric hospital
    Miguel Glatstein
    Division of Pediatric Emergency Medicine, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Canada
    Can J Clin Pharmacol 17:e51-6. 2010
    ..Although the administration of octreotide is considered effective in patients that remain hypoglycaemic despite glucose administration, experience in children is limited...
  37. doi request reprint Heavy in utero ethanol exposure is associated with the use of other drugs of abuse in a high-risk population
    Sarit Shor
    Motherisk Program, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada M5G 1X8
    Alcohol 44:623-7. 2010
    ....
  38. ncbi request reprint Hair as a novel noninvasive method to study the impact of pregnancy on CYP2D6 metabolizing capacity
    Lisa O'Brien
    Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, Toronto, Ontario, Canada
    Ther Drug Monit 31:531-2. 2009
    ..A novel method is described to investigate changes in the drug metabolizing capacity of CYP2D6 during pregnancy using hair analysis...
  39. ncbi request reprint Fatty acid ethyl esters (FAEE); comparative accumulation in human and guinea pig hair as a biomarker for prenatal alcohol exposure
    Vivian Kulaga
    Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, Toronto, Canada
    Alcohol Alcohol 41:534-9. 2006
    ..To compare the incorporation rate (ICR) of fatty acid ethyl esters (FAEE) in hair between guinea pigs and humans, and to assess the relationship between ethanol exposure and FAEE concentrations in hair...
  40. doi request reprint Prenatal exposure to HMG-CoA reductase inhibitors: effects on fetal and neonatal outcomes
    Nobuko Taguchi
    The Motherisk Program, Division of Clinical Pharmacology and Toxicology, Department of Pediatrics, Hospital for Sick Children, University of Toronto, Canada
    Reprod Toxicol 26:175-7. 2008
    ..However, a recent study based on a series of cases reported to FDA suggests possible teratogenic effects of statins on embryogenesis, such as limb defects and severe central nervous system anomalies...
  41. ncbi request reprint Potential role of the placenta in fetal alcohol spectrum disorder
    Joey Gareri
    Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, Ontario, Canada
    Paediatr Drugs 11:26-9. 2009
    ..Meconium is a toxicological matrix unique to the developing fetus that offers an opportunity to quantify fetal exposure to alcohol through the analysis of fatty acid ethyl esters (FAEE) [nonoxidative ethanol metabolites]...
  42. doi request reprint Colchicine poisoning: the dark side of an ancient drug
    Yaron Finkelstein
    Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada
    Clin Toxicol (Phila) 48:407-14. 2010
    ..Although colchicine poisoning is sometimes intentional, unintentional toxicity is common and often associated with a poor outcome...
  43. ncbi request reprint Both parental psychopathology and prenatal maternal alcohol dependency can predict the behavioral phenotype in children
    Arthur Staroselsky
    Division of Clinical Pharmacology, Motherisk Program, The Hospital for Sick Children, Ontario, Canada
    Paediatr Drugs 11:22-5. 2009
    ..To identify whether a child's behavior phenotype can be predicted by parental psychopathology and/or prenatal maternal alcohol dependency by using the Child Behavior List (CBCL) as a screening tool...
  44. doi request reprint Effect of liposomal lidocaine and sucrose alone and in combination for venipuncture pain in newborns
    Anna Taddio
    Leslie Dan Faculty of Pharmacy, University of Toronto, 144 College St, Toronto, Ontario, Canada M5S 3M2
    Pediatrics 127:e940-7. 2011
    ..To determine the relative effectiveness of liposomal lidocaine, sucrose, and their combination for reducing pain in term newborns...
  45. doi request reprint Periconceptional folic acid supplementation: a new indication for therapeutic drug monitoring
    Carolyn Tam
    Department of Pharmacology, University of Toronto, Toronto, Ontario, Canada
    Ther Drug Monit 31:319-26. 2009
    ..This review describes the evolution of the evidence for TDM of RBC folate and preliminary experience with TDM in a population of 12 women who were planning a pregnancy and who were being treated with an atypical antipsychotic...
  46. ncbi request reprint A pilot pharmacokinetic and antiangiogenic biomarker study of celecoxib and low-dose metronomic vinblastine or cyclophosphamide in pediatric recurrent solid tumors
    Diana Stempak
    New Agents and Innovative Therapy Program, Division of Hematology Oncology, Hospital for Sick Children, Toronto, Ontario, Canada
    J Pediatr Hematol Oncol 28:720-8. 2006
    ..However, future studies should include more homogenous patient populations and focus on validating surrogate markers to monitor treatment activity...
  47. ncbi request reprint Effects of aspirin consumption during pregnancy on pregnancy outcomes: meta-analysis
    Eran Kozer
    Department of Paediatrics, The Motherisk Program, Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, and University of Toronto, Toronto, Ontario, Canada
    Birth Defects Res B Dev Reprod Toxicol 68:70-84. 2003
    ..We assessed the effects and safety of aspirin treatment during pregnancy on fetal and neonatal outcomes...
  48. ncbi request reprint Safety and efficacy of blue cohosh (Caulophyllum thalictroides) during pregnancy and lactation
    Jean Jacques Dugoua
    Graduate Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University ofToronto, Toronto, Canada
    Can J Clin Pharmacol 15:e66-73. 2008
    ..This is one article in a series that systematically reviews the evidence for commonly used herbs during pregnancy and lactation...
  49. ncbi request reprint The fetal safety of hydrocortisone-pramoxine (Proctofoam-HC) for the treatment of hemorrhoids in late pregnancy
    Neda Ebrahimi
    Motherisk Program, Hospital for Sick Children, Toronto ON
    J Obstet Gynaecol Can 33:153-8. 2011
    ..The objective of this study was to assess prospectively the fetal safety of third trimester exposure to Proctofoam-HC...
  50. ncbi request reprint Clinical use of meconium fatty acid ethyl esters for identifying children at risk for alcohol-related disabilities: the first reported case
    Irene Zelner
    Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, Toronto, Ontario and Department of Pharmacology and Toxicology, University of Toronto, Ontario, Canada
    J Popul Ther Clin Pharmacol 19:e26-31. 2012
    ....
  51. ncbi request reprint Severe bullous hypersensitivity reactions after exposure to carbamazepine in a Han-Chinese child with a positive HLA-B*1502 and negative in vitro toxicity assays: evidence for different pathophysiological mechanisms
    Abdelbaset A Elzagallaai
    Ivey Chair in Molecular Toxicology, University of Western Ontario, London, Ontario, Canada
    J Popul Ther Clin Pharmacol 18:e1-9. 2011
    ..The aim of this study was to investigate the genetic and metabolic bases of DHS development to help predict patient susceptibility...
  52. ncbi request reprint Back to basics: understanding drugs in children: pharmacokinetic maturation
    Maria Tetelbaum
    Division of Clinical Pharmacology and Toxicology, Department of Pediatrics and Population Health Sciences, The Hospital for Sick Children, Toronto, Ontario, Canada
    Pediatr Rev 26:321-8. 2005
  53. doi request reprint Central nervous system depression of neonates breastfed by mothers receiving oxycodone for postpartum analgesia
    Jessica Lam
    Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada
    J Pediatr 160:33-7.e2. 2012
    ..To quantify the incidence of central nervous system (CNS) depression in neonates breastfed by mothers medicated with oxycodone as compared with neonates whose breastfeeding mothers used codeine or acetaminophen only...
  54. doi request reprint Evaluating the safety of St. John's Wort in human pregnancy
    Myla E Moretti
    The Motherisk Program, Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, 555 University Avenue, Toronto, ON, Canada
    Reprod Toxicol 28:96-9. 2009
    ..Though further large scale studies are still needed, this first study on the effects of St. John's Wort in human pregnancy does provide some evidence of fetal safety...
  55. doi request reprint Examining the health and drug exposures among Canadian children residing in drug-producing homes
    Monique Moller
    Department of Pharmacology and Toxicology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
    J Pediatr 159:766-770.e1. 2011
    ..To examine the health and well-being of children residing in residences where drug production is occurring...
  56. doi request reprint Effectiveness of delayed-release doxylamine and pyridoxine for nausea and vomiting of pregnancy: a randomized placebo controlled trial
    Gideon Koren
    Motherisk Program, Hospital for Sick Children and University of Toronto, Toronto, ON, Canada
    Am J Obstet Gynecol 203:571.e1-7. 2010
    ..To evaluate the effectiveness of Diclectin (doxylamine succinate 10 mg-pyridoxine hydrochloride 10 mg, delayed-release preparation) as compared with placebo for nausea and vomiting of pregnancy...
  57. doi request reprint The effect of amitriptyline, gabapentin, and carbamazepine on morphine-induced hypercarbia in rabbits
    Eran Kozer
    Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada M5G 1X8
    Anesth Analg 107:1216-22. 2008
    ..However, it is unclear if a combination of these drugs intensifies the effects of morphine on the respiratory system and, if so, whether these effects are due to pharmacokinetic or pharmacodynamic interaction...
  58. pmc Methods for quantification of exposure to cigarette smoking and environmental tobacco smoke: focus on developmental toxicology
    Ana Florescu
    Department of Research, The CAMH Center, University of Toronto, Toronto, Ontario, Canada
    Ther Drug Monit 31:14-30. 2009
    ..This review aims at defining the sensitivity, specificity, and clinical utilization of different methods used to estimate exposure to cigarette smoking and environmental tobacco smoke...
  59. ncbi request reprint Prenatal multivitamin supplementation and rates of congenital anomalies: a meta-analysis
    Y Ingrid Goh
    Department of Pharmaceutical Sciences, University of Toronto, and The Motherisk Program, Division of Clinical Pharmacology Toxicology, The Hospital for Sick Children, Toronto, ON, Canada
    J Obstet Gynaecol Can 28:680-9. 2006
    ..Several studies have also proposed the effectiveness of these supplements in preventing other birth defects; however, such effects have never been systematically examined...
  60. doi request reprint Safety of glyburide for gestational diabetes: a meta-analysis of pregnancy outcomes
    Myla E Moretti
    Motherisk Program, Hospital for Sick Children, Toronto, Ontario, Canada
    Ann Pharmacother 42:483-90. 2008
    ..Recent experimental and clinical studies have suggested, however, that the drug is not detectable in umbilical blood...
  61. doi request reprint Systemic bioavailability and pharmacokinetics of the doxylamine-pyridoxine delayed-release combination (Diclectin)
    Simerpal Kaur Gill
    The Motherisk Program, The Hospital for Sick Children, Toronto, Ontario, Canada
    Ther Drug Monit 33:115-9. 2011
    ..To understand and improve its effectiveness, the variability in the pharmacokinetics of the ingredients in this doxylamine succinate/pyridoxine hydrochloride combination must be studied...
  62. ncbi request reprint Safety and efficacy of panax ginseng during pregnancy and lactation
    Dugald Seely
    Department of Research and Clinical Epidemiology, The Canadian College of Naturopathic Medicine, Toronto, Canada
    Can J Clin Pharmacol 15:e87-94. 2008
    ..This is one article in a series that systematically reviews the evidence for herbs commonly used during pregnancy and lactation...
  63. ncbi request reprint Cocaethylene as a biomarker to predict heavy alcohol exposure among cocaine users
    Aniket Natekar
    Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, Toronto, Canada
    J Popul Ther Clin Pharmacol 19:e466-72. 2012
    ..There are no previous studies to assess the effectiveness of hair CE as a biomarker indicating chronic alcohol consumption among individuals who have consumed cocaine...
  64. pmc Is maternal use of selective serotonin reuptake inhibitors in the third trimester of pregnancy harmful to neonates?
    Gideon Koren
    Motherisk Program, The Hospital for Sick Children and University of Toronto, Toronto, Ont
    CMAJ 172:1457-9. 2005
  65. ncbi request reprint Neurocognitive development of children following in-utero exposure to labetalol for maternal hypertension: a cohort study using a prospectively collected database
    Wee Shian Chan
    Department of Medicine, Women s College Hospital, Toronto, Ontario, Canada
    Hypertens Pregnancy 29:271-83. 2010
    ..To identify the effect of prenatal labetalol exposure on children's long-term neurodevelopment...
  66. ncbi request reprint Passive environmental exposure to cocaine in Canadian children
    Facundo Garcia-Bournissen
    The Motherisk Program, Division of Clinical Pharmacology Toxicology, Hospital for Sick Children, University of Toronto, Ontario, Canada
    Paediatr Drugs 11:30-2. 2009
    ..Hair testing is commonly used to confirm potential drug exposure in children living with drug users, as well as abstinence in their caregivers...
  67. ncbi request reprint Nausea and vomiting of pregnancy: using the 24-hour Pregnancy-Unique Quantification of Emesis (PUQE-24) scale
    Neda Ebrahimi
    The Motherisk Program, Hospital for Sick Children, Toronto ON, Canada
    J Obstet Gynaecol Can 31:803-7. 2009
    ..The well-being score, however, correlated significantly with hydration status. Capturing 24 hours rather than 12 hours of symptoms may better direct management of NVP and predict its outcome...
  68. doi request reprint An improved method for rapidly quantifying fatty acid ethyl esters in meconium suitable for prenatal alcohol screening
    Janine R Hutson
    Motherisk Laboratory, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    Alcohol 45:193-9. 2011
    ..This method provides an optimal approach to detecting and quantifying FAEE in meconium that could be used in a universal screening program for prenatal alcohol exposure...
  69. doi request reprint Reliability and validity of observer ratings of pain using the visual analog scale (VAS) in infants undergoing immunization injections
    Anna Taddio
    Leslie Dan Faculty of Pharmacy, University of Toronto, and Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, Ont, Canada
    Pain 147:141-6. 2009
    ..However, different conclusions may be reached about the effectiveness of analgesic interventions depending on the rater. Sources of variability include use of multiple raters, rater focus (procedure vs. child) and experience level...
  70. ncbi request reprint Pharmacokinetic comparison of a delayed-release combination of doxylamine succinate and pyridoxine hydrocholoride (Diclectin) and oral solutions of these drugs in healthy women of childbearing age
    Irena Nulman
    The Motherisk Program, Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, Toronto, Canada
    Can J Clin Pharmacol 16:e400-6. 2009
    ..The drug is widely used today in Canada (Diclectin). The pharmacokinetics of Diclectin has never been described in humans...
  71. ncbi request reprint Does paroxetine cause cardiac malformations?
    Lisa O'Brien
    The Motherisk Program, The Hospital for Sick Children, Toronto, Toronto ON
    J Obstet Gynaecol Can 30:696-701. 2008
    ..Debate has recently arisen about the safety of paroxetine use in pregnancy, prompted by reports of increased risks for cardiac defects following first trimester exposure...
  72. ncbi request reprint Enantioselective metabolism of ifosfamide by the kidney
    Katarina Aleksa
    Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, Toronto, Canada
    Chirality 18:398-405. 2006
    ....
  73. doi request reprint Prevalence of fetal ethanol exposure in a regional population-based sample by meconium analysis of fatty acid ethyl esters
    Joey Gareri
    Motherisk Program, Hospital for Sick Children, Toronto, Ontario, Canada
    Ther Drug Monit 30:239-45. 2008
    ..Meconium FAEE analysis demonstrates a fivefold increase in sensitivity over currently used methods of self-report-based screening in Ontario for the detection of ethanol-exposed pregnancies in a clinical setting...
  74. doi request reprint Hair nicotine:cotinine metabolic ratio in pregnant women: a new method to study metabolism in late pregnancy
    Gideon Koren
    Division of Clinical Pharmacology Toxicology, The Hospital for Sick Children, Toronto, Ontario, Canada
    Ther Drug Monit 30:246-8. 2008
    ..This phenomenon may explain why many pregnant women feel the urge to continue smoking and why standard-dose nicotine replacement therapy has not been effective in reducing smoking during pregnancy in several clinical trials...
  75. doi request reprint Evaluation of the risk of congenital cardiovascular defects associated with use of paroxetine during pregnancy
    Adrienne Einarson
    Motherisk Program, Hospital for Sick Children, Division of Clinical Pharmacology, University of Toronto, 555 University Ave, Toronto, Ontario M5G 1X8, Canada
    Am J Psychiatry 165:749-52. 2008
    ..In this study, the authors sought to determine whether paroxetine was associated with an increased risk of cardiovascular defects in infants of women exposed to the drug during the first trimester of pregnancy...
  76. ncbi request reprint A Guinea pig model for the identification of in utero alcohol exposure using fatty acid ethyl esters in neonatal hair
    Daniela L Caprara
    Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, Toronto, and Department of Pharmacology and Toxicology, Faculty of Health Sciences, Queen s University, Kingston, Ontario, Canada
    Pediatr Res 58:1158-63. 2005
    ..Results of this study suggest that FAEE in neonatal hair may be useful biomarkers in identifying in utero alcohol exposure and may facilitate the early diagnosis and treatment of FASD...
  77. doi request reprint Antenatal use of selective serotonin-reuptake inhibitors and QT interval prolongation in newborns
    Gal Dubnov-Raz
    Hospital for Sick Children, Motherisk Program, Divisions of Clinical Pharmacology and Toxicology and Emergency Medicine, Department of Pediatrics, 555 University Avenue Toronto, Ontario, Canada
    Pediatrics 122:e710-5. 2008
    ..The aim of this study was to determine the effect of maternal use of selective serotonin-reuptake inhibitor antidepressants during pregnancy on the QTc interval of the offspring...
  78. ncbi request reprint Determinants of women's decision making on whether to treat nausea and vomiting of pregnancy pharmacologically
    Anne Baggley
    The Motherisk Program, The Hospital for Sick Children, Toronto, Ontario, Canada
    J Midwifery Womens Health 49:350-4. 2004
    ..Of the women who did use Diclectin, the most convincing reassuring information that it was safe to use came from friends and family. Many other factors play a large role in a women's decision making...
  79. doi request reprint Pregnancy outcome following in utero exposure to bisphosphonates
    Shirley Levy
    The Motherisk Program, Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, University of Toronto, Ontario, Canada
    Bone 44:428-30. 2009
    ..The safety of bisphosphonates in human pregnancy has not been well established. To characterize pregnancy outcome in women receiving bisphosphonates, we conducted a multi-centre, prospective cohort study with a comparison group...
  80. ncbi request reprint Hair mercury levels of women of reproductive age in Ontario, Canada: implications to fetal safety and fish consumption
    Katherine Schoeman
    Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
    J Pediatr 157:127-31. 2010
    ..To study hair mercury concentrations among women of reproductive age in relation to fish intake in Ontario, Canada...
  81. doi request reprint Long-term developmental outcome of children of women with epilepsy, unexposed or exposed prenatally to antiepileptic drugs: a meta-analysis of cohort studies
    Ryan Banach
    Department of Family Medicine, McMaster University, Hamilton, Ontario, Canada
    Drug Saf 33:73-9. 2010
    ..Clinicians should inform families of the potential cognitive adverse effects of valproic acid. More studies are needed to corroborate these findings...
  82. ncbi request reprint Safety and efficacy of ginkgo (Ginkgo biloba) during pregnancy and lactation
    Jean Jacques Dugoua
    Department of Clinical Epidemiology, Canadian College of Naturopathic Medicine, Toronto, Canada
    Can J Clin Pharmacol 13:e277-84. 2006
    ..This is one article in a series that systematically reviews the evidence for commonly used herbs during pregnancy and lactation...
  83. ncbi request reprint The effect of N-acetylcysteine on ifosfamide-induced nephrotoxicity: in vitro studies in renal tubular cells
    Nancy Chen
    Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
    Transl Res 150:51-7. 2007
    ..It is likely that NAC is protecting the cells by partially acting as a precursor for GSH synthesis. This mode of therapy may allow for protecting children from life-threatening nephrotoxicity induced by IF...
  84. ncbi request reprint Validation of the oral mucositis assessment scale in pediatric cancer
    Lillian Sung
    Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada
    Pediatr Blood Cancer 49:149-53. 2007
    ..Our objective was to examine the construct validity of the Oral Mucositis Assessment Scale (OMAS) in children receiving doxorubicin chemotherapy...
  85. ncbi request reprint The way women perceive teratogenic risk
    Gideon Koren
    The Hospital for Sick Children, Toronto, Ontario, Canada
    Can J Clin Pharmacol 14:e10-6. 2007
  86. doi request reprint Defining a lowest observable adverse effect hair concentrations of mercury for neurodevelopmental effects of prenatal methylmercury exposure through maternal fish consumption: a systematic review
    Katherine Schoeman
    Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, Ontario, Canada
    Ther Drug Monit 31:670-82. 2009
    ..Our objective was to systematically review the evidence of neurodevelopmental risks of methylmercury to the unborn child from maternal fish consumption to define the lowest observable adverse effect hair concentration (LOAEHC)...
  87. ncbi request reprint Systemic exposure to morphine and the risk of acute chest syndrome in sickle cell disease
    Ernest A Kopecky
    Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
    Clin Pharmacol Ther 75:140-6. 2004
    ..The etiology of acute chest syndrome, the most severe complication of the sickle cell crisis, is unknown...
  88. ncbi request reprint Pharmacokinetics of high doses of cyanocobalamin administered by intravenous injection for 26 weeks in rats
    Alejandro A Nava-Ocampo
    Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, Toronto, Canada
    Clin Exp Pharmacol Physiol 32:13-8. 2005
    ..The negative relationship between dose and normalized AUC is compatible with possible saturation of tubular reabsorption, thus increasing renal clearance at higher doses...
  89. ncbi request reprint Discrepancies in pharmacokinetic analysis results obtained by using two standard population pharmacokinetics software programs
    Yaron Finkelstein
    Division of Clinical Pharmacology and Toxicology, Department of Pediatrics, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G1X8, Canada
    Fundam Clin Pharmacol 23:53-7. 2009
    ..7 h vs. 206.9 h, respectively). When considering the results reported from a population PK analysis, validation of the results by different software should be considered, especially when extreme, unexpected values are obtained...
  90. ncbi request reprint Clopidogrel use in children
    Yaron Finkelstein
    Division of Clinical Pharmacology, The Hospital for Sick Children, University of Toronto School of Medicine, Toronto, Ontario
    J Pediatr 147:657-61. 2005
    ..To review a pediatric experience with the antiplatelet agent clopidogrel and suggest a dosage regimen...
  91. ncbi request reprint Smoke screen: increase in movie stars' smoking on the big screen and its effect on teen smoking
    Yaron Finkelstein
    Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, Toronto, Canada
    Ther Drug Monit 27:547-8. 2005
    ..Several recent studies show an increase in movie stars' smoking on the big screen, leading to an increased rate of teen smoking...
  92. ncbi request reprint Elimination kinetics of ethanol in pregnant women
    Alejandro A Nava-Ocampo
    The Motherisk Program, Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, Toronto, Ont, Canada
    Reprod Toxicol 18:613-7. 2004
    ..However, ethanol clearance from the AF is slower than ethanol clearance in MB. This process is widely variable, and our findings may partially explain the wide variability of ethanol's toxic effects on the fetus...
  93. ncbi request reprint Binding of acetaldehyde to human and Guinea pig placentae in vitro
    Marjie L Hard
    Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children and Department of Pharmaceutical Sciences, University of Toronto, Ontario, Canada
    Placenta 24:149-54. 2003
    ..Significant interindividual variability exists following maternal alcohol consumption; not all children born to alcoholic women manifest the symptoms associated with foetal alcohol spectrum disorder (FASD)...
  94. ncbi request reprint Gene-expression analysis after alcohol exposure in the developing mouse
    Marjie L Hard
    The Hospital for Sick Children, The Department of Pharmaceutical Sciences, University of Toronto, Ontario M5G 1X8, Canada
    J Lab Clin Med 145:47-54. 2005
    ..Microarray studies may be useful in the identification of a genetic marker for fetal alcohol syndrome, the discovery of novel pathways that may be involved in its origin, or both...
  95. ncbi request reprint Bioavailability of a pediatric amlodipine suspension
    Dorothy A Lyszkiewicz
    Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada
    Pediatr Nephrol 18:675-8. 2003
    ..Bioequivalence of the suspension was not different from the tablets. These results support the use of the suspension in children who cannot take the tablet...
  96. ncbi request reprint Estimation of fetal exposure to drugs of abuse, environmental tobacco smoke, and ethanol
    Gideon Koren
    Motherisk Program, Division of Clinical Pharmacology Toxicology, The Hospital for Sick Children and University of Toronto, Toronto, Ontario, Canada
    Ther Drug Monit 24:23-5. 2002
    ..The identification of biologic markers of intrauterine exposure to xenobiotics will allow better understanding of etiology and dose-response relationships...
  97. ncbi request reprint Effects of perioperative oral amantadine on postoperative pain and morphine consumption in patients after radical prostatectomy: results of a preliminary study
    Dirk G Snijdelaar
    Acute Pain Research Unit, Department of Anesthesia and Pain Management, Toronto General Hospital, Ontario, Canada
    Anesthesiology 100:134-41. 2004
    ..The aim of this pilot study was to evaluate the effects of perioperative oral amantadine on postoperative pain and analgesic consumption...
  98. doi request reprint Establishing causality of CNS depression in breastfed infants following maternal codeine use
    Parvaz Madadi
    Department of Physiology and Pharmacology, The University of Western Ontario, London, Ontario, Canada
    Paediatr Drugs 10:399-404. 2008
    ....
  99. pmc Drinking alcohol while breastfeeding. Will it harm my baby?
    Gideon Koren
    Hospital for Sick Children, Toronto, Ont
    Can Fam Physician 48:39-41. 2002
    ..Motherisk has created an algorithm to estimate how long it takes to eliminate alcohol from breast milk...