Je-Wook Yu

Summary

Affiliation: Yonsei University College of Medicine
Location: Seoul, Korea

Publications

  1. pmc Ribotoxic stress through p38 mitogen-activated protein kinase activates in vitro the human pyrin inflammasome
    Je Wook Yu
    Department of Biochemistry and Molecular Biology and the Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 288:11378-83. 2013
  2. pmc Restoration of ASC expression sensitizes colorectal cancer cells to genotoxic stress-induced caspase-independent cell death
    Sujeong Hong
    Department of Microbiology, Yonsei University College of Medicine, Seoul, Republic of Korea
    Cancer Lett 331:183-91. 2013
  3. pmc The AIM2 inflammasome is critical for innate immunity to Francisella tularensis
    Teresa Fernandes-Alnemri
    Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    Nat Immunol 11:385-93. 2010
  4. pmc AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA
    Teresa Fernandes-Alnemri
    Department of Biochemistry and Molecular Biology, Center for Apoptosis Research, Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Nature 458:509-13. 2009
  5. pmc Pyrin activates the ASC pyroptosome in response to engagement by autoinflammatory PSTPIP1 mutants
    Je Wook Yu
    Department of Biochemistry and Molecular Biology, Center for Apoptosis Research, Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Mol Cell 28:214-27. 2007
  6. ncbi Cryopyrin and pyrin activate caspase-1, but not NF-kappaB, via ASC oligomerization
    J W Yu
    Department of Microbiology and Immunology, Center for Apoptosis Research, Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Cell Death Differ 13:236-49. 2006
  7. pmc Anti-inflammatory compounds parthenolide and Bay 11-7082 are direct inhibitors of the inflammasome
    Christine Juliana
    Department of Biochemistry and Molecular Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 285:9792-802. 2010
  8. pmc Salmonella Promotes ASC Oligomerization-dependent Caspase-1 Activation
    Inhwa Hwang
    Department of Microbiology and Immunology, Yonsei University College of Medicine, Seoul 120 752, Korea Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul 120 752, Korea
    Immune Netw 12:284-90. 2012

Collaborators

  • Emad S Alnemri
  • J Wu
  • Lan Huang
  • Eicke Latz
  • Teresa Fernandes-Alnemri
  • Sujeong Hong
  • Inhwa Hwang
  • Christine Juliana
  • Pinaki Datta
  • Sangjun Park
  • Leobaldo Solorzano
  • Won Keun Lee
  • Yun Sun Lee
  • You Sun Kim
  • Eun Hee Kim
  • Charles P Scott
  • Andrew A Quong
  • Margaret McCormick
  • Carlisle P Landel
  • Seokwon Kang
  • Erin McDermott
  • Laurence Eisenlohr
  • Rong Meng

Detail Information

Publications10

  1. pmc Ribotoxic stress through p38 mitogen-activated protein kinase activates in vitro the human pyrin inflammasome
    Je Wook Yu
    Department of Biochemistry and Molecular Biology and the Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 288:11378-83. 2013
    ..Together, our results indicate that ribotoxic stress activates the human pyrin inflammasome through a mechanism that requires p38 MAPK signaling and microtubule stability...
  2. pmc Restoration of ASC expression sensitizes colorectal cancer cells to genotoxic stress-induced caspase-independent cell death
    Sujeong Hong
    Department of Microbiology, Yonsei University College of Medicine, Seoul, Republic of Korea
    Cancer Lett 331:183-91. 2013
    ..Thus, our data suggest that ASC expression in cancer cells is an important factor in determining their susceptibility to chemotherapy...
  3. pmc The AIM2 inflammasome is critical for innate immunity to Francisella tularensis
    Teresa Fernandes-Alnemri
    Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    Nat Immunol 11:385-93. 2010
    ..tularensis infection or the presence of cytoplasmic DNA. Our study identifies AIM2 as a crucial sensor of F. tularensis infection and provides genetic proof of its critical role in host innate immunity to intracellular pathogens...
  4. pmc AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA
    Teresa Fernandes-Alnemri
    Department of Biochemistry and Molecular Biology, Center for Apoptosis Research, Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Nature 458:509-13. 2009
    ..This study identifies AIM2 as an important inflammasome component that senses potentially dangerous cytoplasmic DNA, leading to activation of the ASC pyroptosome and caspase-1...
  5. pmc Pyrin activates the ASC pyroptosome in response to engagement by autoinflammatory PSTPIP1 mutants
    Je Wook Yu
    Department of Biochemistry and Molecular Biology, Center for Apoptosis Research, Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Mol Cell 28:214-27. 2007
    ..Therefore, constitutive ligation and activation of pyrin by mutant PSTPIP1 proteins explain the autoinflammatory phenotype seen in PAPA syndrome...
  6. ncbi Cryopyrin and pyrin activate caspase-1, but not NF-kappaB, via ASC oligomerization
    J W Yu
    Department of Microbiology and Immunology, Center for Apoptosis Research, Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Cell Death Differ 13:236-49. 2006
    ..Thus, we propose that pyrin could function as a proinflammatory molecule...
  7. pmc Anti-inflammatory compounds parthenolide and Bay 11-7082 are direct inhibitors of the inflammasome
    Christine Juliana
    Department of Biochemistry and Molecular Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 285:9792-802. 2010
    ..Our results thus elucidate the molecular mechanism for the therapeutic anti-inflammatory activity of parthenolide and identify vinyl sulfones as a new class of potential therapeutics that target the NLRP3 inflammasome...
  8. pmc Salmonella Promotes ASC Oligomerization-dependent Caspase-1 Activation
    Inhwa Hwang
    Department of Microbiology and Immunology, Yonsei University College of Medicine, Seoul 120 752, Korea Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul 120 752, Korea
    Immune Netw 12:284-90. 2012
    ..typhimurium infection. Contrary to NLRP3 inflammasome, intracellular potassium depletion is not critical for NLRC4 inflammasome signaling by S. typhimurium...