Dong Min Shin
Affiliation: Yonsei University College of Medicine
Shcheynikov N, Son A, Hong J, Yamazaki O, Ohana E, Kurtz I, et al
. Intracellular Cl- as a signaling ion that potently regulates Na+/HCO3- transporters. Proc Natl Acad Sci U S A. 2015;112:E329-37 pubmed publisher
Park S, Ahuja M, Kim M, Brailoiu G, Jha A, Zeng M, et al
. Fusion of lysosomes with secretory organelles leads to uncontrolled exocytosis in the lysosomal storage disease mucolipidosis type IV. EMBO Rep. 2016;17:266-78 pubmed publisher
..These features were not observed in Niemann-Pick type C1. These findings suggest that TRPML1 may guard against pathological fusion of lysosomes with secretory organelles and suggest a new approach toward developing treatment for MLIV. ..
Son D, Doan K, Yang D, Sun J, Kim S, Kang N, et al
. FoxO1 regulates leptin-induced mood behavior by targeting tyrosine hydroxylase. Metabolism. 2019;91:43-52 pubmed publisher
..This work establishes a novel molecular mechanism of mood behavior regulation by leptin and suggests FoxO1 suppression by leptin might be a key for leptin-induced behavioral manifestation in DA neurons. ..
Son D, Yang D, Sun J, Kim S, Kang N, Kang J, et al
. A Novel Peptide, Nicotinyl⁻Isoleucine⁻Valine⁻Histidine (NA⁻IVH), Promotes Antioxidant Gene Expression and Wound Healing in HaCaT Cells. Mar Drugs. 2018;16: pubmed publisher
..Collectively, our results imply that a novel nicotinyl-peptide, NA⁻IVH, has a wound-healing effect in a hyperglycemic condition, possibly by modulating excessive ROS. ..
Son G, Hong J, Chang I, Shin D. Induction of IL-6 and IL-8 by activation of thermosensitive TRP channels in human PDL cells. Arch Oral Biol. 2015;60:526-32 pubmed publisher
..The activation of thermosensitive TRP channels induced IL-6 and IL-8 expression by increasing [Ca(2+)]i in human PDL cells. Therefore, thermal stress may play a critical role in the inflammatory responses of PDL cells. ..
Son G, Yang Y, Park W, Chang I, Shin D. Hypotonic stress induces RANKL via transient receptor potential melastatin 3 (TRPM3) and vaniloid 4 (TRPV4) in human PDL cells. J Dent Res. 2015;94:473-81 pubmed publisher
..This signaling pathway in PDL cells may play a critical role in mechanical stress-mediated alveolar bone remodeling. ..
Son G, Son A, Yang Y, Park W, Chang I, Lee J, et al
. Airborne allergens induce protease activated receptor-2-mediated production of inflammatory cytokines in human gingival epithelium. Arch Oral Biol. 2016;61:138-43 pubmed publisher
..GCE activates PAR-2, which can induce PLC/IP3-dependent Ca(2+) signaling pathway, ultimately triggering inflammation via the production of pro-inflammatory cytokines such as IL-1Î², IL-6, IL-8, and NLRP 3 in HGECs. ..
Shin D, Son A, Park S, Kim M, Ahuja M, Muallem S. The TRPCs, Orais and STIMs in ER/PM Junctions. Adv Exp Med Biol. 2016;898:47-66 pubmed publisher
..The chapter closes by highlighting open questions and potential future directions in this field. ..
Yang Y, Lee J, Jo H, Park S, Chang I, Muallem S, et al
. Homer2 protein regulates plasma membrane Ca²?-ATPase-mediated Ca²? signaling in mouse parotid gland acinar cells. J Biol Chem. 2014;289:24971-9 pubmed publisher
..These findings reveal an important regulation of PMCA by Homer2 that has a central role on PMCA-mediated Ca(2+) signaling in parotid acinar cells. ..