Affiliation: Yonsei University
Lee S, Kang D, Ra E, Lee T, Ploegh H, Park B. Negative self-regulation of TLR9 signaling by its N-terminal proteolytic cleavage product. J Immunol. 2014;193:3726-35 pubmed publisher
..Together, these results suggest that the N-terminal TLR9 proteolytic cleavage product is a negative self-regulator that prevents excessive TLR9 signaling activity. ..
Lee S, Lee T, Song S, Park T, Park B. Hyperproduction of IL-6 caused by aberrant TDP-43 overexpression in high-fat diet-induced obese mice. FEBS Lett. 2015;589:1825-31 pubmed publisher
..Our findings provide evidence for a link between homeostasis of TDP-43 expression and the risk of developing obesity. ..
Park B, Buti L, Lee S, Matsuwaki T, Spooner E, Brinkmann M, et al
. Granulin is a soluble cofactor for toll-like receptor 9 signaling. Immunity. 2011;34:505-13 pubmed publisher
..Thus, we propose that granulin contributes to innate immunity as a critical soluble cofactor for TLR9 signaling. ..
Huh H, Lee E, Shin J, Park B, Lee S. STRAP positively regulates TLR3-triggered signaling pathway. Cell Immunol. 2017;318:55-60 pubmed publisher
..Furthermore, the C-terminus of STRAP is essential for its functional activity in TLR3-mediated IL-6 and IFN-? production. These data suggest that STRAP is a positive regulator of the TLR3-meditated NF-?B and IRF signaling pathway. ..
Choi H, Park A, Kang S, Lee E, Lee T, Ra E, et al
. Human cytomegalovirus-encoded US9 targets MAVS and STING signaling to evade type I interferon immune responses. Nat Commun. 2018;9:125 pubmed publisher
..Our findings indicate that HCMV US9 is an antagonist of IFN signaling to persistently evade host innate antiviral responses. ..