Hwan Young Lee

Summary

Affiliation: Yonsei University College of Medicine
Country: Korea

Publications

  1. pmc mtDNAmanager: a Web-based tool for the management and quality analysis of mitochondrial DNA control-region sequences
    Hwan Young Lee
    Department of Forensic Medicine, Yonsei University College of Medicine, Seoul, Korea
    BMC Bioinformatics 9:483. 2008
  2. doi request reprint Potential forensic application of DNA methylation profiling to body fluid identification
    Hwan Young Lee
    Department of Forensic Medicine and Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul 120 752, South Korea
    Int J Legal Med 126:55-62. 2012
  3. ncbi request reprint Mitochondrial DNA control region sequences in Koreans: identification of useful variable sites and phylogenetic analysis for mtDNA data quality control
    Hwan Young Lee
    Department of Forensic Medicine and Brain Korea 21 Project for Medical Science, College of Medicine, Yonsei University, 134 Shinchon dong, Seodaemun gu, 120 752, Seoul, South Korea
    Int J Legal Med 120:5-14. 2006
  4. ncbi request reprint Forensic evaluation and haplotypes of 19 Y-chromosomal STR loci in Koreans
    Myung Jin Park
    Department of Forensic Medicine, College of Medicine, Yonsei University, Seoul 120 752, Republic of Korea
    Forensic Sci Int 152:133-47. 2005
  5. ncbi request reprint Genetic characterization and assessment of authenticity of ancient Korean skeletal remains
    Hwan Young Lee
    Department of Forensic Medicine and Brain, Korea 21 Project for Medical Science, Yonsei University College of Medicine, 250 Seongsanno, Seodaemun gu, Seoul 120 752, Korea
    Hum Biol 80:239-50. 2008
  6. ncbi request reprint Selection of twenty-four highly informative SNP markers for human identification and paternity analysis in Koreans
    Hwan Young Lee
    Department of Forensic Medicine, College of Medicine, Yonsei University, Seoul 120 752, Republic of Korea
    Forensic Sci Int 148:107-12. 2005
  7. ncbi request reprint East Asian mtDNA haplogroup determination in Koreans: haplogroup-level coding region SNP analysis and subhaplogroup-level control region sequence analysis
    Hwan Young Lee
    Department of Forensic Medicine, Yonsei University College of Medicine, Seoul, Korea
    Electrophoresis 27:4408-18. 2006
  8. doi request reprint Rapid direct PCR for ABO blood typing
    Hwan Young Lee
    Department of Forensic Medicine, Yonsei University College of Medicine, Seodaemun gu, Seoul, Korea
    J Forensic Sci 56:S179-82. 2011
  9. doi request reprint DNA typing for the identification of old skeletal remains from Korean War victims
    Hwan Young Lee
    Department of Forensic Medicine and Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, 250 Seongsanno, Seodaemun gu, Seoul 120 752, Korea
    J Forensic Sci 55:1422-9. 2010
  10. ncbi request reprint Mitochondrial DNA CA dinucleotide repeats in Koreans: the presence of length heteroplasmy
    Ukhee Chung
    Department of Forensic Medicine and Brain Korea 21 Project for Medical Science, College of Medicine Yonsei University, 134 Shinchon dong Seodaemun gu, 120 752 Seoul, Korea
    Int J Legal Med 119:50-3. 2005

Collaborators

  • Kyoung Jin Shin
  • Woo Ick Yang
  • Myung Jin Park
  • Na Young Kim
  • Ukhee Chung
  • In Seok Yang
  • Ja Hyun An
  • Ajin Choi
  • Jeong Eun Sim
  • Eun Hye Kim
  • Allah Rakha
  • Eun Jin Lim
  • Sang Ho Cho
  • Ji Eun Yoo
  • Eun Young Lee
  • Sun Joo Park
  • Jung Ah Yoon
  • Muhammad Hassan Siddique
  • Seung Chul Kang
  • Seon Yeong Lee

Detail Information

Publications34

  1. pmc mtDNAmanager: a Web-based tool for the management and quality analysis of mitochondrial DNA control-region sequences
    Hwan Young Lee
    Department of Forensic Medicine, Yonsei University College of Medicine, Seoul, Korea
    BMC Bioinformatics 9:483. 2008
    ..However, recent research has shown that using mtDNA phylogeny and referring to known mtDNA haplotypes can be useful for checking the quality of sequence data...
  2. doi request reprint Potential forensic application of DNA methylation profiling to body fluid identification
    Hwan Young Lee
    Department of Forensic Medicine and Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul 120 752, South Korea
    Int J Legal Med 126:55-62. 2012
    ....
  3. ncbi request reprint Mitochondrial DNA control region sequences in Koreans: identification of useful variable sites and phylogenetic analysis for mtDNA data quality control
    Hwan Young Lee
    Department of Forensic Medicine and Brain Korea 21 Project for Medical Science, College of Medicine, Yonsei University, 134 Shinchon dong, Seodaemun gu, 120 752, Seoul, South Korea
    Int J Legal Med 120:5-14. 2006
    ..8%) into various East Asian haplogroups or sub-haplogroups. Haplogroup-directed database comparisons confirmed the absence of any major systematic errors in our data, e.g., a mix-up of site designations, base shifts or mistypings...
  4. ncbi request reprint Forensic evaluation and haplotypes of 19 Y-chromosomal STR loci in Koreans
    Myung Jin Park
    Department of Forensic Medicine, College of Medicine, Yonsei University, Seoul 120 752, Republic of Korea
    Forensic Sci Int 152:133-47. 2005
    ..These results including the haplotype data at 19 Y-STR loci in the present study would provide useful information in forensic practice in a Korean population...
  5. ncbi request reprint Genetic characterization and assessment of authenticity of ancient Korean skeletal remains
    Hwan Young Lee
    Department of Forensic Medicine and Brain, Korea 21 Project for Medical Science, Yonsei University College of Medicine, 250 Seongsanno, Seodaemun gu, Seoul 120 752, Korea
    Hum Biol 80:239-50. 2008
    ....
  6. ncbi request reprint Selection of twenty-four highly informative SNP markers for human identification and paternity analysis in Koreans
    Hwan Young Lee
    Department of Forensic Medicine, College of Medicine, Yonsei University, Seoul 120 752, Republic of Korea
    Forensic Sci Int 148:107-12. 2005
    ..905x10(-10) and 98.9%, respectively. The SNPs in this study offer a small but highly accurate database that will be an essential reference for SNP-based forensic application in the future...
  7. ncbi request reprint East Asian mtDNA haplogroup determination in Koreans: haplogroup-level coding region SNP analysis and subhaplogroup-level control region sequence analysis
    Hwan Young Lee
    Department of Forensic Medicine, Yonsei University College of Medicine, Seoul, Korea
    Electrophoresis 27:4408-18. 2006
    ....
  8. doi request reprint Rapid direct PCR for ABO blood typing
    Hwan Young Lee
    Department of Forensic Medicine, Yonsei University College of Medicine, Seodaemun gu, Seoul, Korea
    J Forensic Sci 56:S179-82. 2011
    ....
  9. doi request reprint DNA typing for the identification of old skeletal remains from Korean War victims
    Hwan Young Lee
    Department of Forensic Medicine and Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, 250 Seongsanno, Seodaemun gu, Seoul 120 752, Korea
    J Forensic Sci 55:1422-9. 2010
    ..The present analysis emphasizes the value of mini- and Y-STR systems as well as an efficient DNA extraction method in DNA testing for the identification of old skeletal remains...
  10. ncbi request reprint Mitochondrial DNA CA dinucleotide repeats in Koreans: the presence of length heteroplasmy
    Ukhee Chung
    Department of Forensic Medicine and Brain Korea 21 Project for Medical Science, College of Medicine Yonsei University, 134 Shinchon dong Seodaemun gu, 120 752 Seoul, Korea
    Int J Legal Med 119:50-3. 2005
    ..A total of 4 alleles with 4-7 repeat units were observed and the genetic diversity was estimated to be 0.5120 in 500 unrelated Koreans. Interestingly, three individuals showed two or three length variants, i.e. length heteroplasmy...
  11. doi request reprint Population genetic study of four closely-linked X-STR trios in Koreans
    Jeong Eun Sim
    Department of Forensic Medicine and Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea
    Mol Biol Rep 37:333-7. 2010
    ..98, and 77.1% of all haplotypes showed a frequency less than 0.01. Therefore, the four closely-linked X-STR trios will contribute to complex kinship testing in Koreans...
  12. doi request reprint Characterization of deletions in the DYS385 flanking region and null alleles associated with AZFc microdeletions in Koreans
    Myung Jin Park
    Department of Forensic Medicine and Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seodaemun gu, Seoul, Korea
    J Forensic Sci 53:331-4. 2008
    ..The DYS448 deletion appears relatively frequent in Asians...
  13. ncbi request reprint Population data of nine miniSTR loci in Koreans
    Ukhee Chung
    Department of Forensic Medicine and Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, 134 Sinchon dong, Seodaemun gu, Seoul 120 752, Republic of Korea
    Forensic Sci Int 168:e51-3. 2007
    ..These data demonstrated that D10S1248, D2S441, D22S1045, D14S1434, and D6S474 are as highly informative as the CODIS STRs suggesting that the miniSTRs could be useful for forensic analysis of degraded DNA...
  14. ncbi request reprint Y-STR analysis of degraded DNA using reduced-size amplicons
    Myung Jin Park
    Department of Forensic Medicine, Yonsei University College of Medicine, 134 Sinchon dong, Seodaemun gu, Seoul, 120 752, South Korea
    Int J Legal Med 121:152-7. 2007
    ..This comparison demonstrated that the new Y-miniplex sets can produce a better signal from degraded DNA than the AmpFlSTR Yfiler kit...
  15. ncbi request reprint Differential distribution of human mitochondrial DNA in somatic tissues and hairs
    Hwan Young Lee
    Department of Forensic Medicine and Brain Korea 21 Project for Medical Science, College of Medicine, Yonsei University, 134 Shinchon dong, Seodaemun gu, Seoul 120 752, Korea
    Ann Hum Genet 70:59-65. 2006
    ..Each hair shaft may have a restricted or clonal set of mtDNA molecules derived from a discrete group of stem cells...
  16. ncbi request reprint Haplotypes and mutation analysis of 22 Y-chromosomal STRs in Korean father-son pairs
    Hwan Young Lee
    Department of Forensic Medicine and BK21 Project for Medical Science, Yonsei University College of Medicine, 134 Sinchon dong, Seodaemun gu, Seoul, 120 752, South Korea
    Int J Legal Med 121:128-35. 2007
    ..36 x 10(-3) (95% ci 2.03-2.73 x 10(-33))...
  17. pmc Genetic polymorphism and haplotype analysis of 4 tightly linked X-STR duos in Koreans
    Eun Jin Lim
    Department of Forensic Medicine, Yonsei University College of Medicine, 250 Seongsanno, Seodaemun gu, Seoul, Korea
    Croat Med J 50:305-12. 2009
    ..To investigate genetic polymorphism and haplotypes of tightly linked X-chromosomal short tandem repeat (X-STR) clusters in Koreans...
  18. doi request reprint A modified mini-primer set for analyzing mitochondrial DNA control region sequences from highly degraded forensic samples
    Hwan Young Lee
    Department of Forensic Medicine, Yonsei University College of Medicine, Yonsei University, Seoul, Korea
    Biotechniques 44:555-6, 558. 2008
    ....
  19. ncbi request reprint Genetic characteristics and population study of 4 X-chromosomal STRs in Koreans: evidence for a null allele at DXS9898
    Hwan Young Lee
    Department of Forensic Medicine, College of Medicine, Yonsei University, 134 Shinchon dong, Seodaemun gu, 120 752 Seoul, Korea
    Int J Legal Med 118:355-60. 2004
    ..The test of homogeneity between allele frequencies revealed that there are some discrepancies in allele distributions between Koreans and Germans...
  20. doi request reprint Understanding the Y chromosome variation in Korea--relevance of combined haplogroup and haplotype analyses
    Myung Jin Park
    Department of Forensic Medicine and Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, 50 Yonsei ro, Seodaemun gu, Seoul, 120 752, South Korea
    Int J Legal Med 126:589-99. 2012
    ..These high-resolution haplogroup and haplotype data will improve our understanding of regional Y-chromosome variation or recent migration routes and will also help to infer haplogroup background or common ancestry...
  21. doi request reprint DNA methylation-specific multiplex assays for body fluid identification
    Ja Hyun An
    Department of Forensic Medicine and Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, 50 Yonsei ro, Seodaemun gu, Seoul, 120 752, South Korea
    Int J Legal Med 127:35-43. 2013
    ..Although including more markers for body fluid identification might be necessary, this study adds to the support that body fluid identification by DNA methylation profiles could be a valuable tool for forensic analysis of body fluids...
  22. doi request reprint Simple and highly effective DNA extraction methods from old skeletal remains using silica columns
    Hwan Young Lee
    Department of Forensic Medicine and Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, 250 Seongsanno, Seodaemun gu, Seoul 120 752, Republic of Korea
    Forensic Sci Int Genet 4:275-80. 2010
    ..We have successfully used this modified technique to perform STR analysis for 55-year-old skeletal remains. The results of this study will contribute to solve the forensic cases dealing with skeletal remains...
  23. ncbi request reprint Quantitative and qualitative profiling of mitochondrial DNA length heteroplasmy
    Hwan Young Lee
    Department of Forensic Medicine, College of Medicine, Seoul, Korea
    Electrophoresis 25:28-34. 2004
    ....
  24. ncbi request reprint Five highly informative X-chromosomal STRs in Koreans
    Kyoung Jin Shin
    Department of Forensic Medicine, College of Medicine, Yonsei University, 134 Shinchon dong, Seodaemun gu, 120 752 Seoul, Korea
    Int J Legal Med 118:37-40. 2004
    ..The forensic efficiency parameters showed that the five X-linked STRs are highly informative for forensic application in Koreans...
  25. doi request reprint Y-SNP miniplexes for East Asian Y-chromosomal haplogroup determination in degraded DNA
    Myung Jin Park
    Department of Forensic Medicine and Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, 50 Yonsei ro, Seodaemun gu, Seoul 120 752, South Korea
    Forensic Sci Int Genet 7:75-81. 2013
    ..3%), followed by haplogroups C3 (xC3c, C3d, C3e) (16.0%) and O3a3c1 (11.0%). These multiplex sets will be useful tools for Y-chromosomal haplogroup determination in anthropological and forensic studies of East Asian populations...
  26. doi request reprint A one step multiplex PCR assay for rapid screening of East Asian mtDNA haplogroups on forensic samples
    Hwan Young Lee
    Department of Forensic Medicine, Yonsei University College of Medicine, 50 Yonsei ro, Seodaemun gu, Seoul, South Korea
    Leg Med (Tokyo) 15:50-4. 2013
    ..Therefore, it would be a simple, rapid, and reliable detection method useful for large-scale screening of mtDNA variations to determine East Asian mtDNA haplogroups...
  27. ncbi request reprint Body fluid identification in forensics
    Ja Hyun An
    Department of Forensic Medicine, Yonsei University College of Medicine, Yonsei University, Seoul, Korea
    BMB Rep 45:545-53. 2012
    ..In this review, we provide an overview of the present knowledge and the most recent developments in forensic body fluid identification and discuss its possible practical application to forensic casework...
  28. doi request reprint A genetic investigation of Korean mummies from the Joseon Dynasty
    Na Young Kim
    Department of Forensic Medicine and Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, 250 Seongsanno, Seodaemun gu, Seoul, 120 752, Korea
    Mol Biol Rep 38:115-21. 2011
    ..The small size amplicon strategy and the authentication process in the present study will be effectively applicable to future genetic analyses of various forensic and ancient samples...
  29. doi request reprint Modified midi- and mini-multiplex PCR systems for mitochondrial DNA control region sequence analysis in degraded samples
    Na Young Kim
    Department of Forensic Medicine, Yonsei University College of Medicine, 50 Yonsei ro, Seodaemun gu, Seoul, 120 752, Korea
    J Forensic Sci 58:738-43. 2013
    ..The multiplex system consisting of smaller amplicons is effective for mtDNA sequence analyses of ancient and forensic degraded samples, saving time, cost, and the amount of DNA sample consumed during analysis...
  30. doi request reprint Forensic and genetic characterization of mtDNA from Pathans of Pakistan
    Allah Rakha
    Department of Forensic Medicine, Yonsei University College of Medicine, 250 Seongsanno, Seodaemun gu, Seoul, South Korea
    Int J Legal Med 125:841-8. 2011
    ..Data presented here may contribute to the accuracy of forensic mtDNA comparisons in the Pathans of Pakistan...
  31. doi request reprint Body fluid identification by integrated analysis of DNA methylation and body fluid-specific microbial DNA
    Ajin Choi
    Department of Forensic Medicine and Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, 50 Yonsei ro, Seodaemun gu, Seoul, 120 752, South Korea
    Int J Legal Med 128:33-41. 2014
    ....
  32. doi request reprint Population data for 30 insertion-deletion markers in a Korean population
    Eun Hye Kim
    Department of Forensic Medicine and Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, 50 Yonsei ro, Seodaemun gu, Seoul, 120 752, Korea
    Int J Legal Med 128:51-2. 2014
    ..This study further demonstrated that some Indels in the DIPplex® kit could be used as Asian ancestry informative markers through a comparison with other population data. ..
  33. doi request reprint mtDNAprofiler: a Web application for the nomenclature and comparison of human mitochondrial DNA sequences
    In Seok Yang
    Department of Forensic Medicine, Yonsei University College of Medicine, 50 Yonsei ro, Seodaemun gu, Seoul, 120 752, Korea
    J Forensic Sci 58:972-80. 2013
    ..mtDNAprofiler is freely available at http://mtprofiler.yonsei.ac.kr...
  34. ncbi request reprint Allele frequencies and haplotypes of six new Y-specific STR loci in Koreans
    Hwan Young Lee
    Department of Forensic Medicine, College of Medicine, Yonsei University, Seoul 120 752, South Korea
    Forensic Sci Int 136:89-91. 2003
    ..Six Y-specific STR loci, DYS434, DYS435, DYS436, DYS437, DYS438, and DYS439 were analyzed in 300 unrelated Korean males using single multiplex PCR system...