Jaewon Ko

Summary

Affiliation: Yonsei University
Country: Korea

Publications

  1. doi request reprint The leucine-rich repeat superfamily of synaptic adhesion molecules: LRRTMs and Slitrks
    Jaewon Ko
    Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul 120 749, Korea
    Mol Cells 34:335-40. 2012
  2. pmc Neuroligins/LRRTMs prevent activity- and Ca2+/calmodulin-dependent synapse elimination in cultured neurons
    Jaewon Ko
    Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Cell Biol 194:323-34. 2011
  3. pmc The neurexin ligands, neuroligins and leucine-rich repeat transmembrane proteins, perform convergent and divergent synaptic functions in vivo
    Gilberto J Soler-Llavina
    Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Department of Molecular and Cellular Physiology, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305 5453, USA
    Proc Natl Acad Sci U S A 108:16502-9. 2011
  4. pmc LRRTM2 functions as a neurexin ligand in promoting excitatory synapse formation
    Jaewon Ko
    Department of Molecular and Cellular Physiology, Stanford University School of Medicine, 1050 Arastradero Road, Palo Alto, CA 94304 5543, USA
    Neuron 64:791-8. 2009
  5. pmc Neurexins physically and functionally interact with GABA(A) receptors
    Chen Zhang
    Department of Molecular and Cellular Physiology, Stanford University, 1050 Arastradero Road, Palo Alto, CA 94304 5543, USA
    Neuron 66:403-16. 2010
  6. pmc An autism-associated point mutation in the neuroligin cytoplasmic tail selectively impairs AMPA receptor-mediated synaptic transmission in hippocampus
    Mark R Etherton
    Department of Molecular and Cellular Physiology, Stanford University, Palo Alto, CA, USA
    EMBO J 30:2908-19. 2011
  7. pmc MDGAs interact selectively with neuroligin-2 but not other neuroligins to regulate inhibitory synapse development
    Kangduk Lee
    Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul 120 749, Korea
    Proc Natl Acad Sci U S A 110:336-41. 2013
  8. pmc High affinity neurexin binding to cell adhesion G-protein-coupled receptor CIRL1/latrophilin-1 produces an intercellular adhesion complex
    Antony A Boucard
    Department of Molecular and Cellular Physiology and Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California 94305, USA
    J Biol Chem 287:9399-413. 2012
  9. pmc Neuroligin-1 performs neurexin-dependent and neurexin-independent functions in synapse validation
    Jaewon Ko
    Department of Molecular and Cellular Physiology, Howard Hughes Medical Institute, Stanford University School of Medicine, Palo Alto, CA 94304 5543, USA
    EMBO J 28:3244-55. 2009

Collaborators

  • Thomas C Sudhof
  • Antony A Boucard
  • H Shawn Je
  • Manu Sharma
  • Hyun Kim
  • Kangduk Lee
  • Gilberto J Soler-Llavina
  • Mark R Etherton
  • Chen Zhang
  • Yoonji Kim
  • Sung Jin Lee
  • Dongmin Lee
  • Yuan Qiang
  • Hyun Woo Lee
  • Robert C Malenka
  • Marc V Fuccillo
  • Katsuhiko Tabuchi
  • ALFRED J ROBISON
  • Demet Arac
  • Deniz Atasoy
  • Axel T Brunger
  • Marc V Fucillo
  • Xiaofei Yang

Detail Information

Publications9

  1. doi request reprint The leucine-rich repeat superfamily of synaptic adhesion molecules: LRRTMs and Slitrks
    Jaewon Ko
    Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul 120 749, Korea
    Mol Cells 34:335-40. 2012
    ..Their basic biochemical properties, proposed functions at synapses, physiological significances, and open questions are summarized...
  2. pmc Neuroligins/LRRTMs prevent activity- and Ca2+/calmodulin-dependent synapse elimination in cultured neurons
    Jaewon Ko
    Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Cell Biol 194:323-34. 2011
    ....
  3. pmc The neurexin ligands, neuroligins and leucine-rich repeat transmembrane proteins, perform convergent and divergent synaptic functions in vivo
    Gilberto J Soler-Llavina
    Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Department of Molecular and Cellular Physiology, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305 5453, USA
    Proc Natl Acad Sci U S A 108:16502-9. 2011
    ..These results show that neurexin ligands in vivo form a dynamic synaptic cell adhesion network, with compensation between NLs and LRRTMs during early synapse development and functional divergence upon synapse maturation...
  4. pmc LRRTM2 functions as a neurexin ligand in promoting excitatory synapse formation
    Jaewon Ko
    Department of Molecular and Cellular Physiology, Stanford University School of Medicine, 1050 Arastradero Road, Palo Alto, CA 94304 5543, USA
    Neuron 64:791-8. 2009
    ..Thus, our data suggest that two unrelated postsynaptic cell-adhesion molecules, LRRTMs and neuroligins, unexpectedly bind to neurexins as the same presynaptic receptor, but that their binding is subject to distinct regulatory mechanisms...
  5. pmc Neurexins physically and functionally interact with GABA(A) receptors
    Chen Zhang
    Department of Molecular and Cellular Physiology, Stanford University, 1050 Arastradero Road, Palo Alto, CA 94304 5543, USA
    Neuron 66:403-16. 2010
    ..Our findings suggest that besides their other well-documented interactions, presynaptic neurexins directly act on postsynaptic GABA(A) receptors, which may contribute to regulate the excitatory/inhibitory balance in brain...
  6. pmc An autism-associated point mutation in the neuroligin cytoplasmic tail selectively impairs AMPA receptor-mediated synaptic transmission in hippocampus
    Mark R Etherton
    Department of Molecular and Cellular Physiology, Stanford University, Palo Alto, CA, USA
    EMBO J 30:2908-19. 2011
    ..Our results suggest that the cytoplasmic tail of neuroligin-3 has a central role in synaptic transmission by modulating the recruitment of AMPA receptors to postsynaptic sites at excitatory synapses...
  7. pmc MDGAs interact selectively with neuroligin-2 but not other neuroligins to regulate inhibitory synapse development
    Kangduk Lee
    Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul 120 749, Korea
    Proc Natl Acad Sci U S A 110:336-41. 2013
    ..Taken together, our data suggest that MDGAs inhibit the activity of neuroligin-2 in controlling the function of inhibitory synapses and that MDGAs do so by binding to neuroligin-2...
  8. pmc High affinity neurexin binding to cell adhesion G-protein-coupled receptor CIRL1/latrophilin-1 produces an intercellular adhesion complex
    Antony A Boucard
    Department of Molecular and Cellular Physiology and Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California 94305, USA
    J Biol Chem 287:9399-413. 2012
    ....
  9. pmc Neuroligin-1 performs neurexin-dependent and neurexin-independent functions in synapse validation
    Jaewon Ko
    Department of Molecular and Cellular Physiology, Howard Hughes Medical Institute, Stanford University School of Medicine, Palo Alto, CA 94304 5543, USA
    EMBO J 28:3244-55. 2009
    ..Thus, neuroligin-1 performs diverse synaptic functions by mechanisms that include as essential components of alpha-neurexin binding and neuroligin dimerization, but extend beyond these activities...