Genomes and Genes


Hyunki Kim


Affiliation: Yonsei University College of Medicine
Country: Korea


  1. Kim H, Kim E, Han K, Kim H, Kwak J. Pathologic spectrum of lymphocytic infiltration and recurrence of papillary thyroid carcinoma. Yonsei Med J. 2014;55:879-85 pubmed publisher
    ..There was no relationship between PTC prognosis and different grades of LT. Pathologic tumor size and taller than wide shape on ultrasound were independent predictors of PTC recurrence regardless of concurrent LT. ..
  2. Jung D, Bae Y, Yoon S, Lee Y, Kim H, Noh S, et al. Poorly Differentiated Carcinoma Component in Submucosal Layer Should be Considered as an Additional Criterion for Curative Endoscopic Resection of Early Gastric Cancer. Ann Surg Oncol. 2015;22 Suppl 3:S772-7 pubmed publisher
    ..The PDC component in the SM layer of differentiated EGC was an independent risk factor of LNM, which might constitute a supplementary criterion in the expanded indications for endoscopic resection in differentiated EGC. ..
  3. Park J, Kim E, Kim Y, Kim J, Bae Y, Lee Y, et al. Epstein-Barr virus positivity, not mismatch repair-deficiency, is a favorable risk factor for lymph node metastasis in submucosa-invasive early gastric cancer. Gastric Cancer. 2016;19:1041-1051 pubmed publisher
    ..Thus, we suggest that examination with EBER ISH could be considered for endoscopic resected specimens, especially in cases of SM EGC showing no LVI and clear resection margins. ..
  4. Park J, Kim H, Bae Y, Cheong J, Rha S, Noh S, et al. Prognostic significance and frequency of EGFR expression and amplification in surgically resected advanced gastric cancer. Jpn J Clin Oncol. 2016;46:507-16 pubmed publisher
    ..3%) did not show different survival outcome with others (P = 0.359). Epidermal growth factor receptor positivity was an independent favorable prognostic factor for gastric cancer, especially in Stage III disease. ..
  5. Kim Y, Park J, Park C, Kim J, Lee S, Lee Y, et al. Histologic purity of signet ring cell carcinoma is a favorable risk factor for lymph node metastasis in poorly cohesive, submucosa-invasive early gastric carcinoma. Gastric Cancer. 2017;20:583-590 pubmed publisher
    ..On the basis of this finding, we propose that the presence of a minor tubular component or the purity of the poorly cohesive/SRC carcinoma component should be reported in daily pathologic practice. ..
  6. Woo H, Bae Y, Kim J, Lee S, Lee Y, Cheong J, et al. Distinct expression profile of key molecules in crawling-type early gastric carcinoma. Gastric Cancer. 2017;20:612-619 pubmed publisher
    ..These results support the classification of CRA as a distinct subgroup of gastric adenocarcinoma. ..
  7. Pak K, Jo A, Choi H, Choi Y, Kim H, Cheong J. The different role of intratumoral and peritumoral lymphangiogenesis in gastric cancer progression and prognosis. BMC Cancer. 2015;15:498 pubmed publisher
    ..05). We conclude that P-LVD had an important role in lymph node metastasis, while I-LVD was more associated with depth of tumor invasion. However, both LVDs contributed to gastric cancer progression and prognosis. ..
  8. Pak K, Kim D, Kim H, Lee D, Cheong J. Differences in TGF-β1 signaling and clinicopathologic characteristics of histologic subtypes of gastric cancer. BMC Cancer. 2016;16:60 pubmed publisher
    ..Although TGF-β1 signaling in gastric cancer cells appears hyper-activated in i-GC compared to d-GC, the Smad-dependent pathway seems down-regulated while the Smad-independent pathway seems up-regulated in both histologic subtypes. ..