Dong Hyun Kim

Summary

Affiliation: Yonsei University
Country: Korea

Publications

  1. pmc Fast 3D (1)H MRSI of the corticospinal tract in pediatric brain
    Dong Hyun Kim
    School of Electrical and Electronic Engineering, Yonsei University, Seoul, Korea
    J Magn Reson Imaging 29:1-6. 2009
  2. pmc Gradient moment compensated magnetic resonance spectroscopic imaging
    Dong Hyun Kim
    School of Electrical and Electronic Engineering, Yonsei University, Seoul, Korea
    Magn Reson Med 61:457-61. 2009
  3. ncbi request reprint Diffusion-weighted imaging of the fetal brain in vivo
    Dong Hyun Kim
    School of Electrical and Electronic Engineering, Yonsei University, Seoul, Korea
    Magn Reson Med 59:216-20. 2008
  4. doi request reprint In vivo (1)H magnetic resonance spectroscopy of amniotic fluid and fetal lung at 1.5 T: technical challenges
    Dong Hyun Kim
    School of Electrical and Electronic Engineering and Department of Radiology, Yonsei University, Seoul, Korea
    J Magn Reson Imaging 28:1033-8. 2008
  5. pmc Fast multivoxel two-dimensional spectroscopic imaging at 3 T
    Dong Hyun Kim
    Department of Radiology, University of California San Francisco, San Francisco, CA, USA
    Magn Reson Imaging 25:1155-61. 2007
  6. ncbi request reprint In vitro and in vivo antiallergic effect of the fructus of Evodia rutaecarpa and its constituents
    Yong Wook Shin
    College of Pharmacy, Kyung Hee University, Seoul, Korea
    Biol Pharm Bull 30:197-9. 2007
  7. ncbi request reprint Inhibitory effect of schizandrin on passive cutaneous anaphylaxis reaction and scratching behaviors in mice
    Bomi Lee
    College of Pharmacy, Kyung Hee University, Seoul, Korea
    Biol Pharm Bull 30:1153-6. 2007
  8. ncbi request reprint In vitro and in vivo antiallergic effects of Glycyrrhiza glabra and its components
    Yong Wook Shin
    College of Pharmacy, Kyung Hee University, Dongdaemun ku, Seoul, Korea
    Planta Med 73:257-61. 2007
  9. ncbi request reprint Metabolism of 20(S)- and 20(R)-ginsenoside Rg3 by human intestinal bacteria and its relation to in vitro biological activities
    Eun Ah Bae
    Department of Food and Nutrition, Kyung Hee University, Seoul, Korea
    Biol Pharm Bull 25:58-63. 2002
  10. ncbi request reprint Beta-glucuronidase inhibitor tectorigenin isolated from the flower of Pueraria thunbergiana protects carbon tetrachloride-induced liver injury
    Hae Woong Lee
    College of Pharmacy, Kyung Hee University, Seoul, Korea
    Liver Int 23:221-6. 2003

Detail Information

Publications114 found, 100 shown here

  1. pmc Fast 3D (1)H MRSI of the corticospinal tract in pediatric brain
    Dong Hyun Kim
    School of Electrical and Electronic Engineering, Yonsei University, Seoul, Korea
    J Magn Reson Imaging 29:1-6. 2009
    ....
  2. pmc Gradient moment compensated magnetic resonance spectroscopic imaging
    Dong Hyun Kim
    School of Electrical and Electronic Engineering, Yonsei University, Seoul, Korea
    Magn Reson Med 61:457-61. 2009
    ..Results indicate that in the presence of motion, ghosting effects are reduced while metabolite signal increases of approximately 10% can be achieved...
  3. ncbi request reprint Diffusion-weighted imaging of the fetal brain in vivo
    Dong Hyun Kim
    School of Electrical and Electronic Engineering, Yonsei University, Seoul, Korea
    Magn Reson Med 59:216-20. 2008
    ..The method can be readily implemented in a clinical setting and is especially useful when scanning mothers who cannot tolerate lengthier breath-holds...
  4. doi request reprint In vivo (1)H magnetic resonance spectroscopy of amniotic fluid and fetal lung at 1.5 T: technical challenges
    Dong Hyun Kim
    School of Electrical and Electronic Engineering and Department of Radiology, Yonsei University, Seoul, Korea
    J Magn Reson Imaging 28:1033-8. 2008
    ..To identify the major technical challenges associated with in utero single-voxel proton spectroscopy of amniotic fluid and fetal lung and to evaluate the feasibility of performing in utero fetal spectroscopy for fetal lung maturity testing...
  5. pmc Fast multivoxel two-dimensional spectroscopic imaging at 3 T
    Dong Hyun Kim
    Department of Radiology, University of California San Francisco, San Francisco, CA, USA
    Magn Reson Imaging 25:1155-61. 2007
    ..All protocols were designed to acquire data within a 17-min scan time at a field strength of 3 T...
  6. ncbi request reprint In vitro and in vivo antiallergic effect of the fructus of Evodia rutaecarpa and its constituents
    Yong Wook Shin
    College of Pharmacy, Kyung Hee University, Seoul, Korea
    Biol Pharm Bull 30:197-9. 2007
    ..These findings suggest that ER and its constituents, evodiamine and rutaecarpine, may be effective for IgE-induced allergic diseases such as atopic dermatitis and rhinitis...
  7. ncbi request reprint Inhibitory effect of schizandrin on passive cutaneous anaphylaxis reaction and scratching behaviors in mice
    Bomi Lee
    College of Pharmacy, Kyung Hee University, Seoul, Korea
    Biol Pharm Bull 30:1153-6. 2007
    ..Schizandrin reduced the protein expressions of TNF-alpha and IL-4 in IgE-induced RBL 2H3 cells. These findings suggest that schizandrin can improve IgE-induced anaphylaxis and scratching behaviors...
  8. ncbi request reprint In vitro and in vivo antiallergic effects of Glycyrrhiza glabra and its components
    Yong Wook Shin
    College of Pharmacy, Kyung Hee University, Dongdaemun ku, Seoul, Korea
    Planta Med 73:257-61. 2007
    ..This suggests that the antiallergic effects of licorice are mainly due to glycyrrhizin, 18beta-glycyrrhetinic acid, and liquiritigenin, which can relieve IgE-induced allergic diseases such as dermatitis and asthma...
  9. ncbi request reprint Metabolism of 20(S)- and 20(R)-ginsenoside Rg3 by human intestinal bacteria and its relation to in vitro biological activities
    Eun Ah Bae
    Department of Food and Nutrition, Kyung Hee University, Seoul, Korea
    Biol Pharm Bull 25:58-63. 2002
    ....
  10. ncbi request reprint Beta-glucuronidase inhibitor tectorigenin isolated from the flower of Pueraria thunbergiana protects carbon tetrachloride-induced liver injury
    Hae Woong Lee
    College of Pharmacy, Kyung Hee University, Seoul, Korea
    Liver Int 23:221-6. 2003
    ..To understand the relationship between the fluctuation in serum beta-glucuronidase and hepatotoxicity, an inhibitor of beta-glucuronidase was isolated from the flowers of Pueraria thunbergiana and its hepatoprotective activity was measured...
  11. ncbi request reprint Antiallergic activity of ginseng and its ginsenosides
    Min Kyung Choo
    College of Pharmacy, Kyung Hee University, Seoul, Korea
    Planta Med 69:518-22. 2003
    ..7:mouse monocyte leukemiaRBL-2H3: rat basophil leukemia SD:Sprague-Dawley..
  12. ncbi request reprint Metabolic activities of ginsenoside Rb1, baicalin, glycyrrhizin and geniposide to their bioactive compounds by human intestinal microflora
    Jang Shim Yim
    College of Oriental Medicine, Kyung Hee University, Dongdaemun ku, Seoul, Korea
    Biol Pharm Bull 27:1580-3. 2004
    ..These results suggest that the human intestinal microflora enzymes that convert herbal components to their bioactive compounds may be used as selection markers of responders to traditional medicines...
  13. ncbi request reprint Metabolism of ginsenoside R(c) by human intestinal bacteria and its related antiallergic activity
    Eun Ah Bae
    College of Pharmacy, Kyung Hee University, Seoul, Korea
    Biol Pharm Bull 25:743-7. 2002
    ..W. 940[+Na]). Among ginsenoside R(c) and its metabolites, compound K exhibited the most potent antiallergic activity on the IgE-induced RBL cell line as well as potent cytotoxic activity against tumor cell lines...
  14. doi request reprint Mangiferin inhibits passive cutaneous anaphylaxis reaction and pruritus in mice
    Bomi Lee
    Department of Life and Nanopharmaceutical Sciences, Kyung Hee University Dongdaemun ku, Seoul, Korea
    Planta Med 75:1415-7. 2009
    ..These findings suggest that mangiferin may improve PCA reaction and pruritus...
  15. ncbi request reprint Magnolol and honokiol: inhibitors against mouse passive cutaneous anaphylaxis reaction and scratching behaviors
    Sang Jun Han
    Department of Life and Nanopharmaceutical Sciences and Department of Pharmaceutical Science, Kyung Hee University, 1 Hoegi, Dongdaemun ku, Seoul, Korea
    Biol Pharm Bull 30:2201-3. 2007
    ..Based on these findings, magnolol and honokiol may improve IgE-induced allergic diseases...
  16. ncbi request reprint Hinokiresinol inhibits IgE-induced mouse passive cutaneous anaphylaxis reaction
    Eun Ah Bae
    College of Pharmacy, Kyung Hee University, Seoul, Korea
    Planta Med 72:1328-30. 2006
    ..Orally and intraperitoneally administered hinokiresinol potently inhibited the passive anaphylaxis reaction in mice induced by IgE...
  17. ncbi request reprint Antiallergic activity of hesperidin is activated by intestinal microflora
    Neung Kee Lee
    School of Oriental Medicine, Kyung Hee University, Seoul, Korea
    Pharmacology 71:174-80. 2004
    ..7 cells. Hesperetin weakly inhibits cyclooxygenase 2 enzyme activities. These results suggest that hesperidin may be a prodrug, which is metabolized to hesperetin by intestinal bacteria...
  18. ncbi request reprint Inhibitory effect of Chunghyuldan in prostaglandin E2 and nitric oxide biosynthesis of lipopolysaccharide-induced RAW 264.7 cells
    Ki Ho Cho
    College of Oriental Medicine, Kyung Hee University, Seoul, Korea
    Biol Pharm Bull 27:1810-3. 2004
    ..MCHD-inhibitory activity against NO and PGE2 productions in LPS-induced RAW264.7 cells was more potent than those of CHD. These results suggest that CHD may show potent anti-inflammatory activity in vivo and can improve brain ischemia...
  19. doi request reprint Anti-pruritic effect of baicalin and its metabolites, baicalein and oroxylin A, in mice
    Hien Trung Trinh
    Department of Pharmaceutical Science and Department of Life and Pharmaceutical Sciences, Kyung Hee University, 1 Hoegi, Dongdaemun ku, Seoul, Korea
    Acta Pharmacol Sin 31:718-24. 2010
    ..To explore whether intestinal microflora plays a role in anti-pruritic activity of baicalin, a main constituent of the rhizome of Scutellaria baicalensis (SB)...
  20. doi request reprint Arctigenin isolated from the seeds of Arctium lappa ameliorates memory deficits in mice
    In Ah Lee
    Department of Life and Nanopharmaceutical Sciences and Department of Pharmacy, Kyung Hee University, Seoul, Korea
    Planta Med 77:1525-7. 2011
    ..o.). Arctigenin also significantly reversed scopolamine-induced memory deficits in the Y-maze and Morris water maze tests. On the basis of these findings, arctigenin may ameliorate memory deficits by inhibiting AChE...
  21. ncbi request reprint The effects of ginsenoside Re and its metabolite, ginsenoside Rh1, on 12-O-tetradecanoylphorbol 13-acetate- and oxazolone-induced mouse dermatitis models
    Yong Wook Shin
    College of Pharmacy, Kyung Hee University, Seoul, Korea
    Planta Med 72:376-8. 2006
    ..Ginsenoside Rh1 potently suppressed the TPA- and oxazolone-induced swellings as well as mRNA expression levels of cyclooxygenase-2, IL-1beta and TNF-alpha, although these were only weakly inhibited by ginsenoside Re...
  22. ncbi request reprint Antithrombotic and antiallergic activities of rhaponticin from Rhei Rhizoma are activated by human intestinal bacteria
    Eun Kyung Park
    College of Pharmacy, Kyung Hee University, Dongdaemun ku, Seoul, Korea
    Arch Pharm Res 25:528-33. 2002
    ..These results suggest that rhaponticin, in the rhizome of Rhei Rhizoma, is a prodrug that has extensive antiallergic and antithrombotic properties...
  23. doi request reprint The effects of daidzin and its aglycon, daidzein, on the scopolamine-induced memory impairment in male mice
    Dong Hyun Kim
    Department of Life and Nanopharmaceutical Sciences, Kyung Hee University, Seoul, Korea
    Arch Pharm Res 33:1685-90. 2010
    ..These results indicate that daidzin or daidzein may be useful in cognitive impairment induced by cholinergic dysfunction, and this beneficial effect is mediated, in part, via estrogen receptor...
  24. ncbi request reprint Ginsenoside Rh1 possesses antiallergic and anti-inflammatory activities
    Eun Kyung Park
    College of Pharmacy, Kyung Hee University, Seoul, Korea
    Int Arch Allergy Immunol 133:113-20. 2004
    ..A. Meyer, Araliaceae) has been reported to possess various biological activities, including anti-inflammatory and antitumor actions. In this study, we investigated the antiallergic activity of ginsenosides isolated from ginseng...
  25. ncbi request reprint Passive cutaneous anaphylaxis-inhibitory activity of flavanones from Citrus unshiu and Poncirus trifoliata
    Sung Hwan Park
    Department of Food and Nutrition, College of Pharmacy, Kyung Hee University, Seoul, Korea
    Planta Med 71:24-7. 2005
    ..This suggests that the flavanone glycosides can be activated by intestinal bacteria, and may be effective toward IgE-induced atopic allergies...
  26. ncbi request reprint Antipruritic effect of ginsenoside rb1 and compound k in scratching behavior mouse models
    Yong Wook Shin
    College of Pharmacy, Kyung Hee University, Seoul, Korea
    J Pharmacol Sci 99:83-8. 2005
    ..8, 6.8, and 4.1 mg/kg, respectively. These results suggest that ginsenoside Rb1 and its metabolite compound K by intestinal microflora can improve scratching behaviors...
  27. ncbi request reprint Hepatoprotective effect of tectoridin and tectorigenin on tert-butyl hyperoxide-induced liver injury
    Hae Ung Lee
    College of Pharmacy, Kyung Hee University, Seoul, Korea
    J Pharmacol Sci 97:541-4. 2005
    ..This protection may have originated from the inhibition of apoptosis. Tectorigenin may be hepatoprotective and tectoridin should be a prodrug that is transformed to tectorigenin...
  28. doi request reprint Anti-scratching behavioral effects of N-stearoyl-phytosphingosine and 4-hydroxysphinganine in mice
    Kwon Ryeol Ryu
    Department of Life and Nanopharmaceutical Sciences, Kyung Hee University, 1, Hoegi, Dongdaemun ku, Seoul, 130 701, Korea
    Lipids 45:613-8. 2010
    ..Based on these results, SPS and PS may improve scratching behavioral reactions in skin by regulating the action of histamine and the activation of the transcription factors NF-kappaB and c-jun...
  29. ncbi request reprint Protective effects of kakkalide from Flos puerariae on ethanol-induced lethality and hepatic injury are dependent on its biotransformation by human intestinal microflora
    Yeo Ok Han
    Department of Food Science, Kyung Hee University, Seoul, Korea
    J Pharmacol Sci 93:331-6. 2003
    ..The results indicate that kakkalide is a prodrug of irisolidone in protecting against ethanol-induced lethality and hepatic injury...
  30. ncbi request reprint Simple analytic variable density spiral design
    Dong Hyun Kim
    Radiological Sciences Laboratory, Department of Radiology, Stanford University, Stanford, California 94305 5488, USA
    Magn Reson Med 50:214-9. 2003
    ..The method enables real-time waveform prescription on scanners with limited computational power. Both slew rate-limited and amplitude-limited regimes are incorporated in the design process...
  31. ncbi request reprint Inhibitory effects of Korean red ginseng and its genuine constituents ginsenosides Rg3, Rf, and Rh2 in mouse passive cutaneous anaphylaxis reaction and contact dermatitis models
    Eun Ah Bae
    Department of Food and Nutrition, Kyung Hee University, Hoegi, Dongdaemun ku, Seoul, Korea
    Biol Pharm Bull 29:1862-7. 2006
    ..7 cells. Based on these findings, KRGS and its ginsenosides are suggested to improve atopic and contact dermatitis by regulating expression of cytokines...
  32. ncbi request reprint Ginsenoside Rh2 reduces ischemic brain injury in rats
    Eun Kyung Park
    College of Pharmacy, Kyung Hee University, Hoegi, Dongdaemun ku, Seoul, Korea
    Biol Pharm Bull 27:433-6. 2004
    ..7 cells, but showed no in vitro antioxidant activity. These results suggest that AG and ginsenoside Rh2 can improve ischemic brain injury...
  33. ncbi request reprint Antithrombotic and antiallergic activities of daidzein, a metabolite of puerarin and daidzin produced by human intestinal microflora
    Min Kyung Choo
    College of Pharmacy, Kyung Hee University, Seoul, Korea
    Biol Pharm Bull 25:1328-32. 2002
    ..Therefore we believe that puerarin and daidzin in the rhizome of Pueraria lobata are prodrugs, which have antiallergic and antithrombotic activities, produced by intestinal microflora...
  34. ncbi request reprint Spiral readout gradients for the reduction of motion artifacts in chemical shift imaging
    Dong Hyun Kim
    Radiological Sciences Laboratory, Department of Radiology, Stanford University, Stanford, California, USA
    Magn Reson Med 51:458-63. 2004
    ..Both phantom and in vivo spectra reconstructed using the new motion artifact reduction algorithm showed significant signal-to-noise ratio (SNR) improvements as compared to uncorrected data...
  35. ncbi request reprint Fecal metabolic activities of herbal components to bioactive compounds
    Dai Sik Lee
    College of Oriental Medicine, Kyung Hee University, Seoul, Korea
    Arch Pharm Res 25:165-9. 2002
    ....
  36. ncbi request reprint Ginsenosides Rg3 and Rh2 inhibit the activation of AP-1 and protein kinase A pathway in lipopolysaccharide/interferon-gamma-stimulated BV-2 microglial cells
    Eun Ah Bae
    College of Pharmacy, Kyung Hee University, Seoul, Korea
    Planta Med 72:627-33. 2006
    ....
  37. pmc GABA(A) receptor blockade enhances memory consolidation by increasing hippocampal BDNF levels
    Dong Hyun Kim
    Department of Life and Nanopharmaceutical Sciences, Kyung Hee University, Dongdaemoon gu, Seoul, Republic of Korea
    Neuropsychopharmacology 37:422-33. 2012
    ..These findings suggest that the increase in the level of mBDNF and its function during a restricted time window after training are required for the enhancement of memory consolidation by GABA(A) receptor blockade...
  38. doi request reprint Anti-scratching behavioral effect of Lactobacillus plantarum PM008 isolated from kimchi in mice
    Se Eun Jang
    Department of Food and Nutrition, Kyung Hee University, Dongdaemun ku, Seoul, Korea
    Immunopharmacol Immunotoxicol 33:539-44. 2011
    ..This inhibitory effect continued, although reduced, at 7 days after stopping the oral administration of PM008 attached in the intestine. Based on these findings, L. plantarum PM008 may improve pruritus by inhibiting IL-4 expression...
  39. doi request reprint Evaluation of antipruritic effects of red ginseng and its ingredients in mice
    Hien Trung Trinh
    Department of Life and Nanopharmaceutical Sciences, Kyung Hee University, 1 Hoegi, Dongdaemun ku, Seoul, Korea
    Planta Med 74:210-4. 2008
    ..These results suggest that red ginseng and its ingredients, ginsenosides Rg3 and Rh2, may inhibit scratching behavior by inhibiting IL-4 and TNF-alpha expression, promoting membrane stability, and inhibiting Ca (++) influx...
  40. pmc Comparative analysis of the gut microbiota in people with different levels of ginsenoside Rb1 degradation to compound K
    Kyung Ah Kim
    Department of Life and Nanopharmaceutical Sciences and Department of Pharmacy, Kyung Hee University, Seoul, Korea
    PLoS ONE 8:e62409. 2013
    ..Intestinal bacterial metabolism of ginseng, particularly ginsenoside Rb1, may be dependent on the composition of gut microbiota, such as Ruminococcus spp., Bacteroides spp. and Bifidobacterium spp...
  41. doi request reprint Inhibitory effects of curcuminoids on passive cutaneous anaphylaxis reaction and scratching behavior in mice
    Hien Trung Trinh
    Department of Life and Nanopharmaceutical Sciences and Department of Pharmaceutical Science, Kyung Hee University, Seoul, 130 701, Korea
    Arch Pharm Res 32:1783-7. 2009
    ..These findings suggest that curcuminoids, particularly curcumin, can improve the symptoms of allergic diseases, such as anaphylaxis and itching...
  42. doi request reprint Inhibitory effect of Lactobacillus plantarum K-1 on passive cutaneous anaphylaxis reaction and scratching behavior in mice
    Se Eun Jang
    Department of Food and Nutrition, Kyung Hee University, Seoul, 130 701, Korea
    Arch Pharm Res 34:2117-23. 2011
    ....
  43. ncbi request reprint Metabolism of kalopanaxsaponin K by human intestinal bacteria and antirheumatoid arthritis activity of their metabolites
    Dong Hyun Kim
    College of Pharmacy, Kyung Hee University, Seoul, Korea
    Biol Pharm Bull 25:68-71. 2002
    ..However, Lactobacillus sp. and Streptococcus sp. transformed KPK to KPI, KPA, and hederagenin only via KPJ. The metabolite KPA of KPK showed potent antirheumatoid arthritis activity...
  44. doi request reprint Lactobacillus casei HY7213 ameliorates cyclophosphamide-induced immunosuppression in mice by activating NK, cytotoxic T cells and macrophages
    Se Eun Jang
    Department of Food and Nutrition, Kyung Hee University, Seoul, Korea
    Immunopharmacol Immunotoxicol 35:396-402. 2013
    ..Based on these findings, we suggest that HY7213 may promote the recovery of immunosuppression caused by chemotherapeutic agents, such as CP, by activating NK cells, cytotoxic T cells and macrophages...
  45. ncbi request reprint Self-navigated interleaved spiral (SNAILS): application to high-resolution diffusion tensor imaging
    Chunlei Liu
    Lucas MRS I Center, Department of Radiology, Stanford University, California 94305 5488, USA
    Magn Reson Med 52:1388-96. 2004
    ..To our knowledge, this was also the first time in vivo 512 x 512 DTI results were reported...
  46. ncbi request reprint Hepatoprotective effects of irisolidone on tert-butyl hyperoxide-induced liver injury
    Hae Ung Lee
    Kyung Hee University, College of Pharmacy, Hoegi, Dongdaemun ku, Seoul, Korea
    Biol Pharm Bull 28:531-3. 2005
    ..When irisolidone was intraperitoneally administered to mice, it exhibited potent hepatoprotective activity. Based on these findings, irisolidone can be hepatoprotective and kakkalide may be a prodrug transformed to irisolidone...
  47. ncbi request reprint Inhibitory effect of ginsenoside Rb1 and compound K on NO and prostaglandin E2 biosyntheses of RAW264.7 cells induced by lipopolysaccharide
    Eun Kyung Park
    College of Pharmacy, Kyung Hee University, Seoul, Korea
    Biol Pharm Bull 28:652-6. 2005
    ..These findings suggest that ginsenoside Rb1 can be transformed to compound K by intestinal bacteria, and compound K may be effective against inflammation...
  48. ncbi request reprint Intestinal bacteria activate estrogenic effect of main constituents puerarin and daidzin of Pueraria thunbergiana
    Eun Kyung Park
    College of Pharmacy, Kyung Hee University, Seoul, Korea
    Biol Pharm Bull 29:2432-5. 2006
    ..These findings suggest that intestinal bacteria, which can hydrolyze puerarin and/or daidzin, may activate a potent estrogenic activity of PT...
  49. ncbi request reprint Anti-allergic effects of fermented Ixeris sonchifolia and its constituent in mice
    Hien Trung Trinh
    Kyung Hee Universitym, Seoul, Korea
    J Microbiol Biotechnol 20:217-23. 2010
    ..These findings suggest that antiallergic effect of IS can be increased by LAB fermentation and fermented IS might improve allergic reactions, such as pruritus, anaphylaxis, and inflammation...
  50. pmc High fat diet-induced gut microbiota exacerbates inflammation and obesity in mice via the TLR4 signaling pathway
    Kyung Ah Kim
    Department of Life and Nanopharmaceutical Sciences, College of Pharmacy, Kyung Hee University, Seoul, Korea
    PLoS ONE 7:e47713. 2012
    ..Here, we investigated the effect of endotoxin-induced inflammation via TLR4 signaling pathway at both systemic and intestinal levels in response to a high-fat diet...
  51. ncbi request reprint Metabolism and excretion of 5-ethyl-2-{5-[4-(2-hydroxyethyl)piperazine-1-sulfonyl]-2-propoxyphenyl}-7-propyl-3,5-dihydropyrrolo[3,2-d]-pyrimidin-4-one (SK3530) in rats
    Jaeick Lee
    Bioanalysis and Biotransformation Research Center, Korea Institute of Science and Technology, P O BOX 131, Chungryang, Seoul, Korea
    Rapid Commun Mass Spectrom 21:1139-49. 2007
    ..An additional metabolite due to aromatic hydroxylation was also identified in hepatic microsomes...
  52. ncbi request reprint Single balloon kyphoplasty using far-lateral extrapedicular approach: technical note and preliminary results
    Kyeong Sik Ryu
    Department of Neurosurgery, Kang Nam St Mary s Hospital, The Catholic University of Korea, Seocho Gu, Seoul, Korea
    J Spinal Disord Tech 20:392-8. 2007
    ..The authors have performed a single-balloon kyphoplasty using far-lateral extrapedicular approach in the treatment of osteoporotic vertebral compression fractures. The authors introduce its surgical technique and early clinical results...
  53. doi request reprint Revisiting the role of nonanatomic resection of small (< or = 4 cm) and single hepatocellular carcinoma in patients with well-preserved liver function
    Chang Moo Kang
    Department of Surgery, Yonsei University College of Medicine, Seoul, Korea
    J Surg Res 160:81-9. 2010
    ..We evaluated the oncologic outcomes of nonanatomic resection performed as a primary treatment for small (<or=4 cm) and single HCC in patients with well-preserved liver function (Child-Pugh class A)...
  54. doi request reprint 1H NMR-based metabonomic assessment of probiotic effects in a colitis mouse model
    Young Shick Hong
    Korea Basic Science Institute, Seoul, Korea
    Arch Pharm Res 33:1091-101. 2010
    ..This work highlights the possibility for alternative approach of metabonomics in feces for assessing the probiotic effect in an animal model of inflammatory bowel disease...
  55. ncbi request reprint Metabolism of ginsenoside Rb1 by human intestinal microflora and cloning of its metabolizing β-D-glucosidase from Bifidobacterium longum H-1
    Il Hoon Jung
    Department of Life and Nanopharmaceutical Sciences, College of Pharmacy, Kyung Hee University, Seoul, Korea
    Biol Pharm Bull 35:573-81. 2012
    ....
  56. pmc Tanshinone I enhances learning and memory, and ameliorates memory impairment in mice via the extracellular signal-regulated kinase signalling pathway
    Dong Hyun Kim
    Department of Life and Nanopharmaceutical Sciences, College of Pharmacy, Kyung Hee University, Seoul, Korea
    Br J Pharmacol 158:1131-42. 2009
    ..Here, we have investigated possible modes of action of tanshinone I on learning and memory, associated with ERK phosphorylation...
  57. ncbi request reprint Daio-Orengedokuto inhibits HMG-CoA reductase and pancreatic lipase
    Young Suk Kim
    College of Oriental Medicine, Kyung Hee University, Seoul, Korea
    Biol Pharm Bull 25:1442-5. 2002
    ..DOT also decreased serum triglyceride levels, but OT did not decrease it. These results suggest that the antihyperlipidemic activity of DOT may originate from the inhibition of pancreatic lipase as well as HMG-CoA reductase...
  58. doi request reprint Artemisia princeps Pamp. Essential oil and its constituents eucalyptol and α-terpineol ameliorate bacterial vaginosis and vulvovaginal candidiasis in mice by inhibiting bacterial growth and NF-κB activation
    Hien Trung Trinh
    Department of Life and Pharmaceutical Sciences, Kyung Hee University, Seoul, Korea
    Planta Med 77:1996-2002. 2011
    ..Based on these findings, APEO and its constituents, particularly α-terpineol, ameliorate bacterial vaginosis and vulvovaginal candidiasis by inhibiting the growths of vaginal pathogens and the activation of NF- κB...
  59. ncbi request reprint Effects of Schisandra lignans on P-glycoprotein-mediated drug efflux in human intestinal Caco-2
    Hye Hyun Yoo
    Bioanalysis and Biotransformation Research Center, Korea Institute of Science and Technology, Seoul, Korea
    Planta Med 73:444-50. 2007
    ..2, respectively. These results demonstrated that deoxyschizandrin effectively inhibited the P-gp-mediated efflux in Caco-2 cells, suggesting they could potentially increase the absorption of drugs that can act as a P-gp substrate...
  60. doi request reprint Conventional laparoscopic and robot-assisted spleen-preserving pancreatectomy: does da Vinci have clinical advantages?
    Chang Moo Kang
    Division of Biliopancreas, Department of Surgery, Yonsei University College of Medicine, 250 Seongsanno, Seodaemun gu, Seoul, 120 752, Korea
    Surg Endosc 25:2004-9. 2011
    ..It requires extensive surgeon experience and learned techniques. A robot surgical system was recently introduced to overcome these limitations and it may potentially provide precise and safe laparoscopic surgery...
  61. doi request reprint LC-ESI/MS/MS method for rapid screening and confirmation of 44 exogenous anabolic steroids in human urine
    Byoung Wook Jeon
    Doping Control Center, Korea Institute of Science and Technology, Seoul, Korea
    Anal Bioanal Chem 401:1353-63. 2011
    ..1-10 ng/mL and 0.2-10 ng/mL, respectively, for 44 steroids. This method was successfully applied to analysis of urine samples from suspected anabolic steroid abusers...
  62. doi request reprint Simple and accurate quantitative analysis of seven prohibited threshold substances in human urine by liquid chromatography/tandem mass spectrometry in doping control
    Kang Mi Lee
    Doping Control Center, Korea Institute of Science and Technology, PO Box 131, Cheongryang, Seoul, Korea
    Rapid Commun Mass Spectrom 25:2261-7. 2011
    ..7-106.6% of nominal values, suggesting that the developed methods can be successfully applied to routine doping analyses...
  63. doi request reprint Robotic central pancreatectomy with pancreaticogastrostomy (transgastric approach) in a solid pseudopapillary tumor of the pancreas
    Dong Hyun Kim
    Department of Surgery, Yonsei University, Wonju College of Medicine, Korea
    Hepatogastroenterology 58:1805-8. 2011
    ..More experiences need to be accumulated in order to evaluate the real value of robot pancreatic surgery...
  64. ncbi request reprint Gluco-obtusifolin and its aglycon, obtusifolin, attenuate scopolamine-induced memory impairment
    Dong Hyun Kim
    Department of Life and Nanopharmaceutical Sciences, College of Pharmacy, Kyung Hee University, Seoul, Korea
    J Pharmacol Sci 111:110-6. 2009
    ..These results suggest that gluco-obtusifolin and its aglycone may be useful for the treatment of cognitive impairment, and that its beneficial effects are mediated, in part, by the enhancement of cholinergic signaling...
  65. pmc The comparison between torsional and conventional mode phacoemulsification in moderate and hard cataracts
    Dong Hyun Kim
    Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea
    Korean J Ophthalmol 24:336-40. 2010
    ..To compare the intraoperative performances and postoperative outcomes of cataract surgery performed with longitudinal phacoemulsification and torsional phacoemulsification in moderate and hard cataracts...
  66. ncbi request reprint Fast CT-PRESS-based spiral chemical shift imaging at 3 Tesla
    Dirk Mayer
    Richard M Lucas Center for Magnetic Resonance Spectroscopy and Imaging, Department of Radiology, Stanford University, Stanford, California 94305 5488, USA
    Magn Reson Med 55:974-8. 2006
    ..Signals from N-acetyl-aspartate, total creatine, choline-containing compounds (Cho), Glu, and mI were detected in a healthy volunteer with no or only minor baseline distortions within 14 min on a 3 T MR scanner...
  67. doi request reprint Fast parallel spiral chemical shift imaging at 3T using iterative SENSE reconstruction
    Dirk Mayer
    Stanford University, Richard M Lucas Center for Magnetic Resonance Spectroscopy and Imaging, Department of Radiology, Stanford, California 94305 5488, USA
    Magn Reson Med 59:891-7. 2008
    ....
  68. ncbi request reprint Effect of chunghyuldan in chronic oxazolone-induced mouse dermatitis
    Sung Sook Wee
    College of Pharmacy, Kyung Hee University, Seoul, Korea
    Biol Pharm Bull 28:1079-82. 2005
    ..Based on these findings, CHD may improve contact dermatitis or psoriasis by the regulation of COX-2 produced by macrophage cells and IFN-gamma and IL-4 produced by Th cells...
  69. ncbi request reprint Purification and characterization of ginsenoside Ra-hydrolyzing beta-D-xylosidase from Bifidobacterium breve K-110, a human intestinal anaerobic bacterium
    Ho Young Shin
    College of Pharmacy, Kyung Hee University, Seoul, Korea
    Biol Pharm Bull 26:1170-3. 2003
    ..These findings suggest that this is the first reported purification of ginsenoside-hydrolyzing beta-D-xylosidase from an anaerobic Bifidobacterium sp...
  70. doi request reprint Artifact reduction from metallic dental materials in T1-weighted spin-echo imaging at 3.0 tesla
    Sang Young Zho
    Department of Electrical and Electronic Engineering, Yonsei University, Seoul, Korea
    J Magn Reson Imaging 37:471-8. 2013
    ..To investigate and propose a method of artifact reduction arising from metallic dental materials by applying a slice-encoding for metal artifact correction (SEMAC) technique on T1-weighted spin-echo (SE) imaging at 3 Tesla...
  71. doi request reprint Long-term results of bilateral congenital cataract treated with early cataract surgery, aphakic glasses and secondary IOL implantation
    Dong Hyun Kim
    Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea
    Acta Ophthalmol 90:231-6. 2012
    ..To evaluate the long-term visual outcome after early surgery of bilateral dense congenital cataracts, aphakic correction with glasses and secondary intraocular lens (IOL) implantation around 2 years of age...
  72. doi request reprint Antioxidant mechanism of isoflavone metabolites in hydrogen peroxide-stimulated rat primary astrocytes: critical role of hemeoxygenase-1 and NQO1 expression
    Jin Sun Park
    Department of Molecular Medicine and Tissue Injury Defense Research Center, Ewha Womans University Medical School, Seoul, Korea
    J Neurochem 119:909-19. 2011
    ..Our data collectively suggest that HO-1 and NQO1 play a critical role in antioxidant effects of isoflavone metabolites in rat brain astrocytes...
  73. pmc Kalopanaxsaponin A ameliorates experimental colitis in mice by inhibiting IRAK-1 activation in the NF-κB and MAPK pathways
    Eun Ha Joh
    Department of Life and Nanopharmaceutical Sciences, Kyung Hee University, Seoul, Korea
    Br J Pharmacol 162:1731-42. 2011
    ..Therefore, we investigated its anti-inflammatory effects in lipopolysaccharide (LPS)- or peptidoglycan-stimulated murine peritoneal macrophages and trinitrobenzene sulphonic acid (TNBS)-induced colitic mice...
  74. ncbi request reprint Validation and application of a screening method for beta2-agonists, anti-estrogenic substances and mesocarb in human urine using liquid chromatography/tandem mass spectrometry
    Min Jung Kang
    Bioanalysis and Biotransformation Center, Korea Institute of Science and Technology, 130 650, Hawolgokdong 39 1, Seoul, Korea
    Rapid Commun Mass Spectrom 21:252-64. 2007
    ..8%. The limit of detection was below 10 ng/mL except formestane (300 ng/mL) and aminoglutethimide (100 ng/mL). The validated method was applied for the analysis of excretion samples...
  75. doi request reprint Ten years of experience with resection of left-sided pancreatic ductal adenocarcinoma: evolution and initial experience to a laparoscopic approach
    Chang Moo Kang
    Department of Surgery, Yonsei University College of Medicine, 250 Seongsanno, Seodaemun gu, Seoul, 120 752, Korea
    Surg Endosc 24:1533-41. 2010
    ....
  76. ncbi request reprint Characteristics of ginsenoside Rg3-mediated brain Na+ current inhibition
    Jun Ho Lee
    Research Laboratory for the Study of Ginseng Signal Transduction, Dept of Physiology, College of Veterinary Medicine, Konkuk University, Seoul, Korea
    Mol Pharmacol 68:1114-26. 2005
    ..These results reveal that Rg(3) is a novel Na(+) channel inhibitor capable of acting on the resting and open states of Na(+) channel via interactions with the S4 voltage-sensor segment of domain II...
  77. ncbi request reprint Regularized higher-order in vivo shimming
    Dong Hyun Kim
    Radiological Sciences Laboratory, Department of Radiology, Stanford University, California, USA
    Magn Reson Med 48:715-22. 2002
    ..The fully automated shimming package is implemented on a 3 T GE Signa system and its robust performance is demonstrated in phantom and in vivo studies...
  78. doi request reprint Effects of Sun ginseng on memory enhancement and hippocampal neurogenesis
    Chang Hwan Lee
    Department of Life Nanopharmaceutical Science, Kyung Hee University, Seoul 130 701, Republic of Korea
    Phytother Res 27:1293-9. 2013
    ..These results suggest that SG has memory-enhancing activities and that these effects are mediated, in part, by the increase in the levels of pERK and pAkt and by the increases in cell proliferation and cell survival...
  79. doi request reprint Time-varying view angle tilting with spiral readout gradients
    Sang Young Zho
    Department of Electrical and Electronic Engineering, Yonsei University, Seoul, Korea
    Magn Reson Med 68:1220-7. 2012
    ..The results show that as long as the readout time is comparable to Cartesian readout, the resulting images have similar quality...
  80. doi request reprint Inhibitory effect of β-sitosterol on TNBS-induced colitis in mice
    In Ah Lee
    Department of Life and Nanopharmaceutical Sciences, Kyung Hee University, Seoul, Korea
    Planta Med 78:896-8. 2012
    ..Based on these findings, β-sitosterol may ameliorate colitis by inhibiting the NF-κB pathway...
  81. doi request reprint Effects of gut microflora on pharmacokinetics of hesperidin: a study on non-antibiotic and pseudo-germ-free rats
    Ming Ji Jin
    Doping Control Center, Korea Institute of Science and Technology, Seoul, Korea
    J Toxicol Environ Health A 73:1441-50. 2010
    ....
  82. pmc Robotic pylorus preserving pancreaticoduodenectomy with mini-laparotomy reconstruction in patient with ampullary adenoma
    Sung Hoon Choi
    Department of Surgery, Yonsei University College of Medicine, Institute of Gastroenterology, Yonsei University Health System, Seoul, Korea
    J Korean Surg Soc 81:355-9. 2011
    ..More experiences are necessary to address real role of robot in far advanced laparoscopic pancreatic surgery...
  83. doi request reprint Gypenoside LXXIV ameliorates scopolamine-induced learning deficit in mice
    Eun Ha Joh
    Department of Life and Nanopharmaceutical Sciences and Department of Pharmaceutical Science, Kyung Hee University, Dongdaemun ku, Seoul, Korea
    Planta Med 76:793-5. 2010
    ..05) and increased the scopolamine-shortened swimming time within the platform quadrant (p < 0.05). Based on these findings, G-74 might improve learning deficits...
  84. ncbi request reprint Ginsenosides: are any of them candidates for drugs acting on the central nervous system?
    Seung Yeol Nah
    Ginsentology Research Laboratory and Department of Physiology, College of Veterinary Medicine, Konkuk University, Seoul, Korea
    CNS Drug Rev 13:381-404. 2007
    ....
  85. doi request reprint MRI of the cat brain in the study of vascular permeability after intraarterial carotid injection of triolein
    Ji Hwa Ryu
    Department of Radiology, Dongrae Paik Hospital, Inje University College of Medicine, Postgraduate School, Pusan National University, Pusan, Korea
    Acta Radiol 51:563-8. 2010
    ..Triolein emulsion embolization into the carotid artery depicts reversible increased vascular permeability that can promote the effect of chemotherapy or can reduce the amount of chemotherapeutic drugs for equivalent effectiveness...
  86. doi request reprint In vivo multi-slice mapping of myelin water content using T2* decay
    DoSik Hwang
    School of Electrical and Electronic Engineering, Yonsei University, Seoul, Republic of Korea
    Neuroimage 52:198-204. 2010
    ..The corrected T(2)* signal decays were analyzed with a three-pool model to quantify MWF. Our results demonstrate the feasibility of in vivo multi-slice mapping of MWF using multi-compartmental analysis of the T(2)* signal decay...
  87. ncbi request reprint Rapid quantitative determination of L-FMAU-TP from human peripheral-blood mononuclear cells of hepatitis B virus-infected patients treated with L-FMAU by ion-pairing, reverse-phase, liquid chromatography/electrospray tandem mass spectrometry
    Jaeick Lee
    Bioanalysis and Biotransformation Research Center, Korea Institute of Science and Technology, Chungryang, Seoul, Korea
    Ther Drug Monit 28:131-7. 2006
    ..The terminal half-life of L-FMAU-TP in PBMCs after drug cessation was estimated to be 15.6 days...
  88. doi request reprint Respiratory motion compensated MR cholangiopancreatography at 3.0 Tesla
    Sang Young Zho
    Department of Electrical and Electronic Engineering, Yonsei University, Seoul, Korea
    J Magn Reson Imaging 32:726-32. 2010
    ..To reduce irregular respiratory motion-induced artifacts in free-breathing prospective navigator-triggered three-dimensional (3D) MR cholangiopancreatography (MRCP)...
  89. doi request reprint Computer-aided detection of metastatic brain tumors using magnetic resonance black-blood imaging
    Seungwook Yang
    Department of Electrical and Electronic Engineering, Yonsei University, Seoul, Korea
    Invest Radiol 48:113-9. 2013
    ....
  90. doi request reprint Cough assistance device for patients with glottis dysfunction and/or tracheostomy
    Won Ah Choi
    Department of Rehabilitation Medicine and Rehabilitation Institute of Muscular Disease, Yonsei University College of Medicine, Seoul, Korea
    J Rehabil Med 44:351-4. 2012
    ..To estimate the efficiency of a cough assistance device, the Cough Aid, in patients with weak respiratory muscles with bulbar palsy and/or tracheostomy. The Cough Aid is a device that has been developed to substitute for glottis function...
  91. doi request reprint Antiallergic effect of the root of Paeonia lactiflora and its constituents paeoniflorin and paeonol
    Bomi Lee
    Department of Life and Nanopharmaceutical Sciences and Department of Pharmaceutical Science, Kyung Hee University, 1 Hoegi, Dongdaemun ku, Seoul, Korea
    Arch Pharm Res 31:445-50. 2008
    ..These findings suggest that PL can improve IgE-induced anaphylaxis and scratching behaviors, and may be due to the effect of its constituents, paeoniflorin and paeonol...
  92. doi request reprint Anti-scratching behavioral effect of the essential oil and phytol isolated from Artemisia princeps Pamp. in mice
    Kwon Ryeol Ryu
    Department of Life and Nanopharmaceutical Sciences, College of Pharmacy, Kyung Hee University, Seoul, Korea
    Planta Med 77:22-6. 2011
    ..Based on these results, APEO and phytol may improve scratching behavior in skin by inhibiting the expression of allergic cytokines via the regulation of NF- κB and AP-1 activation...
  93. ncbi request reprint Reducing gradient imperfections for spiral magnetic resonance spectroscopic imaging
    Dong Hyun Kim
    Department of Radiology, University of California San Francisco, San Francisco, California 94143, USA
    Magn Reson Med 56:198-203. 2006
    ..The use of the measured trajectories in the reconstruction process yielded an up to 20% increase in signal amplitude recovery...
  94. doi request reprint Bifidobacterium longum HY8004 attenuates TNBS-induced colitis by inhibiting lipid peroxidation in mice
    In Ah Lee
    Departments of Life and Nanopharmaceutical Sciences and Pharmaceutical Science, College of Pharmacy, Kyung Hee University, 1, Hoegi, Dongdaemun ku, Seoul, 130 701, Korea
    Inflamm Res 59:359-68. 2010
    ....
  95. doi request reprint On the use of a spin-echo based double inversion recovery acquisition for the measurement of cortical brain thickness
    Yoonho Nam
    Yonsei University, Department of Electrical and Electronic Engineering, Seoul, Korea
    J Magn Reson Imaging 33:1218-23. 2011
    ..To determine whether a spin-echo-based sequence, which are inherently insensitive to magnetic field inhomogeneity, can be used for brain cortical thickness measurement studies...
  96. ncbi request reprint Hippocampus-dependent spatial learning and memory are impaired in growth hormone-deficient spontaneous dwarf rats
    Endan Li
    Department of Pharmacology and Medical Research Center for Bioreaction to ROS and Biomedical Science Institute, School of Medicine, Kyung Hee University, Seoul, Korea
    Endocr J 58:257-67. 2011
    ..The behavioral deficits in the SDRs may be explained by altered basal forebrain cholinergic innervation, imbalance in hippocampal glutamatergic/GABAergic synapses, and decreased neurogenesis in the hippocampus...
  97. doi request reprint Comparison study of the instrumented circumferential fusion with instrumented anterior lumbar interbody fusion as a surgical procedure for adult low-grade isthmic spondylolisthesis
    Jin Sung Kim
    Department of Neurosurgery, Wooridul Spine Hospital, Seoul, Korea
    World Neurosurg 73:565-71. 2010
    ..However, there have been no reports available that compare instrumented circumferential fusion with instrumented ALIF...
  98. ncbi request reprint In vivo prostate magnetic resonance spectroscopic imaging using two-dimensional J-resolved PRESS at 3 T
    Dong Hyun Kim
    Department of Radiology, Stanford University, CA 94305, USA
    Magn Reson Med 53:1177-82. 2005
    ..Phantom and in vivo data are presented to illustrate the multivoxel 2D J-resolved spiral chemical shift imaging sequence...
  99. doi request reprint Local in vivo shimming using adaptive passive shim positioning
    Sejung Yang
    Department of Electronics Engineering, Ewha Womans University, Seoul, 120 750, Korea
    Magn Reson Imaging 29:401-7. 2011
    ..The results show that intersubject variability exists in the optimal shim positions and that the location-sensitive method proposed can be useful for improving main field homogeneity in vivo...
  100. doi request reprint Effects of topically applied Korean red ginseng and its genuine constituents on atopic dermatitis-like skin lesions in NC/Nga mice
    Hei Sung Kim
    Department of Dermatology, Seoul St Mary s Hospital, The Catholic University of Korea, Seoul, Korea
    Int Immunopharmacol 11:280-5. 2011
    ..Our results suggest that KRGS and its ginsenosides Rh2 and Rg3 have potential as a topical agent for the treatment of AD...
  101. ncbi request reprint Purification and characterization of novel chondroitin ABC and AC lyases from Bacteroides stercoris HJ-15, a human intestinal anaerobic bacterium
    Sung Woon Hong
    College of Pharmacy, Kyung Hee University, Seoul, Korea
    Eur J Biochem 269:2934-40. 2002
    ..They did not act on heparin and heparan sulfate. These findings suggest that the biochemical properties of these purified chondroitin lyases are different from those of the previously purified chondroitin lyases...