Dong Hyun Kim

Summary

Affiliation: Yonsei University
Country: Korea

Publications

  1. pmc Noninvasive measurement of conductivity anisotropy at larmor frequency using MRI
    Joonsung Lee
    Department of Electrical and Electronic Engineering, Yonsei University, Seoul 120 749, Republic of Korea
    Comput Math Methods Med 2013:421619. 2013
  2. ncbi request reprint Diffusion-weighted imaging of the fetal brain in vivo
    Dong Hyun Kim
    School of Electrical and Electronic Engineering, Yonsei University, Seoul, Korea
    Magn Reson Med 59:216-20. 2008
  3. pmc Fast 3D (1)H MRSI of the corticospinal tract in pediatric brain
    Dong Hyun Kim
    School of Electrical and Electronic Engineering, Yonsei University, Seoul, Korea
    J Magn Reson Imaging 29:1-6. 2009
  4. pmc Fast multivoxel two-dimensional spectroscopic imaging at 3 T
    Dong Hyun Kim
    Department of Radiology, University of California San Francisco, San Francisco, CA, USA
    Magn Reson Imaging 25:1155-61. 2007
  5. pmc Gradient moment compensated magnetic resonance spectroscopic imaging
    Dong Hyun Kim
    School of Electrical and Electronic Engineering, Yonsei University, Seoul, Korea
    Magn Reson Med 61:457-61. 2009
  6. doi request reprint In vivo (1)H magnetic resonance spectroscopy of amniotic fluid and fetal lung at 1.5 T: technical challenges
    Dong Hyun Kim
    School of Electrical and Electronic Engineering and Department of Radiology, Yonsei University, Seoul, Korea
    J Magn Reson Imaging 28:1033-8. 2008
  7. ncbi request reprint In vitro and in vivo antiallergic effect of the fructus of Evodia rutaecarpa and its constituents
    Yong Wook Shin
    College of Pharmacy, Kyung Hee University, Seoul, Korea
    Biol Pharm Bull 30:197-9. 2007
  8. ncbi request reprint Inhibitory effect of schizandrin on passive cutaneous anaphylaxis reaction and scratching behaviors in mice
    Bomi Lee
    College of Pharmacy, Kyung Hee University, Seoul, Korea
    Biol Pharm Bull 30:1153-6. 2007
  9. ncbi request reprint In vitro and in vivo antiallergic effects of Glycyrrhiza glabra and its components
    Yong Wook Shin
    College of Pharmacy, Kyung Hee University, Dongdaemun ku, Seoul, Korea
    Planta Med 73:257-61. 2007
  10. ncbi request reprint Metabolism of ginsenoside R(c) by human intestinal bacteria and its related antiallergic activity
    Eun Ah Bae
    College of Pharmacy, Kyung Hee University, Seoul, Korea
    Biol Pharm Bull 25:743-7. 2002

Detail Information

Publications130 found, 100 shown here

  1. pmc Noninvasive measurement of conductivity anisotropy at larmor frequency using MRI
    Joonsung Lee
    Department of Electrical and Electronic Engineering, Yonsei University, Seoul 120 749, Republic of Korea
    Comput Math Methods Med 2013:421619. 2013
    ..The limitation of the circulating admittivity is that at least two components of the magnetic fields should be measured to capture anisotropic information...
  2. ncbi request reprint Diffusion-weighted imaging of the fetal brain in vivo
    Dong Hyun Kim
    School of Electrical and Electronic Engineering, Yonsei University, Seoul, Korea
    Magn Reson Med 59:216-20. 2008
    ..The method can be readily implemented in a clinical setting and is especially useful when scanning mothers who cannot tolerate lengthier breath-holds...
  3. pmc Fast 3D (1)H MRSI of the corticospinal tract in pediatric brain
    Dong Hyun Kim
    School of Electrical and Electronic Engineering, Yonsei University, Seoul, Korea
    J Magn Reson Imaging 29:1-6. 2009
    ....
  4. pmc Fast multivoxel two-dimensional spectroscopic imaging at 3 T
    Dong Hyun Kim
    Department of Radiology, University of California San Francisco, San Francisco, CA, USA
    Magn Reson Imaging 25:1155-61. 2007
    ..All protocols were designed to acquire data within a 17-min scan time at a field strength of 3 T...
  5. pmc Gradient moment compensated magnetic resonance spectroscopic imaging
    Dong Hyun Kim
    School of Electrical and Electronic Engineering, Yonsei University, Seoul, Korea
    Magn Reson Med 61:457-61. 2009
    ..Results indicate that in the presence of motion, ghosting effects are reduced while metabolite signal increases of approximately 10% can be achieved...
  6. doi request reprint In vivo (1)H magnetic resonance spectroscopy of amniotic fluid and fetal lung at 1.5 T: technical challenges
    Dong Hyun Kim
    School of Electrical and Electronic Engineering and Department of Radiology, Yonsei University, Seoul, Korea
    J Magn Reson Imaging 28:1033-8. 2008
    ..To identify the major technical challenges associated with in utero single-voxel proton spectroscopy of amniotic fluid and fetal lung and to evaluate the feasibility of performing in utero fetal spectroscopy for fetal lung maturity testing...
  7. ncbi request reprint In vitro and in vivo antiallergic effect of the fructus of Evodia rutaecarpa and its constituents
    Yong Wook Shin
    College of Pharmacy, Kyung Hee University, Seoul, Korea
    Biol Pharm Bull 30:197-9. 2007
    ..These findings suggest that ER and its constituents, evodiamine and rutaecarpine, may be effective for IgE-induced allergic diseases such as atopic dermatitis and rhinitis...
  8. ncbi request reprint Inhibitory effect of schizandrin on passive cutaneous anaphylaxis reaction and scratching behaviors in mice
    Bomi Lee
    College of Pharmacy, Kyung Hee University, Seoul, Korea
    Biol Pharm Bull 30:1153-6. 2007
    ..Schizandrin reduced the protein expressions of TNF-alpha and IL-4 in IgE-induced RBL 2H3 cells. These findings suggest that schizandrin can improve IgE-induced anaphylaxis and scratching behaviors...
  9. ncbi request reprint In vitro and in vivo antiallergic effects of Glycyrrhiza glabra and its components
    Yong Wook Shin
    College of Pharmacy, Kyung Hee University, Dongdaemun ku, Seoul, Korea
    Planta Med 73:257-61. 2007
    ..This suggests that the antiallergic effects of licorice are mainly due to glycyrrhizin, 18beta-glycyrrhetinic acid, and liquiritigenin, which can relieve IgE-induced allergic diseases such as dermatitis and asthma...
  10. ncbi request reprint Metabolism of ginsenoside R(c) by human intestinal bacteria and its related antiallergic activity
    Eun Ah Bae
    College of Pharmacy, Kyung Hee University, Seoul, Korea
    Biol Pharm Bull 25:743-7. 2002
    ..W. 940[+Na]). Among ginsenoside R(c) and its metabolites, compound K exhibited the most potent antiallergic activity on the IgE-induced RBL cell line as well as potent cytotoxic activity against tumor cell lines...
  11. ncbi request reprint Beta-glucuronidase inhibitor tectorigenin isolated from the flower of Pueraria thunbergiana protects carbon tetrachloride-induced liver injury
    Hae Woong Lee
    College of Pharmacy, Kyung Hee University, Seoul, Korea
    Liver Int 23:221-6. 2003
    ..To understand the relationship between the fluctuation in serum beta-glucuronidase and hepatotoxicity, an inhibitor of beta-glucuronidase was isolated from the flowers of Pueraria thunbergiana and its hepatoprotective activity was measured...
  12. ncbi request reprint The memory ameliorating effects of INM-176, an ethanolic extract of Angelica gigas, against scopolamine- or Aβ(1-42)-induced cognitive dysfunction in mice
    Se Jin Park
    Department of Life and Nanopharmaceutical Science, Seoul, Republic of Korea
    J Ethnopharmacol 143:611-20. 2012
    ..We investigated whether INM-176 exhibits anti-amnesic effects...
  13. doi request reprint The effects of daidzin and its aglycon, daidzein, on the scopolamine-induced memory impairment in male mice
    Dong Hyun Kim
    Department of Life and Nanopharmaceutical Sciences, Kyung Hee University, Seoul, Korea
    Arch Pharm Res 33:1685-90. 2010
    ..These results indicate that daidzin or daidzein may be useful in cognitive impairment induced by cholinergic dysfunction, and this beneficial effect is mediated, in part, via estrogen receptor...
  14. ncbi request reprint Metabolism of 20(S)- and 20(R)-ginsenoside Rg3 by human intestinal bacteria and its relation to in vitro biological activities
    Eun Ah Bae
    Department of Food and Nutrition, Kyung Hee University, Seoul, Korea
    Biol Pharm Bull 25:58-63. 2002
    ....
  15. ncbi request reprint Antiallergic activity of ginseng and its ginsenosides
    Min Kyung Choo
    College of Pharmacy, Kyung Hee University, Seoul, Korea
    Planta Med 69:518-22. 2003
    ..7:mouse monocyte leukemiaRBL-2H3: rat basophil leukemia SD:Sprague-Dawley..
  16. ncbi request reprint Prunella vulgaris attenuates prepulse inhibition deficit and attention disruption induced by MK-801 in mice
    Se Jin Park
    Department of Life and Nanopharmaceutical Science, Kyung Hee University, Seoul, 130 701, Korea
    Phytother Res 27:1763-9. 2013
    ..These results suggest that EEPV could be useful for treating schizophrenia because EEPV ameliorates prepulse inhibition disruption and attention deficits induced by MK-801...
  17. ncbi request reprint Sinapic acid attenuates kainic acid-induced hippocampal neuronal damage in mice
    Dong Hyun Kim
    Department of Life and Nanopharmaceutical Sciences, Biomedical Science Institute, School of Medicine, Kyung Hee University, Seoul, Republic of Korea
    Neuropharmacology 59:20-30. 2010
    ..These results suggest that the potential therapeutic effect of SA is due to its attenuation of KA-induced neuronal damage in the brain via its anti-convulsive activity through GABA(A) receptor activation and radical scavenging activity...
  18. ncbi request reprint Metabolic activities of ginsenoside Rb1, baicalin, glycyrrhizin and geniposide to their bioactive compounds by human intestinal microflora
    Jang Shim Yim
    College of Oriental Medicine, Kyung Hee University, Dongdaemun ku, Seoul, Korea
    Biol Pharm Bull 27:1580-3. 2004
    ..These results suggest that the human intestinal microflora enzymes that convert herbal components to their bioactive compounds may be used as selection markers of responders to traditional medicines...
  19. ncbi request reprint Hinokiresinol inhibits IgE-induced mouse passive cutaneous anaphylaxis reaction
    Eun Ah Bae
    College of Pharmacy, Kyung Hee University, Seoul, Korea
    Planta Med 72:1328-30. 2006
    ..Orally and intraperitoneally administered hinokiresinol potently inhibited the passive anaphylaxis reaction in mice induced by IgE...
  20. ncbi request reprint Anti-pruritic effect of baicalin and its metabolites, baicalein and oroxylin A, in mice
    Hien Trung Trinh
    Department of Pharmaceutical Science and Department of Life and Pharmaceutical Sciences, Kyung Hee University, 1 Hoegi, Dongdaemun ku, Seoul, Korea
    Acta Pharmacol Sin 31:718-24. 2010
    ..To explore whether intestinal microflora plays a role in anti-pruritic activity of baicalin, a main constituent of the rhizome of Scutellaria baicalensis (SB)...
  21. ncbi request reprint The effects of ginsenoside Re and its metabolite, ginsenoside Rh1, on 12-O-tetradecanoylphorbol 13-acetate- and oxazolone-induced mouse dermatitis models
    Yong Wook Shin
    College of Pharmacy, Kyung Hee University, Seoul, Korea
    Planta Med 72:376-8. 2006
    ..Ginsenoside Rh1 potently suppressed the TPA- and oxazolone-induced swellings as well as mRNA expression levels of cyclooxygenase-2, IL-1beta and TNF-alpha, although these were only weakly inhibited by ginsenoside Re...
  22. doi request reprint Mangiferin inhibits passive cutaneous anaphylaxis reaction and pruritus in mice
    Bomi Lee
    Department of Life and Nanopharmaceutical Sciences, Kyung Hee University Dongdaemun ku, Seoul, Korea
    Planta Med 75:1415-7. 2009
    ..These findings suggest that mangiferin may improve PCA reaction and pruritus...
  23. ncbi request reprint Magnolol and honokiol: inhibitors against mouse passive cutaneous anaphylaxis reaction and scratching behaviors
    Sang Jun Han
    Department of Life and Nanopharmaceutical Sciences and Department of Pharmaceutical Science, Kyung Hee University, 1 Hoegi, Dongdaemun ku, Seoul, Korea
    Biol Pharm Bull 30:2201-3. 2007
    ..Based on these findings, magnolol and honokiol may improve IgE-induced allergic diseases...
  24. ncbi request reprint Ginsenoside Rh1 possesses antiallergic and anti-inflammatory activities
    Eun Kyung Park
    College of Pharmacy, Kyung Hee University, Seoul, Korea
    Int Arch Allergy Immunol 133:113-20. 2004
    ..A. Meyer, Araliaceae) has been reported to possess various biological activities, including anti-inflammatory and antitumor actions. In this study, we investigated the antiallergic activity of ginsenosides isolated from ginseng...
  25. ncbi request reprint Antiallergic activity of hesperidin is activated by intestinal microflora
    Neung Kee Lee
    School of Oriental Medicine, Kyung Hee University, Seoul, Korea
    Pharmacology 71:174-80. 2004
    ..7 cells. Hesperetin weakly inhibits cyclooxygenase 2 enzyme activities. These results suggest that hesperidin may be a prodrug, which is metabolized to hesperetin by intestinal bacteria...
  26. ncbi request reprint Inhibitory effect of Chunghyuldan in prostaglandin E2 and nitric oxide biosynthesis of lipopolysaccharide-induced RAW 264.7 cells
    Ki Ho Cho
    College of Oriental Medicine, Kyung Hee University, Seoul, Korea
    Biol Pharm Bull 27:1810-3. 2004
    ..MCHD-inhibitory activity against NO and PGE2 productions in LPS-induced RAW264.7 cells was more potent than those of CHD. These results suggest that CHD may show potent anti-inflammatory activity in vivo and can improve brain ischemia...
  27. doi request reprint Anti-inflammatory mechanism of exogenous C2 ceramide in lipopolysaccharide-stimulated microglia
    Ji Sun Jung
    Department of Molecular Medicine, Ewha Womans University Medical School, Seoul, Republic of Korea
    Biochim Biophys Acta 1831:1016-26. 2013
    ..Therefore, our data collectively suggests the therapeutic potential of short chain ceramides such as C2 for neuroinflammatory disorders such as Alzheimer's disease and Parkinson's disease...
  28. ncbi request reprint Protective effects of kakkalide from Flos puerariae on ethanol-induced lethality and hepatic injury are dependent on its biotransformation by human intestinal microflora
    Yeo Ok Han
    Department of Food Science, Kyung Hee University, Seoul, Korea
    J Pharmacol Sci 93:331-6. 2003
    ..The results indicate that kakkalide is a prodrug of irisolidone in protecting against ethanol-induced lethality and hepatic injury...
  29. pmc Hippocampal extracellular signal-regulated kinase signaling has a role in passive avoidance memory retrieval induced by GABAA Receptor modulation in mice
    Dong Hyun Kim
    Department of Life and Nanopharmaceutical Sciences, Kyung Hee University, Seoul, Republic of Korea
    Neuropsychopharmacology 37:1234-44. 2012
    ..Finally, the effects of BMI were blocked by the co-application of a sub-effective dose of U0126. These results suggest that GABA(A) receptor-mediated memory retrieval is closely related to ERK activity...
  30. ncbi request reprint Antithrombotic and antiallergic activities of rhaponticin from Rhei Rhizoma are activated by human intestinal bacteria
    Eun Kyung Park
    College of Pharmacy, Kyung Hee University, Dongdaemun ku, Seoul, Korea
    Arch Pharm Res 25:528-33. 2002
    ..These results suggest that rhaponticin, in the rhizome of Rhei Rhizoma, is a prodrug that has extensive antiallergic and antithrombotic properties...
  31. doi request reprint Arctigenin isolated from the seeds of Arctium lappa ameliorates memory deficits in mice
    In Ah Lee
    Department of Life and Nanopharmaceutical Sciences and Department of Pharmacy, Kyung Hee University, Seoul, Korea
    Planta Med 77:1525-7. 2011
    ..o.). Arctigenin also significantly reversed scopolamine-induced memory deficits in the Y-maze and Morris water maze tests. On the basis of these findings, arctigenin may ameliorate memory deficits by inhibiting AChE...
  32. ncbi request reprint Ginsenosides Rg3 and Rh2 inhibit the activation of AP-1 and protein kinase A pathway in lipopolysaccharide/interferon-gamma-stimulated BV-2 microglial cells
    Eun Ah Bae
    College of Pharmacy, Kyung Hee University, Seoul, Korea
    Planta Med 72:627-33. 2006
    ....
  33. doi request reprint Neuroprotective effects of a traditional herbal prescription on transient cerebral global ischemia in gerbils
    Mudan Cai
    Department of Life and Nanopharmaceutical Science, Kyung Hee University, Seoul, Republic of Korea
    J Ethnopharmacol 138:723-30. 2011
    ..However, the effects of KOK on transient cerebral global ischemia-induced brain damage are unclear...
  34. ncbi request reprint Lancemaside A inhibits microglial activation via modulation of JNK signaling pathway
    Yeon Hui Jeong
    Department of Molecular Medicine, Tissue Injury Defense Research Center, Ewha Womans University Medical School, Seoul, Republic of Korea
    Biochem Biophys Res Commun 431:369-75. 2013
    ..Collectively, our data suggest that JNK pathway plays a key role mediating anti-inflammatory effects of lancemaside A in LPS-stimulated microglia...
  35. ncbi request reprint Antipruritic effect of ginsenoside rb1 and compound k in scratching behavior mouse models
    Yong Wook Shin
    College of Pharmacy, Kyung Hee University, Seoul, Korea
    J Pharmacol Sci 99:83-8. 2005
    ..8, 6.8, and 4.1 mg/kg, respectively. These results suggest that ginsenoside Rb1 and its metabolite compound K by intestinal microflora can improve scratching behaviors...
  36. ncbi request reprint Passive cutaneous anaphylaxis-inhibitory activity of flavanones from Citrus unshiu and Poncirus trifoliata
    Sung Hwan Park
    Department of Food and Nutrition, College of Pharmacy, Kyung Hee University, Seoul, Korea
    Planta Med 71:24-7. 2005
    ..This suggests that the flavanone glycosides can be activated by intestinal bacteria, and may be effective toward IgE-induced atopic allergies...
  37. ncbi request reprint Hepatoprotective effect of tectoridin and tectorigenin on tert-butyl hyperoxide-induced liver injury
    Hae Ung Lee
    College of Pharmacy, Kyung Hee University, Seoul, Korea
    J Pharmacol Sci 97:541-4. 2005
    ..This protection may have originated from the inhibition of apoptosis. Tectorigenin may be hepatoprotective and tectoridin should be a prodrug that is transformed to tectorigenin...
  38. doi request reprint Antidepressant-like activity of the aqueous extract of Allium macrostemon in mice
    Seungjoo Lee
    Department of Life and Nanopharmaceutical Sciences, College of Pharmacy, Kyung Hee University, Dongdaemoon Ku, Seoul, Republic of Korea
    J Ethnopharmacol 131:386-95. 2010
    ..The aim of this study was to identify the effects of water extracts of Allium macrostemon Bunge (AM-W), a traditional herb, in mice...
  39. doi request reprint Lancemaside A ameliorates colitis by inhibiting NF-kappaB activation in TNBS-induced colitis mice
    Eun Ha Joh
    Department of Life and Nanopharmaceutical Sciences and Department of Pharmaceutical Science, Kyung Hee University, 1, Hoegi, Dongdaemun ku, Seoul, 130 701, Republic of Korea
    Int J Colorectal Dis 25:545-51. 2010
    ..Therefore, we investigated its inhibitory effect in 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis in mice...
  40. doi request reprint Anti-scratching behavioral effects of N-stearoyl-phytosphingosine and 4-hydroxysphinganine in mice
    Kwon Ryeol Ryu
    Department of Life and Nanopharmaceutical Sciences, Kyung Hee University, 1, Hoegi, Dongdaemun ku, Seoul, 130 701, Korea
    Lipids 45:613-8. 2010
    ..Based on these results, SPS and PS may improve scratching behavioral reactions in skin by regulating the action of histamine and the activation of the transcription factors NF-kappaB and c-jun...
  41. ncbi request reprint Inhibitory effects of Korean red ginseng and its genuine constituents ginsenosides Rg3, Rf, and Rh2 in mouse passive cutaneous anaphylaxis reaction and contact dermatitis models
    Eun Ah Bae
    Department of Food and Nutrition, Kyung Hee University, Hoegi, Dongdaemun ku, Seoul, Korea
    Biol Pharm Bull 29:1862-7. 2006
    ..7 cells. Based on these findings, KRGS and its ginsenosides are suggested to improve atopic and contact dermatitis by regulating expression of cytokines...
  42. ncbi request reprint Fecal metabolic activities of herbal components to bioactive compounds
    Dai Sik Lee
    College of Oriental Medicine, Kyung Hee University, Seoul, Korea
    Arch Pharm Res 25:165-9. 2002
    ....
  43. ncbi request reprint Antithrombotic and antiallergic activities of daidzein, a metabolite of puerarin and daidzin produced by human intestinal microflora
    Min Kyung Choo
    College of Pharmacy, Kyung Hee University, Seoul, Korea
    Biol Pharm Bull 25:1328-32. 2002
    ..Therefore we believe that puerarin and daidzin in the rhizome of Pueraria lobata are prodrugs, which have antiallergic and antithrombotic activities, produced by intestinal microflora...
  44. ncbi request reprint Simple analytic variable density spiral design
    Dong Hyun Kim
    Radiological Sciences Laboratory, Department of Radiology, Stanford University, Stanford, California 94305 5488, USA
    Magn Reson Med 50:214-9. 2003
    ..The method enables real-time waveform prescription on scanners with limited computational power. Both slew rate-limited and amplitude-limited regimes are incorporated in the design process...
  45. ncbi request reprint Spiral readout gradients for the reduction of motion artifacts in chemical shift imaging
    Dong Hyun Kim
    Radiological Sciences Laboratory, Department of Radiology, Stanford University, Stanford, California, USA
    Magn Reson Med 51:458-63. 2004
    ..Both phantom and in vivo spectra reconstructed using the new motion artifact reduction algorithm showed significant signal-to-noise ratio (SNR) improvements as compared to uncorrected data...
  46. ncbi request reprint Ginsenoside Rh2 reduces ischemic brain injury in rats
    Eun Kyung Park
    College of Pharmacy, Kyung Hee University, Hoegi, Dongdaemun ku, Seoul, Korea
    Biol Pharm Bull 27:433-6. 2004
    ..7 cells, but showed no in vitro antioxidant activity. These results suggest that AG and ginsenoside Rh2 can improve ischemic brain injury...
  47. ncbi request reprint Anti-scratching behavioral effect of Lactobacillus plantarum PM008 isolated from kimchi in mice
    Se Eun Jang
    Department of Food and Nutrition, Kyung Hee University, Dongdaemun ku, Seoul, Korea
    Immunopharmacol Immunotoxicol 33:539-44. 2011
    ..This inhibitory effect continued, although reduced, at 7 days after stopping the oral administration of PM008 attached in the intestine. Based on these findings, L. plantarum PM008 may improve pruritus by inhibiting IL-4 expression...
  48. doi request reprint Evaluation of antipruritic effects of red ginseng and its ingredients in mice
    Hien Trung Trinh
    Department of Life and Nanopharmaceutical Sciences, Kyung Hee University, 1 Hoegi, Dongdaemun ku, Seoul, Korea
    Planta Med 74:210-4. 2008
    ..These results suggest that red ginseng and its ingredients, ginsenosides Rg3 and Rh2, may inhibit scratching behavior by inhibiting IL-4 and TNF-alpha expression, promoting membrane stability, and inhibiting Ca (++) influx...
  49. ncbi request reprint Characteristics of ginsenoside Rg3-mediated brain Na+ current inhibition
    Jun Ho Lee
    Research Laboratory for the Study of Ginseng Signal Transduction, Dept of Physiology, College of Veterinary Medicine, Konkuk University, Seoul, Korea
    Mol Pharmacol 68:1114-26. 2005
    ..These results reveal that Rg(3) is a novel Na(+) channel inhibitor capable of acting on the resting and open states of Na(+) channel via interactions with the S4 voltage-sensor segment of domain II...
  50. doi request reprint Klebsiella pneumoniae increases the risk of inflammation and colitis in a murine model of intestinal bowel disease
    In Ah Lee
    Department of Life and Nanopharmaceutical Sciences, College of Pharmacy, Kyung Hee University, Seoul, Republic of Korea
    Scand J Gastroenterol 46:684-93. 2011
    ..Therefore, we investigated the effects of these bacteria in TNBS-induced colitis in mice...
  51. doi request reprint The ameliorating effect of the extract of the flower of Prunella vulgaris var. lilacina on drug-induced memory impairments in mice
    Se Jin Park
    Department of Life and Nanopharmaceutical Sciences, College of Pharmacy, Kyung Hee University, Seoul, Republic of Korea
    Food Chem Toxicol 48:1671-6. 2010
    ..These results suggest that EEPV would be useful for treating cognitive impairments induced by cholinergic dysfunction, and that it exerts its effects via NMDA receptor signaling...
  52. ncbi request reprint Intestinal bacteria activate estrogenic effect of main constituents puerarin and daidzin of Pueraria thunbergiana
    Eun Kyung Park
    College of Pharmacy, Kyung Hee University, Seoul, Korea
    Biol Pharm Bull 29:2432-5. 2006
    ..These findings suggest that intestinal bacteria, which can hydrolyze puerarin and/or daidzin, may activate a potent estrogenic activity of PT...
  53. ncbi request reprint Hepatoprotective effects of irisolidone on tert-butyl hyperoxide-induced liver injury
    Hae Ung Lee
    Kyung Hee University, College of Pharmacy, Hoegi, Dongdaemun ku, Seoul, Korea
    Biol Pharm Bull 28:531-3. 2005
    ..When irisolidone was intraperitoneally administered to mice, it exhibited potent hepatoprotective activity. Based on these findings, irisolidone can be hepatoprotective and kakkalide may be a prodrug transformed to irisolidone...
  54. pmc Comparative analysis of the gut microbiota in people with different levels of ginsenoside Rb1 degradation to compound K
    Kyung Ah Kim
    Department of Life and Nanopharmaceutical Sciences and Department of Pharmacy, Kyung Hee University, Seoul, Korea
    PLoS ONE 8:e62409. 2013
    ..Intestinal bacterial metabolism of ginseng, particularly ginsenoside Rb1, may be dependent on the composition of gut microbiota, such as Ruminococcus spp., Bacteroides spp. and Bifidobacterium spp...
  55. doi request reprint Inhibitory effects of curcuminoids on passive cutaneous anaphylaxis reaction and scratching behavior in mice
    Hien Trung Trinh
    Department of Life and Nanopharmaceutical Sciences and Department of Pharmaceutical Science, Kyung Hee University, Seoul, 130 701, Korea
    Arch Pharm Res 32:1783-7. 2009
    ..These findings suggest that curcuminoids, particularly curcumin, can improve the symptoms of allergic diseases, such as anaphylaxis and itching...
  56. doi request reprint Inhibitory effect of Lactobacillus plantarum K-1 on passive cutaneous anaphylaxis reaction and scratching behavior in mice
    Se Eun Jang
    Department of Food and Nutrition, Kyung Hee University, Seoul, 130 701, Korea
    Arch Pharm Res 34:2117-23. 2011
    ....
  57. ncbi request reprint Metabolism of kalopanaxsaponin K by human intestinal bacteria and antirheumatoid arthritis activity of their metabolites
    Dong Hyun Kim
    College of Pharmacy, Kyung Hee University, Seoul, Korea
    Biol Pharm Bull 25:68-71. 2002
    ..However, Lactobacillus sp. and Streptococcus sp. transformed KPK to KPI, KPA, and hederagenin only via KPJ. The metabolite KPA of KPK showed potent antirheumatoid arthritis activity...
  58. doi request reprint Protopanaxatriol ginsenoside Rh1 inhibits the expression of matrix metalloproteinases and the in vitro invasion/migration of human astroglioma cells
    Ji Sun Jung
    Department of Molecular Medicine and Tissue Injury Defense Research Center, Ewha Womans University Medical School, Seoul, Republic of Korea
    Neurochem Int 63:80-6. 2013
    ..The data collectively suggest that ginsenoside Rh1 may have a therapeutic potential for malignant gliomas...
  59. doi request reprint Artemisia princeps Pamp. Essential oil and its constituents eucalyptol and α-terpineol ameliorate bacterial vaginosis and vulvovaginal candidiasis in mice by inhibiting bacterial growth and NF-κB activation
    Hien Trung Trinh
    Department of Life and Pharmaceutical Sciences, Kyung Hee University, Seoul, Korea
    Planta Med 77:1996-2002. 2011
    ..Based on these findings, APEO and its constituents, particularly α-terpineol, ameliorate bacterial vaginosis and vulvovaginal candidiasis by inhibiting the growths of vaginal pathogens and the activation of NF- κB...
  60. pmc GABA(A) receptor blockade enhances memory consolidation by increasing hippocampal BDNF levels
    Dong Hyun Kim
    Department of Life and Nanopharmaceutical Sciences, Kyung Hee University, Dongdaemoon gu, Seoul, Republic of Korea
    Neuropsychopharmacology 37:422-33. 2012
    ..These findings suggest that the increase in the level of mBDNF and its function during a restricted time window after training are required for the enhancement of memory consolidation by GABA(A) receptor blockade...
  61. doi request reprint Anti-inflammatory mechanism of ginsenoside Rh1 in lipopolysaccharide-stimulated microglia: critical role of the protein kinase A pathway and hemeoxygenase-1 expression
    Ji Sun Jung
    Department of Molecular Medicine and Tissue Injury Defense Research Center, Ewha Womans University Medical School, Seoul, Korea
    J Neurochem 115:1668-80. 2010
    ..Through this study, we have demonstrated that protein kinase A and its downstream effector, HO-1, play a critical role in the anti-inflammatory mechanism of Rh1 by modulating pro- and anti-inflammatory molecules in activated microglia...
  62. doi request reprint 3D imaging using magnetic resonance tomosynthesis (MRT) technique
    Min Oh Kim
    Department of Electrical and Electronic Engineering, Yonsei University, Seodaemun gu, Seoul 120 749, South Korea
    Med Phys 39:4733-41. 2012
    ..To introduce an alternative approach to three-dimensional (3D) magnetic resonance (MR) imaging using a method that is similar to x-ray tomosynthesis...
  63. doi request reprint The ameliorating effects of 5,7-dihydroxy-6-methoxy-2(4-phenoxyphenyl)-4H-chromene-4-one, an oroxylin A derivative, against memory impairment and sensorimotor gating deficit in mice
    Xiaotong Liu
    Department of Life and Nanopharmaceutical Sciences, Kyung Hee University, Seoul, 130 701, Republic of Korea
    Arch Pharm Res 36:854-63. 2013
    ....
  64. doi request reprint Lactobacillus casei HY7213 ameliorates cyclophosphamide-induced immunosuppression in mice by activating NK, cytotoxic T cells and macrophages
    Se Eun Jang
    Department of Food and Nutrition, Kyung Hee University, Seoul, Korea
    Immunopharmacol Immunotoxicol 35:396-402. 2013
    ..Based on these findings, we suggest that HY7213 may promote the recovery of immunosuppression caused by chemotherapeutic agents, such as CP, by activating NK cells, cytotoxic T cells and macrophages...
  65. ncbi request reprint Self-navigated interleaved spiral (SNAILS): application to high-resolution diffusion tensor imaging
    Chunlei Liu
    Lucas MRS I Center, Department of Radiology, Stanford University, California 94305 5488, USA
    Magn Reson Med 52:1388-96. 2004
    ..To our knowledge, this was also the first time in vivo 512 x 512 DTI results were reported...
  66. ncbi request reprint Inhibitory effect of ginsenoside Rb1 and compound K on NO and prostaglandin E2 biosyntheses of RAW264.7 cells induced by lipopolysaccharide
    Eun Kyung Park
    College of Pharmacy, Kyung Hee University, Seoul, Korea
    Biol Pharm Bull 28:652-6. 2005
    ..These findings suggest that ginsenoside Rb1 can be transformed to compound K by intestinal bacteria, and compound K may be effective against inflammation...
  67. ncbi request reprint Anti-allergic effects of fermented Ixeris sonchifolia and its constituent in mice
    Hien Trung Trinh
    Kyung Hee Universitym, Seoul, Korea
    J Microbiol Biotechnol 20:217-23. 2010
    ..These findings suggest that antiallergic effect of IS can be increased by LAB fermentation and fermented IS might improve allergic reactions, such as pruritus, anaphylaxis, and inflammation...
  68. pmc High fat diet-induced gut microbiota exacerbates inflammation and obesity in mice via the TLR4 signaling pathway
    Kyung Ah Kim
    Department of Life and Nanopharmaceutical Sciences, College of Pharmacy, Kyung Hee University, Seoul, Korea
    PLoS ONE 7:e47713. 2012
    ..Here, we investigated the effect of endotoxin-induced inflammation via TLR4 signaling pathway at both systemic and intestinal levels in response to a high-fat diet...
  69. doi request reprint Revisiting the role of nonanatomic resection of small (< or = 4 cm) and single hepatocellular carcinoma in patients with well-preserved liver function
    Chang Moo Kang
    Department of Surgery, Yonsei University College of Medicine, Seoul, Korea
    J Surg Res 160:81-9. 2010
    ..We evaluated the oncologic outcomes of nonanatomic resection performed as a primary treatment for small (<or=4 cm) and single HCC in patients with well-preserved liver function (Child-Pugh class A)...
  70. ncbi request reprint Single balloon kyphoplasty using far-lateral extrapedicular approach: technical note and preliminary results
    Kyeong Sik Ryu
    Department of Neurosurgery, Kang Nam St Mary s Hospital, The Catholic University of Korea, Seocho Gu, Seoul, Korea
    J Spinal Disord Tech 20:392-8. 2007
    ..The authors have performed a single-balloon kyphoplasty using far-lateral extrapedicular approach in the treatment of osteoporotic vertebral compression fractures. The authors introduce its surgical technique and early clinical results...
  71. ncbi request reprint Metabolism and excretion of 5-ethyl-2-{5-[4-(2-hydroxyethyl)piperazine-1-sulfonyl]-2-propoxyphenyl}-7-propyl-3,5-dihydropyrrolo[3,2-d]-pyrimidin-4-one (SK3530) in rats
    Jaeick Lee
    Bioanalysis and Biotransformation Research Center, Korea Institute of Science and Technology, P O BOX 131, Chungryang, Seoul, Korea
    Rapid Commun Mass Spectrom 21:1139-49. 2007
    ..An additional metabolite due to aromatic hydroxylation was also identified in hepatic microsomes...
  72. ncbi request reprint 1H NMR-based metabonomic assessment of probiotic effects in a colitis mouse model
    Young Shick Hong
    Korea Basic Science Institute, Seoul, Korea
    Arch Pharm Res 33:1091-101. 2010
    ..This work highlights the possibility for alternative approach of metabonomics in feces for assessing the probiotic effect in an animal model of inflammatory bowel disease...
  73. ncbi request reprint Daio-Orengedokuto inhibits HMG-CoA reductase and pancreatic lipase
    Young Suk Kim
    College of Oriental Medicine, Kyung Hee University, Seoul, Korea
    Biol Pharm Bull 25:1442-5. 2002
    ..DOT also decreased serum triglyceride levels, but OT did not decrease it. These results suggest that the antihyperlipidemic activity of DOT may originate from the inhibition of pancreatic lipase as well as HMG-CoA reductase...
  74. pmc Tanshinone I enhances learning and memory, and ameliorates memory impairment in mice via the extracellular signal-regulated kinase signalling pathway
    Dong Hyun Kim
    Department of Life and Nanopharmaceutical Sciences, College of Pharmacy, Kyung Hee University, Seoul, Korea
    Br J Pharmacol 158:1131-42. 2009
    ..Here, we have investigated possible modes of action of tanshinone I on learning and memory, associated with ERK phosphorylation...
  75. ncbi request reprint Metabolism of ginsenoside Rb1 by human intestinal microflora and cloning of its metabolizing β-D-glucosidase from Bifidobacterium longum H-1
    Il Hoon Jung
    Department of Life and Nanopharmaceutical Sciences, College of Pharmacy, Kyung Hee University, Seoul, Korea
    Biol Pharm Bull 35:573-81. 2012
    ....
  76. ncbi request reprint LC-ESI/MS/MS method for rapid screening and confirmation of 44 exogenous anabolic steroids in human urine
    Byoung Wook Jeon
    Doping Control Center, Korea Institute of Science and Technology, Seoul, Korea
    Anal Bioanal Chem 401:1353-63. 2011
    ..1-10 ng/mL and 0.2-10 ng/mL, respectively, for 44 steroids. This method was successfully applied to analysis of urine samples from suspected anabolic steroid abusers...
  77. doi request reprint Simple and accurate quantitative analysis of seven prohibited threshold substances in human urine by liquid chromatography/tandem mass spectrometry in doping control
    Kang Mi Lee
    Doping Control Center, Korea Institute of Science and Technology, PO Box 131, Cheongryang, Seoul, Korea
    Rapid Commun Mass Spectrom 25:2261-7. 2011
    ..7-106.6% of nominal values, suggesting that the developed methods can be successfully applied to routine doping analyses...
  78. ncbi request reprint Gluco-obtusifolin and its aglycon, obtusifolin, attenuate scopolamine-induced memory impairment
    Dong Hyun Kim
    Department of Life and Nanopharmaceutical Sciences, College of Pharmacy, Kyung Hee University, Seoul, Korea
    J Pharmacol Sci 111:110-6. 2009
    ..These results suggest that gluco-obtusifolin and its aglycone may be useful for the treatment of cognitive impairment, and that its beneficial effects are mediated, in part, by the enhancement of cholinergic signaling...
  79. doi request reprint Robotic central pancreatectomy with pancreaticogastrostomy (transgastric approach) in a solid pseudopapillary tumor of the pancreas
    Dong Hyun Kim
    Department of Surgery, Yonsei University, Wonju College of Medicine, Korea
    Hepatogastroenterology 58:1805-8. 2011
    ..More experiences need to be accumulated in order to evaluate the real value of robot pancreatic surgery...
  80. doi request reprint Conventional laparoscopic and robot-assisted spleen-preserving pancreatectomy: does da Vinci have clinical advantages?
    Chang Moo Kang
    Division of Biliopancreas, Department of Surgery, Yonsei University College of Medicine, 250 Seongsanno, Seodaemun gu, Seoul, 120 752, Korea
    Surg Endosc 25:2004-9. 2011
    ..It requires extensive surgeon experience and learned techniques. A robot surgical system was recently introduced to overcome these limitations and it may potentially provide precise and safe laparoscopic surgery...
  81. ncbi request reprint Effects of Schisandra lignans on P-glycoprotein-mediated drug efflux in human intestinal Caco-2
    Hye Hyun Yoo
    Bioanalysis and Biotransformation Research Center, Korea Institute of Science and Technology, Seoul, Korea
    Planta Med 73:444-50. 2007
    ..2, respectively. These results demonstrated that deoxyschizandrin effectively inhibited the P-gp-mediated efflux in Caco-2 cells, suggesting they could potentially increase the absorption of drugs that can act as a P-gp substrate...
  82. ncbi request reprint Effect of chunghyuldan in chronic oxazolone-induced mouse dermatitis
    Sung Sook Wee
    College of Pharmacy, Kyung Hee University, Seoul, Korea
    Biol Pharm Bull 28:1079-82. 2005
    ..Based on these findings, CHD may improve contact dermatitis or psoriasis by the regulation of COX-2 produced by macrophage cells and IFN-gamma and IL-4 produced by Th cells...
  83. ncbi request reprint Fast CT-PRESS-based spiral chemical shift imaging at 3 Tesla
    Dirk Mayer
    Richard M Lucas Center for Magnetic Resonance Spectroscopy and Imaging, Department of Radiology, Stanford University, Stanford, California 94305 5488, USA
    Magn Reson Med 55:974-8. 2006
    ..Signals from N-acetyl-aspartate, total creatine, choline-containing compounds (Cho), Glu, and mI were detected in a healthy volunteer with no or only minor baseline distortions within 14 min on a 3 T MR scanner...
  84. pmc Fast parallel spiral chemical shift imaging at 3T using iterative SENSE reconstruction
    Dirk Mayer
    Stanford University, Richard M Lucas Center for Magnetic Resonance Spectroscopy and Imaging, Department of Radiology, Stanford, California 94305 5488, USA
    Magn Reson Med 59:891-7. 2008
    ....
  85. ncbi request reprint Purification and characterization of ginsenoside Ra-hydrolyzing beta-D-xylosidase from Bifidobacterium breve K-110, a human intestinal anaerobic bacterium
    Ho Young Shin
    College of Pharmacy, Kyung Hee University, Seoul, Korea
    Biol Pharm Bull 26:1170-3. 2003
    ..These findings suggest that this is the first reported purification of ginsenoside-hydrolyzing beta-D-xylosidase from an anaerobic Bifidobacterium sp...
  86. pmc The comparison between torsional and conventional mode phacoemulsification in moderate and hard cataracts
    Dong Hyun Kim
    Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea
    Korean J Ophthalmol 24:336-40. 2010
    ..To compare the intraoperative performances and postoperative outcomes of cataract surgery performed with longitudinal phacoemulsification and torsional phacoemulsification in moderate and hard cataracts...
  87. doi request reprint Artifact reduction from metallic dental materials in T1-weighted spin-echo imaging at 3.0 tesla
    Sang Young Zho
    Department of Electrical and Electronic Engineering, Yonsei University, Seoul, Korea
    J Magn Reson Imaging 37:471-8. 2013
    ..To investigate and propose a method of artifact reduction arising from metallic dental materials by applying a slice-encoding for metal artifact correction (SEMAC) technique on T1-weighted spin-echo (SE) imaging at 3 Tesla...
  88. doi request reprint Long-term results of bilateral congenital cataract treated with early cataract surgery, aphakic glasses and secondary IOL implantation
    Dong Hyun Kim
    Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea
    Acta Ophthalmol 90:231-6. 2012
    ..To evaluate the long-term visual outcome after early surgery of bilateral dense congenital cataracts, aphakic correction with glasses and secondary intraocular lens (IOL) implantation around 2 years of age...
  89. doi request reprint Antioxidant mechanism of isoflavone metabolites in hydrogen peroxide-stimulated rat primary astrocytes: critical role of hemeoxygenase-1 and NQO1 expression
    Jin Sun Park
    Department of Molecular Medicine and Tissue Injury Defense Research Center, Ewha Womans University Medical School, Seoul, Korea
    J Neurochem 119:909-19. 2011
    ..Our data collectively suggest that HO-1 and NQO1 play a critical role in antioxidant effects of isoflavone metabolites in rat brain astrocytes...
  90. ncbi request reprint Validation and application of a screening method for beta2-agonists, anti-estrogenic substances and mesocarb in human urine using liquid chromatography/tandem mass spectrometry
    Min Jung Kang
    Bioanalysis and Biotransformation Center, Korea Institute of Science and Technology, 130 650, Hawolgokdong 39 1, Seoul, Korea
    Rapid Commun Mass Spectrom 21:252-64. 2007
    ..8%. The limit of detection was below 10 ng/mL except formestane (300 ng/mL) and aminoglutethimide (100 ng/mL). The validated method was applied for the analysis of excretion samples...
  91. doi request reprint Ten years of experience with resection of left-sided pancreatic ductal adenocarcinoma: evolution and initial experience to a laparoscopic approach
    Chang Moo Kang
    Department of Surgery, Yonsei University College of Medicine, 250 Seongsanno, Seodaemun gu, Seoul, 120 752, Korea
    Surg Endosc 24:1533-41. 2010
    ....
  92. pmc Kalopanaxsaponin A ameliorates experimental colitis in mice by inhibiting IRAK-1 activation in the NF-κB and MAPK pathways
    Eun Ha Joh
    Department of Life and Nanopharmaceutical Sciences, Kyung Hee University, Seoul, Korea
    Br J Pharmacol 162:1731-42. 2011
    ..Therefore, we investigated its anti-inflammatory effects in lipopolysaccharide (LPS)- or peptidoglycan-stimulated murine peritoneal macrophages and trinitrobenzene sulphonic acid (TNBS)-induced colitic mice...
  93. ncbi request reprint Regularized higher-order in vivo shimming
    Dong Hyun Kim
    Radiological Sciences Laboratory, Department of Radiology, Stanford University, California, USA
    Magn Reson Med 48:715-22. 2002
    ..The fully automated shimming package is implemented on a 3 T GE Signa system and its robust performance is demonstrated in phantom and in vivo studies...
  94. doi request reprint Effects of Sun ginseng on memory enhancement and hippocampal neurogenesis
    Chang Hwan Lee
    Department of Life Nanopharmaceutical Science, Kyung Hee University, Seoul 130 701, Republic of Korea
    Phytother Res 27:1293-9. 2013
    ..These results suggest that SG has memory-enhancing activities and that these effects are mediated, in part, by the increase in the levels of pERK and pAkt and by the increases in cell proliferation and cell survival...
  95. doi request reprint Time-varying view angle tilting with spiral readout gradients
    Sang Young Zho
    Department of Electrical and Electronic Engineering, Yonsei University, Seoul, Korea
    Magn Reson Med 68:1220-7. 2012
    ..The results show that as long as the readout time is comparable to Cartesian readout, the resulting images have similar quality...
  96. doi request reprint Inhibitory effect of β-sitosterol on TNBS-induced colitis in mice
    In Ah Lee
    Department of Life and Nanopharmaceutical Sciences, Kyung Hee University, Seoul, Korea
    Planta Med 78:896-8. 2012
    ..Based on these findings, β-sitosterol may ameliorate colitis by inhibiting the NF-κB pathway...
  97. doi request reprint Respiratory motion compensated MR cholangiopancreatography at 3.0 Tesla
    Sang Young Zho
    Department of Electrical and Electronic Engineering, Yonsei University, Seoul, Korea
    J Magn Reson Imaging 32:726-32. 2010
    ..To reduce irregular respiratory motion-induced artifacts in free-breathing prospective navigator-triggered three-dimensional (3D) MR cholangiopancreatography (MRCP)...
  98. ncbi request reprint Ginsenosides: are any of them candidates for drugs acting on the central nervous system?
    Seung Yeol Nah
    Ginsentology Research Laboratory and Department of Physiology, College of Veterinary Medicine, Konkuk University, Seoul, Korea
    CNS Drug Rev 13:381-404. 2007
    ....
  99. ncbi request reprint Gypenoside LXXIV ameliorates scopolamine-induced learning deficit in mice
    Eun Ha Joh
    Department of Life and Nanopharmaceutical Sciences and Department of Pharmaceutical Science, Kyung Hee University, Dongdaemun ku, Seoul, Korea
    Planta Med 76:793-5. 2010
    ..05) and increased the scopolamine-shortened swimming time within the platform quadrant (p < 0.05). Based on these findings, G-74 might improve learning deficits...
  100. pmc Robotic pylorus preserving pancreaticoduodenectomy with mini-laparotomy reconstruction in patient with ampullary adenoma
    Sung Hoon Choi
    Department of Surgery, Yonsei University College of Medicine, Institute of Gastroenterology, Yonsei University Health System, Seoul, Korea
    J Korean Surg Soc 81:355-9. 2011
    ..More experiences are necessary to address real role of robot in far advanced laparoscopic pancreatic surgery...
  101. doi request reprint Effects of gut microflora on pharmacokinetics of hesperidin: a study on non-antibiotic and pseudo-germ-free rats
    Ming Ji Jin
    Doping Control Center, Korea Institute of Science and Technology, Seoul, Korea
    J Toxicol Environ Health A 73:1441-50. 2010
    ....