Research Topics


Kyu Chang Won


Affiliation: Yeungnam University
Country: Korea


  1. Chung S, Moon J, Yoon J, Won K, Lee H. Sex-specific effects of blood cadmium on thyroid hormones and thyroid function status: Korean nationwide cross-sectional study. J Trace Elem Med Biol. 2019;53:55-61 pubmed publisher
    ..813, pā€‰=ā€‰0.032) but not in women. These results suggest that cadmium accumulation is closely associated with thyroid dysfunction, and there is a difference in metabolic capacity according to sex. ..
  2. Karunakaran U, Moon J, Lee H, Won K. CD36 initiated signaling mediates ceramide-induced TXNIP expression in pancreatic beta-cells. Biochim Biophys Acta. 2015;1852:2414-22 pubmed publisher
    ..These data suggest that CD36 dependent NF-?B-TXNIP signaling contributes to the ceramide-induced pathogenesis of pancreatic ?-cell dysfunction and failure. ..
  3. Moon J, Kim J, Park I, Lee J, Kim H, Lee J, et al. Impaired RBC deformability is associated with diabetic retinopathy in patients with type 2 diabetes. Diabetes Metab. 2016;42:448-452 pubmed publisher
    ..These results suggest that RBC deformability might be contributory to the development of the microvascular complication. ..
  4. Moon J, Karunakaran U, Elumalai S, Lee I, Lee H, Kim Y, et al. Metformin prevents glucotoxicity by alleviating oxidative and ER stress-induced CD36 expression in pancreatic beta cells. J Diabetes Complications. 2017;31:21-30 pubmed publisher
    ..This report provides evidence that the inhibition of CD36 may have potential therapeutic effects against hyperglycemia-induced beta cell damage in diabetes. ..
  5. Won K, Moon J, Eun M, Yoon J, Chun K, Cho I, et al. A protective role for heme oxygenase-1 in INS-1 cells and rat islets that are exposed to high glucose conditions. J Korean Med Sci. 2006;21:418-24 pubmed
    ..These results suggest HO-1 seems to mediate the protective response of pancreatic islets against the oxidative stress that is due to high glucose conditions. ..
  6. Elumalai S, Karunakaran U, Lee I, Moon J, Won K. Rac1-NADPH oxidase signaling promotes CD36 activation under glucotoxic conditions in pancreatic beta cells. Redox Biol. 2017;11:126-134 pubmed publisher
    ..These results suggest that Rac1-NADPH oxidase dependent CD36 expression contributes to high glucose-induced beta cell dysfunction and cell death. ..