Kyung Hee Lee

Summary

Affiliation: Yeungnam University
Country: Korea

Publications

  1. doi request reprint Regulation of HGF-mediated cell proliferation and invasion through NF-κB, JunB, and MMP-9 cascades in stomach cancer cells
    Kyung Hee Lee
    Department of Hematology Oncology, College of Medicine, Yeungnam University, Daegu, Republic of Korea
    Clin Exp Metastasis 29:263-72. 2012
  2. doi request reprint Hepatocyte growth factor induced up-regulations of VEGF through Egr-1 in hepatocellular carcinoma cells
    Kyung Hee Lee
    Department of Hemato Oncology, College of Medicine, Yeungnam University, Daegu 705 717, Republic of Korea
    Clin Exp Metastasis 26:685-92. 2009
  3. ncbi request reprint Involvement of MAPK pathway in hypoxia-induced up-regulation of urokinase plasminogen activator receptor in a human prostatic cancer cell line, PC3MLN4
    Kyung Hee Lee
    Department of Hemato Oncology, College of Medicine, Yeungnam University Daegu 705 717, Korea
    Exp Mol Med 36:57-64. 2004
  4. doi request reprint Inhibition of histone deacetylase activity down-regulates urokinase plasminogen activator and matrix metalloproteinase-9 expression in gastric cancer
    Kyung Hee Lee
    Department of Hematology Oncology, College of Medicine, Yeungnam University, Daegu, Korea
    Mol Cell Biochem 343:163-71. 2010
  5. ncbi request reprint Hepatocyte growth factor promotes cell survival by phosphorylation of BAD in gastric cancer cells
    Kyung Hee Lee
    Department of Hematology Oncology, College of Medicine, Yeungnam University, Daegu, Korea
    Oncol Res 17:23-32. 2008
  6. pmc Reactive oxygen species regulate urokinase plasminogen activator expression and cell invasion via mitogen-activated protein kinase pathways after treatment with hepatocyte growth factor in stomach cancer cells
    Kyung Hee Lee
    Biochemistry and Molecular Biology, College of Medicine, Yeungnam University, Daegu, Korea
    J Exp Clin Cancer Res 28:73. 2009
  7. ncbi request reprint Regulation of hepatocyte growth factor-mediated urokinase plasminogen activator secretion by MEK/ERK activation in human stomach cancer cell lines
    Kyung Hee Lee
    Department of Hemato Oncology, College of Medicine, Yeungnam University, Daegu 705 717, Korea
    Exp Mol Med 38:27-35. 2006
  8. ncbi request reprint Cellular mechanisms of hepatocyte growth factor-mediated urokinase plasminogen activator secretion by MAPK signaling in hepatocellular carcinoma
    Kyung Hee Lee
    Department of Hemato Oncology, College of Medicine, Yeungnam University, Daegu, Republic of Korea
    Tumori 94:523-30. 2008
  9. ncbi request reprint Multicenter phase II study of weekly paclitaxel plus cisplatin combination chemotherapy in patients with advanced gastric cancer
    Jong Gwang Kim
    Department of Oncology Hematology, Kyungpook National University Hospital, Kyungpook National University School of Medicine, Daegu, Korea
    Cancer Chemother Pharmacol 60:863-9. 2007
  10. ncbi request reprint Role of hepatocyte growth factor/c-Met signaling in regulating urokinase plasminogen activator on invasiveness in human hepatocellular carcinoma: a potential therapeutic target
    Kyung Hee Lee
    Department of Hemato Oncology, College of Medicine, Yeungnam University, Daegu, Republic of Korea
    Clin Exp Metastasis 25:89-96. 2008

Collaborators

Detail Information

Publications42

  1. doi request reprint Regulation of HGF-mediated cell proliferation and invasion through NF-κB, JunB, and MMP-9 cascades in stomach cancer cells
    Kyung Hee Lee
    Department of Hematology Oncology, College of Medicine, Yeungnam University, Daegu, Republic of Korea
    Clin Exp Metastasis 29:263-72. 2012
    ..In conclusion, these results may contribute to the JunB-associated malignant phenotype of gastric cancers by regulating MMP-9, and serve as a novel therapeutic target for stomach cancer therapy in the future...
  2. doi request reprint Hepatocyte growth factor induced up-regulations of VEGF through Egr-1 in hepatocellular carcinoma cells
    Kyung Hee Lee
    Department of Hemato Oncology, College of Medicine, Yeungnam University, Daegu 705 717, Republic of Korea
    Clin Exp Metastasis 26:685-92. 2009
    ..Egr-1 might play an important role in the up-regulation of VEGF and IL-8 induced by HGF and contribute to HGF-mediated angiogenesis, which might be promising targets for hepatocellular carcinoma therapy...
  3. ncbi request reprint Involvement of MAPK pathway in hypoxia-induced up-regulation of urokinase plasminogen activator receptor in a human prostatic cancer cell line, PC3MLN4
    Kyung Hee Lee
    Department of Hemato Oncology, College of Medicine, Yeungnam University Daegu 705 717, Korea
    Exp Mol Med 36:57-64. 2004
    ..From these results, hypoxia increased tumor cell invasion by up-regulating uPAR expression, which might be mediated through ERK and p38 kinase signaling pathways in PC3MLN4 prostate cancer cell line...
  4. doi request reprint Inhibition of histone deacetylase activity down-regulates urokinase plasminogen activator and matrix metalloproteinase-9 expression in gastric cancer
    Kyung Hee Lee
    Department of Hematology Oncology, College of Medicine, Yeungnam University, Daegu, Korea
    Mol Cell Biochem 343:163-71. 2010
    ..Our data probably suggest that such activities serve as anti-tumor mechanisms of the HDAC inhibitor...
  5. ncbi request reprint Hepatocyte growth factor promotes cell survival by phosphorylation of BAD in gastric cancer cells
    Kyung Hee Lee
    Department of Hematology Oncology, College of Medicine, Yeungnam University, Daegu, Korea
    Oncol Res 17:23-32. 2008
    ..In conclusion, increases in BAD levels as well as BAD phosphoryation by HGF might contribute to HGF-mediated cell survival in NUGC-3 cells...
  6. pmc Reactive oxygen species regulate urokinase plasminogen activator expression and cell invasion via mitogen-activated protein kinase pathways after treatment with hepatocyte growth factor in stomach cancer cells
    Kyung Hee Lee
    Biochemistry and Molecular Biology, College of Medicine, Yeungnam University, Daegu, Korea
    J Exp Clin Cancer Res 28:73. 2009
    ..In this study, we investigated the underlying signal pathways in ROS-induced urokinase plasminogen activator (uPA) expression in the human gastric cancer cells, NUGC-3 and MKN-28...
  7. ncbi request reprint Regulation of hepatocyte growth factor-mediated urokinase plasminogen activator secretion by MEK/ERK activation in human stomach cancer cell lines
    Kyung Hee Lee
    Department of Hemato Oncology, College of Medicine, Yeungnam University, Daegu 705 717, Korea
    Exp Mol Med 38:27-35. 2006
    ..These results suggest that interaction of a MEK/ERK and a p38 kinase might play an important role in proliferation and invasiveness of stomach cancer cells...
  8. ncbi request reprint Cellular mechanisms of hepatocyte growth factor-mediated urokinase plasminogen activator secretion by MAPK signaling in hepatocellular carcinoma
    Kyung Hee Lee
    Department of Hemato Oncology, College of Medicine, Yeungnam University, Daegu, Republic of Korea
    Tumori 94:523-30. 2008
    ....
  9. ncbi request reprint Multicenter phase II study of weekly paclitaxel plus cisplatin combination chemotherapy in patients with advanced gastric cancer
    Jong Gwang Kim
    Department of Oncology Hematology, Kyungpook National University Hospital, Kyungpook National University School of Medicine, Daegu, Korea
    Cancer Chemother Pharmacol 60:863-9. 2007
    ....
  10. ncbi request reprint Role of hepatocyte growth factor/c-Met signaling in regulating urokinase plasminogen activator on invasiveness in human hepatocellular carcinoma: a potential therapeutic target
    Kyung Hee Lee
    Department of Hemato Oncology, College of Medicine, Yeungnam University, Daegu, Republic of Korea
    Clin Exp Metastasis 25:89-96. 2008
    ..These results suggest that hepatoma cells express functional c-Met, which may provide a target for a therapeutic basis to interfere with metastases of cancer cells by inhibiting uPA system-mediated proteolysis...
  11. ncbi request reprint Kiss-1 suppresses MMP-9 expression by activating p38 MAP kinase in human stomach cancer
    Kyung Hee Lee
    Department of Hematology Oncology, College of Medicine, Yeungnam University, Daegu, Korea
    Oncol Res 18:107-16. 2009
    ..Downregulation of Kiss-1 using Kiss-1 shRNA also increased in vitro cell invasion. In conclusion, Kiss-1 suppresses MMP-9 expression by activating the p38 MAP kinase signaling pathway...
  12. ncbi request reprint Hepatoma-derived growth factor regulates the bad-mediated apoptotic pathway and induction of vascular endothelial growth factor in stomach cancer cells
    Kyung Hee Lee
    Department of Hematology Oncology, College of Medicine, Yeungnam University, Daegu, Korea
    Oncol Res 19:67-76. 2010
    ..These qualities may contribute to the HDGF-associated aggressive biological behavior of gastric cancer and thus serve as a potential target for cancer therapy...
  13. doi request reprint Multicenter phase II trial of S-1, paclitaxel and cisplatin triplet combination chemotherapy in patients with advanced gastric cancer
    Jin Young Kim
    Department of Hematooncology, Dongsan Medical Center, Keimyung University School of Medicine, Jung ku, Daegu, 700 712, Korea
    Cancer Chemother Pharmacol 67:527-32. 2011
    ..The present study was conducted to evaluate the efficacy and safety of a combination regimen of S-1, paclitaxel plus cisplatin in patients with advanced gastric cancer...
  14. pmc Down-regulation of survivin suppresses uro-plasminogen activator through transcription factor JunB
    Kyung Hee Lee
    Department of Hematology Oncology, College of Medicine, Yeungnam University, Daegu 705 717, Korea
    Exp Mol Med 43:501-9. 2011
    ....
  15. pmc Clinical overview of extrapulmonary small cell carcinoma
    Kyeong Ok Kim
    Division of Oncology Hematology, Department of Medicine, Yeungnam University College of Medicine, Daegu, Korea
    J Korean Med Sci 21:833-7. 2006
    ..Combination chemotherapy plays a central role for treatment of extensive disease in EPSCC. Further multicenter studies are now needed to determine more details regarding disease sub-class and optimal treatment modality...
  16. ncbi request reprint Relationship between E-cadherin, matrix metalloproteinase-7 gene expression and clinicopathological features in gastric carcinoma
    Kyung Hee Lee
    Division of Hemato Oncology, Department of Medicine, Yeungnam University, Daegu, Korea
    Oncol Rep 16:823-30. 2006
    ..0025). Overexpression of MMP-7 may be considered as a useful marker for determining metastasis and the prognosis of human gastric carcinoma rather than the abnormal expression of E-cadherin...
  17. pmc Hepatocyte growth factor/c-met signaling in regulating urokinase plasminogen activator in human stomach cancer: A potential therapeutic target for human stomach cancer
    Kyung Hee Lee
    Department of Hemato Oncology, Yeungnam University College of Medicine, Daegu, Korea
    Korean J Intern Med 21:20-7. 2006
    ..However, the mechanisms by which HGF/c-Met signaling mediates cancer progression and metastasis are unclear...
  18. pmc Biweekly irinotecan and cisplatin as second-line chemotherapy in pretreated patients with advanced gastric cancer: a multicenter phase II study
    Jin Ho Baek
    Department of Oncology Hematology, Kyungpook National University Hospital, Daegu, Korea
    J Korean Med Sci 20:966-70. 2005
    ..Accordingly, this regimen can be regarded as an important second-line treatment option for advanced gastric cancer...
  19. ncbi request reprint Relationship between urokinase-type plasminogen receptor, interleukin-8 gene expression and clinicopathological features in gastric cancer
    Kyung Hee Lee
    Division of Hemato Oncology, Department of Internal Medicine, College of Medicine, Yeungnam University, Daegu, Korea
    Oncology 66:210-7. 2004
    ..Interleukin-8 (IL-8) acts as an angiogenic factor in solid cancer. The purpose of this study was to determine whether the expression of IL-8 and the uPAR gene correlates with clinicopathological parameters in human gastric carcinoma...
  20. pmc Reactive oxygen species regulate the generation of urokinase plasminogen activator in human hepatoma cells via MAPK pathways after treatment with hepatocyte growth factor
    Kyung Hee Lee
    Department of Hemato Oncology, College of Medicine, Yeungnam University, Daegu 705 717, Korea
    Exp Mol Med 41:180-8. 2009
    ..We found that HGF modulate Rac-1-regulated ROS production through activation of Akt and ROS regulates uPA production via MAP kinase, which provides a novel clue to clarify the mechanism underlying hepatoma progression...
  21. ncbi request reprint A phase II study of biweekly irinotecan and cisplatin for patients with extensive stage disease small cell lung cancer
    Sung Hwa Bae
    Department of Oncology Hematology, Daegu Catholic University Medical Center, Daegu Catholic University School of Medicine, Daegu, Republic of Korea
    Lung Cancer 59:76-80. 2008
    ..However, a 4-week cycle of irinotecan treatment can result in significant myelosuppression and diarrhea. Therefore, the present study was conducted to evaluate the efficacy and safety of biweekly IP in patients with ED SCLC...
  22. doi request reprint Hepatocyte growth factor-mediated gastrin-releasing peptide induces IL-8 expression through Ets-1 in gastric cancer cells
    Kyung Hee Lee
    Department of Hematology Oncology, College of Medicine, Yeungnam University, Daegu, Korea
    Oncol Res 20:393-402. 2013
    ..Downregulation of IL-8 also decreased in vitro cell invasion. In conclusion, HGF mediated the GRP induction of IL-8 expression through Ets-1, which thus might serve as a promising target for gastric cancer therapy. ..
  23. doi request reprint Gemcitabine and oxaliplatin combination as first-line treatment for advanced pancreatic cancer: a multicenter phase II study
    Kyung Hee Lee
    Division of Hemato Oncology, College of Medicine, Yeungnam University, Daegu, South Korea
    Cancer Chemother Pharmacol 64:317-25. 2009
    ..Gemcitabine is the only drug approved for single-agent therapy in advanced pancreatic carcinoma (APC). Gemcitabine-based combination chemotherapy has not yet shown promising results...
  24. ncbi request reprint Growth factor-dependent activation of the MAPK pathway in human pancreatic cancer: MEK/ERK and p38 MAP kinase interaction in uPA synthesis
    Kyung Hee Lee
    Department of Hemato Oncology, College of Medicine, Yeungnam University, Daegu, Korea
    Clin Exp Metastasis 20:499-505. 2003
    ..These results suggest that ERK activation by HGF might play important roles in the metastasis of pancreatic cancer and the p38 MAPK pathway also involved in the HGF-mediated uPA secretion and metastasis by regulation of ERK pathway...
  25. ncbi request reprint Effects of the proteasome inhibitor bortezomib alone and in combination with chemotherapeutic agents in gastric cancer cell lines
    Sung Hwa Bae
    Division of Hematology Oncology, Department of Internal Medicine, Daegu Catholic University College of Medicine, Daegu 705 717, Korea
    Oncol Rep 19:1027-32. 2008
    ....
  26. pmc The hematologic response to anti-apoptotic cytokine therapy: results of pentoxifylline, ciprofloxacin, and dexamethasone treatment for patients with myelodysplastic syndrome
    Min Kyoung Kim
    Department of Medicine, Yeungnam University College of Medicine, Daegu, Korea
    J Korean Med Sci 21:40-5. 2006
    ..These preliminary results indicate that anti-cytokine therapy with PCD is an effective and well tolerated palliative treatment for patients with MDS...
  27. doi request reprint Biological characterization of nodal versus extranodal presentation of diffuse large B-Cell lymphoma using immunohistochemistry
    Min Kyoung Kim
    Division of Hematology Oncology, Department of Internal Medicine, Yeungnam University College of Medicine, Daegu, Korea
    Clin Lymphoma Myeloma Leuk 11:403-8. 2011
    ..We evaluated the relationship between DLBCL clinicopathological features, including expression of B-cell differentiation markers, and primary tumor site...
  28. ncbi request reprint IL-1β-stimulated urokinase plasminogen activator expression through NF-κB in gastric cancer after HGF treatment
    Kyung Hee Lee
    Department of Hematology Oncology, College of Medicine, Yeungnam University, Daegu 705 717, Republic of Korea
    Oncol Rep 31:2123-30. 2014
    ..IL-1β stimulated uPA expression through ERK and NF-κB in gastric cancer, which may therefore be promising targets for gastric cancer therapy...
  29. ncbi request reprint Myelodysplastic syndrome with complex karyotypic abnormality in a patient with Waldenström's macroglobulinemia after sequential treatment with chlorambucil and fludarabine
    Sang Joon Shin
    Division of Oncology Hematology, Department of Internal Medicine, Yeungnam University College of Medicine, Daegu, Korea
    Jpn J Clin Oncol 35:622-5. 2005
    ..When decision is made to treat WM with chlorambucil and/or fludarabine, a potential risk for t-MDS or therapy-related acute myeloid leukemia should be considered and a close hematologic monitoring is needed...
  30. pmc The efficacy of paclitaxel and cisplatin combination chemotherapy for the treatment of metastatic or recurrent gastric cancer: a multicenter phase II study
    Sang Joon Shin
    Division of Oncology Hematology, Department of Internal Medicine, Yeungnam University College of Medicine, Daegu, Korea
    Korean J Intern Med 20:135-40. 2005
    ..We performed a prospective study on the combination chemotherapy of paclitaxel and cisplatin (PC). The primary objectives of the study were elucidating the disease response and evaluating the drug regimen's safety...
  31. doi request reprint VEGFA and VEGFR2 genetic polymorphisms and survival in patients with diffuse large B cell lymphoma
    Min Kyoung Kim
    Department of Internal Medicine, Yeungnam University College of Medicine, Daegu, Korea
    Cancer Sci 103:497-503. 2012
    ..The VEGFR2 rs1870377 polymorphism might affect survival in patients with DLBCL, suggesting that angiogenesis might be related to poor survival in these patients...
  32. pmc Therapeutic experience of Bing-Neel Syndrome associated with Waldenstrom's macroglobulinemia
    Hyun Do Kim
    Department of Internal Medicine, Yeoungnam University College of Medicine, Daegu, Korea
    J Korean Med Sci 22:1079-81. 2007
    ..A stereotactic biopsy of dural tissue from the falx was performed and showed plasmacytoid lymphocyte infiltration. The patient became symptom- free with irradiation of the whole brain followed by chemotherapy with fludarabine...
  33. pmc Randomized, Multicenter, Phase III Trial of Heptaplatin 1-hour Infusion and 5-Fluorouracil Combination Chemotherapy Comparing with Cisplatin and 5-Fluorouracil Combination Chemotherapy in Patients with Advanced Gastric Cancer
    Kyung Hee Lee
    College of Medicine, Yeungnam University, Daegu, Korea
    Cancer Res Treat 41:12-8. 2009
    ..There were no treatment-related deaths. CONCLUSION: Heptaplatin showed similar effects to cisplatin when combined with 5-FU in advanced gastric cancer patients with tolerable toxicities...
  34. ncbi request reprint Two cases of trisomy 19 as a sole chromosomal abnormality in myeloid disorders
    Soon Il Jung
    Department of Laboratory Medicine, Yeungnam University College of Medicine, Daegu, Korea
    Korean J Lab Med 28:174-8. 2008
    ....
  35. ncbi request reprint Clinical significance of vascular endothelial growth factor and vascular endothelial growth factor receptor-2 gene polymorphisms in patients with gastrointestinal stromal tumors
    Byung Woog Kang
    Department of Hematology Oncology, Kyungpook National University Hospital, Kyungpook National University School of Medicine, Daegu, South Korea
    Asia Pac J Clin Oncol 10:e40-5. 2014
    ..Accordingly, the present study analyzed the impact of VEGF and VEGF receptor-2 (VEGFR-2) gene polymorphisms on the prognosis for GIST patients...
  36. pmc A case of spine origin chondroblastoma metastasis to lung
    Se Hoon Sohn
    Division of Hematoocology, Department of Internal Medicine, College of Medicine, Yeungnam University, Daegu, Korea
    Cancer Res Treat 41:241-4. 2009
    ..And primary tumor site was also unusual. The histologic characteristics of the primary, metastatic tumors were those of a conventional chondroblastoma...
  37. ncbi request reprint Beneficial effects of rosmarinic acid on suppression of collagen induced arthritis
    Jeehee Youn
    Department of Anatomy and Cell Biology and Institute of Biomedical Science, College of Medicine, Hanyang University, Seoul, Korea
    J Rheumatol 30:1203-7. 2003
    ..To assess the therapeutic potential of rosmarinic acid (RosA) in an inflammatory autoimmune arthritis model...
  38. doi request reprint Bimodal actions of selenium essential for antioxidant and toxic pro-oxidant activities: the selenium paradox (Review)
    Kyung Hee Lee
    Department of Microbiology and Aging associated Vascular Disease Research Center, Yeungnam University College of Medicine, Daegu 705 717, Republic of Korea
    Mol Med Rep 5:299-304. 2012
    ..Collectively, selenium seems to have both harmful and beneficial attributes. The aim of this review is to summarize the various biological functions of selenium and to illustrate its opposite roles as a pro-oxidant and an antioxidant...
  39. pmc Meningeal relapse in a patient with acute promyelocytic leukemia: a case report and review of the literature
    Sung Hwa Bae
    Department of Internal Medicine, Daegu Catholic University College of Medicine, Daegu, Korea
    J Korean Med Sci 19:311-4. 2004
    ..The examination of cerebrospinal fluid showed the presence of promyelocyte. Bone marrow studies showed cytogenetic remission but with molecular relapse. He was treated with intrathecal and systemic chemotherapy...
  40. pmc A case of pulmonary inflammatory pseudotumor: Recurrence appearing as several consolidative lesions after complete resection
    Hong Lyeol Lee
    Department of Internal Medicine, College of Medicine, Inha University, Incheon, Korea
    Korean J Intern Med 20:168-72. 2005
    ..This is an unusual finding with regard to inflammatory pseudotumors...