Genomes and Genes


Inho Choi


Affiliation: Yeungnam University
Country: Korea


  1. Kim T, Ahmad K, Shaikh S, Jan A, Seo M, Lee E, et al. Dermatopontin in Skeletal Muscle Extracellular Matrix Regulates Myogenesis. Cells. 2019;8: pubmed publisher
    ..Taken together, our findings have determined the role of DPT at different stages of the myogenic process. ..
  2. Baig M, Rahman S, Rabbani G, Imran M, Ahmad K, Choi I. Multi-Spectroscopic Characterization of Human Serum Albumin Binding with Cyclobenzaprine Hydrochloride: Insights from Biophysical and In Silico Approaches. Int J Mol Sci. 2019;20: pubmed publisher
    ..The results of the molecular docking and molecular dynamics simulation studies also confirmed the stability of the complex and supported the experimental results. ..
  3. Jan A, Rahman S, Khan S, Tasduq S, Choi I. Biology, Pathophysiological Role, and Clinical Implications of Exosomes: A Critical Appraisal. Cells. 2019;8: pubmed publisher
    ..The present study presents diverse biological aspects of exosomes, and highlights their diagnostic and therapeutic potentials. ..
  4. Baig M, Rashid I, Srivastava P, Ahmad K, Jan A, Rabbani G, et al. NeuroMuscleDB: a Database of Genes Associated with Muscle Development, Neuromuscular Diseases, Ageing, and Neurodegeneration. Mol Neurobiol. 2019;: pubmed publisher
    ..NeuroMuscleDB is freely available on the web at and supports all major browsers. ..
  5. Ahmad K, Lee E, Moon J, Park S, Choi I. Multifaceted Interweaving Between Extracellular Matrix, Insulin Resistance, and Skeletal Muscle. Cells. 2018;7: pubmed publisher
    ..Understanding this complex interplay between the ECM, muscle, and IR may improve knowledge and help develop new ideas for novel therapeutics for several IR-associated myopathies and diabetes. ..
  6. Ashraf J, Shahab U, Tabrez S, Lee E, Choi I, Ahmad S. Quercetin as a finer substitute to aminoguanidine in the inhibition of glycation products. Int J Biol Macromol. 2015;77:188-92 pubmed publisher
    ..Inhibition in the formation of glycation has established that quercetin is a better and a more potent antiglycating agent than aminoguanidine at all stages of glycation. ..
  7. Lee E, Nam J, Choi I. Fibromodulin modulates myoblast differentiation by controlling calcium channel. Biochem Biophys Res Commun. 2018;503:580-585 pubmed publisher
    ..Summarizing, the study demonstrates ECM components secreted by myoblasts during differentiation provide an essential environment for muscle differentiation and regeneration. ..
  8. Baig M, Ahmad K, Saeed M, Alharbi A, Barreto G, Ashraf G, et al. Peptide based therapeutics and their use for the treatment of neurodegenerative and other diseases. Biomed Pharmacother. 2018;103:574-581 pubmed publisher
    ..The role of peptides as anti-cancer, antimicrobial and antidiabetic agents has also been discussed. ..
  9. Lee E, Jan A, Baig M, Ashraf J, Nahm S, Kim Y, et al. Fibromodulin: a master regulator of myostatin controlling progression of satellite cells through a myogenic program. FASEB J. 2016;30:2708-19 pubmed publisher
    ..Lee, E. J., Jan, A. T., Baig, M. H., Ashraf, J. M., Nahm, S.-S., Kim, Y.-W., Park, S.-Y., Choi, I. Fibromodulin: a master regulator of myostatin controlling progression of satellite cells through a myogenic program. ..

More Information


  1. Ashraf J, Shahab U, Tabrez S, Lee E, Choi I, Aslam Yusuf M, et al. DNA Glycation from 3-Deoxyglucosone Leads to the Formation of AGEs: Potential Role in Cancer Auto-antibodies. Cell Biochem Biophys. 2016;74:67-77 pubmed publisher
    ..The glycoxidative lesions were also detected in the lymphocyte DNA isolated from selected cancer patients. The results show structural perturbations in 3-DG-Arg-Fe(3+)-DNA generating new epitopes that render the molecule immunogenic. ..
  2. request reprint
    Baig M, Ahmad K, Roy S, Ashraf J, Adil M, Siddiqui M, et al. Computer Aided Drug Design: Success and Limitations. Curr Pharm Des. 2016;22:572-81 pubmed
    ..Finally, we discuss the principles and concepts of molecular docking, pharmacophores and other methods used in computer-aided drug design. ..
  3. Jan A, Azam M, Siddiqui K, Ali A, Choi I, Haq Q. Heavy Metals and Human Health: Mechanistic Insight into Toxicity and Counter Defense System of Antioxidants. Int J Mol Sci. 2015;16:29592-630 pubmed publisher
  4. Lee E, Pokharel S, Jan A, Huh S, Galope R, Lim J, et al. Transthyretin: A Transporter Protein Essential for Proliferation of Myoblast in the Myogenic Program. Int J Mol Sci. 2017;18: pubmed publisher
    ..The results of this study will be highly useful to the strategic development of novel therapeutics to combat muscular dystrophies. ..
  5. Baig M, Jan A, Rabbani G, Ahmad K, Ashraf J, Kim T, et al. Methylglyoxal and Advanced Glycation End products: Insight of the regulatory machinery affecting the myogenic program and of its modulation by natural compounds. Sci Rep. 2017;7:5916 pubmed publisher
    ..The findings of this study suggest enhanced AGE production and subsequent RAGE-AGE interaction obstruct the muscle development program, and that curcumin and gingerol attenuate the effect of AGEs on myoblasts. ..
  6. Baig M, Adil M, Khan R, Dhadi S, Ahmad K, Rabbani G, et al. Enzyme targeting strategies for prevention and treatment of cancer: Implications for cancer therapy. Semin Cancer Biol. 2017;: pubmed publisher
    ..This review indicates that the targeting of metabolic signaling offers a promising means of developing novel anti-cancer therapies. ..
  7. Rabbani G, Choi I. Roles of osmolytes in protein folding and aggregation in cells and their biotechnological applications. Int J Biol Macromol. 2018;109:483-491 pubmed publisher
  8. Ahmad S, Jan A, Baig M, Lee E, Choi I. Matrix gla protein: An extracellular matrix protein regulates myostatin expression in the muscle developmental program. Life Sci. 2017;172:55-63 pubmed publisher
  9. Jan A, Lee E, Choi I. Fibromodulin: A regulatory molecule maintaining cellular architecture for normal cellular function. Int J Biochem Cell Biol. 2016;80:66-70 pubmed publisher
    ..Thus, a clear view of the impact FMOD has on tissue integrity would aid its exploitation for tissue modelling and in the treatment of different disorders. ..
  10. Kamli M, Kim J, Pokharel S, Jan A, Lee E, Choi I. Expressional studies of the aldehyde oxidase (AOX1) gene during myogenic differentiation in C2C12 cells. Biochem Biophys Res Commun. 2014;450:1291-6 pubmed publisher
    ..Taken together, these findings suggest that AOX1 acts as a contributor to the process of myogenesis by influencing the level of H2O2. ..
  11. Rabbani G, Baig M, Jan A, Ju Lee E, Khan M, Zaman M, et al. Binding of erucic acid with human serum albumin using a spectroscopic and molecular docking study. Int J Biol Macromol. 2017;105:1572-1580 pubmed publisher
    ..The information generated in the study reflects greater pharmacological significance of EA and highlights its importance in the clinical medicine. ..
  12. Lee E, Jan A, Baig M, Ahmad K, Malik A, Rabbani G, et al. Fibromodulin and regulation of the intricate balance between myoblast differentiation to myocytes or adipocyte-like cells. FASEB J. 2018;32:768-781 pubmed publisher
    ..T., Baig, M. H., Ahmad, K., Malik, A., Rabbani, G., Kim, T., Lee, I.-K., Lee, Y. H., Park, S.-Y., Choi, I. Fibromodulin and regulation of the intricate balance between myoblast differentiation to myocytes or adipocyte-like cells. ..