Hyukjae Choi


Affiliation: Yeungnam University
Country: Korea


  1. Ku S, Jeong S, Yang S, Kim K, Choi H, Bae J. Suppressive effects of collismycin C on polyphosphate-mediated vascular inflammatory responses. Fitoterapia. 2019;134:447-453 pubmed publisher
    ..In conclusion, based on the anti-inflammatory effects of collismycins C in PolyP-mediated septic response, collismycins C have therapeutic potential for various systemic inflammatory diseases. ..
  2. Le T, Lee E, Lee J, Hong A, Yim C, Yang I, et al. Saccharoquinoline, a Cytotoxic Alkaloidal Meroterpenoid from Marine-Derived Bacterium Saccharomonospora sp. Mar Drugs. 2019;17: pubmed publisher
    ..Saccharoquinoline (1) was found to have cytotoxicity against the HCT-116 cancer cell line by inducing G1 arrest, which leads to cell growth inhibition. ..
  3. Yang I, Lee J, Lee J, Hahn D, Chin J, Won D, et al. Scalalactams A⁻D, Scalarane Sesterterpenes with a γ-Lactam Moiety from a Korean Spongia Sp. Marine Sponge. Molecules. 2018;23: pubmed publisher
    ..Scalalactams A⁻D (14) did not show FXR antagonistic activity nor cytotoxicity up to 100 μM. ..
  4. Kang K, Gao M, Kim G, Choi H, Sung S. Rhamnellosides A and B, ω-Phenylpentaene Fatty Acid Amide Diglycosides from the Fruits of Rhamnella franguloides. Molecules. 2018;23: pubmed publisher
    ..The pentaene groups of 1 and 2 were found to have (6E, 8E, 10Z, 12Z, 14E)-geometry, which is the same as that found in berchemioside A. ..
  5. Kim D, Lee E, Lee J, Leutou A, Shin Y, Choi B, et al. Antartin, a Cytotoxic Zizaane-Type Sesquiterpenoid from a Streptomyces sp. Isolated from an Antarctic Marine Sediment. Mar Drugs. 2018;16: pubmed publisher
    ..Antartin (1) showed cytotoxicity against A549, H1299, and U87 cancer cell lines by causing cell cycle arrest at the G1 phase. ..
  6. Choi H, Oh D. Considerations of the chemical biology of microbial natural products provide an effective drug discovery strategy. Arch Pharm Res. 2015;38:1591-605 pubmed publisher
  7. Jung B, Ku S, Gao M, Kim K, Han M, Choi H, et al. Suppressive effects of three diketopiperazines from marine-derived bacteria on TGFBIp-mediated septic responses in human endothelial cells and mice. Arch Pharm Res. 2016;39:843-54 pubmed publisher
    ..Therefore, 1-3 could be a potential therapeutic agent for treatment of various severe vascular inflammatory diseases via inhibition of the TGFBIp signaling pathway. ..
  8. Kim G, Lee J, Choi H, Kim S, Kim E, Shim S, et al. Cinnamomulactone, a new butyrolactone from the twigs of Cinnamomum cassia and its inhibitory activity of matrix metalloproteinases. Arch Pharm Res. 2017;40:304-310 pubmed publisher
    ..Among them, compound 1 has been revealed to suppress the gene expression of MMP-3 and interleukin (IL)-1? as well as MMP-1 in tumor necrosis factor (TNF)-? stimulated rheumatoid arthritis synovial fibroblasts. ..
  9. Yoon J, Kim S, Park S, Choi H. Characterization of Marinovum faecis sp. nov., an alphaproteobacterium isolated from marine sediment. Antonie Van Leeuwenhoek. 2017;110:963-969 pubmed publisher
    ..nov. is proposed. The type strain of M. faecis sp. nov. is YP194T (= KCCM 90263T = NBRC 111905T). ..

More Information


  1. Le T, Yim C, Park S, Katila N, Yang I, Song M, et al. Lodopyridones B and C from a marine sediment-derived bacterium Saccharomonospora sp. Bioorg Med Chem Lett. 2017;27:3123-3126 pubmed publisher
    ..Lodopyridones A-C show weak inhibitory activities on the ?-site amyloid precursor protein cleaving enzyme 1 (BACE1). ..
  2. Li L, Sapkota M, Gao M, Choi H, Soh Y. Macrolactin F inhibits RANKL-mediated osteoclastogenesis by suppressing Akt, MAPK and NFATc1 pathways and promotes osteoblastogenesis through a BMP-2/smad/Akt/Runx2 signaling pathway. Eur J Pharmacol. 2017;815:202-209 pubmed publisher
    ..Taken together, these results indicate that MF may be useful as a therapeutic agent to enhance bone health and treat osteoporosis. ..
  3. Lee J, Kim E, Choi H, Lee J. Collismycin C from the Micronesian Marine Bacterium Streptomyces sp. MC025 Inhibits Staphylococcus aureus Biofilm Formation. Mar Drugs. 2017;15: pubmed publisher
    ..The antibiofilm activity of collismycin C was speculated to be related to iron acquisition and the presence and position of the hydroxyl group of 2,2'-bipyridines. ..