Rina Yu

Summary

Affiliation: University of Ulsan
Country: Korea

Publications

  1. doi request reprint Inflammatory components of adipose tissue as target for treatment of metabolic syndrome
    Rina Yu
    Department of Food Science and Nutrition, University of Ulsan, Ulsan, South Korea
    Forum Nutr 61:95-103. 2009
  2. ncbi request reprint Mesenteric adipose tissue-derived monocyte chemoattractant protein-1 plays a crucial role in adipose tissue macrophage migration and activation in obese mice
    Rina Yu
    Department of Food Science and Nutrition, University of Ulsan, Ulsan 680 749, Korea
    Obesity (Silver Spring) 14:1353-62. 2006
  3. ncbi request reprint Involvement of leukotactin-1, a novel CC chemokine, in human atherosclerosis
    Rina Yu
    Department of Food Science and Nutrition, University of Ulsan, Ulsan 680 749, South Korea
    Atherosclerosis 174:35-42. 2004
  4. doi request reprint HVEM-deficient mice fed a high-fat diet are protected from adipose tissue inflammation and glucose intolerance
    Ha Jung Kim
    Department of Food Science and Nutrition, University of Ulsan, Ulsan, South Korea
    FEBS Lett 585:2285-90. 2011
  5. doi request reprint Dietary capsaicin attenuates metabolic dysregulation in genetically obese diabetic mice
    Ji Hye Kang
    Department of Food Science and Nutrition, University of Ulsan, Nam Ku, Ulsan, Republic of Korea
    J Med Food 14:310-5. 2011
  6. doi request reprint Dietary capsaicin reduces obesity-induced insulin resistance and hepatic steatosis in obese mice fed a high-fat diet
    Ji Hye Kang
    Department of Food Science and Nutrition, University of Ulsan, Ulsan, South Korea
    Obesity (Silver Spring) 18:780-7. 2010
  7. ncbi request reprint Active spice-derived components can inhibit inflammatory responses of adipose tissue in obesity by suppressing inflammatory actions of macrophages and release of monocyte chemoattractant protein-1 from adipocytes
    Hae Mi Woo
    Department of Food Science and Nutrition, University of Ulsan, Mugeo dong, Nam Ku, Ulsan, South Korea
    Life Sci 80:926-31. 2007
  8. ncbi request reprint Capsaicin, a spicy component of hot peppers, modulates adipokine gene expression and protein release from obese-mouse adipose tissues and isolated adipocytes, and suppresses the inflammatory responses of adipose tissue macrophages
    Ji Hye Kang
    Department of Food Science and Nutrition, University of Ulsan, Ulsan 680 749, South Korea
    FEBS Lett 581:4389-96. 2007
  9. pmc 4-1BB/4-1BBL interaction promotes obesity-induced adipose inflammation by triggering bidirectional inflammatory signaling in adipocytes/macrophages
    Thai Hien Tu
    Department of Food Science and Nutrition, University of Ulsan, Ulsan, Republic of Korea
    Mediators Inflamm 2012:972629. 2012
  10. doi request reprint Topical application of capsaicin reduces visceral adipose fat by affecting adipokine levels in high-fat diet-induced obese mice
    Gong Rak Lee
    Department of Medical Science, School of Medicine, University of Ulsan, Ulsan, Korea
    Obesity (Silver Spring) 21:115-22. 2013

Collaborators

  • Hoon Yoo
  • Mi Kyung Sung
  • Hyun Ju Kim
  • Sung Nim Han
  • Myung Sook Choi
  • Hong Rae Cho
  • Nobuyuki Takahashi
  • Shizuka Hirai
  • Byoung S Kwon
  • Chu Sook Kim
  • Teruo Kawada
  • Ji Hye Kang
  • Byung Sam Kim
  • Thai Hien Tu
  • In Seob Han
  • Woon Ki Kim
  • Jae Hee Suh
  • Hye Seon Choi
  • Tsuyoshi Goto
  • Eun Kyung Choi
  • Ngoc Hoan Le
  • Ok Joo Sul
  • Seong A Ju
  • Eun Sook Kim
  • Quang Tam Nguyen
  • Gong Rak Lee
  • Yea Sol Lee
  • Hye Sun Choi
  • Byung Ju Lee
  • Goto Tsuyoshi
  • Jun Young Park
  • So Ra Oh
  • Han Sam Lee
  • Tae Wook Kyung
  • Sang Hee Kwon
  • Suck Young Choe
  • Hae Mi Woo
  • Jeong Sang Kim
  • Hye Soon Park
  • Byung S Youn
  • Tadao Kurata
  • Yun Kyung Park
  • Ah Ram Kim
  • Sang Chul Lee
  • Taesun Park
  • Jung Han Yoon Park
  • Thu Ha T Nguyen
  • Yeon Kyung Park
  • Neung Hwa Park
  • Dong Joon Yoon
  • Gyu Yeol Kim
  • Mi Kyung Shin
  • Jun Hyeong Bae
  • Sang Min Park
  • Sunhye Shin
  • Won G An
  • Kawada Teruo
  • Choon Soo Jeong
  • Shin Yoon Kim
  • Mi Hyun Lee
  • Jae Geun Kim
  • Kent L Erickson
  • Hoan Le Ngoc
  • Hye Ji Noh
  • Ki Up Lee
  • Thomas N Blankenship
  • Youn Young Kim
  • Young Min Kim
  • Jin Hee Park
  • Tien Van Phan
  • Ji Eun Lee
  • Min Sook Kang
  • Taku Uemura
  • In Hee Han
  • Young Gyun Kim
  • Young Kyoon Kim
  • Jung Yul Park
  • Mi Ock Kim
  • Kyong Soo Park
  • Sung Shik Min
  • Tohru Fushiki
  • Hyeon W Lee
  • Won Hyung Park

Detail Information

Publications37

  1. doi request reprint Inflammatory components of adipose tissue as target for treatment of metabolic syndrome
    Rina Yu
    Department of Food Science and Nutrition, University of Ulsan, Ulsan, South Korea
    Forum Nutr 61:95-103. 2009
    ..In particular, we focus on the hypothesis that anti-inflammatory food factors/phytochemicals may be useful for inhibiting the initiation and development of obesity-induced inflammation and metabolic syndrome...
  2. ncbi request reprint Mesenteric adipose tissue-derived monocyte chemoattractant protein-1 plays a crucial role in adipose tissue macrophage migration and activation in obese mice
    Rina Yu
    Department of Food Science and Nutrition, University of Ulsan, Ulsan 680 749, Korea
    Obesity (Silver Spring) 14:1353-62. 2006
    ..To determine whether chemokines, which play a pivotal role in monocyte/macrophage trafficking, modulate macrophage infiltration into and activation in the adipose tissues...
  3. ncbi request reprint Involvement of leukotactin-1, a novel CC chemokine, in human atherosclerosis
    Rina Yu
    Department of Food Science and Nutrition, University of Ulsan, Ulsan 680 749, South Korea
    Atherosclerosis 174:35-42. 2004
    ..Lkn-1 stimulated endothelial cells to release ICAM-1, which is implicated in atherogenesis. Taken together, our data suggest that Lkn-1 plays an important role in the development of atherosclerosis...
  4. doi request reprint HVEM-deficient mice fed a high-fat diet are protected from adipose tissue inflammation and glucose intolerance
    Ha Jung Kim
    Department of Food Science and Nutrition, University of Ulsan, Ulsan, South Korea
    FEBS Lett 585:2285-90. 2011
    ..These findings indicate that HVEM may be a useful target for combating obesity-induced inflammatory responses and insulin resistance...
  5. doi request reprint Dietary capsaicin attenuates metabolic dysregulation in genetically obese diabetic mice
    Ji Hye Kang
    Department of Food Science and Nutrition, University of Ulsan, Nam Ku, Ulsan, Republic of Korea
    J Med Food 14:310-5. 2011
    ..Capsaicin may be useful as a dietary factor for reducing obesity-related metabolic dysregulation...
  6. doi request reprint Dietary capsaicin reduces obesity-induced insulin resistance and hepatic steatosis in obese mice fed a high-fat diet
    Ji Hye Kang
    Department of Food Science and Nutrition, University of Ulsan, Ulsan, South Korea
    Obesity (Silver Spring) 18:780-7. 2010
    ..The effects of capsaicin in adipose tissue and liver are related to its dual action on PPARalpha and TRPV-1 expression/activation...
  7. ncbi request reprint Active spice-derived components can inhibit inflammatory responses of adipose tissue in obesity by suppressing inflammatory actions of macrophages and release of monocyte chemoattractant protein-1 from adipocytes
    Hae Mi Woo
    Department of Food Science and Nutrition, University of Ulsan, Mugeo dong, Nam Ku, Ulsan, South Korea
    Life Sci 80:926-31. 2007
    ..These spice-derived components may have a potential to improve chronic inflammatory conditions in obesity...
  8. ncbi request reprint Capsaicin, a spicy component of hot peppers, modulates adipokine gene expression and protein release from obese-mouse adipose tissues and isolated adipocytes, and suppresses the inflammatory responses of adipose tissue macrophages
    Ji Hye Kang
    Department of Food Science and Nutrition, University of Ulsan, Ulsan 680 749, South Korea
    FEBS Lett 581:4389-96. 2007
    ..Capsaicin may be a useful phytochemical for attenuating obesity-induced inflammation and obesity-related complications...
  9. pmc 4-1BB/4-1BBL interaction promotes obesity-induced adipose inflammation by triggering bidirectional inflammatory signaling in adipocytes/macrophages
    Thai Hien Tu
    Department of Food Science and Nutrition, University of Ulsan, Ulsan, Republic of Korea
    Mediators Inflamm 2012:972629. 2012
    ..These findings indicate that 4-1BB/4-1BBL-mediated bidirectional signaling in adipocytes/macrophages promotes adipose inflammation. 4-1BB and 4-1BBL may be useful targets for protection against obesity-induced adipose inflammation...
  10. doi request reprint Topical application of capsaicin reduces visceral adipose fat by affecting adipokine levels in high-fat diet-induced obese mice
    Gong Rak Lee
    Department of Medical Science, School of Medicine, University of Ulsan, Ulsan, Korea
    Obesity (Silver Spring) 21:115-22. 2013
    ..In this study, we determined whether topical application of capsaicin can reduce fat accumulation in visceral adipose tissues...
  11. ncbi request reprint Soybean saponin inhibits tumor cell metastasis by modulating expressions of MMP-2, MMP-9 and TIMP- 2
    Ji Hye Kang
    Department of Food Science and Nutrition, University of Ulsan, Mugeo dong, Nam Ku, Ulsan 680 749, Republic of Korea
    Cancer Lett 261:84-92. 2008
    ....
  12. pmc Deficiency for costimulatory receptor 4-1BB protects against obesity-induced inflammation and metabolic disorders
    Chu Sook Kim
    Department of Food Science and Nutrition, University of Ulsan, Ulsan, South Korea
    Diabetes 60:3159-68. 2011
    ..Both 4-1BB and 4-1BBL have been shown to play an important role in the pathogenesis of various inflammatory diseases...
  13. doi request reprint Chemokine and chemokine receptor gene expression in the mesenteric adipose tissue of KKAy mice
    Han Sam Lee
    Department of Biological Sciences and Immunomodulation Research Center, University of Ulsan, Nam Ku Moogu Dong San29, Ulsan 680 749, Republic of Korea
    Cytokine 46:160-5. 2009
    ..To investigate chemokines and their receptors gene expression in the intra-abdominal adipose tissue of diabetic/obese mice...
  14. doi request reprint The immune signaling molecule 4-1BB stimulation reduces adiposity, insulin resistance, and hepatosteatosis in obese mice
    Chu Sook Kim
    Department of Food Science and Nutrition, University of Ulsan, Mugeo dong, Nam Ku, Ulsan 680 749, South Korea
    Endocrinology 151:4725-35. 2010
    ..Manipulation of 4-1BB may provide a unique immunological strategy against obesity and metabolic disorders...
  15. ncbi request reprint Capsaicin inhibits the production of tumor necrosis factor alpha by LPS-stimulated murine macrophages, RAW 264.7: a PPARgamma ligand-like action as a novel mechanism
    Jun Young Park
    Department of Food Science and Nutrition, University of Ulsan, Ulsan 680 749, Republic of Korea
    FEBS Lett 572:266-70. 2004
    ..7 cells, indicating that capsaicin acts like a ligand for PPARgamma. Our data demonstrate for the first time that the anti-inflammatory action of capsaicin may be mediated by PPARgamma activation in LPS-stimulated RAW 264.7 cells...
  16. ncbi request reprint Capsaicin, a spicy component of hot pepper, induces apoptosis by activation of the peroxisome proliferator-activated receptor gamma in HT-29 human colon cancer cells
    Chu Sook Kim
    Department of Food Science and Nutrition, University of Ulsan, Ulsan
    J Med Food 7:267-73. 2004
    ..Capsaicin may have a beneficial effect for the treatment of colon cancer...
  17. ncbi request reprint Macrophage inflammatory protein-related protein-2, a novel CC chemokine, can regulate preadipocyte migration and adipocyte differentiation
    Chu Sook Kim
    Department of Food Science and Nutrition, University of Ulsan, Mugeo dong, Nam Ku, Ulsan 680 749, South Korea
    FEBS Lett 548:125-30. 2003
    ..MRP-2 may be another adipocytokine, which can be involved in the adipocyte-related pathological process...
  18. ncbi request reprint Soybean saponins suppress the release of proinflammatory mediators by LPS-stimulated peritoneal macrophages
    Ji Hye Kang
    Department of Food Science and Nutrition, University of Ulsan, Mugeo dong, Nam Ku, Ulsan 680 749, South Korea
    Cancer Lett 230:219-27. 2005
    ..The anti-inflammatory properties of soybean saponins may be useful for ameliorating inflammatory diseases as well as suppressing tumor progression...
  19. ncbi request reprint Absence of herpes virus entry mediator (HVEM) increases bone mass by attenuating receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclastogenesis
    Woon Ki Kim
    Department of Biological Sciences, University of Ulsan, Ulsan 680 749, Korea
    Endocrinology 153:4808-17. 2012
    ..The higher bone mass in the femurs of HVEM-knockout mice could be, at least in part, due to attenuated osteoclastogenesis and bone resorption resulting from decreased receptor activator of nuclear factor-κB ligand signaling in the OC...
  20. doi request reprint Blockade of 4-1BB and 4-1BBL Interaction Reduces Obesity-Induced Skeletal Muscle Inflammation
    Ngoc Hoan Le
    Department of Food Science and Nutrition, University of Ulsan, Ulsan 680 749, Republic of Korea
    Mediators Inflamm 2013:865159. 2013
    ..Therefore, 4-1BB and 4-1BBL may be useful targets for prevention of obesity-induced inflammation in skeletal muscle. ..
  21. doi request reprint LIGHT/TNFSF14 enhances adipose tissue inflammatory responses through its interaction with HVEM
    Hong Min Kim
    Department of Biological Science, University of Ulsan, Nam Ku, Ulsan, South Korea
    FEBS Lett 585:579-84. 2011
    ..These findings indicate that sLIGHT enhances adipose tissue inflammatory responses through its interaction with HVEM...
  22. doi request reprint TNFRSF14 deficiency protects against ovariectomy-induced adipose tissue inflammation
    Eun Kyung Choi
    Department of Biological Sciences, University of Ulsan, Ulsan 680 749, Korea Department of Endocrinology, Ulsan University Hospital, Ulsan 682 714, Korea Department of Pathology, Ulsan University Hospital, Ulsan 682 714, Korea Department of Food Science and Nutrition, University of Ulsan, Ulsan 680 749, Korea
    J Endocrinol 220:25-33. 2014
    ..TNFRSF14 could be used as a therapeutic target for the treatment of postmenopausal syndrome by reducing AT inflammation. ..
  23. pmc CD137 expressed on neutrophils plays dual roles in antibacterial responses against Gram-positive and Gram-negative bacterial infections
    Quang Tam Nguyen
    Department of Biological Sciences, University of Ulsan, Ulsan, Republic of Korea
    Infect Immun 81:2168-77. 2013
    ..Our data strongly suggest that CD137 may play a dual role in sepsis in association with TLRs...
  24. ncbi request reprint Alteration of a macrophages inflammatory protein-related protein-2 (MRP-2) response by high fat and cholesterol diet in mice
    Rina Yu
    Department of Food Science and Nutrition, University of Ulsan, Mugeo dong Nam ku, Ulsan 680 749, South Korea
    Life Sci 70:2535-45. 2002
    ..These results suggest that MRP-2 may be an important contributing factor in the development of atherosclerosis...
  25. pmc Monocyte chemoattractant protein-1 deficiency attenuates oxidative stress and protects against ovariectomy-induced chronic inflammation in mice
    Woon Ki Kim
    Department of Biological Sciences, University of Ulsan, Ulsan, Korea
    PLoS ONE 8:e72108. 2013
    ..Monocyte chemoattractant protein-1 (MCP-1, C-C chemokine ligand 2) plays critical roles in the development of inflammation, but its role in ovariectomy (OVX)-induced metabolic disturbance has not been known...
  26. doi request reprint Potential involvement of CCL23 in atherosclerotic lesion formation/progression by the enhancement of chemotaxis, adhesion molecule expression, and MMP-2 release from monocytes
    Chu Sook Kim
    Department of Food Science and Nutrition, University of Ulsan, Ulsan, 680 749, South Korea
    Inflamm Res 60:889-95. 2011
    ..In the present study, we investigated the role of CCL23 in the development of human atherosclerosis, which is characterized by an inflammatory disease...
  27. doi request reprint Diet enriched with korean pine nut oil improves mitochondrial oxidative metabolism in skeletal muscle and brown adipose tissue in diet-induced obesity
    Ngoc Hoan Le
    Department of Food Science and Nutrition, University of Ulsan, Ulsan 680 749, South Korea
    J Agric Food Chem 60:11935-41. 2012
    ..Our findings suggest that PNO may have potential as a dietary supplement for counteracting obesity and metabolic dysregulation...
  28. doi request reprint Osteoclastogenesis by bone marrow-derived macrophages is enhanced in obese mice
    Tae Wook Kyung
    Department of Biological Sciences BK21 Program and the Immunomodulation Research Center, University of Ulsan, Ulsan 680 749, Korea
    J Nutr 139:502-6. 2009
    ..Our results suggest that obesity is associated with bone loss via enhanced osteoclastogenesis due to reduced IL-10 production by the BMM from obese mice...
  29. pmc Saturated fatty acids enhance osteoclast survival
    So Ra Oh
    Department of Biological Sciences BK21 Program, University of Ulsan, Ulsan 680 749, Korea
    J Lipid Res 51:892-9. 2010
    ..SFA caused the production of MIP-1alpha and led to activation of nuclear factor (NF)-kappaB in the OC. The absence of Toll-like receptor 4 (TLR4) or myeloid differentiation factor 88 (MyD88) abolished the survival effect of SFA on OC...
  30. ncbi request reprint Capsaicin exhibits anti-inflammatory property by inhibiting IkB-a degradation in LPS-stimulated peritoneal macrophages
    Chu Sook Kim
    Department of Food Science and Nutrition, University of Ulsan, Mugeo dong, Nam Ku, Ulsan 680 749, South Korea
    Cell Signal 15:299-306. 2003
    ..Both capsaicin and capsazepine may be a promising drug candidates for ameliorating inflammatory diseases and cancer...
  31. doi request reprint Administration of 6-gingerol greatly enhances the number of tumor-infiltrating lymphocytes in murine tumors
    Seong A Ju
    Biomedical Research Center, Ulsan University Hospital, College of Medicine, University of Ulsan, Ulsan, Republic of Korea
    Int J Cancer 130:2618-28. 2012
    ..Our results strongly suggest that 6-gingerol can be used in tumor immunotherapy to increase the number of TILs...
  32. pmc Chemokine Lkn-1/CCL15 enhances matrix metalloproteinase-9 release from human macrophages and macrophage-derived foam cells
    Sang Hee Kwon
    Department of Food Science and Nutrition, University of Ulsan, Ulsan 680 749, Korea
    Nutr Res Pract 2:134-7. 2008
    ..Our data suggest that the action of Lkn-1/CCL15 on macrophages and foam cells to release MMP-9 may contribute to plaque destabilization in the progression of atherosclerosis...
  33. ncbi request reprint Relationship of obesity and visceral adiposity with serum concentrations of CRP, TNF-alpha and IL-6
    Hye Soon Park
    Department of Family Medicine, Asan Medical Center, University of Ulsan College of Medicine, 388 1 Pungnap dong, Songpa Gu, Seoul 138 736, South Korea
    Diabetes Res Clin Pract 69:29-35. 2005
    ..To investigate the relationship between serum concentrations of the cytokines C-reactive protein (CRP), tumor necrosis factor (TNF)-alpha, and interleukin (IL)-6, and obesity and visceral adiposity...
  34. ncbi request reprint Inhibitory effect of naringenin chalcone on inflammatory changes in the interaction between adipocytes and macrophages
    Shizuka Hirai
    Laboratory of Molecular Function of Food, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Gokasho, Uji, Kyoto 611 0011, Japan
    Life Sci 81:1272-9. 2007
    ..Naringenin chalcone may be useful for ameliorating the inflammatory changes in obese adipose tissue...
  35. ncbi request reprint Abietic acid activates peroxisome proliferator-activated receptor-gamma (PPARgamma) in RAW264.7 macrophages and 3T3-L1 adipocytes to regulate gene expression involved in inflammation and lipid metabolism
    Nobuyuki Takahashi
    Laboratory of Nutrition Chemistry, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto 606 8502, Japan
    FEBS Lett 550:190-4. 2003
    ..The present work suggests a novel possibility that abietic acid, a naturally occurring compound, can be used not only for anti-inflammation but also for regulating lipid metabolism and atherosclerosis...
  36. ncbi request reprint The role of adipocytokines in adipocyte-related pathological processes
    Byung S Youn
    KOMED Institute for Life Science, Korea University, Seoul, Korea
    Drug News Perspect 17:293-8. 2004
    ..In this review, we summarize recent advances in understanding the roles of adiponectin and resistin in the causation of metabolic diseases and consider the prospects for treating metabolic disorders by targeting these two adipocytokines...
  37. ncbi request reprint Dietary regulation of nuclear receptors in obesity-related metabolic syndrome
    Teruo Kawada
    Kyoto University, Laboratory of Molecular Function of Food, Division of Food Science and Biotechnology, Graduate School of Agriculture, Uji, Kyoto 611 0011, Japan
    Asia Pac J Clin Nutr 17:126-30. 2008
    ..These findings indicate that dietary factor acts as an agonist of PPARs and is a valuable medical and food component for the gradual improvement of metabolic syndrome...