Joo Yong Lee
Affiliation: University of Ulsan
Beck M, Oh S, Kerr R, Lee H, Kim S, Kim S, et al
. A rationally designed small molecule for identifying an in vivo link between metal-amyloid-? complexes and the pathogenesis of Alzheimer's disease. Chem Sci. 2015;6:1879-1886 pubmed publisher
Lee J, Son H, Choi J, Cho E, Kim J, Chung S, et al
. Cytosolic labile zinc accumulation in degenerating dopaminergic neurons of mouse brain after MPTP treatment. Brain Res. 2009;1286:208-14 pubmed publisher
..These findings support the supposition that cytosolic labile zinc accumulation is an indicator of degenerating dopaminergic neurons in animal models of Parkinson's disease. ..
Lee J, Oh S, Hwang J, Suh N, Jo D, Kim J, et al
. Indomethacin preconditioning induces ischemic tolerance by modifying zinc availability in the brain. Neurobiol Dis. 2015;81:186-95 pubmed publisher
..Therefore, indomethacin preconditioning can modulate intracellular zinc availability, contributing to ischemic tolerance in the brain after stroke. ..
Kim M, Oh S, Kim J, Kim K, Ryu H, Kim M, et al
. Association of metals with the risk and clinical characteristics of Parkinson's disease. Parkinsonism Relat Disord. 2018;55:117-121 pubmed publisher
..This clinical study suggests significant associations between serum metal levels and PD risk or essential clinical features, demonstrating the possible roles of metals in PD pathogenesis or symptom development. ..
Lee J, Kweon H, Cho E, Lee J, Byun H, Kim D, et al
. Upregulation of tPA/plasminogen proteolytic system in the periphery of amyloid deposits in the Tg2576 mouse model of Alzheimer's disease. Neurosci Lett. 2007;423:82-7 pubmed
..These results suggest that the assembled Abeta42 may promote upregulation of the tPA/plasminogen proteolytic system, which can modulate the deposition of amyloid plaques in vivo. ..
Bi Oh S, Suh N, Kim I, Lee J. Impacts of aging and amyloid-Î² deposition on plasminogen activators and plasminogen activator inhibitor-1 in the Tg2576 mouse model of Alzheimer's disease. Brain Res. 2015;1597:159-67 pubmed publisher
Lee J, Cho E, Ko Y, Kim I, Lee K, Kwon S, et al
. Ibudilast, a phosphodiesterase inhibitor with anti-inflammatory activity, protects against ischemic brain injury in rats. Brain Res. 2012;1431:97-106 pubmed publisher
..Expression of various inflammatory mediator molecules in both hemispheres was markedly suppressed by ibudilast. We conclude that ibudilast exerts beneficial effects against acute brain ischemia in an animal model. ..
Lee J, Kim J, Byun H, Palmiter R, Koh J. Dependence of the histofluorescently reactive zinc pool on zinc transporter-3 in the normal brain. Brain Res. 2011;1418:12-22 pubmed publisher
..Thus, the physiological activity of free zinc in the normal brain might largely depend on the pool of synaptic vesicle zinc that is determined by ZnT3. ..