Hun Sik Kim

Summary

Affiliation: University of Ulsan
Country: Korea

Publications

  1. ncbi request reprint Role of pancreatic β-cell death and cell death-associated inflammation in diabetes
    M S Lee
    Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Curr Mol Med 12:1297-310. 2012
  2. doi request reprint Complementary phosphorylation sites in the adaptor protein SLP-76 promote synergistic activation of natural killer cells
    Hun Sik Kim
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    Sci Signal 5:ra49. 2012
  3. doi request reprint A defect in cell death of macrophages is a conserved feature of nonobese diabetic mouse
    Hun Sik Kim
    Department of Medicine, Graduate School, University of Ulsan, South Korea
    Biochem Biophys Res Commun 421:145-51. 2012
  4. ncbi request reprint Essential role for signal transducer and activator of transcription-1 in pancreatic beta-cell death and autoimmune type 1 diabetes of nonobese diabetic mice
    Sunshin Kim
    Department of Medicine, Samsung Medical Center, 50 Irwon dong Kangnam ku, Seoul 135 710, Korea
    Diabetes 56:2561-8. 2007
  5. ncbi request reprint Toll-like receptor 2 senses beta-cell death and contributes to the initiation of autoimmune diabetes
    Hun Sik Kim
    Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135 710, Korea
    Immunity 27:321-33. 2007
  6. pmc NF-kappa B prevents beta cell death and autoimmune diabetes in NOD mice
    Sunshin Kim
    Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Irwon dong, Kangnam Ku, Seoul, Korea
    Proc Natl Acad Sci U S A 104:1913-8. 2007
  7. ncbi request reprint Role of innate immunity in triggering and tuning of autoimmune diabetes
    Hun Sik Kim
    Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Curr Mol Med 9:30-44. 2009
  8. ncbi request reprint IFN-gamma sensitizes MIN6N8 insulinoma cells to TNF-alpha-induced apoptosis by inhibiting NF-kappaB-mediated XIAP upregulation
    Hun Sik Kim
    Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
    Biochem Biophys Res Commun 336:847-53. 2005
  9. pmc Synergistic signals for natural cytotoxicity are required to overcome inhibition by c-Cbl ubiquitin ligase
    Hun Sik Kim
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institute of Health, Rockville, MD 20852, USA
    Immunity 32:175-86. 2010
  10. doi request reprint Role of TLR2 in the pathogenesis of autoimmune diabetes and its therapeutic implication
    Myung Shik Lee
    Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Diabetes Metab Res Rev 27:797-801. 2011

Collaborators

Detail Information

Publications13

  1. ncbi request reprint Role of pancreatic β-cell death and cell death-associated inflammation in diabetes
    M S Lee
    Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Curr Mol Med 12:1297-310. 2012
    ..We also discuss the role of dying β-cells in the control of inflammation which contributes to the pathogenesis of diabetes...
  2. doi request reprint Complementary phosphorylation sites in the adaptor protein SLP-76 promote synergistic activation of natural killer cells
    Hun Sik Kim
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    Sci Signal 5:ra49. 2012
    ..Together, these data suggest that combined phosphorylation of separate tyrosine residues in SLP-76 forms the basis of synergistic NK cell activation...
  3. doi request reprint A defect in cell death of macrophages is a conserved feature of nonobese diabetic mouse
    Hun Sik Kim
    Department of Medicine, Graduate School, University of Ulsan, South Korea
    Biochem Biophys Res Commun 421:145-51. 2012
    ..Taken together, our results suggest a macrophage-intrinsic defect in cell death as a potential mechanism that promotes an immune attack towards pancreatic β-cells and the development of autoimmune diabetes in NOD mice...
  4. ncbi request reprint Essential role for signal transducer and activator of transcription-1 in pancreatic beta-cell death and autoimmune type 1 diabetes of nonobese diabetic mice
    Sunshin Kim
    Department of Medicine, Samsung Medical Center, 50 Irwon dong Kangnam ku, Seoul 135 710, Korea
    Diabetes 56:2561-8. 2007
    ..However, in vivo evidence supporting the role for STAT1 in natural type 1 diabetes has not been reported. We studied whether STAT1 plays an important role in the development of natural type 1 diabetes...
  5. ncbi request reprint Toll-like receptor 2 senses beta-cell death and contributes to the initiation of autoimmune diabetes
    Hun Sik Kim
    Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135 710, Korea
    Immunity 27:321-33. 2007
    ..These findings suggest that beta-cell death and its sensing via TLR2 may be an initial event for the stimulation of antigen-presenting cells and development of autoimmune diabetes...
  6. pmc NF-kappa B prevents beta cell death and autoimmune diabetes in NOD mice
    Sunshin Kim
    Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Irwon dong, Kangnam Ku, Seoul, Korea
    Proc Natl Acad Sci U S A 104:1913-8. 2007
    ..This differs from the proapoptotic function of NF-kappaB in IL-1beta-stimulated beta cells...
  7. ncbi request reprint Role of innate immunity in triggering and tuning of autoimmune diabetes
    Hun Sik Kim
    Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Curr Mol Med 9:30-44. 2009
    ....
  8. ncbi request reprint IFN-gamma sensitizes MIN6N8 insulinoma cells to TNF-alpha-induced apoptosis by inhibiting NF-kappaB-mediated XIAP upregulation
    Hun Sik Kim
    Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
    Biochem Biophys Res Commun 336:847-53. 2005
    ....
  9. pmc Synergistic signals for natural cytotoxicity are required to overcome inhibition by c-Cbl ubiquitin ligase
    Hun Sik Kim
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institute of Health, Rockville, MD 20852, USA
    Immunity 32:175-86. 2010
    ..Therefore, NK cell activation by synergizing receptors is regulated at the level of Vav1 by a hierarchy of inhibitory mechanisms...
  10. doi request reprint Role of TLR2 in the pathogenesis of autoimmune diabetes and its therapeutic implication
    Myung Shik Lee
    Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Diabetes Metab Res Rev 27:797-801. 2011
    ..These findings present evidence suggesting that apoptosis of pancreatic β-cells could be one of the initial events in T1D and provide a novel strategy for therapeutic or preventive intervention in T1D...
  11. ncbi request reprint STAT1 as a key modulator of cell death
    Hun Sik Kim
    Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
    Cell Signal 19:454-65. 2007
    ....
  12. doi request reprint Macrophages from nonobese diabetic mouse have a selective defect in IFN-γ but not IFN-α/β receptor pathway
    Myung Shik Lee
    Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    J Clin Immunol 32:753-61. 2012
    ..We aimed to uncover a mechanism underlying this phenomenon...
  13. pmc Essential role of STAT1 in caspase-independent cell death of activated macrophages through the p38 mitogen-activated protein kinase/STAT1/reactive oxygen species pathway
    Hun Sik Kim
    Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon dong, Kangnam Ku, Seoul 135 710, South Korea
    Mol Cell Biol 25:6821-33. 2005
    ..Furthermore, our study may provide significant insights in regards to the unanticipated critical role of STAT1 in the caspase-independent death pathway...