Hun Sik Kim

Summary

Affiliation: University of Ulsan
Country: Korea

Publications

  1. ncbi request reprint Attenuation of natural killer cell functions by capsaicin through a direct and TRPV1-independent mechanism
    Hun Sik Kim
    Department of Biomedical Sciences, Department of Microbiology, Cellular Dysfunction Research Center and
    Carcinogenesis 35:1652-60. 2014
  2. pmc Signaling for synergistic activation of natural killer cells
    Hyung Joon Kwon
    Department of Medicine, Graduate School, University of Ulsan College of Medicine, Seoul 138 736, Korea
    Immune Netw 12:240-6. 2012
  3. ncbi request reprint Role of pancreatic β-cell death and cell death-associated inflammation in diabetes
    M S Lee
    Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Curr Mol Med 12:1297-310. 2012
  4. pmc Complementary phosphorylation sites in the adaptor protein SLP-76 promote synergistic activation of natural killer cells
    Hun Sik Kim
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    Sci Signal 5:ra49. 2012
  5. doi request reprint A defect in cell death of macrophages is a conserved feature of nonobese diabetic mouse
    Hun Sik Kim
    Department of Medicine, Graduate School, University of Ulsan, South Korea
    Biochem Biophys Res Commun 421:145-51. 2012
  6. ncbi request reprint Essential role for signal transducer and activator of transcription-1 in pancreatic beta-cell death and autoimmune type 1 diabetes of nonobese diabetic mice
    Sunshin Kim
    Department of Medicine, Samsung Medical Center, 50 Irwon dong Kangnam ku, Seoul 135 710, Korea
    Diabetes 56:2561-8. 2007
  7. ncbi request reprint Toll-like receptor 2 senses beta-cell death and contributes to the initiation of autoimmune diabetes
    Hun Sik Kim
    Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135 710, Korea
    Immunity 27:321-33. 2007
  8. pmc NF-kappa B prevents beta cell death and autoimmune diabetes in NOD mice
    Sunshin Kim
    Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Irwon dong, Kangnam Ku, Seoul, Korea
    Proc Natl Acad Sci U S A 104:1913-8. 2007
  9. pmc Synergistic signals for natural cytotoxicity are required to overcome inhibition by c-Cbl ubiquitin ligase
    Hun Sik Kim
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institute of Health, Rockville, MD 20852, USA
    Immunity 32:175-86. 2010
  10. doi request reprint Macrophages from nonobese diabetic mouse have a selective defect in IFN-γ but not IFN-α/β receptor pathway
    Myung Shik Lee
    Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    J Clin Immunol 32:753-61. 2012

Collaborators

Detail Information

Publications18

  1. ncbi request reprint Attenuation of natural killer cell functions by capsaicin through a direct and TRPV1-independent mechanism
    Hun Sik Kim
    Department of Biomedical Sciences, Department of Microbiology, Cellular Dysfunction Research Center and
    Carcinogenesis 35:1652-60. 2014
    ..Thus, the mechanism of action of capsaicin on NK cells is largely independent of TRPV1. Taken together, capsaicin may have chemotherapeutic potential but may impair NK cell function, which plays a central role in tumor surveillance. ..
  2. pmc Signaling for synergistic activation of natural killer cells
    Hyung Joon Kwon
    Department of Medicine, Graduate School, University of Ulsan College of Medicine, Seoul 138 736, Korea
    Immune Netw 12:240-6. 2012
    ..This review focuses on the signaling events during NK cells activation and recent advances in the study of NK cell synergy...
  3. ncbi request reprint Role of pancreatic β-cell death and cell death-associated inflammation in diabetes
    M S Lee
    Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Curr Mol Med 12:1297-310. 2012
    ..We also discuss the role of dying β-cells in the control of inflammation which contributes to the pathogenesis of diabetes...
  4. pmc Complementary phosphorylation sites in the adaptor protein SLP-76 promote synergistic activation of natural killer cells
    Hun Sik Kim
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    Sci Signal 5:ra49. 2012
    ..Together, these data suggest that combined phosphorylation of separate tyrosine residues in SLP-76 forms the basis of synergistic NK cell activation...
  5. doi request reprint A defect in cell death of macrophages is a conserved feature of nonobese diabetic mouse
    Hun Sik Kim
    Department of Medicine, Graduate School, University of Ulsan, South Korea
    Biochem Biophys Res Commun 421:145-51. 2012
    ..Taken together, our results suggest a macrophage-intrinsic defect in cell death as a potential mechanism that promotes an immune attack towards pancreatic β-cells and the development of autoimmune diabetes in NOD mice...
  6. ncbi request reprint Essential role for signal transducer and activator of transcription-1 in pancreatic beta-cell death and autoimmune type 1 diabetes of nonobese diabetic mice
    Sunshin Kim
    Department of Medicine, Samsung Medical Center, 50 Irwon dong Kangnam ku, Seoul 135 710, Korea
    Diabetes 56:2561-8. 2007
    ..However, in vivo evidence supporting the role for STAT1 in natural type 1 diabetes has not been reported. We studied whether STAT1 plays an important role in the development of natural type 1 diabetes...
  7. ncbi request reprint Toll-like receptor 2 senses beta-cell death and contributes to the initiation of autoimmune diabetes
    Hun Sik Kim
    Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135 710, Korea
    Immunity 27:321-33. 2007
    ..These findings suggest that beta-cell death and its sensing via TLR2 may be an initial event for the stimulation of antigen-presenting cells and development of autoimmune diabetes...
  8. pmc NF-kappa B prevents beta cell death and autoimmune diabetes in NOD mice
    Sunshin Kim
    Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Irwon dong, Kangnam Ku, Seoul, Korea
    Proc Natl Acad Sci U S A 104:1913-8. 2007
    ..This differs from the proapoptotic function of NF-kappaB in IL-1beta-stimulated beta cells...
  9. pmc Synergistic signals for natural cytotoxicity are required to overcome inhibition by c-Cbl ubiquitin ligase
    Hun Sik Kim
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institute of Health, Rockville, MD 20852, USA
    Immunity 32:175-86. 2010
    ..Therefore, NK cell activation by synergizing receptors is regulated at the level of Vav1 by a hierarchy of inhibitory mechanisms...
  10. doi request reprint Macrophages from nonobese diabetic mouse have a selective defect in IFN-γ but not IFN-α/β receptor pathway
    Myung Shik Lee
    Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    J Clin Immunol 32:753-61. 2012
    ..We aimed to uncover a mechanism underlying this phenomenon...
  11. ncbi request reprint Role of innate immunity in triggering and tuning of autoimmune diabetes
    Hun Sik Kim
    Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Curr Mol Med 9:30-44. 2009
    ....
  12. ncbi request reprint IFN-gamma sensitizes MIN6N8 insulinoma cells to TNF-alpha-induced apoptosis by inhibiting NF-kappaB-mediated XIAP upregulation
    Hun Sik Kim
    Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
    Biochem Biophys Res Commun 336:847-53. 2005
    ....
  13. pmc Essential role of STAT1 in caspase-independent cell death of activated macrophages through the p38 mitogen-activated protein kinase/STAT1/reactive oxygen species pathway
    Hun Sik Kim
    Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon dong, Kangnam Ku, Seoul 135 710, South Korea
    Mol Cell Biol 25:6821-33. 2005
    ..Furthermore, our study may provide significant insights in regards to the unanticipated critical role of STAT1 in the caspase-independent death pathway...
  14. doi request reprint Role of TLR2 in the pathogenesis of autoimmune diabetes and its therapeutic implication
    Myung Shik Lee
    Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Diabetes Metab Res Rev 27:797-801. 2011
    ..These findings present evidence suggesting that apoptosis of pancreatic β-cells could be one of the initial events in T1D and provide a novel strategy for therapeutic or preventive intervention in T1D...
  15. pmc Controlling natural killer cell responses: integration of signals for activation and inhibition
    Eric O Long
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852, USA
    Annu Rev Immunol 31:227-58. 2013
    ..These different facets of inhibitory signaling are incorporated into a revocable license model for the reversible tuning of NK cell responsiveness...
  16. ncbi request reprint STAT1 as a key modulator of cell death
    Hun Sik Kim
    Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
    Cell Signal 19:454-65. 2007
    ....
  17. ncbi request reprint Immunotherapeutic treatment of autoimmune diabetes
    Jae Hyeon Kim
    Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Kyunggi do 410 773, Korea
    Crit Rev Immunol 33:245-81. 2013
    ....
  18. ncbi request reprint Caspase-mediated p65 cleavage promotes TRAIL-induced apoptosis
    Hun Sik Kim
    Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Kangnam Ku, Seoul, Korea
    Cancer Res 65:6111-9. 2005
    ....