Young Hwa Chung

Summary

Affiliation: University of Ulsan
Country: Korea

Publications

  1. ncbi request reprint Isocitrate dehydrogenase as a marker of centrilobular hepatic necrosis in the experimental model of rats
    Y H Chung
    Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea
    J Gastroenterol Hepatol 16:328-32. 2001
  2. ncbi request reprint A strategy for early detection of recurrent hepatocellular carcinoma following initial remission by transcatheter arterial chemoembolization
    Young Hwa Chung
    Division of Gastroenterology, Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea
    Intervirology 48:46-51. 2005
  3. ncbi request reprint Individualization of interferon therapy using serum hepatitis B virus DNA to reduce viral relapse in patients with chronic hepatitis B: a randomized controlled trial
    Young Hwa Chung
    Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Centre, Seoul, Korea
    Eur J Gastroenterol Hepatol 15:489-93. 2003
  4. doi request reprint rtL180M mutation of hepatitis B virus is closely associated with frequent virological resistance to adefovir dipivoxil therapy
    Yoon Seon Lee
    Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea
    J Gastroenterol Hepatol 27:300-5. 2012
  5. ncbi request reprint Recurrences of hepatocellular carcinoma following initial remission by transcatheter arterial chemoembolization
    Jae Kyun Lee
    Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea
    J Gastroenterol Hepatol 17:52-8. 2002
  6. doi request reprint Safety and efficacy of adjuvant pegylated interferon therapy for metastatic tumor antigen 1-positive hepatocellular carcinoma
    Danbi Lee
    Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea
    Cancer 119:2239-46. 2013
  7. ncbi request reprint Increased risk of adefovir resistance in patients with lamivudine-resistant chronic hepatitis B after 48 weeks of adefovir dipivoxil monotherapy
    Yoon Seon Lee
    Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea
    Hepatology 43:1385-91. 2006
  8. ncbi request reprint Precore stop codon mutation of hepatitis B virus is associated with low breakthrough rate following long-term lamivudine therapy
    Jung Woo Shin
    Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, 388 1 Poongnap dong Songpa ku, 138 040 Seoul, Korea
    J Gastroenterol Hepatol 20:844-9. 2005
  9. ncbi request reprint Long-term additional lamivudine therapy enhances durability of lamivudine-induced HBeAg loss: a prospective study
    Soo Hyung Ryu
    Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, 388 1 Poongnap dong Songpa ku, 138 040, Seoul, South Korea
    J Hepatol 39:614-9. 2003
  10. doi request reprint Factors predisposing metastatic tumor antigen 1 overexpression in hepatitis B virus associated hepatocellular carcinoma
    Young Joo Jin
    Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic ro 43 gil, Songpa Gu, Seoul 138 736, Korea
    Dig Dis Sci 57:2917-23. 2012

Detail Information

Publications87

  1. ncbi request reprint Isocitrate dehydrogenase as a marker of centrilobular hepatic necrosis in the experimental model of rats
    Y H Chung
    Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea
    J Gastroenterol Hepatol 16:328-32. 2001
    ..The aim of this study was to evaluate the usefulness of plasma isocitrate dehydrogenase (ICDH), which is located predominantly in the centrilobular zone, as a marker of CLN...
  2. ncbi request reprint A strategy for early detection of recurrent hepatocellular carcinoma following initial remission by transcatheter arterial chemoembolization
    Young Hwa Chung
    Division of Gastroenterology, Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea
    Intervirology 48:46-51. 2005
    ..To find a better surveillance method in detecting recurrent HCCs, patterns of recurrences following initial remission by transcatheter arterial chemoembolization (TACE) were evaluated...
  3. ncbi request reprint Individualization of interferon therapy using serum hepatitis B virus DNA to reduce viral relapse in patients with chronic hepatitis B: a randomized controlled trial
    Young Hwa Chung
    Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Centre, Seoul, Korea
    Eur J Gastroenterol Hepatol 15:489-93. 2003
    ..To reduce viral relapse in patients with chronic hepatitis B who responded to IFN, we individualized the duration of therapy according to serum HBV-DNA levels...
  4. doi request reprint rtL180M mutation of hepatitis B virus is closely associated with frequent virological resistance to adefovir dipivoxil therapy
    Yoon Seon Lee
    Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea
    J Gastroenterol Hepatol 27:300-5. 2012
    ....
  5. ncbi request reprint Recurrences of hepatocellular carcinoma following initial remission by transcatheter arterial chemoembolization
    Jae Kyun Lee
    Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea
    J Gastroenterol Hepatol 17:52-8. 2002
    ....
  6. doi request reprint Safety and efficacy of adjuvant pegylated interferon therapy for metastatic tumor antigen 1-positive hepatocellular carcinoma
    Danbi Lee
    Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea
    Cancer 119:2239-46. 2013
    ..In this study, the authors examined whether postoperative adjuvant Peg-IFN therapy can reduce the recurrence of MTA1-positive HCC after curative surgical resection...
  7. ncbi request reprint Increased risk of adefovir resistance in patients with lamivudine-resistant chronic hepatitis B after 48 weeks of adefovir dipivoxil monotherapy
    Yoon Seon Lee
    Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea
    Hepatology 43:1385-91. 2006
    ....
  8. ncbi request reprint Precore stop codon mutation of hepatitis B virus is associated with low breakthrough rate following long-term lamivudine therapy
    Jung Woo Shin
    Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, 388 1 Poongnap dong Songpa ku, 138 040 Seoul, Korea
    J Gastroenterol Hepatol 20:844-9. 2005
    ..The purpose of the present study was to evaluate the effects of precore stop codon mutation (G to A mutation at nucleotide 1896; A(1896)) of hepatitis B virus (HBV) on the occurrence of viral breakthrough following lamivudine therapy...
  9. ncbi request reprint Long-term additional lamivudine therapy enhances durability of lamivudine-induced HBeAg loss: a prospective study
    Soo Hyung Ryu
    Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, 388 1 Poongnap dong Songpa ku, 138 040, Seoul, South Korea
    J Hepatol 39:614-9. 2003
    ..In this prospective study, the authors intended to investigate whether long-term additional administration of lamivudine might enhance the durability of lamivudine-induced HBeAg seroconversion...
  10. doi request reprint Factors predisposing metastatic tumor antigen 1 overexpression in hepatitis B virus associated hepatocellular carcinoma
    Young Joo Jin
    Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic ro 43 gil, Songpa Gu, Seoul 138 736, Korea
    Dig Dis Sci 57:2917-23. 2012
    ....
  11. ncbi request reprint Preoperative portal vein embolization and surgical resection in patients with hepatocellular carcinoma and small future liver remnant volume: comparison with transarterial chemoembolization
    Dong Dae Seo
    Department of Internal Medicine, University of Inje College of Medicine, Sanggye Paik Hospital, Seoul, Korea
    Ann Surg Oncol 14:3501-9. 2007
    ..It is unclear, however, if this approach can enhance survival in patients with hepatocellular carcinoma (HCC). We therefore compared the outcomes of preoperative PVE and surgical resection with transarterial chemoembolization (TACE)...
  12. ncbi request reprint Recent increase in antibiotic-resistant microorganisms in patients with spontaneous bacterial peritonitis adversely affects the clinical outcome in Korea
    Young Hwan Park
    Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
    J Gastroenterol Hepatol 18:927-33. 2003
    ..The present study investigated the changing pattern of antibiotic resistance and its effects on the clinical outcome in treating SBP...
  13. ncbi request reprint Role of additional angiography and chemoembolization in patients with hepatocellular carcinoma who achieved complete necrosis following transarterial chemoembolization
    Myoung Kuk Jang
    Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
    J Gastroenterol Hepatol 19:1074-80. 2004
    ..We therefore prospectively analyzed the effects of additional angiography and chemoembolization on HCC recurrence and survival in patients who underwent TACE and achieved complete necrosis (CN)...
  14. doi request reprint Effect of response to interferon-α therapy on the occurrence of hepatocellular carcinoma in patients with chronic hepatitis B
    Danbi Lee
    Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea
    Dig Dis 30:568-73. 2012
    ..The aim of this study was to examine whether interferon-α (IFN-α) therapy may reduce the occurrence of hepatocellular carcinoma (HCC) in chronic hepatitis B (CHB) and to determine its effect based on responsiveness to IFN-α therapy...
  15. doi request reprint Lamivudine plus adefovir or entecavir for patients with chronic hepatitis B resistant to lamivudine and adefovir
    Nae Yun Heo
    Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea
    J Hepatol 53:449-54. 2010
    ..Little is known about the optimal management of patients with chronic hepatitis B (CHB) who developed multiple-drug resistance...
  16. doi request reprint Exercise and diet modification in non-obese non-alcoholic fatty liver disease: analysis of biopsies of living liver donors
    Young Joo Jin
    Department of Internal Medicine, Asan Liver Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
    J Gastroenterol Hepatol 27:1341-7. 2012
    ..We evaluated efficacy of exercise and diet modification for steatosis improvement of non-obese non-alcoholic fatty liver disease (NAFLD) patients...
  17. doi request reprint HLA-DRB1*010101 allele is closely associated with poor virological response to lamivudine therapy in patients with chronic hepatitis B
    Young Joo Jin
    Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea
    Digestion 84:35-42. 2011
    ..We intended to evaluate the association between specific human leukocyte antigen (HLA)-DRB1 gene polymorphism and antiviral response to lamivudine (LAM) therapy in chronic hepatitis B (CHB) patients...
  18. doi request reprint Genetic predisposition of hand-foot skin reaction after sorafenib therapy in patients with hepatocellular carcinoma
    Joo Ho Lee
    Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea
    Cancer 119:136-42. 2013
    ..The authors investigated the association between sorafenib-induced HFSR and genetic polymorphisms in Korean patients with HCC...
  19. ncbi request reprint Combination of alpha-interferon with lamivudine reduces viral breakthrough during long-term therapy
    Myoung Kuk Jang
    Department of Internal Medicine, Research Institute for Digestive Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
    J Gastroenterol Hepatol 19:1363-8. 2004
    ..In this study, we investigated the effects of alpha-interferon (IFN-alpha) combined with lamivudine on the occurrence of viral breakthrough during long-term lamivudine therapy...
  20. ncbi request reprint Transforming growth factor-beta1 as a useful serologic marker of small hepatocellular carcinoma
    Byung Cheol Song
    Department of Internal Medicine, University of Ulsan College of Medicine, Seoul, Korea
    Cancer 94:175-80. 2002
    ..The current study investigated the usefulness of TGFbeta1 compared with AFP in the diagnosis of small HCCs...
  21. ncbi request reprint Characteristic clinical features of hepatocellular carcinoma associated with Budd-Chiari syndrome: evidence of different carcinogenic process from hepatitis B virus-associated hepatocellular carcinoma
    Sang Hyo Shin
    Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Centre, Seoul, South Korea
    Eur J Gastroenterol Hepatol 16:319-24. 2004
    ..Considering the pathophysiological mechanism of BCS, BCS-associated HCC may have a different carcinogenic process to hepatitis B virus (HBV)-associated HCC, resulting in different characteristic clinical features...
  22. doi request reprint Clevudine-induced viral response, associated with continued reduction of HBsAg titer, was durable after the withdrawal of therapy
    Hyo Suk Lee
    Seoul National University Hospital, Seoul, Korea
    J Gastroenterol 46:410-4. 2011
    ..This study was conducted to evaluate the durability of clevudine-induced viral response after the withdrawal of treatment...
  23. doi request reprint Predisposing factors of hepatocellular carcinoma recurrence following complete remission in response to transarterial chemoembolization
    Young Joo Jin
    Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, 88 Olympic ro 43 gil, Songpa Gu, Seoul, 138 736, Korea
    Dig Dis Sci 58:1758-65. 2013
    ..The aim of our study was to determine the predictors of recurrences in hepatocellular carcinoma (HCC) patients who had achieved complete remission (CR) by transarterial chemoembolization (TACE)...
  24. doi request reprint Relationship of HLA-DRB1 alleles with hepatocellular carcinoma development in chronic hepatitis B patients
    Young Joo Jin
    Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
    J Clin Gastroenterol 46:420-6. 2012
    ..We intended to analyze the relationship between specific human leukocyte antigen (HLA)-DRB1 alleles and development of hepatocellular carcinoma (HCC) in chronic hepatitis B (CHB) patients...
  25. doi request reprint Radiotherapy plus transarterial chemoembolization for hepatocellular carcinoma invading the portal vein: long-term patient outcomes
    Sang Min Yoon
    Department of Radiation Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea
    Int J Radiat Oncol Biol Phys 82:2004-11. 2012
    ..We have evaluated the clinical outcomes of patients after transarterial chemoembolization (TACE) and 3-dimensional conformal radiotherapy for hepatocellular carcinoma (HCC) with portal vein tumor thrombosis (PVTT)...
  26. doi request reprint Complete necrosis after transarterial chemoembolization could predict prolonged survival in patients with recurrent intrahepatic hepatocellular carcinoma after curative resection
    Ju Hyun Shim
    Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
    Ann Surg Oncol 17:869-77. 2010
    ....
  27. doi request reprint [Mutations within the interferon sensitivity determining region in Korean patients infected with hepatitis C virus genotype 1b]
    Young Joo Jin
    Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
    Korean J Hepatol 16:158-67. 2010
    ..We examined the pattern of ISDR mutations and analyzed whether the number of amino acid substitutions influences the treatment response to peginterferon plus ribavirin in chronic hepatitis or cirrhotic patients infected with HCV-Ib...
  28. ncbi request reprint Neural cadherin overexpression is a predictive marker for early postoperative recurrence in hepatocellular carcinoma patients
    Dong Dae Seo
    Department of Internal Medicine, University of Inje College of Medicine, Sanggye Paik Hospital, University of Ulsan College of Medicine, Seoul, Korea
    J Gastroenterol Hepatol 23:1112-8. 2008
    ..In this study, we investigated the expression patterns of neural and epithelial cadherins and their clinical implications in HCC...
  29. doi request reprint Metastatic tumor antigen 1 is closely associated with frequent postoperative recurrence and poor survival in patients with hepatocellular carcinoma
    Soo Hyung Ryu
    Department of Internal Medicine, University of Inje College of Medicine, Seoul, Korea
    Hepatology 47:929-36. 2008
    ..0001). In conclusion, our data indicate that MTA1 is closely associated with microvascular invasion, frequent postoperative recurrence, and poor survival of HCC patients, especially in those with HBV-associated HCC...
  30. doi request reprint Clinical implications of arrest-defective protein 1 expression in hepatocellular carcinoma: a novel predictor of microvascular invasion
    Ju Hyun Shim
    Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea
    Dig Dis 30:603-8. 2012
    ..The associations between arrest-defective protein 1 (ARD1) gene expression and the clinicopathological characteristics and clinical outcomes of 94 patients undergoing hepatectomy for hepatocellular carcinoma (HCC) were investigated...
  31. pmc Clinical course of chronic hepatitis B patients who were off-treated after lamivudine treatment: analysis of 138 consecutive patients
    Young Joo Jin
    Department of Internal Medicine, Asan Liver Center, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic ro 43 gil, Songpa Gu, Seoul, 138 736, South Korea
    Virol J 9:239. 2012
    ..We intended to analyze the long-term outcome of CHB patients who discontinued lamivudine therapy and to evaluate predictors for post-treatment outcome...
  32. doi request reprint High HBV-DNA titer in surrounding liver rather than in hepatocellular carcinoma tissue predisposes to recurrence after curative surgical resection
    Jong Gi Choi
    Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea
    J Clin Gastroenterol 46:413-9. 2012
    ..In this study the authors intended to investigate the relationship between intrahepatic hepatitis B virus (HBV)-DNA concentrations and posthepatectomy recurrence of HBV-associated hepatocellular carcinoma (HCC)...
  33. ncbi request reprint Prognostic impact of telomere maintenance gene polymorphisms on hepatocellular carcinoma patients with chronic hepatitis B
    Seok Won Jung
    Department of Internal Medicine, University of Ulsan College of Medicine, Ulsan University Hospital, Ulsan, Korea
    Hepatology 59:1912-20. 2014
    ..483 × 10(-5) ), and this was demonstrated in the replication cohort (52 versus 37 months, log-rank P = 0.026)...
  34. ncbi request reprint Prevalence and risk factors of non-alcoholic fatty liver disease in potential living liver donors in Korea: a review of 589 consecutive liver biopsies in a single center
    Ji Young Lee
    Department of Internal Medicine, Asan Medical Centre, University of Ulsan College of Medicine, Seoul, Republic of Korea
    J Hepatol 47:239-44. 2007
    ....
  35. pmc Adefovir dipivoxil alone or in combination with ongoing lamivudine in patients with decompensated liver disease and lamivudine-resistant hepatitis B virus
    Kang Mo Kim
    Department of Internal Medicine, Asan Medical Centre, University of Ulsan College of Medicine, Seoul, Korea
    J Korean Med Sci 20:821-8. 2005
    ..Combination with lamivudine showed no additional benefit over monotherapy during 24 weeks of treatment in these patients...
  36. doi request reprint Transforming growth factor beta 1 overexpression is closely related to invasiveness of hepatocellular carcinoma
    Danbi Lee
    Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Songpa Gu, Seoul, Korea
    Oncology 82:11-8. 2012
    ..The study was aimed to investigate the relationship between plasma transforming growth factor beta 1 (TGF-β(1)) expression and the characteristics of hepatocellular carcinoma (HCC)...
  37. pmc Could HBx protein expression affect signal pathway inhibition by gefitinib or selumetinib, a MEK inhibitor, in hepatocellular carcinoma cell lines?
    Yoon Kyung Park
    Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
    J Korean Med Sci 26:214-21. 2011
    ..Future experiments are needed to understand the role of HBx protein expression in HCC treatment using molecular targeting agent...
  38. doi request reprint Efficacy of entecavir in patients with chronic hepatitis B resistant to both lamivudine and adefovir or to lamivudine alone
    Ju Hyun Shim
    Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
    Hepatology 50:1064-71. 2009
    ..18 versus -0.97 and -5.37 versus -2.15 log(10) copies/mL, respectively; both P < 0.05)...
  39. doi request reprint Prognostic value of serum osteopontin in hepatocellular carcinoma patients treated with transarterial chemoembolization
    Sung Hoon Kim
    Department of Internal Medicine, Seoul Veterans Hospital, Korea
    Korean J Hepatol 15:320-30. 2009
    ..However, its prognostic value in patients treated with transarterial chemoembolization (TACE) is unclear. We investigated the utility of serum OPN levels and changes therein as prognostic markers in HCC patients who have received TACE...
  40. doi request reprint Efficacy of entecavir in treatment-naïve patients with hepatitis B virus-related decompensated cirrhosis
    Ju Hyun Shim
    Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea
    J Hepatol 52:176-82. 2010
    ..The effect of entecavir (ETV) therapy on viral suppression and hepatic function in hepatitis B virus (HBV) patients with decompensated cirrhosis has not been established. We evaluated ETV as first-line monotherapy in these patients...
  41. doi request reprint Clinical outcome of 251 patients with extrahepatic metastasis at initial diagnosis of hepatocellular carcinoma: does transarterial chemoembolization improve survival in these patients?
    Dong Jun Yoo
    Department of Internal Medicine, Asan Medical Centre, University of Ulsan College of Medicine, Seoul, Korea
    J Gastroenterol Hepatol 26:145-54. 2011
    ..We investigated the efficacy of TACE with/without systemic chemotherapy (s-chemo) in these patients...
  42. ncbi request reprint Twenty-four-week clevudine therapy showed potent and sustained antiviral activity in HBeAg-positive chronic hepatitis B
    Byung Chul Yoo
    Samsung Medical Center, Sungkyunkwan University, and Yonsei University Hospital, Seoul, Korea
    Hepatology 45:1172-8. 2007
    ..The incidence of adverse events (AEs) was similar between the clevudine group and the placebo group. No resistance to clevudine was detected with 24 weeks of administration of drug...
  43. ncbi request reprint [Therapeutic efficacy of lamivudine in patients with hepatitis B virus-related decompensated cirrhosis in Korea]
    Saera Jung
    Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea
    Taehan Kan Hakhoe Chi 8:418-27. 2002
    ..The aim of this study is to evaluate the efficacy of lamivudine in consecutively enrolled patients with decompensated cirrhosis...
  44. ncbi request reprint Four cases of hepatitis B virus-related fibrosing cholestatic hepatitis treated with lamivudine
    Saera Jung
    Department of Internal Medicine, University of Ulsan College of Medicine, Seoul, Korea
    J Gastroenterol Hepatol 17:345-50. 2002
    ..However, the other two patients died of sepsis, possibly as a consequence of the immunosuppression with hepatic failure despite lamivudine treatment. Our experience suggests that lamivudine can alter the grave natural history of FCH...
  45. ncbi request reprint Diagnosis of hepatic steatosis and fibrosis by transient elastography in asymptomatic healthy individuals: a prospective study of living related potential liver donors
    Kang Mo Kim
    Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, 388 1 Pungnap dong, Songpa Gu, Seoul 138 736, Korea
    J Gastroenterol 42:382-8. 2007
    ....
  46. doi request reprint Half-life of serum alpha-fetoprotein: an early prognostic index of recurrence and survival after hepatic resection for hepatocellular carcinoma
    Ju Hyun Shim
    Departments of Gastroenterology, Asan Cancer Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
    Ann Surg 257:708-17. 2013
    ..To explore the prognostic value of the postsurgical half-life (HL) of serum alpha-fetoprotein (AFP)...
  47. doi request reprint Is serum alpha-fetoprotein useful for predicting recurrence and mortality specific to hepatocellular carcinoma after hepatectomy? A test based on propensity scores and competing risks analysis
    Ju Hyun Shim
    Department of Gastroenterology, Asan Liver Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
    Ann Surg Oncol 19:3687-96. 2012
    ..Therefore, we assessed the prognostic significance of AFP status...
  48. doi request reprint Single nucleotide polymorphisms associated with metastatic tumour antigen 1 overexpression in patients with hepatocellular carcinoma
    Sae Hwan Lee
    Department of Internal Medicine, Soonchunhyang University College of Medicine, Cheonan, Korea
    Liver Int 32:457-66. 2012
    ..In this study, we determined single nucleotide polymorphisms (SNPs) in angiogenesis-related genes that are associated with MTA1 overexpression in HCC tissues...
  49. doi request reprint Posttransplantation prophylaxis with primary high-dose hepatitis B immunoglobulin monotherapy and complementary preemptive antiviral add-on
    Shin Hwang
    Department of Surgery, Division of Hepatobiliary Surgery and Liver Transplantation, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
    Liver Transpl 17:456-65. 2011
    ..Preemptive conversion to combination therapy has a complementary role in prophylaxis with primary high-dose HBIG monotherapy, especially for patients at high risk of HBV recurrence...
  50. ncbi request reprint Lens culinaris agglutinin-reactive alpha-fetoprotein as a prognostic marker in patients with hepatocellular carcinoma undergoing transcatheter arterial chemoembolization
    Byung Cheol Song
    Department of Internal Medicine, Cheju National University College of Medicine, Cheju National University Hospital, Korea
    J Clin Gastroenterol 35:398-402. 2002
    ..In conclusion, pretreatment status of AFP-L3 could be considered a useful marker for predicting clinical outcome in patients with HCC who underwent TACE...
  51. ncbi request reprint [Therapeutic efficacy of transjugular intrahepatic portosystemic shunt on bleeding gastric varices]
    Hee Gon Song
    Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea
    Taehan Kan Hakhoe Chi 8:448-57. 2002
    ..The purpose of this study was to determine the efficacy of transjugular intrahepatic portosystemic shunt (TIPS) in patients with gastric variceal bleedings and predictive factors for survival...
  52. ncbi request reprint [The effects of tamoxifen on human hepatocellular carcinoma cell proliferation and transforming growth factor-beta1 expression]
    Jung Woo Shin
    Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea
    Taehan Kan Hakhoe Chi 9:10-6. 2003
    ..In this study, we evaluated the effects of tamoxifen on HCC cell growth and the expression of transforming growth factor-beta1 (TGF-beta1) which had been known as an important cytokine in growth of HCC...
  53. doi request reprint Polymorphisms of DNA repair genes in Korean hepatocellular carcinoma patients with chronic hepatitis B: possible implications on survival
    Seok Won Jung
    Department of Internal Medicine, University of Ulsan College of Medicine, Ulsan University Hospital, Ulsan, South Korea
    J Hepatol 57:621-7. 2012
    ..We aimed at determining whether single nucleotide polymorphisms (SNPs) of DNA repair genes influence the development and clinical outcomes of hepatitis B virus (HBV)-associated hepatocellular carcinoma (HCC)...
  54. doi request reprint Hepatic myelopathy as a presenting neurological complication in patients with cirrhosis and spontaneous splenorenal shunt
    Ja Eun Koo
    Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
    Korean J Hepatol 14:89-96. 2008
    ..One patient experienced improved neurologic symptoms after liver transplantation, whereas the other patient only received medical treatment, which did not prevent the progression of spastic paraparesis...
  55. doi request reprint Interim analysis of START: Study in Asia of the combination of TACE (transcatheter arterial chemoembolization) with sorafenib in patients with hepatocellular carcinoma trial
    Young Hwa Chung
    Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea
    Int J Cancer 132:2448-58. 2013
    ..Clinically, the disease control rate was 91.2% while the overall response rate was calculated as 52.4%. Our study shows that concurrent sorafenib and TACE therapy is safe and effective with no unexpected side effects...
  56. doi request reprint Estimation of the healthy upper limits for serum alanine aminotransferase in Asian populations with normal liver histology
    Jae Keun Lee
    Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
    Hepatology 51:1577-83. 2010
    ..Age, BMI, and/or other metabolic parameters significantly affect ALT levels, even in subjects with normal livers...
  57. pmc Applicability of the BCLC staging system to patients with hepatocellular carcinoma in Korea: analysis at a single center with a liver transplant center
    Sung Eun Kim
    Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
    Korean J Hepatol 17:113-9. 2011
    ..This study evaluated the applicability of the BCLC staging system and reasons for divergence from BCLC-recommended treatments in Korean HCC patients...
  58. ncbi request reprint [Clinical outcome after living donor liver transplantation in patients with hepatitis C virus-associated cirrhosis]
    Jeong Ik Park
    Division of Hepatobiliary Surgery and Liver Transplantation, Department of Surgery, Asan Medical Center, Korea
    Korean J Hepatol 13:543-55. 2007
    ....
  59. doi request reprint Antifibrogenic effects of tamoxifen in a rat model of periportal hepatic fibrosis
    Soo Hyung Ryu
    Department of Internal Medicine, University of Inje College of Medicine, Seoul Paik Hospital, Seoul, Republic of Korea
    Liver Int 29:308-14. 2009
    ..Thus, we examined whether tamoxifen might suppress TGF-beta1 expression and consequently inhibit the process of hepatic fibrosis in vivo...
  60. doi request reprint Hepatitis B virus with the rtL80V/I mutation is associated with a poor response to adefovir dipivoxil therapy
    Yoon Seon Lee
    Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea
    Liver Int 29:552-6. 2009
    ..We intended to examine the effects of these genotypic variants on the antiviral efficacy of adefovir dipivoxil (ADV) therapy...
  61. ncbi request reprint Clevudine therapy for 24 weeks further reduced serum hepatitis B virus DNA levels and increased ALT normalization rates without emergence of viral breakthrough than 12 weeks of clevudine therapy
    Kwan Sik Lee
    Yonsei University Hospital, Seoul, Korea
    Intervirology 50:296-302. 2007
    ..The objectives of the study were to evaluate the safety and antiviral activity of 24-week treatment with clevudine 30 mg in HBeAg(+) chronic hepatitis B patients. Biochemical and serological responses were also assessed...
  62. ncbi request reprint [Clinical and microbiological characteristics of spontaneous bacterial peritonitis (SBP) in a recent five year period]
    Hee Gon Song
    Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea
    Taehan Kan Hakhoe Chi 8:61-70. 2002
    ..We therefore were to evaluate the pattern of antibiotic resistance and its clinical significance...
  63. doi request reprint Cholestyramine resin for erythropoietic protoporphyria with severe hepatic disease: a case report
    Dong Jun Yoo
    Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
    Korean J Hepatol 16:83-8. 2010
    ..He was treated with cholestyramine resin. Six months after the treatment, he was doing well without any abdominal pain or photosensitivity...
  64. pmc Biochemical Rather than Virologic Response to Interferon Therapy may be More Closely Associated with Decrease of Hepatocellular Carcinoma Incidence in Patients with Chronic Hepatitis B
    Danbi Lee
    Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
    Gut Liver 1:49-55. 2007
    ..The authors examined whether the response to interferon (IFN) therapy can affect the development of hepatocellular carcinoma (HCC) in chronic hepatitis B (CHB) patients...
  65. pmc Osler-Weber-Rendu disease presenting with hepatocellular carcinoma: radiologic and genetic findings
    Joo Ho Lee
    Department of Internal Medicine, Vievis Namuh Hospital, Seoul, Korea
    Korean J Hepatol 17:313-8. 2011
    ..Some cases of HCC in association with HHT have been reported, but are very rare. We present herein the characteristic radiologic and genetic findings of HHT that was diagnosed during the evaluation and treatment of HCC...
  66. ncbi request reprint Reappraisal of repeated transarterial chemoembolization in the treatment of hepatocellular carcinoma with portal vein invasion
    Kang Mo Kim
    Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
    J Gastroenterol Hepatol 24:806-14. 2009
    ..This study aimed to evaluate the therapeutic efficacy and safety of repeated transarterial chemoembolization (TACE) with additional radiation therapy (RT) in hepatocellular carcinoma (HCC) with portal vein (PV) invasion...
  67. doi request reprint Noninvasive diagnostic criteria for hepatocellular carcinoma in hepatic masses >2 cm in a hepatitis B virus-endemic area
    Sung Eun Kim
    Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
    Liver Int 31:1468-76. 2011
    ....
  68. ncbi request reprint [Molecular mechanisms of hepatitis B virus-associated hepatocellular carcinoma]
    Neung Hwa Park
    Department of Internal Medicine, University of Ulsan College of Medicine, Biomedical Research Center, Ulsan University Hospital, Ulsan, Korea
    Korean J Hepatol 13:320-40. 2007
    ..This review summarizes the current knowledge of the mechanisms involved in HBV-associated hepatocarcinogenesis...
  69. doi request reprint Overexpression of metastasis-associated protein 2 is associated with hepatocellular carcinoma size and differentiation
    Hyunseung Lee
    NeuroVascular Coordination Research Center, College of Pharmacy, Seoul National University, Seoul, Korea
    J Gastroenterol Hepatol 24:1445-50. 2009
    ..In this study, we found that the overexpression of MTA2 is associated with HCC size and differentiation after hepatectomy...
  70. pmc Sigmoid colon metastasis from hepatocellular carcinoma
    Dong Jun Yoo
    Department of Internal Medicine, University of Ulsan College of Medicine, Seoul, Korea
    Korean J Hepatol 16:397-400. 2010
    ..The patient underwent anterior resection for the metastatic HCC...
  71. doi request reprint Impacts of vaccination on hepatitis B viral infections in Korea over a 25-year period
    Neung Hwa Park
    Department of Internal Medicine and Biomedical Research Center, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea
    Intervirology 53:20-8. 2010
    ..Hepatitis B virus (HBV) vaccination has effectively reduced the acute and chronic infection rates in recent years. Since 1983, HBV vaccination has been recommended for all neonates in Korea...
  72. ncbi request reprint [Clinical features of fulminant hepatic failure in a tertiary hospital with a liver transplant center in Korea]
    Nae Yun Heo
    Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
    Korean J Hepatol 12:82-92. 2006
    ..This study intended to identify the etiology and outcome of FHF in Korean adults and to examine the role of urgent living-donor liver transplantation (LDLT) for treating this unique situation...
  73. doi request reprint Surgical treatments and prognoses of patients with combined hepatocellular carcinoma and cholangiocarcinoma
    Ki Hun Kim
    Department of Hepatobiliary Surgery and Liver Transplantation, University of Ulsan College of Medicine and Asan Medical Center, Seoul, South Korea
    Ann Surg Oncol 16:623-9. 2009
    ..We evaluated the effectiveness of surgical treatment and factors related to survival and recurrence...
  74. ncbi request reprint Adult-to-adult living donor liver transplantation at the Asan Medical Center, Korea
    S G Lee
    Department of General Surgery, Asan Medical Center, Ulsan University Medical School, Seoul, Korea
    Asian J Surg 25:277-84. 2002
    ....
  75. doi request reprint High prevalence of hepatitis B and hepatitis C virus infections in Korean patients with hematopoietic malignancies
    Jun Kang
    Department of Pathology, University of Ulsan College of Medicine, Asan Medical Center, 388 1 Poongnap dong, Songpa Gu, Seoul, South Korea
    Ann Hematol 90:159-64. 2011
    ..HBV seems to have a more important role than HCV in the pathogenesis of specific hematologic malignancies in Korea...
  76. ncbi request reprint [Validation of international autoimmune hepatitis group scoring system for diagnosis of type 1 autoimmune hepatitis in Korea]
    Saera Jung
    Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea
    Taehan Kan Hakhoe Chi 8:35-43. 2002
    ..Its diagnosis requires the exclusion of various other conditions. The aim of this study was to validate indirectly the International Autoimmune Hepatitis Group (IAHG) scoring system in diagnosing AIH...
  77. ncbi request reprint Plasma isocitrate dehydrogenase as a marker of centrilobular hepatic necrosis in patients with hyperthyroidism
    Y H Chung
    Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea
    J Clin Gastroenterol 33:118-22. 2001
    ..Thus, the plasma ICDH or ICDH/ALT ratio might be useful for differentiating centrilobular from periportal necrosis and for monitoring the degree of hepatic necrosis in patients with hyperthyroidism...
  78. pmc Molecular Pathogenesis of Hepatitis-B-virus-associated Hepatocellular Carcinoma
    Neung Hwa Park
    Division of Gastroenterology, Department of Internal Medicine, University of Ulsan College of Medicine, Ulsan University Hospital, Ulsan, Korea
    Gut Liver 1:101-17. 2007
    ..This review summarizes the current knowledge on the mechanisms involved in HBV-associated hepatocarcinogenesis...
  79. ncbi request reprint Angiotensin-converting enzyme gene polymorphism and vascular manifestations in Korean patients with SLE
    W S Uhm
    The Hospital for Rheumatic Diseases, Hanyang University, Seoul, Korea
    Lupus 11:227-33. 2002
    ..However, it would be valuable to evaluate the role of other genes potentially related to vascular events, such as endothelin, nitric oxide or angiotensin II receptor as well as ACE gene...
  80. pmc Cancer patients' awareness of clinical trials, perceptions on the benefit and willingness to participate: Korean perspectives
    J W Kim
    Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea
    Br J Cancer 99:1593-9. 2008
    ..This information would be very helpful for investigators to properly conduct CTs in eastern cancer patients...
  81. ncbi request reprint Close correlation of p53 mutation to microvascular invasion in hepatocellular carcinoma
    N H Park
    Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea
    J Clin Gastroenterol 33:397-401. 2001
    ..In conclusion, it is suggested that p53 mutations tend to be commonly associated with microvascular invasions, which may result in micrometastasis, followed by frequent recurrences...
  82. ncbi request reprint Which patients with chronic hepatitis B are more likely to relapse after interferon alpha-induced hepatitis B e antigen loss in Korea?
    Byung Cheol Song
    Department of Internal Medicine Cheju National University College of Medicine, Jeju, Korea
    J Clin Gastroenterol 38:124-9. 2004
    ..This study was to evaluate the durability of interferon-induced HBeAg loss and find the risk factors for relapse...
  83. ncbi request reprint [Resistance to adefovir in patients with chronic hepatitis B]
    Soo Hyung Ryu
    Division of Gastroenterology, Department of Internal Medicine, University of Inje College of Medicine, Seoul Paik Hospital, Seoul, Korea
    Korean J Hepatol 12:484-92. 2006
    ..To reduce adefovir resistance, combination therapy with adefovir and lamivudine in patients with lamivudine resistance may be a treatment option...
  84. ncbi request reprint Clevudine is highly efficacious in hepatitis B e antigen-negative chronic hepatitis B with durable off-therapy viral suppression
    Byung Chul Yoo
    Sungkyunkwan University Samsung Medical Center, Seoul, South Korea
    Hepatology 46:1041-8. 2007
    ..0006). ALT normalization in the clevudine group was well-maintained during the post-treatment follow-up period. The incidence of adverse events was similar in the 2 groups. No resistance to clevudine was detected during treatment...
  85. ncbi request reprint [Therapeutic strategy for YMDD mutants of hepatitis B virus]
    Soo Hyung Ryu
    Division of Gastroenterology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Korea
    Korean J Hepatol 10:1-10. 2004
  86. ncbi request reprint A 12-week clevudine therapy showed potent and durable antiviral activity in HBeAg-positive chronic hepatitis B
    Hyo Suk Lee
    Seoul National University Hospital, South Korea
    Hepatology 43:982-8. 2006
    ....
  87. ncbi request reprint Aberrant epigenetic modifications in hepatocarcinogenesis induced by hepatitis B virus X protein
    In Young Park
    Liver Cell Signal Transduction Laboratory, Molecular Cancer Research Center, KRIBB, Daejeon, Korea
    Gastroenterology 132:1476-94. 2007
    ..The aim of the present study was to identify the involvement of HBx in regional hypermethylation and global hypomethylation during the formation of hepatocellular carcinoma (HCC)...