Sung Hwan Park


Affiliation: The Catholic University of Korea
Country: Korea


  1. Min H, Cho H, Park S. Baseline severity of sacroiliitis can predict acute inflammatory status of sacroiliac joint in early axial spondyloarthritis of male patients: a cross sectional study. BMC Musculoskelet Disord. 2019;20:144 pubmed publisher
    ..AS patients might need more intense initial treatment to resolve active inflammatory lesion of SIJ and prevent further radiologic progression. ..
  2. Min H, Lee J, Ju J, Park S, Kwok S. Predictors of Assessment of Spondyloarthritis International Society (ASAS) Health Index in Axial Spondyloarthritis and Comparison of ASAS Health Index between Ankylosing Spondylitis and Nonradiographic Axial Spondyloarthritis: Data from the Catholic . J Clin Med. 2019;8: pubmed publisher
    ..Spinal structural damage (higher mSASSS), high NSAID intake, alcohol consumption, and economic status were predictors of ASAS HI in patients with axSpA, especially those with AS. ..
  3. Lee J, Lee J, Baek S, Koh J, Kim J, Kim S, et al. Soluble siglec-5 is a novel salivary biomarker for primary Sjogren's syndrome. J Autoimmun. 2019;: pubmed publisher
    ..This novel salivary biomarker may provide benefits for pSS diagnosis. ..
  4. Min H, Choi J, Lee S, Seo H, Jung K, Na H, et al. Protein inhibitor of activated STAT3 reduces peripheral arthritis and gut inflammation and regulates the Th17/Treg cell imbalance via STAT3 signaling in a mouse model of spondyloarthritis. J Transl Med. 2019;17:18 pubmed publisher
    ..In addition, BMPs were decreased in the spines of PIAS3-treated mice. These findings suggest that PIAS3 could have therapeutic benefits in patients with SpA. ..
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    Kim S, Lee J, Choi Y, Kim J, Kwok S, Park Y, et al. Do I sound dry? Comparative voice analysis of primary Sjögren's syndrome. Clin Exp Rheumatol. 2018;36 Suppl 112:130-136 pubmed
    ..The likelihood of voice problems should be addressed with pSS patients, and vocal hygiene education will be important in those patients. ..
  6. Lee J, Koh J, Kim J, Sung Y, Lee S, Choe J, et al. Performance of the 2016 ACR-EULAR classification criteria for primary Sjogren's syndrome in a Korean cohort. Rheumatol Int. 2018;38:1651-1660 pubmed publisher
    ..769, respectively). The newly proposed 2016 ACR/EULAR criteria were met by most patients diagnosed with pSS according to previous criteria and showed higher sensitivity and lower specificity compared with both previous criteria sets. ..
  7. Kim J, Park S, Kim H, Kwok S. A Plasmacytoid Dendritic Cells-Type I Interferon Axis Is Critically Implicated in the Pathogenesis of Systemic Lupus Erythematosus. Int J Mol Sci. 2015;16:14158-70 pubmed publisher
  8. Jhun J, Lee S, Byun J, Jeong J, Kim E, Lee J, et al. Coenzyme Q10 suppresses Th17 cells and osteoclast differentiation and ameliorates experimental autoimmune arthritis mice. Immunol Lett. 2015;166:92-102 pubmed publisher
    ..CoQ10 alleviates arthritis in mice with ZIA declining inflammation, Th17 cells and osteoclast differentiation. These findings suggest that CoQ10 can be a potential therapeutic substance for RA. ..
  9. Lee J, Lee S, Lee J, Lee J, Baek S, Lee D, et al. Monosodium urate crystal-induced triggering receptor expressed on myeloid cells 1 is associated with acute gouty inflammation. Rheumatology (Oxford). 2016;55:156-61 pubmed publisher
    ..TREM-1 is induced by MSU and is associated with the inflammation of human acute gouty arthritis. ..

More Information


  1. Koh J, Ko H, Kwok S, Ju J, Park S. Hydroxychloroquine and pregnancy on lupus flares in Korean patients with systemic lupus erythematosus. Lupus. 2015;24:210-7 pubmed publisher
    ..Our study indicates that achieving pre-pregnancy remission and continuing HCQ treatment during pregnancy are important for preventing lupus flares. ..
  2. Kwon J, Lee S, Seo H, Moon Y, Ryu J, Jung K, et al. YinYang1 deficiency ameliorates joint inflammation in a murine model of rheumatoid arthritis by modulating Th17 cell activation. Immunol Lett. 2018;197:63-69 pubmed publisher
    ..Our findings suggest that future RA therapies should target the regulatory mechanism involved in Th17 cell differentiation, in which YY1 may cooperate with the STAT3 signaling pathway. ..
  3. Yi H, Kang K, Kim Y, Jung H, Rim Y, Park N, et al. Human adipose-derived mesenchymal stem cells attenuate collagen antibody-induced autoimmune arthritis by inducing expression of FCGIIB receptors. BMC Musculoskelet Disord. 2015;16:170 pubmed publisher
    ..This is a study to show that ASCs have anti-arthritic effects in CAIA mice. Modulation of FCGRs by ASCs might be a therapeutic mechanism in this antibody-associated arthritis model. ..
  4. Koh J, Lee J, Kim S, Kwok S, Ju J, Park S. Safety, and Humoral and Cell-mediated Immune Responses to Herpes Zoster Vaccine in Patients with Rheumatoid Arthritis. J Rheumatol. 2018;45:465-469 pubmed publisher
    ..Although patients with RA showed a weaker vaccine-induced VZV-specific cellular immune response than patients with OA, the vaccine may be considered in patients with RA receiving cDMARD and/or low dose GC. ..
  5. Koh J, Ko H, Lee J, Jung S, Kwok S, Ju J, et al. Pregnancy and patients with preexisting lupus nephritis: 15 years of experience at a single center in Korea. Lupus. 2015;24:764-72 pubmed publisher
    ..When patients experience renal flares during pregnancy, it is important to reduce the proteinuria level by >50% within six months and to achieve early remission for excellent long-term renal outcomes. ..
  6. Jung S, Lee J, Baek S, Lee J, Jang S, Hong S, et al. Fraxinellone Attenuates Rheumatoid Inflammation in Mice. Int J Mol Sci. 2018;19: pubmed publisher
    ..The data suggests that fraxinellone could be a novel treatment for inflammatory arthritis, including rheumatoid arthritis. ..
  7. Min H, Kim J, Lee S, Kim E, Lee S, Lee J, et al. Rebamipide prevents peripheral arthritis and intestinal inflammation by reciprocally regulating Th17/Treg cell imbalance in mice with curdlan-induced spondyloarthritis. J Transl Med. 2016;14:190 pubmed publisher
  8. Park J, Choi J, Kwon J, Jung K, Yang C, Park S, et al. A probiotic complex, rosavin, zinc, and prebiotics ameliorate intestinal inflammation in an acute colitis mouse model. J Transl Med. 2018;16:37 pubmed publisher
    ..These results suggest that the combination of a probiotic complex with rosavin, zinc, and prebiotics exerts a therapeutic effect on IBD by modulating production of pro- and anti-inflammatory cytokines and the development of fibrosis. ..
  9. Min H, Kim S, Park J, Byun J, Lee J, Kwok S, et al. Fn14-Fc suppresses germinal center formation and pathogenic B cells in a lupus mouse model via inhibition of the TWEAK/Fn14 Pathway. J Transl Med. 2016;14:98 pubmed publisher
    ..Fn14-Fc had beneficial effects in a SLE mouse model by repressing B cells, plasma cells, Tfh, and renal damage. This suggested that Fn14-Fc represents a potential therapeutic agent for SLE. ..
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    Lee J, Koh J, Kwok S, Park S. The EULAR Sjögren's Syndrome Patient-Reported Index is an independent determinant of health-related utility values of Korean patients with primary Sjögren's syndrome. Clin Exp Rheumatol. 2016;34:663-7 pubmed
    ..053, p<0.001). The HRQoL of pSS patients is significantly lower than that of the general population, and the ESSPRI is an independent predictor of the HRQoL in pSS patients. ..
  11. Lee S, Kim E, Kwon J, Lee J, Lee D, Kim S, et al. Ssu72 attenuates autoimmune arthritis via targeting of STAT3 signaling and Th17 activation. Sci Rep. 2017;7:5506 pubmed publisher
    ..Based on these data, Ssu72 is related to STAT3 activation and the inflammatory response; and Ssu72 overexpression in T-cell-mediated immunity has potential utility for the treatment of autoimmune arthritis. ..
  12. Kim S, Kwon J, Park J, Seo H, Jung K, Moon Y, et al. Achaete-scute complex homologue 2 accelerates the development of Sjögren's syndrome-like disease in the NOD/ShiLtJ mouse. Immunol Lett. 2017;190:26-33 pubmed publisher
    ..Our findings suggest that Ascl2 may play a role in the development and progression of SS and may be a therapeutic target in the treatment of SS. ..
  13. Lee S, Jhun J, Byun J, Kim E, Jung K, Lee J, et al. IL-17 axis accelerates the inflammatory progression of obese in mice via TBK1 and IKBKE pathway. Immunol Lett. 2017;184:67-75 pubmed publisher
    ..As well, the inhibition of TBK1 reduces inflammation induced by IL-17. Therefore, IL-17 may be involved in the development of obesity and metabolic dysfunction in a TBK1-dependent manner. ..
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    Kang K, Jung J, Hong Y, Ju J, Park S. Positive correlation between inflammation on sacroiliac joint MRI and serum C-terminal telopeptide of type-I collagen in ankylosing spondylitis but not in non-radiographic axial spondyloarthritis. Clin Exp Rheumatol. 2017;35:415-422 pubmed
    ..038). Inflammatory markers and ASDAS correlated with active sacroiliitis on MRI in nr-axSpA only. In AS, only sCTX-I correlated with active inflammation on SIJ MRI. sCTX-I may be useful as a marker of objective inflammation in AS. ..
  15. Lee S, Min H, Lee S, Shin H, Lee W, Cho Y, et al. IL-1 receptor antagonist (IL-1Ra)-Fc ameliorate autoimmune arthritis by regulation of the Th17 cells/Treg balance and arthrogenic cytokine activation. Immunol Lett. 2016;172:56-66 pubmed publisher
    ..The anti-arthritis effects of hIL-1RA-Fc are associated with regulation of balance between Th17 cells and Treg cells and suppression of osteoclastogenesis and angiogenesis in the affected joints. ..
  16. Lee J, Lee J, Lee J, Jung S, Suh Y, Koh J, et al. Visceral fat obesity is highly associated with primary gout in a metabolically obese but normal weighted population: a case control study. Arthritis Res Ther. 2015;17:79 pubmed publisher
    ..Therefore, VFO might more properly represent metabolic derangements in patients with gout than general obesity. ..
  17. Lee J, Kim Y, Yi H, Diecke S, Kim J, Jung H, et al. Generation of disease-specific induced pluripotent stem cells from patients with rheumatoid arthritis and osteoarthritis. Arthritis Res Ther. 2014;16:R41 pubmed publisher
    ..FLSs derived from RA and OA could be cell resources for iPSC reprogramming. Disease- and patient-specific iPSCs have the potential to be applied in clinical settings as source materials for molecular diagnosis and regenerative therapy. ..
  18. Kang K, Kim H, Kwok S, Ju J, Park K, Sun D, et al. Impact of interleukin-21 in the pathogenesis of primary Sjögren's syndrome: increased serum levels of interleukin-21 and its expression in the labial salivary glands. Arthritis Res Ther. 2011;13:R179 pubmed publisher
    ..The expression of IL-21 is increased as more lymphocytes infiltrated in LSGs. These observations suggest that IL-21 may play an important role in primary SS pathogenesis. ..
  19. Kim W, Min S, Cho M, Hong K, Shin Y, Park S, et al. Elevated matrix metalloproteinase-9 in patients with systemic sclerosis. Arthritis Res Ther. 2005;7:R71-9 pubmed
    ..These findings suggest that the enhanced production of MMP-9 may contribute to fibrogenic remodeling during the progression of skin sclerosis in SSc. ..
  20. Park M, Min S, Park K, Cho Y, Cho M, Jung Y, et al. Indoleamine 2,3-dioxygenase-expressing dendritic cells are involved in the generation of CD4+CD25+ regulatory T cells in Peyer's patches in an orally tolerized, collagen-induced arthritis mouse model. Arthritis Res Ther. 2008;10:R11 pubmed publisher
    ..Our data suggest that tolerogenic CD11c+ DCs are closely linked with the induction of oral tolerance through an IDO-dependent mechanism and that this pathway may provide a new therapeutic modality to treat autoimmune arthritis. ..