Chi Un Pae

Summary

Affiliation: The Catholic University of Korea
Country: Korea

Publications

  1. ncbi request reprint Tryptophan hydroxylase and serotonin transporter gene polymorphism does not affect the diagnosis, clinical features and treatment outcome of panic disorder in the Korean population
    Won Kim
    Department of Psychiatry and Stress Research Institute, Seoul Paik Hospital, Inje University, Seoul, Republic of Korea
    Prog Neuropsychopharmacol Biol Psychiatry 30:1413-8. 2006
  2. doi request reprint Agomelatine: a new option for treatment of depression?
    Chi Un Pae
    The Catholic University of Korea, College of Medicine, Department of Psychiatry, Seoul, South Korea 82 32 340 7067 82 32 340 2255
    Expert Opin Pharmacother 15:443-7. 2014
  3. doi request reprint Antidepressant and QT interval prolongation, how should we look at this issue? Focus on citalopram
    Chi Un Pae
    The Catholic University of Korea, Psychiatry, Sosa Dong, Wonmi gu, Bucheon, 420717, Republic of Korea
    Expert Opin Drug Saf 13:197-205. 2014
  4. pmc Experiences and barriers to implementation of clinical practice guideline for depression in Korea
    Jaewon Yang
    Department of Psychiatry, Korea University College of Medicine, Seoul, South Korea
    BMC Psychiatry 13:150. 2013
  5. doi request reprint Clinical issues in use of atypical antipsychotics for depressed patients
    Chi Un Pae
    Department of Psychiatry, Bucheon St Mary s Hospital, The Catholic University of Korea, College of Medicine, 2 Sosa Dong, Wonmi gu, Bucheon, Kyounggi Do, 420 717, Republic of Korea
    CNS Drugs 27:S39-45. 2013
  6. doi request reprint Sertindole: dilemmas for its use in clinical practice
    Chi Un Pae
    The Catholic University of Korea College of Medicine, Department of Psychiatry, Bucheon St Mary s Hospital, Sosa Dong, Wonmi gu, Bucheon, Kyeonggi Do 420 717, Republic of Korea
    Expert Opin Drug Saf 12:321-6. 2013
  7. doi request reprint Atypical antipsychotics as a possible treatment option for irritable bowel syndrome
    Chi Un Pae
    The Catholic University of Korea College of Medicine, Bucheon St Mary s Hospital, Department of Psychiatry, 2 Sosa Dong, Wonmi gu, Bucheon, Kyeonggi Do 420 717, Republic of Korea
    Expert Opin Investig Drugs 22:565-72. 2013
  8. doi request reprint Achieving and sustaining remission in bipolar I disorder with ziprasidone : a post hoc analysis of a 24-week, double-blind, placebo-controlled study
    Chi Un Pae
    Department of Psychiatry, The Catholic University of Korea College of Medicine, Seoul, Republic of Korea
    Clin Drug Investig 32:747-54. 2012
  9. doi request reprint Role of the cholinesterase inhibitors in the treatment of schizophrenia
    Chi Un Pae
    The Catholic University of Korea College of Medicine, Bucheon St Mary s Hospital, Department of Psychiatry, 2 Sosa Dong, Wonmi gu, Pucheon, Kyounggi do 420 717, Republic of Korea
    Expert Opin Investig Drugs 22:293-8. 2013
  10. doi request reprint Early versus conventional switching of antidepressant: a post-hoc analysis of clinical trial data for major depressive disorder with moderate to severe pain symptoms
    Chi Un Pae
    The Catholic University of Korea College of Medicine, Bucheon St Mary s Hospital, Department of Psychiatry, 2 Sosa Dong, Wonmi gu, Pucheon, Kyounggi do 420 717, Seoul, Republic of Korea
    Expert Opin Pharmacother 13:2711-5. 2012

Detail Information

Publications116 found, 100 shown here

  1. ncbi request reprint Tryptophan hydroxylase and serotonin transporter gene polymorphism does not affect the diagnosis, clinical features and treatment outcome of panic disorder in the Korean population
    Won Kim
    Department of Psychiatry and Stress Research Institute, Seoul Paik Hospital, Inje University, Seoul, Republic of Korea
    Prog Neuropsychopharmacol Biol Psychiatry 30:1413-8. 2006
    ..Our findings suggest that the TPH A218C polymorphism and 5-HTTLPR play no significant roles in the pathogenesis and clinical symptomatologies, at least in a Korean population...
  2. doi request reprint Agomelatine: a new option for treatment of depression?
    Chi Un Pae
    The Catholic University of Korea, College of Medicine, Department of Psychiatry, Seoul, South Korea 82 32 340 7067 82 32 340 2255
    Expert Opin Pharmacother 15:443-7. 2014
    ....
  3. doi request reprint Antidepressant and QT interval prolongation, how should we look at this issue? Focus on citalopram
    Chi Un Pae
    The Catholic University of Korea, Psychiatry, Sosa Dong, Wonmi gu, Bucheon, 420717, Republic of Korea
    Expert Opin Drug Saf 13:197-205. 2014
    ..Evidence increasingly points to the potential development of harmful cardiac side effects concomitant with the use of a number of psychotropic drugs, primarily traditional antipsychotics and tricyclic antidepressants...
  4. pmc Experiences and barriers to implementation of clinical practice guideline for depression in Korea
    Jaewon Yang
    Department of Psychiatry, Korea University College of Medicine, Seoul, South Korea
    BMC Psychiatry 13:150. 2013
    ..The aim of this study was to determine clinical experiences and perceived barriers to the implementation of these guidelines in psychiatric care...
  5. doi request reprint Clinical issues in use of atypical antipsychotics for depressed patients
    Chi Un Pae
    Department of Psychiatry, Bucheon St Mary s Hospital, The Catholic University of Korea, College of Medicine, 2 Sosa Dong, Wonmi gu, Bucheon, Kyounggi Do, 420 717, Republic of Korea
    CNS Drugs 27:S39-45. 2013
    ..This is because the use of AAs is likely to expand as there is good evidence for their effectiveness and tolerability as augmentation therapy for patients with MDD...
  6. doi request reprint Sertindole: dilemmas for its use in clinical practice
    Chi Un Pae
    The Catholic University of Korea College of Medicine, Department of Psychiatry, Bucheon St Mary s Hospital, Sosa Dong, Wonmi gu, Bucheon, Kyeonggi Do 420 717, Republic of Korea
    Expert Opin Drug Saf 12:321-6. 2013
    ..After extensive post-marketing analysis and epidemiological studies regarding its safety, sertindole was relaunched in Europe in 2005...
  7. doi request reprint Atypical antipsychotics as a possible treatment option for irritable bowel syndrome
    Chi Un Pae
    The Catholic University of Korea College of Medicine, Bucheon St Mary s Hospital, Department of Psychiatry, 2 Sosa Dong, Wonmi gu, Bucheon, Kyeonggi Do 420 717, Republic of Korea
    Expert Opin Investig Drugs 22:565-72. 2013
    ..A variety of psychotropic medications are widely used in the treatment of IBS, particularly older antidepressants such as tricyclic antidepressants (TCAs)...
  8. doi request reprint Achieving and sustaining remission in bipolar I disorder with ziprasidone : a post hoc analysis of a 24-week, double-blind, placebo-controlled study
    Chi Un Pae
    Department of Psychiatry, The Catholic University of Korea College of Medicine, Seoul, Republic of Korea
    Clin Drug Investig 32:747-54. 2012
    ..We carried out a post hoc analysis of rates of symptomatic point remission and sustained remission using four different remission criteria that had been evaluated in a previously published 24-week, double-blind, placebo-controlled study...
  9. doi request reprint Role of the cholinesterase inhibitors in the treatment of schizophrenia
    Chi Un Pae
    The Catholic University of Korea College of Medicine, Bucheon St Mary s Hospital, Department of Psychiatry, 2 Sosa Dong, Wonmi gu, Pucheon, Kyounggi do 420 717, Republic of Korea
    Expert Opin Investig Drugs 22:293-8. 2013
    ..This paper reviews a brief background information and discusses current clinical issues regarding the use of ChEIs in patients with schizophrenia...
  10. doi request reprint Early versus conventional switching of antidepressant: a post-hoc analysis of clinical trial data for major depressive disorder with moderate to severe pain symptoms
    Chi Un Pae
    The Catholic University of Korea College of Medicine, Bucheon St Mary s Hospital, Department of Psychiatry, 2 Sosa Dong, Wonmi gu, Pucheon, Kyounggi do 420 717, Seoul, Republic of Korea
    Expert Opin Pharmacother 13:2711-5. 2012
    ..This article discusses clinical significance, practical issues, potential limitations, and future research implications based on the findings from Dr. Romera and colleagues' study...
  11. doi request reprint Early switch strategy in patients with major depressive disorder
    Chi Un Pae
    Department of Psychiatry, The Catholic University of Korea College of Medicine, Seoul, Republic of Korea
    Expert Rev Neurother 12:1185-8. 2012
    ..This article will discuss the clinical significance, related practical issues, potential limitations and future research implications based on findings from the original study...
  12. ncbi request reprint Delirium: underrecognized and undertreated
    Chi Un Pae
    Chi Un Pae, MD, PhD Department of Psychiatry, The Catholic University of Korea College of Medicine, 505 Banpo Don, Seocho Gu, Seoul 137701, South Korea and Department of Psychiatry and Behavioral Medicine, Duke University Medical Center, 2218 Elder Street, Durham, NC 27705, USA
    Curr Treat Options Neurol 10:386-95. 2008
    ..Still, the indisputable health and financial costs of delirium indicate that prevention and identification should be a high priority...
  13. doi request reprint Desvenlafaxine in the treatment of major depressive disorder
    Chi Un Pae
    The Catholic University of Korea College of Medicine, Bucheon St Mary s Hospital, Department of Psychiatry, 2 Sosa Dong, Wonmi gu, Pucheon, Kyounggi do 420 717, Republic of Korea
    Expert Opin Pharmacother 12:2923-8. 2011
    ..This mini-review summarizes the clinical data and practical use of DESV under this approved indication...
  14. doi request reprint TAAR 6 and HSP-70 variations associated with bipolar disorder
    Chi Un Pae
    Department of Psychiatry, The Catholic University of Korea College of Medicine, Republic of Korea
    Neurosci Lett 465:257-61. 2009
    ..This study provides preliminary evidence that HSP-70 may play a role in the disrupted mechanisms that lead to BPD. Further confirmatory analyses in this direction are mandatory...
  15. ncbi request reprint Manganese superoxide dismutase (MnSOD: Ala-9Val) gene polymorphism may not be associated with schizophrenia and tardive dyskinesia
    Chi Un Pae
    Department of Psychiatry, Kangnam St Mary s Hospital, The Catholic University of Korea College of Medicine, Seocho Gu, Seoul, South Korea
    Psychiatry Res 153:77-81. 2007
    ..Taken together, these results suggest that the MnSOD polymorphism does not contribute to the development of schizophrenia and/or TD, at least in the Korean population...
  16. ncbi request reprint Extended-release formulation of venlafaxine in the treatment of post-traumatic stress disorder
    Chi Un Pae
    The Catholic University of Korea College of Medicine, Department of Psychiatry, Kangnam St Mary s Hospital, Seoul 137 701, South Korea
    Expert Rev Neurother 7:603-15. 2007
    ..This review focuses on the potential role of venlafaxine XR in the treatment of PTSD, based on currently available evidence...
  17. doi request reprint Pharmacological treatment of chronic fatigue syndrome: focusing on the role of antidepressants
    Chi Un Pae
    Holy Family Hospital, The Catholic University of Korea College of Medicine, Department of Psychiatry, Bucheon 420717, Kyeonggi Do, South Korea
    Expert Opin Pharmacother 10:1561-70. 2009
    ..The authors thoroughly reviewed major findings from the scanned literatures and eventually synthesized them, providing summary, interpretation, and future directions...
  18. doi request reprint Investigation of an epistastic effect between a set of TAAR6 and HSP-70 genes variations and major mood disorders
    Chi Un Pae
    Department of Psychiatry, Holy Family Hospital, The Catholic University of Korea College of Medicine, Seoul, Republic of Korea
    Am J Med Genet B Neuropsychiatr Genet 153:680-3. 2010
    ..001) and the testing balancing accuracy over 0.62 suggest a cautious optimism toward this result, although the possibility of false positivity warrants further analyses in independent samples...
  19. doi request reprint Milnacipran: beyond a role of antidepressant
    Chi Un Pae
    Department of Psychiatry, Holy Family Hospital, The Catholic University of Korea College of Medicine, Bucheon, Kyounggi Do, Republic of Korea
    Clin Neuropharmacol 32:355-63. 2009
    ..Future directions of research are also identified...
  20. ncbi request reprint Association of the trace amine associated receptor 6 (TAAR6) gene with schizophrenia and bipolar disorder in a Korean case control sample
    Chi Un Pae
    Department of Psychiatry, Catholic University of Korea, Seoul, South Korea
    J Psychiatr Res 42:35-40. 2008
    ..Further studies are needed to confirm these findings in this and other populations and to identify functional variants in TAAR6 that may be implicated in pathogenesis...
  21. ncbi request reprint Delirium: where do we stand?
    Chi Un Pae
    Department of Psychiatry, The Catholic University of Korea College of Medicine, Seoul 137701, South Korea
    Curr Psychiatry Rep 10:240-8. 2008
    ..Available research is reviewed, limitations of the research are discussed, and future directions for further delirium research are identified...
  22. doi request reprint Epistasis between a set of variations located in the TAAR6 and HSP-70 genes toward schizophrenia and response to antipsychotic treatment
    Chi Un Pae
    Department of Psychiatry, The Catholic University of Korea College of Medicine, Seocho Gu, Seoul 150 713, Republic of Korea
    Eur Neuropsychopharmacol 19:806-11. 2009
    ..Explanations for these findings and possible future directions are also discussed...
  23. ncbi request reprint Dysbindin associated with selective serotonin reuptake inhibitor antidepressant efficacy
    Chi Un Pae
    Department of Psychiatry, Kangnam St Mary s Hospital, The Catholic University of Korea College of Medicine, Seocho Gu, Seoul, Korea
    Pharmacogenet Genomics 17:69-75. 2007
    ..In the search for further genes influencing antidepressant response we focused on the dysbindin gene (dystrobrevin-binding-protein 1, DTNBP1)...
  24. ncbi request reprint Therapeutic implication of cocaine- and amphetamine-regulated transcript (CART) in the treatment of depression
    Chi Un Pae
    Department of Psychiatry, Kangnam St Mary Hospital, The Catholic University of Korea, College of Medicine, 505 Banpo Dong, Seocho Gu, Seoul 137 701, South Korea
    Med Hypotheses 69:132-5. 2007
    ..Hence, further studies on therapeutic implications of CART for depression are warranted and will contribute to the development of newer selective antidepressants...
  25. ncbi request reprint Therapeutic possibilities of cysteamine in the treatment of schizophrenia
    Chi Un Pae
    Department of Psychiatry, Kangnam St Mary Hospital, The Catholic University of Korea, College of Medicine, 505 Banpo Dong, Seocho Gu, Seoul 137 701, South Korea
    Med Hypotheses 69:199-202. 2007
    ..Hence, further explorations of therapeutic implication of cysteamine for schizophrenia in preclinical studies should be warranted in future...
  26. ncbi request reprint Potential role of lymphotoxin-alpha (tumor necrosis factor-beta) in the development of schizophrenia
    Chi Un Pae
    Department of Psychiatry, Kangnam St Mary Hospital, The Catholic University of Korea, College of Medicine, 505 Banpo Dong, Seocho Gu, Seoul 137 701, Republic of Korea
    Med Hypotheses 68:1359-62. 2007
    ..Therefore, TNF-beta may provide a new insight for understanding schizophrenia, providing a more systematic organization of immunological contributing factors to the development of schizophrenia...
  27. ncbi request reprint Aripiprazole augmentation for treatment of patients with inadequate antidepressants response
    Chi Un Pae
    Department of Psychiatry, The Catholic University of Korea, College of Medicine, Seoul, South Korea
    Depress Anxiety 24:522-6. 2007
    ..These results highlight the potential benefits of aripiprazole for these patients. However, adequately powered, randomized, controlled trials are needed to confirm these results...
  28. ncbi request reprint Selegiline transdermal system: current awareness and promise
    Chi Un Pae
    Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA
    Prog Neuropsychopharmacol Biol Psychiatry 31:1153-63. 2007
    ....
  29. ncbi request reprint Quinone oxidoreductase (NQO1) gene polymorphism may not confer a susceptibility to mood disorders
    Chi Un Pae
    Department of Psychiatry, Kangnam St Mary s Hospital, The Catholic University of Korea College of Medicine, 505 Banpo Dong, Seocho Gu, Seoul 137 701, South Korea
    Psychiatry Res 153:83-6. 2007
    ..These preliminary results showed that the NQO1 gene polymorphism was not related to a susceptibility to mood disorders...
  30. ncbi request reprint Desvenlafaxine, a serotonin-norepinephrine uptake inhibitor for major depressive disorder, neuropathic pain and the vasomotor symptoms associated with menopause
    Chi Un Pae
    Department of Psychiatry, Holy Family Hospital, The Catholic University of Korea College of Medicine, Sosa Dong, Wonmi gu, Pucheon, Kyounggi Do, Republic of Korea
    Curr Opin Investig Drugs 10:75-90. 2009
    ..However, concerns including mixed efficacy and adverse events need to be further explored in future studies...
  31. doi request reprint Additive effect between quinine oxidoreductase gene (NQO1: Pro187Ser) and manganese superoxide dismutase gene (MnSOD: Ala-9Val) polymorphisms on tardive dyskinesia in patients with schizophrenia
    Chi Un Pae
    Department of Psychiatry, Kangnam St Mary s Hospital, The Catholic University of Korea, College of Medicine, Seocho Gu, Seoul, Republic of Korea
    Psychiatry Res 161:336-8. 2008
    ..However, further adequately powered studies will be needed to confirm these preliminary findings...
  32. doi request reprint Does neurotropin-3 have a therapeutic implication in major depression?
    Chi Un Pae
    Department of Psychiatry, The Catholic University of Korea College of Medicine, Seoul, South Korea
    Int J Neurosci 118:1515-22. 2008
    ..Therefore, further studies on the therapeutic implications of NT3 for depression are warranted and are expected for the development of newer, effective antidepressants...
  33. doi request reprint Pregabalin augmentation of antidepressants in patients with accident-related posttraumatic stress disorder: an open label pilot study
    Chi Un Pae
    Department of Psychiatry, The Catholic University of Korea College of Medicine, Seoul, South Korea
    Int Clin Psychopharmacol 24:29-33. 2009
    ..Our findings warrant adequately powered, placebo-controlled clinical trials to confirm the usefulness of pregabalin augmentation of antidepressants in patients with PTSD...
  34. ncbi request reprint Do estradiol levels influence on the cognitive function during antidepressant treatments in post-menopausal women with major depressive disorder? A comparison with pre-menopausal women
    Chi Un Pae
    Department of Psychiatry, The Catholic University of Korea College of Medicine, Seoul, South Korea
    Neuro Endocrinol Lett 29:500-6. 2008
    ..Hence, this study aimed to investigate the role of menopausal status including the level of sex hormones on cognitive function during antidepressant treatment...
  35. doi request reprint The impact of heat shock protein 70 gene variations on clinical presentation and outcome in schizophrenic inpatients
    Chi Un Pae
    Department of Psychiatry, Holy Family Hospital, Catholic University of Korea College of Medicine, Wonmi gu, Bucheon, Republic of Korea
    Neuropsychobiology 59:135-41. 2009
    ..These findings further support a role of heat shock proteins in the pathophysiology of SZ...
  36. doi request reprint TAAR6 variation effect on clinic presentation and outcome in a sample of schizophrenic in-patients: an open label study
    Chi Un Pae
    Department of Psychiatry, Kangnam St Mary s Hospital, The Catholic University of Korea College of Medicine, Seoul, Republic of Korea
    Eur Psychiatry 23:390-5. 2008
    ..Haplotype analysis was not informative in our sample, probably also because of the incomplete SNPs' coverage of the gene we performed. Further studies in this direction are warranted...
  37. doi request reprint DTNBP1 haplotype influences baseline assessment scores of schizophrenic in-patients
    Chi Un Pae
    Department of Psychiatry, Kangnam St Mary s Hospital, The Catholic University of Korea College of Medicine, South Korea
    Neurosci Lett 440:150-4. 2008
    ..008; 0.005). Covariate analysis revealed a more stable significant association between A-A haplotype and baseline scores. These results suggest a protective effect of A-A haplotype on psychotic positive symptoms at baseline...
  38. doi request reprint Effectiveness of antidepressant treatments in pre-menopausal versus post-menopausal women: a pilot study on differential effects of sex hormones on antidepressant effects
    Chi Un Pae
    Department of Psychiatry, The Catholic University of Korea College of Medicine, Seoul, South Korea
    Biomed Pharmacother 63:228-35. 2009
    ..Furthermore, the FSH may interfere with the mechanism of action of the antidepressant agents. Hence, larger, randomized and controlled trials are warranted to expand our understanding of this area...
  39. ncbi request reprint Aripiprazole in the treatment of depressive and anxiety disorders: a review of current evidence
    Chi Un Pae
    Department of Psychiatry, Kangnam St Mary s Hospital, The Catholic University of Korea College of Medicine, Seoul, South Korea
    CNS Drugs 22:367-88. 2008
    ..Clinical data also suggest that aripiprazole may have a lower adverse effect burden than the other atypical drugs. Future research may confirm the potential utility of aripiprazole in the treatment of depressive and anxiety disorders...
  40. doi request reprint Immediate versus gradual suspension of previous treatments during switch to aripiprazole: results of a randomized, open label study
    Chi Un Pae
    Department of Psychiatry, The Catholic University of Korea College of Medicine, Seoul, South Korea
    Eur Neuropsychopharmacol 19:562-70. 2009
    ....
  41. ncbi request reprint The atypical antipsychotics olanzapine and risperidone in the treatment of posttraumatic stress disorder: a meta-analysis of randomized, double-blind, placebo-controlled clinical trials
    Chi Un Pae
    Department of Psychiatry, The Catholic University of Korea, College of Medicine, Seoul, South Korea
    Int Clin Psychopharmacol 23:1-8. 2008
    ..Clinical significance of the results, however, should be carefully interpreted and translated into clinical practice, given that the quality and availability of currently existing RCTs included in the analysis...
  42. ncbi request reprint Fatigue as a core symptom in major depressive disorder: overview and the role of bupropion
    Chi Un Pae
    Department of Psychiatry, Kangnam St Mary s Hospital, The Catholic University of Korea College of Medicine, Seoul 137 701, South Korea
    Expert Rev Neurother 7:1251-63. 2007
    ....
  43. ncbi request reprint Desvenlafaxine: a new antidepressant or just another one?
    Chi Un Pae
    Department of Psychiatry, The Catholic University of Korea College of Medicine, Holy Family Hospital, Pucheon, Kyounggi Do, Republic of Korea
    Expert Opin Pharmacother 10:875-87. 2009
    ..Preliminary evidence also suggests the clinical usefulness of DVS in the treatment of vasomotor symptoms of menopause, anxiety symptoms and painful physical symptoms, although only MDD is the approved indication...
  44. ncbi request reprint Paroxetine: current status in psychiatry
    Chi Un Pae
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27705, USA
    Expert Rev Neurother 7:107-20. 2007
    ..It also discusses emerging evidence in other clinical areas and recent data that have led to modifications in the safety profile of paroxetine...
  45. ncbi request reprint Do we need more than one antidepressant for patients with major depressive disorder?
    Chi Un Pae
    Department of Psychiatry, The Catholic University of Korea College of Medicine, Seoul, South Korea
    Expert Rev Neurother 11:1561-4. 2011
    ..7) than for monotherapy (4.7) at 12 weeks. This article will discuss the clinical and further research implications in the context of the potential limitations and significance of this recent study...
  46. doi request reprint No influence of DTNBP1 polymorphisms on the response to aripiprazole
    Chi Un Pae
    Department of Psychiatry, Bucheon St Mary s Hospital, Catholic University of Korea College of Medicine, Bucheon, Republic of Korea
    Neuropsychobiology 62:245-9. 2010
    ....
  47. doi request reprint TAAR6 variations possibly associated with antidepressant response and suicidal behavior
    Chi Un Pae
    Department of Psychiatry, Kangnam St Mary s Hospital, The Catholic University of Korea College of Medicine, Republic of Korea
    Psychiatry Res 180:20-4. 2010
    ..Heterogeneity of treatment, possible stratification bias not controlled by the statistical analyses, and the risk of false-positive finding mandate further analysis in this direction...
  48. doi request reprint Influence of DAOA gene variants on antipsychotic response after switch to aripiprazole
    Chi Un Pae
    Department of Psychiatry, Bucheon St Mary s Hospital, The Catholic University of Korea, College of Medicine, Bucheon, Kyonggi Do, Republic of Korea
    Psychiatry Res 178:430-2. 2010
    ..Further research is needed to determine the role of DAOA on the response to antipsychotics...
  49. doi request reprint Quetiapine XR: current status for the treatment of major depressive disorder
    Chi Un Pae
    Department of Psychiatry, Bucheon St Mary s Hospital, The Catholic University of Korea College of Medicine, 2 Sosa Dong, Wonmi gu, Pucheon, Kyounggi do 420 717, Republic of Korea
    Prog Neuropsychopharmacol Biol Psychiatry 34:1165-73. 2010
    ....
  50. doi request reprint Predictors of early worsening after switch to aripiprazole: a randomized, controlled, open-label study
    Chi Un Pae
    Department of Psychiatry, The Catholic University of Korea College of Medicine, Seoul, South Korea
    Clin Drug Investig 30:187-93. 2010
    ....
  51. ncbi request reprint Association between antidepressants and breast/ovarian cancer
    Chi Un Pae
    The Catholic University of Korea College of Medicine, Bucheon St Mary s Hospital, Department of Psychiatry, 2 Sosa Dong, Wonmi gu, Pucheon, Kyounggi do 420 717, Republic of Korea
    Expert Opin Pharmacother 13:441-4. 2012
    ....
  52. doi request reprint Aripiprazole as adjunctive therapy for patients with major depressive disorder: overview and implications of clinical trial data
    Chi Un Pae
    Department of Psychiatry, Bucheon St Marys Hospital, The Catholic University of Korea College of Medicine, Bucheon, Kyounggi Do, Republic of Korea
    CNS Drugs 25:109-27. 2011
    ....
  53. doi request reprint The relationship between fibromyalgia and major depressive disorder: a comprehensive review
    Chi Un Pae
    Department of Psychiatry, Kangnam St Mary s Hospital, The Catholic University of Korea College of Medicine, Seoul, South Korea
    Curr Med Res Opin 24:2359-71. 2008
    ..Improved understanding of this relationship promises to provide clinicians with better assessment and treatment options for both disorders...
  54. doi request reprint Paroxetine mesylate: comparable to paroxetine hydrochloride?
    Chi Un Pae
    The Catholic University of Korea College of Medicine, Bucheon St Mary s Hospital, Department of Psychiatry, 2 Sosa Dong, Wonmi gu, Bucheon Kyounggi Do 420 717, South Korea
    Expert Opin Pharmacother 11:185-93. 2010
    ..Currently available small case reports clearly propose that existing regulatory procedures to approve generic versions only require essential bioequivalence, have limitations and fail to meet stricter scientific and clinical demands...
  55. ncbi request reprint Paroxetine-associated spontaneous sexual stimulation
    Chi Un Pae
    Department of Psychiatry, Kangnam St Mary s Hospital, Seoul, Korea
    Int Clin Psychopharmacol 20:339-41. 2005
    ..Because there is little information in the existing literature on this issue, we report three female cases who developed frequent spontaneous orgasm and increased libido during paroxetine treatment...
  56. doi request reprint A review of the safety and tolerability of aripiprazole
    Chi Un Pae
    Catholic University of Korea College of Medicine, Holy Family Hospital, Department of Psychiatry, Sosa Dong, Wonmi gu, Bucheon 420 717, Kyounggi Do, Republic of Korea
    Expert Opin Drug Saf 8:373-86. 2009
    ....
  57. doi request reprint Atypical depression: a comprehensive review
    Chi Un Pae
    Department of Psychiatry, The Catholic University of Korea College of Medicine, Seoul, South Korea
    CNS Drugs 23:1023-37. 2009
    ....
  58. ncbi request reprint Low-dose mirtazapine may be successful treatment option for severe nausea and vomiting
    Chi Un Pae
    Department of Psychiatry, The Catholic University of Korea College of Medicine, Seoul, South Korea
    Prog Neuropsychopharmacol Biol Psychiatry 30:1143-5. 2006
    ..The authors report two cases with severe nausea and vomiting that were dramatically treated with mirtazapine in the Korean population...
  59. ncbi request reprint Manganese superoxide dismutase (MnSOD: Ala-9Val) gene polymorphism and mood disorders: a preliminary study
    Chi Un Pae
    Department of Psychiatry, Kangnam St Mary s Hospital, The Catholic University of Korea College of Medicine, 505 Banpo Dong, Seocho Gu, Seoul 137 701, Korea
    Prog Neuropsychopharmacol Biol Psychiatry 30:1326-9. 2006
    ..However, more study with a larger population sample will be needed...
  60. ncbi request reprint Adjunctive risperidone, olanzapine and quetiapine for the treatment of hospitalized patients with bipolar I disorder: a retrospective study
    Chi Un Pae
    Department of Psychiatry, Kangnam St Mary s Hospital, The Catholic University of Korea College of Medicine, South Korea
    Prog Neuropsychopharmacol Biol Psychiatry 30:1322-5. 2006
    ..However, there were some differences in tolerability between these results as reported from previous Western studies...
  61. doi request reprint Influence of BDNF variants on diagnosis and response to treatment in patients with major depression, bipolar disorder and schizophrenia
    Chi Un Pae
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA
    Neuropsychobiology 65:1-11. 2012
    ....
  62. ncbi request reprint Polymorphism of CTLA-4 gene at position 49 of exon 1 may be associated with schizophrenia in the Korean population
    Tae Youn Jun
    Department of Psychiatry, College of Medicine, The Catholic University of Korea, 62 Youido dong, Youngdeungpo gu, Seoul, 150 713, South Korea
    Psychiatry Res 110:19-25. 2002
    ..This study suggests a putative role of the CTLA-4 gene polymorphism at position 49 of exon 1 for schizophrenia in the Korean population, although the detailed mechanisms remained to be elucidated...
  63. ncbi request reprint Is there protective haplotype of dysbindin gene (DTNBP1) 3 polymorphisms for major depressive disorder
    Jung Jin Kim
    Department of Psychiatry, The Catholic University of Korea College of Medicine, 505 Banpo Dong, Seocho Gu, Seoul 137 701, South Korea
    Prog Neuropsychopharmacol Biol Psychiatry 32:375-9. 2008
    ..Coupled with previous findings on schizophrenia, our finding suggests that dysbindin gene variants may have a role in the susceptibility to MDD. Adequately powered further studies in different ethnic groups are warranted...
  64. ncbi request reprint TNFB polymorphism may be associated with schizophrenia in the Korean population
    Tae Youn Jun
    Department of Psychiatry, College of Medicine, The Catholic University of Korea, St Mary s Hospital, 62 Yoido dong, Youngdeungpo gu, Seoul, 150 713, South Korea
    Schizophr Res 61:39-45. 2003
    ..Subjects with the TNFB*2 allele had an increased risk for schizophrenia (Odds Ratio=1.76, 95% CI=1.27-2.45). The present study suggests that the TNFB polymorphism may confer susceptibility to schizophrenia in the Korean population...
  65. ncbi request reprint Monocyte chemoattractant protein-1 (MCP1) promoter -2518 polymorphism may confer a susceptibility to major depressive disorder in the Korean population
    Chi Un Pae
    Department of Psychiatry, Kangnam St Mary s Hospital, Catholic University of Korea College of Medicine, 505 Banpo Dong, Seocho Gu, Seoul 137 701, Republic of Korea
    Psychiatry Res 127:279-81. 2004
    ..We found significant differences in genotype and allele frequencies. The present study suggests that this polymorphism may confer a susceptibility to major depressive disorder in the Korean population...
  66. ncbi request reprint Polymorphism of the serotonin transporter gene and symptomatic dimensions of schizophrenia in the Korean population
    Chi Un Pae
    Department of Psychiatry, Kangnam St Mary s Hospital, The Catholic University of Korea College of Medicine, 505 Banpo Dong, Seocho Gu, Seoul 137 701, South Korea
    Neuropsychobiology 47:182-6. 2003
    ..These results suggest that 5-HTTLPR may contribute to the susceptibility to the symptomatology of schizophrenia but not to the development of the disorder itself, at least in the Korean population...
  67. ncbi request reprint Quinone oxidoreductase (NQO1) gene polymorphism (609C/T) may be associated with tardive dyskinesia, but not with the development of schizophrenia
    Chi Un Pae
    Department of Psychiatry, Kangnam St Mary s Hospital, The Catholic University of Korea College of Medicine, Banpo dong, Seocho Gu, Seoul 137 701, Korea
    Int J Neuropsychopharmacol 7:495-500. 2004
    ..004). This study suggests that the NQO1 gene polymorphism (609C/T) may confer susceptibility to the development of TD in schizophrenia, at least in the Korean population...
  68. ncbi request reprint BanI polymorphism of the cytosolic phospholipase A2 gene and mood disorders in the Korean population
    Chi Un Pae
    Department of Psychiatry, Kangnam St Mary s Hospital, The Catholic University of Korea, College of Medicine, Seoul, Korea
    Neuropsychobiology 49:185-8. 2004
    ..This preliminary study indicates the need for further studies on the potential role of the cPLA2 gene polymorphism in the susceptibility to mood disorders...
  69. ncbi request reprint Report on IL-10 gene polymorphism at position -819 for major depression and schizophrenia in Korean population
    Tae Youn Jun
    Department of Psychiatry, St Mary s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea
    Psychiatry Clin Neurosci 56:177-80. 2002
    ..Further systematic studies including various clinical variables would be required...
  70. ncbi request reprint Heat-shock protein-70 genes and response to antidepressants in major depression
    Chi Un Pae
    Department of Psychiatry, Kangnam St Mary s Hospital, The Catholic University of Korea College of Medicine, Seoul, South Korea
    Prog Neuropsychopharmacol Biol Psychiatry 31:1006-11. 2007
    ..In conclusion, genetic variants within the genes coding for HSP-70 family proteins may affect the action of antidepressants and thus their therapeutic efficacy...
  71. ncbi request reprint No evidence for an association of the CTLA4 gene with bipolar I disorder
    Tae Youn Jun
    Department of Psychiatry, College of Medicine, Catholic University of Korea, Seoul, Korea
    Psychiatry Clin Neurosci 58:21-4. 2004
    ..1% vs 66.1%; 28.9% vs 33.9%, respectively). In the present study an association was not found of exon 1 (+49) polymorphism of CTLA4 gene with bipolar disorder in the Korean population...
  72. ncbi request reprint Monocyte chemoattractant protein-1 promoter -2518 polymorphism may have an influence on clinical heterogeneity of bipolar I disorder in the Korean population
    Chi Un Pae
    Department of Psychiatry, Kangnam St Mary s Hospital, The Catholic University of Korea College of Medicine, Seoul, Korea
    Neuropsychobiology 49:111-4. 2004
    ..The present study suggests that the MCP1 promoter -2518 polymorphism may not confer susceptibility to BID itself, but could have an influence on the clinical heterogeneity of BID, at least in the Korean population...
  73. ncbi request reprint Polymorphisms of heat shock protein 70 gene (HSPA1A, HSPA1B and HSPA1L) and schizophrenia
    Chi Un Pae
    Department of Psychiatry, The Catholic University of Korea College of Medicine, Kangnam St Mary s Hospital, 505 Banpo Dong, Seocho Gu, Seoul 137 701, Republic of Korea
    Neurosci Res 53:8-13. 2005
    ..Therefore, larger studies from different ethnic groups should be performed to confirm these results...
  74. ncbi request reprint VNTR polymorphism of tyrosine hydroxylase gene and schizophrenia in the Korean population
    Chi Un Pae
    Department of Psychiatry, College of Medicine, Catholic University of Korea, Kangnam St Mary s Hospital, Seocho Gu, Seoul, Korea
    Neuropsychobiology 47:131-6. 2003
    ..This finding suggests that the TH10 allele may be a liability factor for positive schizophrenia in the Korean population...
  75. ncbi request reprint Tumor necrosis factor-beta gene polymorphism may not be associated with major depressive disorder in the Korean population
    Tae Youn Jun
    Department of Psychiatry, St Mary s Hospital, The Catholic University of Korea, College of Medicine, Seoul, Korea
    Psychiatry Clin Neurosci 57:31-5. 2003
    ..This study suggests that the TNF-beta gene polymorphism does not confer a susceptibility to MDD in the Korean population. A larger scaled study to examine different races is necessary to determine a role in the pathogenesis of MDD...
  76. ncbi request reprint Association study between glutathione S-transferase P1 polymorphism and schizophrenia in the Korean population
    Chi Un Pae
    Department of Psychiatry, Kangnam St Mary s Hospital, The Catholic University of Korea College of Medicine, Banpo dong, Seocho Gu, Seoul, South Korea
    Prog Neuropsychopharmacol Biol Psychiatry 27:519-23. 2003
    ..The present study suggests that GSTP1 polymorphism may not confer susceptibility to development of schizophrenia in the Korean population...
  77. ncbi request reprint No evidence for interaction between 5-HT2A receptor and serotonin transporter genes in schizophrenia
    Chi Un Pae
    Department of Psychiatry, Kangnam St Mary s Hospital, The Catholic University of Korea, College of Medicine, 505 Banpo Dong, Seocho Gu, Seoul 137 701, South Korea
    Neurosci Res 52:195-9. 2005
    ....
  78. doi request reprint No influence of FAT polymorphisms in response to aripiprazole
    Chi Un Pae
    Department of Psychiatry, Bucheon St Mary s Hospital, The CatholicUniversity of Korea College of Medicine, Bucheon, Republic of Korea and Department of Psychiatry and Behavioral Science, Duke University Medical Center, Durham, NC, USA
    J Hum Genet 55:32-6. 2010
    ..Our data suggest no association between investigated alleles and genotypes in FAT and response to aripiprazole. However, because several limitations characterize the present study, further investigations on larger studies are required...
  79. doi request reprint Taq1A polymorphism in the dopamine D2 receptor gene as a predictor of clinical response to aripiprazole
    Jun Soo Kwon
    Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea
    Eur Neuropsychopharmacol 18:897-907. 2008
    ..The results suggest an association between the DRD2 Taq1A polymorphism status and the variation in the clinical response to aripiprazole...
  80. doi request reprint Dysbindin gene (DTNBP1) and schizophrenia in Korean population
    Chi Un Pae
    Department of Psychiatry, The Catholic University of Korea College of Medicine, 505 Banpo Dong, Seocho Gu, Seoul 137 701, South Korea
    Eur Arch Psychiatry Clin Neurosci 259:137-42. 2009
    ..In conclusion, the present study suggests a possible protective effect of rare DTNBP1 variants in schizophrenia, although subsequent studies in different ethnic groups are warranted...
  81. ncbi request reprint Effect of 5-haplotype of dysbindin gene (DTNBP1) polymorphisms for the susceptibility to bipolar I disorder
    Chi Un Pae
    Department of Psychiatry, The Catholic University of Korea College of Medicine, Seoul, South Korea
    Am J Med Genet B Neuropsychiatr Genet 144:701-3. 2007
    ..Adequately powered studies from different ethnicities will be necessary to confirm our findings...
  82. doi request reprint Association analysis of heat shock protein 70 gene polymorphisms in schizophrenia
    Jung Jin Kim
    Department of Psychiatry, The Catholic University of Korea College of Medicine, Kangnam St Mary s Hospital, 505 Banpo Dong, Seocho Gu, Seoul 137 701, Republic of Korea
    Eur Arch Psychiatry Clin Neurosci 258:239-44. 2008
    ..Therefore, this study investigated the association between an enlarged set of SNPs at HSP70 gene and schizophrenia...
  83. ncbi request reprint Comparison of venlafaxine extended release versus paroxetine for treatment of patients with generalized anxiety disorder
    Tae Suk Kim
    Department of Psychiatry, Kangnam St Mary s Hospital, and Department of Rehabilitation Medicine, Catholic University of Korea, College of Medicine, Seoul, Korea
    Psychiatry Clin Neurosci 60:347-51. 2006
    ..Double blind, placebo-controlled head-to-head comparison studies are needed to draw a definite conclusion...
  84. ncbi request reprint A randomized, double-blind, placebo-controlled trial of augmentation with an extended release formulation of methylphenidate in outpatients with treatment-resistant depression
    Ashwin A Patkar
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27704, USA
    J Clin Psychopharmacol 26:653-6. 2006
    ..Combination of methylphenidate with antidepressants was well tolerated. Adequately powered, randomized, controlled trials are necessary to fully evaluate the efficacy of extended-release methylphenidate in TRD...
  85. ncbi request reprint Venlafaxine versus mirtazapine in the treatment of undifferentiated somatoform disorder: a 12-week prospective, open-label, randomized, parallel-group trial
    Changsu Han
    Department of Psychiatry, Korea University, College of Medicine, Seoul, Korea
    Clin Drug Investig 28:251-61. 2008
    ..We set out to compare the efficacy and tolerability of mirtazapine versus venlafaxine in patients with undifferentiated somatoform disorder (USD) using the Patient Health Questionnaire-15 (PHQ-15)...
  86. ncbi request reprint Human leukocyte antigen alleles in patients with bipolar disorder in the Korean population
    Tae Youn Jun
    Department of Psychiatry, College of Medicine, The Catholic University of Korea, Seoul, Korea
    Psychiatry Clin Neurosci 56:453-7. 2002
    ..To clarify the genetic influence of HLA on bipolar disorder, we should conduct a consecutive study with a larger cohort of subjects...
  87. ncbi request reprint Association of the serotonin transporter gene polymorphism with Korean male alcoholics
    Yong Sil Kweon
    Department of Psychiatry, College of Medicine, Uijongbu St Mary s Hospital, The Catholic University of Korea, 65 1, Geumo dong, Uijongbu city, Gyeonggi do 480 130, Republic of Korea
    J Psychiatr Res 39:371-6. 2005
    ..005, df=1, p=0.045). This study suggests a putative role of the 5-HTTLPR for alcoholism in the Korean population. However, a replication study with larger different ethnic samples and a refinement of the subtype of alcoholism is needed...
  88. ncbi request reprint No association of TAP2 polymorphisms in Korean patients with schizophrenia
    Tae Youn Jun
    Department of Psychiatry, College of Medicine, The Catholic University of Korea, Seoul, Korea
    Psychiatr Genet 14:173-6. 2004
    ..The aim of this study was to verify the relationship between schizophrenia and the polymorphisms of TAP2 genes...
  89. doi request reprint Long-term efficacy and safety of aripiprazole in patients with schizophrenia, schizophreniform disorder, or schizoaffective disorder: 26-week prospective study
    Jun Soo Kwon
    Department of Psychiatry, Seoul National University College of Medicine, Seoul, Korea
    Psychiatry Clin Neurosci 63:73-81. 2009
    ..The aim of the present study was therefore to investigate the long-term efficacy, safety and tolerability of aripiprazole in a large number of patients with schizophrenia, schizophreniform disorder, or schizoaffective disorder in Korea...
  90. ncbi request reprint Tumor necrosis factor-alpha gene polymorphism at position -308 and schizophrenia in the Korean population
    Chi Un Pae
    Department of Psychiatry, Kangnam St Mary s Hospital, Catholic University of Korea College of Medicine, Seocho Gu, Seoul
    Psychiatry Clin Neurosci 57:399-403. 2003
    ..In the light of these results, the TNFA polymorphism seems not to confer susceptibility to the pathogenesis of schizophrenia, at least in the Korean population...
  91. ncbi request reprint Polymorphisms of interleukin-4 promoter and receptor gene for schizophrenia in the Korean population
    Tae Youn Jun
    Departments of Psychiatry and Microbiology and Immunology, College of Medicine, The Catholic University of Korea, Seoul, Korea
    Psychiatry Clin Neurosci 57:283-8. 2003
    ..In conclusion, these results suggest that the polymorphisms in IL-4 promoter gene -590 and IL-4 Ralpha gene 1902 are not involved in the pathophysiology of schizophrenia in the Korean population...
  92. doi request reprint A double-blind, randomized, placebo-controlled trial of paroxetine controlled-release in irritable bowel syndrome
    Prakash S Masand
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, 1001 Winstead Dr, Suite 200, Cary, NC 27513, USA
    Psychosomatics 50:78-86. 2009
    ..Irritable bowel syndrome (IBS) is a functional gastrointestinal (GI) disease that causes significant impairment in quality of life and accounts for $8 billion per year to the healthcare system and loss of productivity in the workplace...
  93. ncbi request reprint Effectiveness and tolerability of paroxetine controlled release (CR) in the treatment of major depressive disorder: an open-label, prospective, multi-center trial in Korea
    Chi Un Pae
    Department of Psychiatry, Kangnam St Mary s Hospital, The Catholic University of Korea College of Medicine, Seoul, Republic of Korea
    Hum Psychopharmacol 22:351-9. 2007
    ..This study evaluated the effectiveness and tolerability of paroxetine controlled release (CR) for the treatment of Korean patients with major depressive disorder (MDD) in a naturalistic treatment setting...
  94. doi request reprint History of depressive and/or anxiety disorders as a predictor of treatment response: a post hoc analysis of a 12-week, randomized, double-blind, placebo-controlled trial of paroxetine controlled release in patients with fibromyalgia
    Chi Un Pae
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27704, USA
    Prog Neuropsychopharmacol Biol Psychiatry 33:996-1002. 2009
    ..We investigated whether a history of depressive and/or anxiety disorders was associated with response to paroxetine controlled release (CR) in the treatment of fibromyalgia...
  95. ncbi request reprint Transdermal selegiline
    Ashwin A Patkar
    Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC 27705, USA
    Drugs Today (Barc) 43:361-77. 2007
    ..It is important for health-care professionals to be informed about the properties of STS...
  96. ncbi request reprint Interleukin-10 gene promoter polymorphism is not associated with schizophrenia in the Korean population
    Tae Youn Jun
    Department of Psychiatry, College of Medicine, Catholic University of Korea, St Mary s Hospital, Seoul, Korea
    Psychiatry Clin Neurosci 57:153-9. 2003
    ..The present study suggests that IL-10 gene promoter polymorphism is not associated with the development of schizophrenia in the Korean population...
  97. ncbi request reprint Topiramate and divalproex in combination with risperidone for acute mania: a randomized open-label study
    Won Myong Bahk
    Department of Psychiatry, St Mary s Hospital, The Catholic University of Korea College of Medicine, Seoul, South Korea
    Prog Neuropsychopharmacol Biol Psychiatry 29:115-21. 2005
    ..Despite the methodological limitations, topiramate was effective and tolerable for treating acute mania and may also be a promising alternative to a weight-gain liable mood stabilizer (MS) such as divalproex...
  98. ncbi request reprint BanI polymorphism of the cytosolic phospholipase A2 gene may confer susceptibility to the development of schizophrenia
    Chi Un Pae
    Department of Psychiatry, Kangnam St Mary Hospital, The Catholic University of Korea College of Medicine, 505 Banpo Dong, Seocho Gu, Seoul 137 701, South Korea
    Prog Neuropsychopharmacol Biol Psychiatry 28:739-41. 2004
    ..The results of this study replicated those of previous findings from Western countries and indicates the need for further studies on the potential role of the cPLA2 gene polymorphism in the susceptibility to schizophrenia...
  99. ncbi request reprint Open label study of the effect of amantadine on weight gain induced by olanzapine
    Won Myong Bahk
    Department of Psychiatry, College of Medicine, Catholic University of Korea, Seoul, Korea
    Psychiatry Clin Neurosci 58:163-7. 2004
    ..001). No significant changes were present in ESRS. Amantadine did not have an effect on weight gain induced by olanzapine. Randomized placebo-controlled prospective studies are needed...
  100. ncbi request reprint Switching to quetiapine in patients with acute mania who were intolerant to risperidone
    Chi Un Pae
    Department of Psychiatry, The Catholic University of Korea College of Medicine, Seoul, Korea
    Hum Psychopharmacol 19:47-51. 2004
    ....
  101. ncbi request reprint Possible association between -G308A tumour necrosis factor-alpha gene polymorphism and major depressive disorder in the Korean population
    Tae Youn Jun
    Department of Psychiatry, Kangnam St Mary s Hospital, The Catholic University of Korea College of Medicine, 505 Banpo Dong, Seocho Gu, Seoul 137 401, Korea
    Psychiatr Genet 13:179-81. 2003
    ..The present study was aimed at examining the association between the -G308A tumour necrosis factor-alpha gene polymorphism and major depressive disorder (MDD) in the Korean population...