Wan Uk Kim

Summary

Affiliation: The Catholic University of Korea
Country: Korea

Publications

  1. pmc Toll-like receptors in systemic lupus erythematosus; prospects for therapeutic intervention
    Wan Uk Kim
    Department of Internal Medicine, School of Medicine, Catholic University of Korea, Seoul, South Korea
    Autoimmun Rev 8:204-8. 2009
  2. ncbi request reprint T cell proliferative response to type II collagen in the inflammatory process and joint damage in patients with rheumatoid arthritis
    Wan Uk Kim
    Division of Rheumatology, Department of Internal Medicine, School of Medicine, Catholic University of Korea, St Vincent s Hospital, Suwon, South Korea
    J Rheumatol 32:225-30. 2005
  3. pmc Soluble Fas ligand inhibits angiogenesis in rheumatoid arthritis
    Wan Uk Kim
    Division of Rheumatology, Department of Internal Medicine, School of Medicine, Catholic University of Korea, Seoul 137 701, Korea
    Arthritis Res Ther 9:R42. 2007
  4. pmc Elevated matrix metalloproteinase-9 in patients with systemic sclerosis
    Wan Uk Kim
    Division of Rheumatology, Department of Internal Medicine, Catholic Research Institutes of Medical Science, School of Medicine, The Catholic University of Korea, Seoul, Republic of Korea
    Arthritis Res Ther 7:R71-9. 2005
  5. ncbi request reprint Cyclosporine differentially regulates interleukin-10, interleukin-15, and tumor necrosis factor a production by rheumatoid synoviocytes
    Mi La Cho
    The Center for Rheumatic Diseases in Kang Nam St Mary s Hospital, Catholic University of Korea, Seoul
    Arthritis Rheum 46:42-51. 2002
  6. ncbi request reprint Elevated vascular endothelial growth factor in systemic sclerosis
    Jin Jung Choi
    Department of Internal Medicine, Division of Rheumatology, St Mary s Hospital, Research Institute of Immunobiology, The Catholic University of Korea, Seoul, Korea
    J Rheumatol 30:1529-33. 2003
  7. ncbi request reprint Suppression of collagen-induced arthritis by single administration of poly(lactic-co-glycolic acid) nanoparticles entrapping type II collagen: a novel treatment strategy for induction of oral tolerance
    Wan Uk Kim
    The Catholic University of Korea, Seoul, Republic of South Korea
    Arthritis Rheum 46:1109-20. 2002
  8. ncbi request reprint Arginine-rich anti-vascular endothelial growth factor (anti-VEGF) hexapeptide inhibits collagen-induced arthritis and VEGF-stimulated productions of TNF-alpha and IL-6 by human monocytes
    Seung Ah Yoo
    Department of Internal Medicine, Division of Rheumatology, Catholic University of Korea, Seoul
    J Immunol 174:5846-55. 2005
  9. ncbi request reprint Increase of cyclooxygenase-2 expression by interleukin 15 in rheumatoid synoviocytes
    So Youn Min
    Department of Internal Medicine, Division of Rheumatology, Catholic University of Korea, Seoul, Korea
    J Rheumatol 31:875-83. 2004
  10. doi request reprint Anti-neuropilin-1 peptide inhibition of synoviocyte survival, angiogenesis, and experimental arthritis
    Jin Sun Kong
    The Catholic University of Korea, Seoul, South Korea
    Arthritis Rheum 62:179-90. 2010

Collaborators

Detail Information

Publications46

  1. pmc Toll-like receptors in systemic lupus erythematosus; prospects for therapeutic intervention
    Wan Uk Kim
    Department of Internal Medicine, School of Medicine, Catholic University of Korea, Seoul, South Korea
    Autoimmun Rev 8:204-8. 2009
    ..Pharmacologic modulation of TLR-directed pathways may offer new therapeutic approaches for the treatment of SLE...
  2. ncbi request reprint T cell proliferative response to type II collagen in the inflammatory process and joint damage in patients with rheumatoid arthritis
    Wan Uk Kim
    Division of Rheumatology, Department of Internal Medicine, School of Medicine, Catholic University of Korea, St Vincent s Hospital, Suwon, South Korea
    J Rheumatol 32:225-30. 2005
    ..To investigate the role of T cell responses to type II collagen (CII) in disease progression in patients with rheumatoid arthritis (RA)...
  3. pmc Soluble Fas ligand inhibits angiogenesis in rheumatoid arthritis
    Wan Uk Kim
    Division of Rheumatology, Department of Internal Medicine, School of Medicine, Catholic University of Korea, Seoul 137 701, Korea
    Arthritis Res Ther 9:R42. 2007
    ....
  4. pmc Elevated matrix metalloproteinase-9 in patients with systemic sclerosis
    Wan Uk Kim
    Division of Rheumatology, Department of Internal Medicine, Catholic Research Institutes of Medical Science, School of Medicine, The Catholic University of Korea, Seoul, Republic of Korea
    Arthritis Res Ther 7:R71-9. 2005
    ..These findings suggest that the enhanced production of MMP-9 may contribute to fibrogenic remodeling during the progression of skin sclerosis in SSc...
  5. ncbi request reprint Cyclosporine differentially regulates interleukin-10, interleukin-15, and tumor necrosis factor a production by rheumatoid synoviocytes
    Mi La Cho
    The Center for Rheumatic Diseases in Kang Nam St Mary s Hospital, Catholic University of Korea, Seoul
    Arthritis Rheum 46:42-51. 2002
    ..To determine the direct effect of cyclosporin A (CSA) on the production of cytokines by rheumatoid synovial fibroblasts...
  6. ncbi request reprint Elevated vascular endothelial growth factor in systemic sclerosis
    Jin Jung Choi
    Department of Internal Medicine, Division of Rheumatology, St Mary s Hospital, Research Institute of Immunobiology, The Catholic University of Korea, Seoul, Korea
    J Rheumatol 30:1529-33. 2003
    ..To determine the serum levels of vascular endothelial growth factor (VEGF) in patients with systemic sclerosis (SSc) and to search for relationships between its serum levels and the clinical manifestations...
  7. ncbi request reprint Suppression of collagen-induced arthritis by single administration of poly(lactic-co-glycolic acid) nanoparticles entrapping type II collagen: a novel treatment strategy for induction of oral tolerance
    Wan Uk Kim
    The Catholic University of Korea, Seoul, Republic of South Korea
    Arthritis Rheum 46:1109-20. 2002
    ..This study was undertaken to investigate the tolerogenic effect of single administration of PLGA entrapping type II collagen (CII) on the development of collagen-induced arthritis (CIA)...
  8. ncbi request reprint Arginine-rich anti-vascular endothelial growth factor (anti-VEGF) hexapeptide inhibits collagen-induced arthritis and VEGF-stimulated productions of TNF-alpha and IL-6 by human monocytes
    Seung Ah Yoo
    Department of Internal Medicine, Division of Rheumatology, Catholic University of Korea, Seoul
    J Immunol 174:5846-55. 2005
    ..These data suggest that dRK6 may be an effective strategy in the treatment of RA, and could be applied to modulate various chronic VEGF-dependent inflammatory diseases...
  9. ncbi request reprint Increase of cyclooxygenase-2 expression by interleukin 15 in rheumatoid synoviocytes
    So Youn Min
    Department of Internal Medicine, Division of Rheumatology, Catholic University of Korea, Seoul, Korea
    J Rheumatol 31:875-83. 2004
    ..To determine the effect of interleukin 15 (IL-15) on cyclooxygenase-2 (COX-2) expression in rheumatoid synoviocytes...
  10. doi request reprint Anti-neuropilin-1 peptide inhibition of synoviocyte survival, angiogenesis, and experimental arthritis
    Jin Sun Kong
    The Catholic University of Korea, Seoul, South Korea
    Arthritis Rheum 62:179-90. 2010
    ..To delineate the role of neuropilin-1 (NP-1), a vascular endothelial growth factor receptor (VEGFR), in rheumatoid inflammation and to determine whether blockade of NP-1 could suppress synoviocyte survival and angiogenesis...
  11. ncbi request reprint Calcineurin is expressed and plays a critical role in inflammatory arthritis
    Seung Ah Yoo
    Department of Internal Medicine, Catholic University of Korea, Seoul, Korea
    J Immunol 177:2681-90. 2006
    ....
  12. ncbi request reprint Prostaglandin E2 suppresses nuclear factor-kappaB mediated interleukin 15 production in rheumatoid synoviocytes
    So Youn Min
    Department of Medicine, The Center for Rheumatic Diseases, Kangnam St Mary s Hospital, Seoul, Korea
    J Rheumatol 29:1366-76. 2002
    ..Prostaglandin E2 (PGE2) has a wide range of regulatory action in diverse cell types. To investigate the role of PGE2 in rheumatoid arthritis (RA), we tested the effect of exogenous PGE2 on the production of cytokines in synoviocytes...
  13. ncbi request reprint Augmented production of chemokines by the interaction of type II collagen-reactive T cells with rheumatoid synovial fibroblasts
    Do June Min
    Catholic Research Institutes of Medical Sciences, Catholic University of Korea, Seoul, Korea
    Arthritis Rheum 50:1146-55. 2004
    ..To determine the impact of type II collagen (CII)-reactive T cells on the production of chemokines in the joints of patients with rheumatoid arthritis (RA)...
  14. ncbi request reprint Cyclosporine inhibition of vascular endothelial growth factor production in rheumatoid synovial fibroblasts
    Mi La Cho
    The Center for Rheumatic diseases in Kangnam St Mary s Hospital, and Research Institute of Immunobiology, Catholic Research Institutes of Medical Sciences, Catholic University of Korea, Seoul, Korea
    Arthritis Rheum 46:1202-9. 2002
    ..To determine the antiangiogenic effect of cyclosporin A (CSA) in rheumatoid arthritis (RA)...
  15. doi request reprint Inhibition of synovial hyperplasia, rheumatoid T cell activation, and experimental arthritis in mice by sulforaphane, a naturally occurring isothiocyanate
    Jin Sun Kong
    Catholic University of Korea, Seoul, South Korea
    Arthritis Rheum 62:159-70. 2010
    ..To investigate whether sulforaphane (SFN), an isothiocyanate derived from cruciferous vegetables such as broccoli, regulates synoviocyte hyperplasia and T cell activation in rheumatoid arthritis (RA)...
  16. pmc A novel pathogenic role of the ER chaperone GRP78/BiP in rheumatoid arthritis
    Seung Ah Yoo
    Research Institute of Immunobiology, Catholic Research Institute of Medical Science, Catholic University of Korea, Seoul 137 701, South Korea
    J Exp Med 209:871-86. 2012
    ..In summary, this study shows that the ER chaperone GRP78 is crucial for synoviocyte proliferation and angiogenesis, the pathological hallmark of RA...
  17. ncbi request reprint Type II collagen autoimmunity in rheumatoid arthritis
    Wan Uk Kim
    Rheumatism Research Center, Catholic University of Korea, Seoul, Korea
    Am J Med Sci 327:202-11. 2004
    ..Taken together, the authors' recent studies have suggested that autoimmunity to CII could play a crucial role not only in the initiation but also in the amplification and perpetuation of the inflammatory process in RA...
  18. ncbi request reprint Antiphospholipid antibodies induce monocyte chemoattractant protein-1 in endothelial cells
    Chul Soo Cho
    Department of Medicine, Division of Rheumatology, Center for Rheumatic Diseases, Kangnam St Mary s Hospital, Catholic University of Korea, Seoul, Korea
    J Immunol 168:4209-15. 2002
    ..Collectively, these results indicate that aCL could promote endothelial cell-monocyte cross-talk by enhancing the endothelial production of MCP-1, thereby shifting the hemostatic balance toward the prothrombotic state of APS...
  19. doi request reprint Osteoprotegerin causes apoptosis of endothelial progenitor cells by induction of oxidative stress
    Ji Young Kim
    Catholic Research Institutes of Medical Sciences, Seoul, Republic of Korea
    Arthritis Rheum 65:2172-82. 2013
    ..The aim of this study was to investigate the association of serum OPG levels and circulating endothelial progenitor cell (EPC) numbers, and to explore the effect of OPG on EPC apoptosis and its underlying mechanisms...
  20. ncbi request reprint Interaction of vascular endothelial growth factor 165 with neuropilin-1 protects rheumatoid synoviocytes from apoptotic death by regulating Bcl-2 expression and Bax translocation
    Wan Uk Kim
    Department of Internal Medicine, Division of Rheumatology, School of Medicine, Catholic University of Korea, Seoul, Korea
    J Immunol 177:5727-35. 2006
    ....
  21. doi request reprint Role of placenta growth factor and its receptor flt-1 in rheumatoid inflammation: a link between angiogenesis and inflammation
    Seung Ah Yoo
    Catholic University of Korea, Seoul, Korea
    Arthritis Rheum 60:345-54. 2009
    ..To investigate the direct effects of placenta growth factor (PlGF) and its specific receptor, flt-1, which are known to mediate angiogenesis, on the inflammatory process of rheumatoid arthritis (RA)...
  22. doi request reprint Suppression of neovascularization and experimental arthritis by D-form of anti-flt-1 peptide conjugated with mini-PEG(™)
    Jin Sun Kong
    Research Institute of Immunobiology, Catholic Research Institute of Medical Science, Seoul, Korea
    Angiogenesis 14:431-42. 2011
    ....
  23. ncbi request reprint Calcineurin modulates the catabolic and anabolic activity of chondrocytes and participates in the progression of experimental osteoarthritis
    Seung Ah Yoo
    Catholic University of Korea, Seoul, South Korea
    Arthritis Rheum 56:2299-311. 2007
    ..To determine whether intracellular calcineurin (Cn), a calcium-activated phosphatase, regulates the anabolic and catabolic activities of chondrocytes, and is a potential target in the treatment of osteoarthritis (OA)...
  24. pmc MLN51 and GM-CSF involvement in the proliferation of fibroblast-like synoviocytes in the pathogenesis of rheumatoid arthritis
    Jinah Jang
    Department of Biological Science, Sungkyunkwan University, 300 Cheoncheon dong, Suwon, Gyeonggi 440 746, Korea
    Arthritis Res Ther 8:R170. 2006
    ..Taken together, our results imply that MLN51, induced by GM-CSF, is important in the proliferation of RA FLSs in the pathogenesis of RA...
  25. ncbi request reprint The APOM polymorphism as a novel risk factor for dyslipidaemia in rheumatoid arthritis: a possible shared link between disease susceptibility and dyslipidaemia
    Yune Jung Park
    Department of Internal Medicine, The Catholic University of Korea, Korea
    Clin Exp Rheumatol 31:180-8. 2013
    ..Recently, apoM polymorphisms have been related with RA susceptibility. We investigated the possible association between an APOM polymorphism and dyslipidaemia in Korean RA patients...
  26. pmc Association of MICA polymorphism with HLA-B51 and disease severity in Korean patients with Behcet's disease
    Sung Hwan Park
    Center for Rheumatic Diseases, Kangnam St Mary s Hospital, The Catholic University of Korea, Seoul, Korea
    J Korean Med Sci 17:366-70. 2002
    ..In conclusion, MICA*A6 rather than HLA-B51 was strongly associated with Korean patients with BD, and the MICA*A6 allele is a useful susceptibility marker of BD, especially in the HLA-B5-negative..
  27. ncbi request reprint Association of homozygous deletion of the Humhv3005 and the VH3-30.3 genes with renal involvement in systemic lupus erythematosus
    Mi La Cho
    Division of Rheumatology, Department of Internal Medicine, St Mary s Hospital, Research Institute of Immunobiology, Catholic Research Institutes of Medical Sciences, School of Medicine, The Catholic University of Korea, Seoul, Korea
    Lupus 12:400-5. 2003
    ..044] when biopsy-proven LN was studied. Collectively, our data suggest that deletion of the hv3005 and the 3-30.3 genes may predispose individual SLE patients to the development of LN...
  28. pmc NF-AT5 is a critical regulator of inflammatory arthritis
    Hyung Ju Yoon
    Catholic University of Korea, Seoul, Republic of Korea
    Arthritis Rheum 63:1843-52. 2011
    ..To investigate the role of NF-AT5, an osmoprotective transcription factor, in synovial hyperplasia and angiogenesis in patients with rheumatoid arthritis (RA)...
  29. pmc IL-17 induces production of IL-6 and IL-8 in rheumatoid arthritis synovial fibroblasts via NF-kappaB- and PI3-kinase/Akt-dependent pathways
    Sue Yun Hwang
    Rheumatism Research Center, Catholic Institutes of Medical Science, The Catholic University of Korea, Seoul, Korea
    Arthritis Res Ther 6:R120-8. 2004
    ..Together these results suggest that IL-17 is capable of more than accessory roles in the activation of RA FLS and provide grounds for targeting IL-17-associated pathways in therapeutic modulation of arthritis inflammation...
  30. pmc Reactive oxygen species regulate context-dependent inhibition of NFAT5 target genes
    Nam Hoon Kim
    Research Institute of Immunobiology, Catholic Research Institute of Medical Science, Seoul, Korea
    Exp Mol Med 45:e32. 2013
    ..7 macrophages, directing NFAT5 activity toward proinflammatory or hypertonic responses in a context-dependent manner. ..
  31. doi request reprint Involvement of endoplasmic reticulum stress in homocysteine-induced apoptosis of osteoblastic cells
    Su Jung Park
    Division of Rheumatology, Department of Internal Medicine, College of Medicine, Yeouido St Mary s Hospital, The Catholic University of Korea, 62 Yeouido dong, Yeongdeungpo ku, Seoul, South Korea
    J Bone Miner Metab 30:474-84. 2012
    ..Silencing IRE-1α expression by small interfering RNA effectively suppressed Hcy-induced apoptosis of osteoblastic cells. Our results suggest that hyperhomocysteinemia induces apoptotic cell death in osteoblasts via ER stress...
  32. doi request reprint Serum leptin levels are associated with the presence of syndesmophytes in male patients with ankylosing spondylitis
    Ki Jo Kim
    Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea
    Clin Rheumatol 31:1231-8. 2012
    ..Serum leptin levels are elevated in male AS patients with syndesmophytes and were found to be correlated with bone formation marker, suggesting a potential role of leptin in new bone formation in AS...
  33. pmc Proinflammatory role of vascular endothelial growth factor in the pathogenesis of rheumatoid arthritis: prospects for therapeutic intervention
    Seung Ah Yoo
    Division of Rheumatology, Department of Internal Medicine, School of Medicine, Catholic University of Korea, Seoul, South Korea
    Mediators Inflamm 2008:129873. 2008
    ....
  34. doi request reprint Simultaneous presentation of hemophagocytic syndrome and mesenteric vasculitis in a patient with systemic lupus erythematosus
    Su Jin Moon
    Division of Rheumatology, Department of Internal Medicine, School of Medicine, The Catholic University of Korea, Seoul St Mary s Hospital, 505 Banpo Dong, Seocho Gu, Seoul 137 040, South Korea
    Mod Rheumatol 21:330-3. 2011
    ..Serologic tests for Epstein-Barr virus (EBV) indicated its reactivation. This case demonstrates that HPS and concomitant LMV associated with viral reactivation can occur as clinical manifestations of SLE flare...
  35. doi request reprint Invasive fungal infections in patients with systemic lupus erythematosus: experience from affiliated hospitals of Catholic University of Korea
    Hyun Jin Kim
    Division of Rheumatology, Department of Internal Medicine, St Mary s Hospital, The Catholic University of Korea, 62 Yeouido dong, Yeongdeungpo gu, Seoul 150 713, Korea
    Lupus 18:661-6. 2009
    ..High disease activity in patients with SLE might contribute to increased risk of IFI. In addition, mortality was associated with aspergillus infection, leukopenia and high anti-DNA antibodies...
  36. ncbi request reprint Elevated soluble Fas in aqueous humor of patients with Behcet's uveitis: correlation with uveitis severity
    Wan Uk Kim
    Department of Internal Medicine, Kang Nam St Mary s Hospital, Seoul, South Korea
    Jpn J Ophthalmol 46:18-23. 2002
    ..To examine the role of soluble Fas (sFas) in patients with Behcet's uveitis...
  37. doi request reprint Low C3 levels is associated with neutropenia in a proportion of patients with myelodysplastic syndrome: retrospective analysis
    Ki Jo Kim
    Division of Rheumatology, Department of Internal Medicine, College of Medicine, Catholic University of Korea, Seoul, Korea
    Int J Rheum Dis 15:86-94. 2012
    ..MDS patients are known to manifest overt rheumatic manifestations and have distinct immunological abnormalities but their clinical significance has yet to be elucidated...
  38. doi request reprint The Wnt inhibitor secreted Frizzled-Related Protein 1 (sFRP1) promotes human Th17 differentiation
    Yoon Sook Lee
    Laboratory of Immunology, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, Korea
    Eur J Immunol 42:2564-73. 2012
    ..Our findings reveal a novel function for sFRP1 as a potent inducer of human Th17-cell differentiation. Consequently, sFRP1 may represent a promising target for the treatment of Th17-mediated disease in humans...
  39. doi request reprint The efficacy of tramadol/acetaminophen combination tablets (Ultracet®) as add-on and maintenance therapy in knee osteoarthritis pain inadequately controlled by nonsteroidal anti-inflammatory drug (NSAID)
    Kyung Su Park
    Division of Rheumatology, Seoul St Mary s Hospital, The Catholic University of Korea, Seoul, South Korea
    Clin Rheumatol 31:317-23. 2012
    ....
  40. pmc Role of placenta growth factor in cancer and inflammation
    Ki Jo Kim
    Research Institute of Immunobiology, Catholic Research Institute of Medical Science, Seoul, Korea
    Exp Mol Med 44:10-9. 2012
    ..However, there have been conflicting results about the efficacy of PlGF inhibition depending on the experimental and clinical settings. Further close investigations for resolving the puzzle of PlGF biology are required...
  41. pmc Patients with systemic lupus erythematosus have abnormally elevated Epstein-Barr virus load in blood
    Uk Yeol Moon
    Research Institute of Immunobiology, Catholic Research Institutes of Medical Science, Catholic University of Korea, Seoul, Korea
    Arthritis Res Ther 6:R295-302. 2004
    ..001), suggesting that EBV infection is abnormally regulated in SLE. The abnormally increased proportion of EBV-infected B cells in the SLE patients may contribute to enhanced autoantibody production in this disease...
  42. doi request reprint Thrombotic risk in patients with immune thrombocytopenia and its association with antiphospholipid antibodies
    Ki Jo Kim
    Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea
    Br J Haematol 161:706-14. 2013
    ..Detection of aPL can provide useful information for identifying patients at high-risk for developing thrombosis...
  43. doi request reprint Association of polymorphisms modulating low-density lipoprotein cholesterol with susceptibility, severity, and progression of rheumatoid arthritis
    Yune Jung Park
    Department of Internal Medicine, The Catholic University of Korea, School of Medicine, and the Research Institute of Immunobiology, The Catholic University of Korea, Gyeonggi Do, Korea
    J Rheumatol 40:798-808. 2013
    ..We investigated whether single-nucleotide polymorphisms (SNP) modulating low-density lipoprotein (LDL) cholesterol affect susceptibility, severity, and progression of RA...
  44. pmc LDL cholesterolemia as a novel risk factor for radiographic progression of rheumatoid arthritis: a single-center prospective study
    Yune Jung Park
    Divsion of Rheumatology, Department of Internal Medicine, The Catholic University of Korea, School of Medicine, Seoul, Korea
    PLoS ONE 8:e68975. 2013
    ..We suggest that personalized and more aggressive anti-rheumatic therapy is required for dyslipidemic subgroups in RA patients...
  45. doi request reprint Phase 2 enzyme inducer sulphoraphane blocks matrix metalloproteinase production in articular chondrocytes
    Hyun Ah Kim
    Division of Rheumatology, Department of Internal Medicine, Hallym University Sacred Heart Hospital, Dongan Gu, Anyang, Korea
    Rheumatology (Oxford) 48:932-8. 2009
    ..In this study, we examined the influence of sulphoraphane (SPN), one of the most potent inducers of the phase II enzymes on the production of MMPs by pro-inflammatory cytokines in human articular chondrocytes...
  46. pmc Comparison of the clinical manifestations, brain MRI and prognosis between neuroBeçhet's disease and neuropsychiatric lupus
    Byung Sik Cho
    Division of Rheumatology, Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea
    Korean J Intern Med 22:77-86. 2007
    ..This study compared the clinical manifestations, brain MRI findings and prognosis of NPSLE and NBD patients...