Yu Seok Youn


Affiliation: Sungkyunkwan University
Country: Korea


  1. Park S, Kim H, Lim S, Lim K, Lee E, Oh K, et al. Gold nanocluster-loaded hybrid albumin nanoparticles with fluorescence-based optical visualization and photothermal conversion for tumor detection/ablation. J Control Release. 2019;: pubmed publisher
    ..We believe that the AuNC/BSA-NPs formulation presented here can serve as a potential platform for both optically visualizing and treating colon cancers. ..
  2. Seo B, Lim K, Kim S, Oh K, Lee E, Choi H, et al. Small gold nanorods-loaded hybrid albumin nanoparticles with high photothermal efficacy for tumor ablation. Colloids Surf B Biointerfaces. 2019;179:340-351 pubmed publisher
    ..We believe our AuNRs-Alb-NPs should be considered promising photothermal agents that are safer, have good targetability, and exhibit excellent tumor ablation. ..
  3. Lee C, Lim K, Kim S, Thien L, Lee E, Oh K, et al. Near infrared light-responsive heat-emitting hemoglobin hydrogels for photothermal cancer therapy. Colloids Surf B Biointerfaces. 2019;176:156-166 pubmed publisher
    ..This is a first report of a biocompatible photothermal hydrogel based on hemoglobin, and our overall results suggest that Hb hydrogels are commercially-promising PTT systems that have excellent anti-cancer effects. ..
  4. Lee C, Lim K, Kim S, Thien L, Lee E, Oh K, et al. Chlorella-gold nanorods hydrogels generating photosynthesis-derived oxygen and mild heat for the treatment of hypoxic breast cancer. J Control Release. 2018;294:77-90 pubmed publisher
    ..We believe that our oxygen-generating and mild heat-emitting hydrogel should be considered to be a valid prototype of a local depot system for treatment of hypoxic tumors. ..
  5. Lee S, Lee C, Park S, Lim K, Kim S, Kim J, et al. Facile fabrication of highly photothermal-effective albumin-assisted gold nanoclusters for treating breast cancer. Int J Pharm. 2018;553:363-374 pubmed publisher
    ..Consequently, our gold nanoclusters should be considered as a promising photothermal agent that are easy to manufacture and exhibit marked anticancer effects in terms of tumor ablation. ..
  6. Kim I, Choi J, Lee S, Byeon H, Lee E, Shin B, et al. In situ facile-forming PEG cross-linked albumin hydrogels loaded with an apoptotic TRAIL protein. J Control Release. 2015;214:30-9 pubmed publisher
  7. Phuong P, Lee S, Lee C, Seo B, Park S, Oh K, et al. Beta-carotene-bound albumin nanoparticles modified with chlorin e6 for breast tumor ablation based on photodynamic therapy. Colloids Surf B Biointerfaces. 2018;171:123-133 pubmed publisher
    ..We believe that our Ce6-BSA-BC-NPs with PDT offer a promising new potential therapeutic platform for breast cancer treatment. ..
  8. Choi S, Byeon H, Choi J, Thao L, Kim I, Lee E, et al. Inhalable self-assembled albumin nanoparticles for treating drug-resistant lung cancer. J Control Release. 2015;197:199-207 pubmed publisher
    ..Furthermore, the synergism displayed by combined use of Dox and TRAIL could be used to markedly reduce doxorubicin doses and minimize its side effects. ..
  9. Lee C, Seo J, Hwang H, Thao L, Lee S, Lee E, et al. Treatment of bleomycin-induced pulmonary fibrosis by inhaled tacrolimus-loaded chitosan-coated poly(lactic-co-glycolic acid) nanoparticles. Biomed Pharmacother. 2016;78:226-233 pubmed publisher
    ..TAC-loaded PLGA nanoparticles should be considered to be an efficient sustained-release type inhalation system that reduces administration frequency and relevant side effects. ..

More Information


  1. Lee C, Lee S, Thao L, Hwang H, Kim J, Lee E, et al. An albumin nanocomplex-based endosomal pH-activatable on/off probe system. Colloids Surf B Biointerfaces. 2016;144:327-334 pubmed publisher
    ..Based on these results, we believe that this albumin nanocomplex is an attractive biocompatible tumor targeting probe carrier for the theranostic purpose. ..
  2. Lee S, Lee C, Kim B, Thao L, Lee E, Kim J, et al. A novel prototype of albumin nanoparticles fabricated by supramolecular cyclodextrin-adamantane association. Colloids Surf B Biointerfaces. 2016;147:281-290 pubmed publisher
    ..Based on these results, these albumin NPs will be promising for a new NP platform that can be applied for cancer therapy or imaging. ..
  3. Seo J, Lee C, Hwang H, Kim B, Thao L, Lee E, et al. Therapeutic advantage of inhaled tacrolimus-bound albumin nanoparticles in a bleomycin-induced pulmonary fibrosis mouse model. Pulm Pharmacol Ther. 2016;36:53-61 pubmed publisher
    ..Additionally, these NPs would be particularly useful as an effective and safe prototype for delivering practically insoluble therapeutic agents into the lungs. ..
  4. Thao L, Byeon H, Lee C, Lee S, Lee E, Choi H, et al. Pharmaceutical potential of tacrolimus-loaded albumin nanoparticles having targetability to rheumatoid arthritis tissues. Int J Pharm. 2016;497:268-76 pubmed publisher
    ..TAC HSA-NPs are a promising drug delivery system to enhance water solubility and increase accumulation in joints for treatment of rheumatoid arthritis. ..
  5. Thao L, Byeon H, Lee C, Lee S, Lee E, Choi Y, et al. Doxorubicin-Bound Albumin Nanoparticles Containing a TRAIL Protein for Targeted Treatment of Colon Cancer. Pharm Res. 2016;33:615-26 pubmed publisher
    ..Data indicate that TRAIL 1.0%/Dox HSA NPs offer advantages of co-delivery of Dox and TRAIL in tumors, with potential synergistic apoptosis-based anticancer therapy. ..
  6. Min S, Byeon H, Lee C, Seo J, Lee E, Shin B, et al. Facile one-pot formulation of TRAIL-embedded paclitaxel-bound albumin nanoparticles for the treatment of pancreatic cancer. Int J Pharm. 2015;494:506-15 pubmed publisher
    ..80 g, respectively). These improved in vitro and in vivo performances were due to the combined synergistic effects of PTX and TRAIL. We believe that this TRAIL/PTX HSA-NP would have potential as a novel apoptosis-based anticancer agent. ..
  7. Byeon H, Thao L, Lee S, Min S, Lee E, Shin B, et al. Doxorubicin-loaded nanoparticles consisted of cationic- and mannose-modified-albumins for dual-targeting in brain tumors. J Control Release. 2016;225:301-13 pubmed publisher
    ..The c/m-HSA NPs have potential as a novel anti-brain cancer agent with good targetability. ..
  8. Thao L, Lee C, Kim B, Lee S, Kim T, Kim J, et al. Doxorubicin and paclitaxel co-bound lactosylated albumin nanoparticles having targetability to hepatocellular carcinoma. Colloids Surf B Biointerfaces. 2017;152:183-191 pubmed publisher
    ..Based on these results, we suggest that lactose-modified albumin-based nanoparticles fabricated with the Nab® technique can be a potential therapeutic vector for treating HCC via hepatocyte targeting. ..
  9. Kim B, Seo B, Park S, Lee C, Kim J, Oh K, et al. Albumin nanoparticles with synergistic antitumor efficacy against metastatic lung cancers. Colloids Surf B Biointerfaces. 2017;158:157-166 pubmed publisher
    ..Albumin nanoparticles encapsulating two anticancer drugs were shown to have an effective therapeutic result and would be an excellent way to treat resistant lung cancers. ..