Affiliation: Sungkyunkwan University
- Kwon I, Kim J, Rhee D, Kim B, Pyo S. Pneumolysin induces cellular senescence by increasing ROS production and activation of MAPK/NF-?B signal pathway in glial cells. Toxicon. 2017;129:100-112 pubmed publisher..Overall, the results suggest that PLY regulates microglial cellular senescence by enhancing production of reactive oxygen species, activation of MAPK and NF-?B, and phosphorylation of SIRT-1. ..
- Jang Y, Park B, Lee H, Park H, Koo H, Kim B, et al. Sinigrin attenuates the progression of atherosclerosis in ApoE-/- mice fed a high-cholesterol diet potentially by inhibiting VCAM-1 expression. Chem Biol Interact. 2017;272:28-36 pubmed publisher..Overall, sinigrin has the potential to be used in reducing the risks of atherosclerosis. ..
- Koo H, Lee S, Chang K, Sohn E, Sohn E, Kang S, et al. Hepatic anti-inflammatory effect of hexane extracts of Dioscorea batatas Decne: Possible suppression of toll-like receptor 4-mediated signaling. Biomed Pharmacother. 2017;92:157-167 pubmed publisher..Taken together, EDH-1e and EDH-2b attenuated hepatic inflammation and fibrosis via suppression of the TLR4-AP1-mediated signaling pathway. ..
- Kim J, Lee H, Rhee D, Paton J, Pyo S. Pneumolysin-induced autophagy contributes to inhibition of osteoblast differentiation through downregulation of Sp1 in human osteosarcoma cells. Biochim Biophys Acta. 2017;1861:2663-2673 pubmed publisher..This study proposes a molecular mechanism for inhibition of osteoblast differentiation in response to PLY. ..