Suhkneung Pyo


Affiliation: Sungkyunkwan University
Country: Korea


  1. Lee K, Kwak J, Pyo S. Inhibition of LPS-induced inflammatory mediators by 3-hydroxyanthranilic acid in macrophages through suppression of PI3K/NF-κB signaling pathways. Food Funct. 2016;7:3073-82 pubmed publisher
    ..Collectively, the results suggest that 3-HAA has an immunomodulatory effect that may result from inhibition of PI3K/Akt/mTOR and NF-κB activation, thereby decreasing the production of pro-inflammatory mediators. ..
  2. Kim Y, Pyo S. Interleukin-10 suppresses adipogenesis via Wnt5a signaling pathway in 3T3-L1 preadipocytes. Biochem Biophys Res Commun. 2019;509:877-885 pubmed publisher
    ..Taken together, these results indicate that IL-10 can inhibit the early phase of adipogenesis via suppressing Wnt5a signaling pathway in 3T3-L1 preadipocytes. ..
  3. Lee H, Pyo S. Acrylamide induces adipocyte differentiation and obesity in mice. Chem Biol Interact. 2019;298:24-34 pubmed publisher
    ..Collectively, these result showed that ACR can act as an enhancer of adipocyte. Therefore, we suggest that up-regulation of the adipogenesis by ACR may be related to the regulation of the MAPKs and AMPK-ACC pathway. ..
  4. Lee C, Rhee D, Kim B, Um S, Pyo S. Allicin induces beige-like adipocytes via KLF15 signal cascade. J Nutr Biochem. 2019;64:13-24 pubmed publisher
  5. Jang Y, Koo H, Sohn E, Kang S, Rhee D, Pyo S. Theobromine inhibits differentiation of 3T3-L1 cells during the early stage of adipogenesis via AMPK and MAPK signaling pathways. Food Funct. 2015;6:2365-74 pubmed publisher
  6. Lee H, Rhee D, Kim B, Pyo S. Inhibitory effect of sinigrin on adipocyte differentiation in 3T3-L1 cells: Involvement of AMPK and MAPK pathways. Biomed Pharmacother. 2018;102:670-680 pubmed publisher
    ..Taken together, these data suggest that sinigrin inhibits early-stage adipogenesis of 3T3-L1 adipocytes through the AMPK and MAPK signaling pathways. ..
  7. Kim K, Kim J, Kwak J, Pyo S. Different anticancer effects of Saxifragifolin A on estrogen receptor-positive and estrogen receptor-negative breast cancer cells. Phytomedicine. 2015;22:820-8 pubmed publisher
    ..Thus, Saxi A may have a potential therapeutic use for treating breast cancer. ..
  8. Lee K, Yim J, Lee H, Pyo S. Inhibition of VCAM-1 expression on mouse vascular smooth muscle cells by lobastin via downregulation of p38, ERK 1/2 and NF-κB signaling pathways. Arch Pharm Res. 2016;39:83-93 pubmed publisher
    ..Thus, lobastin may be an important regulator of inflammation in the atherosclerotic lesion and a novel therapeutic drug for the treatment of atherosclerosis. ..
  9. Lee K, Um S, Rhee D, Pyo S. Interferon-alpha inhibits adipogenesis via regulation of JAK/STAT1 signaling. Biochim Biophys Acta. 2016;1860:2416-2427 pubmed publisher
    ..Our study provides new insights into possible mechanisms of the anti-adipogenetic effects of IFN-?. ..

More Information


  1. Kim S, Jang Y, Park B, Yim J, Lee H, Rhee D, et al. Ramalin inhibits differentiation of 3T3-L1 preadipocytes and suppresses adiposity and body weight in a high-fat diet-fed C57BL/6J mice. Chem Biol Interact. 2016;257:71-80 pubmed publisher
    ..The present study also provides insight into the mechanisms underlying the anti-obesity activity of ramalin and suggests that ramalin has the potential to prevent obesity. ..
  2. Kim K, Kim J, Kwak J, Kim B, Pyo S. Different apoptotic effects of saxifragifolin C in human breast cancer cells. Arch Pharm Res. 2016;39:577-589 pubmed publisher
    ..Thus, Saxi C is a potential chemotherapeutic agent in breast cancer. ..
  3. Lee H, Lee C, Rhee D, Um S, Pyo S. Sinigrin inhibits production of inflammatory mediators by suppressing NF-?B/MAPK pathways or NLRP3 inflammasome activation in macrophages. Int Immunopharmacol. 2017;45:163-173 pubmed publisher
    ..Our findings also provide evidence that the pharmacological modulation of sinigrin could have an anti-inflammatory effect. ..
  4. Kwon I, Kim J, Rhee D, Kim B, Pyo S. Pneumolysin induces cellular senescence by increasing ROS production and activation of MAPK/NF-?B signal pathway in glial cells. Toxicon. 2017;129:100-112 pubmed publisher
    ..Overall, the results suggest that PLY regulates microglial cellular senescence by enhancing production of reactive oxygen species, activation of MAPK and NF-?B, and phosphorylation of SIRT-1. ..
  5. Jang Y, Park B, Lee H, Park H, Koo H, Kim B, et al. Sinigrin attenuates the progression of atherosclerosis in ApoE-/- mice fed a high-cholesterol diet potentially by inhibiting VCAM-1 expression. Chem Biol Interact. 2017;272:28-36 pubmed publisher
    ..Overall, sinigrin has the potential to be used in reducing the risks of atherosclerosis. ..
  6. Koo H, Lee S, Chang K, Sohn E, Sohn E, Kang S, et al. Hepatic anti-inflammatory effect of hexane extracts of Dioscorea batatas Decne: Possible suppression of toll-like receptor 4-mediated signaling. Biomed Pharmacother. 2017;92:157-167 pubmed publisher
    ..Taken together, EDH-1e and EDH-2b attenuated hepatic inflammation and fibrosis via suppression of the TLR4-AP1-mediated signaling pathway. ..
  7. Kim J, Lee H, Rhee D, Paton J, Pyo S. Pneumolysin-induced autophagy contributes to inhibition of osteoblast differentiation through downregulation of Sp1 in human osteosarcoma cells. Biochim Biophys Acta Gen Subj. 2017;1861:2663-2673 pubmed publisher
    ..This study proposes a molecular mechanism for inhibition of osteoblast differentiation in response to PLY. ..