B M Lee

Summary

Affiliation: Sungkyunkwan University
Country: Korea

Publications

  1. ncbi request reprint Dietary exposure estimation of benzo[a]pyrene and cancer risk assessment
    Byung Mu Lee
    Division of Toxicology, College of Pharmacy, Sungkyunkwan University, Suwon, Gyeonggi Do, Republic of Korea
    J Toxicol Environ Health A 70:1391-4. 2007
  2. ncbi request reprint Ras transgene expression in TG-AC mice treated with benzo[a]pyrene
    Byung Mu Lee
    Division of Toxicology, College of Pharmacy, Sungkyunkwan University, Chunchun dong, Suwon, Kyonggi Do, South Korea
    Biol Pharm Bull 26:733-5. 2003
  3. ncbi request reprint A proposed methodology of cancer risk assessment modeling using biomarkers
    Byung Mu Lee
    College of Pharmacy, Sungkyunkwan University, Suwon, Kyonggi Do, Korea
    J Toxicol Environ Health A 65:341-54. 2002
  4. ncbi request reprint Risk reduction of endocrine disruption by antioxidants
    Byung Mu Lee
    Division of Toxicology, College of Pharmacy, Sungkyunkwan University, Suwon, South Korea
    Forum Nutr 56:405-7. 2003
  5. ncbi request reprint Beneficial and adverse effects of chemopreventive agents
    Byung Mu Lee
    Division of Toxicology, College of Pharmacy, Sungkyunkwan University, Changan Ku, Chunchun dong, Kyunggi Do, Suwon 440 746, South Korea
    Mutat Res 523:265-78. 2003
  6. ncbi request reprint Hershberger assay for antiandrogenic effects of phthalates
    Byung Mu Lee
    Division of Toxicology, College of Pharmacy, Sungkyunkwan University, Suwon, Gyeonggi Do, Republic of Korea
    J Toxicol Environ Health A 70:1365-70. 2007
  7. ncbi request reprint Inducible nitric oxide synthase mRNA is upregulated in skin tumors of v-ha-ras transgenic TG-AC mice treated with 12-o-tetradecanoylphorbol-13-acetate
    B M Lee
    Division of Toxicology, College of Pharmacy, Sungkyunkwan University, Suwon, Kyunggi Do, South Korea
    Biol Pharm Bull 23:826-9. 2000
  8. ncbi request reprint Pharmacokinetic disposition and tissue distribution of bisphenol A in rats after intravenous administration
    S D Yoo
    College of Pharmacy, Sungkyunkwan University, Kyonggi Do, Korea
    J Toxicol Environ Health A 61:131-9. 2000
  9. ncbi request reprint Benzo[a]pyrene diol-epoxide-I-DNA and oxidative DNA adducts associated with gastric adenocarcinoma
    B M Lee
    Division of Toxicology, College of Pharmacy, Sung Kyun Kwan University, Suwon, South Korea
    Cancer Lett 125:61-8. 1998
  10. ncbi request reprint Inhibition of oxidative DNA damage, 8-OHdG, and carbonyl contents in smokers treated with antioxidants (vitamin E, vitamin C, beta-carotene and red ginseng)
    B M Lee
    Division of Toxicology, School of Pharmacy, Sungkyunkwan University, Suwon, South Korea
    Cancer Lett 132:219-27. 1998

Collaborators

  • S D Yoo
  • Dong Hyun Kim
  • Myung Haing Cho
  • G H Jeohn
  • S K Lee
  • H Kim
  • Y S Kim
  • Seung Jun Kwack
  • Soon Young Han
  • Duck Soo Lim
  • Ena Lee
  • Hyun Jung Koo
  • Beom Soo Shin
  • Kui Lea Park
  • Se Chan Kang
  • Tae Hyung Kim
  • Seung Hee Kim
  • Kyu Bong Kim
  • Jaewon Lee
  • Tae Seok Kang
  • Seul Min Choi
  • Mi Young Ahn
  • Na Young Kim
  • Lan Choi
  • Nabanita Patra
  • Chang Youn Cho
  • C K Oh
  • Kyung Hwan Lee
  • Rhee Da Lee
  • Ji Hoon Jung
  • Kang Choon Lee
  • Hyun Sun Park
  • Dong Eun Jang
  • Mi Ok Shin
  • Jea Yeon Jung
  • Min Young Kwak
  • Eun Hwa Kwak
  • Jung Yun Bae
  • Taehyun Roh
  • Il Young Ahn
  • Seong Kwang Lim
  • Mi Jung Kwon
  • Eun Young Han
  • Jong Bong Lee
  • Jurgen B Bulitta
  • Sang Wook Hwang
  • Young Jun Lee
  • Jeung Yeul Han
  • Hae Seong Yoon
  • Seok Hyun Hong
  • Ki Kyung Chung
  • Seung Du Yang
  • Ji Young Im
  • Kee Kyung Jung
  • Keun Aee Shim
  • Ju Young Ryu
  • S I Kim
  • Jeonga Kim
  • Hyeyoung Park
  • Jin Hwan Hong
  • Mee Young Ahn
  • In Young Kim
  • Bum Soo Shin
  • Iksoo Kim
  • Eun Jeong Yoo
  • Chul Hoon Park
  • Hye Jin Bae
  • In Sun Kim
  • Sang Mi An
  • Jin Won Kim
  • Soo Yeong Chae
  • Gyu Seek Rhee
  • Soon Sun Kim
  • Hee Sam Lee
  • Yo Woo Choi
  • Hong Yon Cho
  • Kang Sun Ryu
  • Ji Hyun Seok
  • Jung Ha Kim
  • Yo An Park

Detail Information

Publications40

  1. ncbi request reprint Dietary exposure estimation of benzo[a]pyrene and cancer risk assessment
    Byung Mu Lee
    Division of Toxicology, College of Pharmacy, Sungkyunkwan University, Suwon, Gyeonggi Do, Republic of Korea
    J Toxicol Environ Health A 70:1391-4. 2007
    ..52 x 10(-5). These data suggest that cancer risk due to dietary exposure to BaP is of concern in Koreans and needs to be reduced either by regulatory efforts or by modifying food manufacturing procedures...
  2. ncbi request reprint Ras transgene expression in TG-AC mice treated with benzo[a]pyrene
    Byung Mu Lee
    Division of Toxicology, College of Pharmacy, Sungkyunkwan University, Chunchun dong, Suwon, Kyonggi Do, South Korea
    Biol Pharm Bull 26:733-5. 2003
    ..These data suggest that BP was tumorigenic in a dose-dependent manner in TG-AC mice and that TG-AC mice were dependent on transgene expression during BP carcinogenesis...
  3. ncbi request reprint A proposed methodology of cancer risk assessment modeling using biomarkers
    Byung Mu Lee
    College of Pharmacy, Sungkyunkwan University, Suwon, Kyonggi Do, Korea
    J Toxicol Environ Health A 65:341-54. 2002
    ..Moreover, this methodology could be further applied to human cancer risk assessment after appropriate safety factors were employed...
  4. ncbi request reprint Risk reduction of endocrine disruption by antioxidants
    Byung Mu Lee
    Division of Toxicology, College of Pharmacy, Sungkyunkwan University, Suwon, South Korea
    Forum Nutr 56:405-7. 2003
  5. ncbi request reprint Beneficial and adverse effects of chemopreventive agents
    Byung Mu Lee
    Division of Toxicology, College of Pharmacy, Sungkyunkwan University, Changan Ku, Chunchun dong, Kyunggi Do, Suwon 440 746, South Korea
    Mutat Res 523:265-78. 2003
    ..Therefore, definitive preventive guidelines should be carefully offered for various types of tumors, which properly consider ethnic variations, and the efficacies and the safety of chemopreventive agents...
  6. ncbi request reprint Hershberger assay for antiandrogenic effects of phthalates
    Byung Mu Lee
    Division of Toxicology, College of Pharmacy, Sungkyunkwan University, Suwon, Gyeonggi Do, Republic of Korea
    J Toxicol Environ Health A 70:1365-70. 2007
    ..These data suggest that some phthalates possess antiandrogenic activity, and that multiple cross-talk between androgen, estrogen, and steroid hormone receptors occurs...
  7. ncbi request reprint Inducible nitric oxide synthase mRNA is upregulated in skin tumors of v-ha-ras transgenic TG-AC mice treated with 12-o-tetradecanoylphorbol-13-acetate
    B M Lee
    Division of Toxicology, College of Pharmacy, Sungkyunkwan University, Suwon, Kyunggi Do, South Korea
    Biol Pharm Bull 23:826-9. 2000
    ..However, the tissues surrounding the papillomas showed only a minor increase in the steady-state level of iNOS mRNA. These data suggest that iNOS gene expressions may underlie tumorigenesis during TPA promotion in TG-AC mice...
  8. ncbi request reprint Pharmacokinetic disposition and tissue distribution of bisphenol A in rats after intravenous administration
    S D Yoo
    College of Pharmacy, Sungkyunkwan University, Kyonggi Do, Korea
    J Toxicol Environ Health A 61:131-9. 2000
    ..0-5.8) except for brain (ratio 0.75). Given the high systemic clearance and short elimination half-life, bisphenol A is unlikely to accumulate significantly in the rat...
  9. ncbi request reprint Benzo[a]pyrene diol-epoxide-I-DNA and oxidative DNA adducts associated with gastric adenocarcinoma
    B M Lee
    Division of Toxicology, College of Pharmacy, Sung Kyun Kwan University, Suwon, South Korea
    Cancer Lett 125:61-8. 1998
    ....
  10. ncbi request reprint Inhibition of oxidative DNA damage, 8-OHdG, and carbonyl contents in smokers treated with antioxidants (vitamin E, vitamin C, beta-carotene and red ginseng)
    B M Lee
    Division of Toxicology, School of Pharmacy, Sungkyunkwan University, Suwon, South Korea
    Cancer Lett 132:219-27. 1998
    ..3%). These preliminary data suggest that supplementation with antioxidants might protect smokers from oxidative damages and could reduce cancer risk or other diseases caused by free radicals associated with smoking...
  11. ncbi request reprint Protective effects of antioxidant supplementation on plasma lipid peroxidation in smokers
    H S Kim
    Division of Toxicology, School of Pharmacy, Sungkyunkwan University, Kyunggi-do, Suwon, Korea
    J Toxicol Environ Health A 63:583-98. 2001
    ..Our data suggest that smokers have insufficient concentrations of antioxidant vitamins in plasma and that supplementation with antioxidants might protect smokers from oxidative damage...
  12. ncbi request reprint An alternative mode of action of endocrine-disrupting chemicals and chemoprevention
    Seul Min Choi
    Division of Toxicology, College of Pharmacy, Sungkyunkwan University, Suwon, Kyonggi Do, South Korea
    J Toxicol Environ Health B Crit Rev 7:451-63. 2004
    ..Here, an alternative mode of action of EDCs and their possible chemoprevention are proposed...
  13. ncbi request reprint Bioavailability and mammary excretion of bisphenol a in Sprague-Dawley rats
    S D Yoo
    College of Pharmacy, Sungkyunkwan University, Suwon, Kyonggi Do, Korea
    J Toxicol Environ Health A 64:417-26. 2001
    ..The systemic clearance (mean range, 119.2-154.1 ml/min/kg) remained unaltered over the dosing rate studied. The levels of bisphenol A in milk exceeded those in serum, with the steady-state milk to serum concentration ratio being 2.4-2.7...
  14. ncbi request reprint Estimated exposure to phthalates in cosmetics and risk assessment
    Hyun Jung Koo
    College of Pharmacy, Sungkyunkwan University, Suwon, Kyonggi Do, South Korea
    J Toxicol Environ Health A 67:1901-14. 2004
    ..347 for DBP. These data suggest that estimated exposure to-phthalates in the cosmetics mentioned are relatively small. However, total exposure levels from several sources may be greater and require further investigation...
  15. ncbi request reprint Human monitoring of phthalates and risk assessment
    Hyun Jung Koo
    Division of Toxicology, College of Pharmacy, Sungkyunkwan University, Suwon, Kyonggi Do, South Korea
    J Toxicol Environ Health A 68:1379-92. 2005
    ..These data suggest that Koreans (women and children) were exposed to significant levels of phthalates, which should be reduced to as low a level as technologically feasible to protect Koreans from the exposure to toxic phthalates...
  16. ncbi request reprint Age-related changes in oxidative DNA damage and benzo(a)pyrene diolepoxide-I (BPDE-I)-DNA adduct levels in human stomach
    Byung Mu Lee
    Division of Toxicology, College of Pharmacy, Sungkyunkwan University, Changan Ku, Kyunggi Do, Suwon
    J Toxicol Environ Health A 68:1599-610. 2005
    ..It is possible that such damage contributes to the known increased incidence of gastric tumor with aging...
  17. doi request reprint Potential risk of bisphenol A migration from polycarbonate containers after heating, boiling, and microwaving
    Duck Soo Lim
    Division of Toxicology, College of Pharmacy, Sungkyunkwan University, Suwon, Gyeonggi Do, South Korea
    J Toxicol Environ Health A 72:1285-91. 2009
    ..Data suggest that the use of PC plastic bottles in our daily life is considered safe in Korea...
  18. doi request reprint Risk assessment of bisphenol A migrated from canned foods in Korea
    Duck Soo Lim
    Division of Toxicology, College of Pharmacy, Sungkyunkwan University, Suwon, Gyeonggi Do, South Korea
    J Toxicol Environ Health A 72:1327-35. 2009
    ..03, which is the hazard index [HI = exposure level/(RfD or TDI)]. Evidence indicates that the levels of BPA levels in canned foods are not likely to constitute a safety concern for consumers in Korea...
  19. ncbi request reprint Pharmacokinetic scaling of bisphenol A by species-invariant time methods
    Chang Youn Cho
    College of Pharmacy, Sungkyunkwan University, 300 Chonchon dong, Changan gu, Suwon, Kyonggi Do, 440 746, Korea
    Xenobiotica 32:925-34. 2002
    ..These preliminary parameter values may be useful in interpreting toxicity data in humans on environmental exposure to bisphenol A...
  20. ncbi request reprint Effects of pH and temperature on benzo[a]pyrene-DNA, -protein, and -lipid adducts in primary rat hepatocytes
    Hyun Sun Park
    Division of Toxicology, School of Pharmacy, Sungkyunkwan University, Kyunggi Do, Suwon, Korea
    J Toxicol Environ Health A 65:205-14. 2002
    ..These results suggest that the physicochemical properties of BaP-DNA, -protein, and -TG adducts might be important to consider when cells or humans who have been exposed to BaP are monitored for biomarkers...
  21. ncbi request reprint Toxicological characteristics of endocrine-disrupting chemicals: developmental toxicity, carcinogenicity, and mutagenicity
    Seul Min Choi
    Division of Toxicology Pharmacokinetics, College of Pharmacy, Sungkyunkwan University, Suwon, Kyonggi Do, South Korea
    J Toxicol Environ Health B Crit Rev 7:1-24. 2004
    ....
  22. doi request reprint Comparative nephrotoxicitiy induced by melamine, cyanuric acid, or a mixture of both chemicals in either Sprague-Dawley rats or renal cell lines
    Lan Choi
    Division of Toxicology, School of Pharmacy, Sungkyunkwan University, Suwon, Gyeonggi Do, Korea
    J Toxicol Environ Health A 73:1407-19. 2010
    ..Furthermore, the 24-h IC(50) value for MC was found to be 208 μg/ml in ACHN cells. Data suggest that NOAELs based upon acute nephrotoxic parameters for MC were low, which might require further reassessment of the current TDI...
  23. doi request reprint Predicting the ideal serum creatinine of kidney transplant recipients by a simple formula based on the balance between metabolic demands of recipients and renal mass supply from donors
    C K Oh
    Department of Surgery, Ajou University School of Medicine, Yeongtong Gu, Suwon, Korea
    Transplant Proc 40:2307-9. 2008
    ..When recipient Scr is significantly higher than that predicted by the formula, a clinician should suspect an underlying graft injury...
  24. doi request reprint Exposure assessment of polybrominated diphenyl ethers (PBDE) in umbilical cord blood of Korean infants
    Tae Hyung Kim
    Laboratory of Molecular Toxicology, College of Pharmacy, Pusan National University, Pusan, South Korea
    J Toxicol Environ Health A 72:1318-26. 2009
    ..Therefore, further study on the relationship between the maternal and fetal blood concentrations of PBDE is recommended for a more comprehensive exposure assessment of PBDE in Koreans...
  25. ncbi request reprint Hypothyroidism protects di(n-butyl) phthalate-induced reproductive organs damage in Sprague-Dawley male rats
    Ena Lee
    College of Pharmacy, Pusan National University, Busan, Korea
    J Toxicol Sci 33:299-306. 2008
    ..This data suggests that the hypothyroid status might offer some protection from male reproductive organ toxicity caused by a disturbance in the metabolic activation of the parent compound, DBP...
  26. doi request reprint Functional role of phospholipase D (PLD) in di(2-ethylhexyl) phthalate-induced hepatotoxicity in Sprague-Dawley rats
    Na Young Kim
    Laboratory of Molecular Toxicology, College of Pharmacy, Pusan National University, Busan, South Korea
    J Toxicol Environ Health A 73:1560-9. 2010
    ..Our results suggest that DEHP significantly enhanced the expression of PLD, which may be correlated with PPARα-induced hepatotoxicity through a complex interaction with nuclear receptors including CAR and PXR...
  27. doi request reprint Physiologically based pharmacokinetics of zearalenone
    Beom Soo Shin
    College of Pharmacy, Catholic University of Daegu, Gyeongsan si, Gyeongbuk, Korea
    J Toxicol Environ Health A 72:1395-405. 2009
    ..0312 mg/kg/d). The developed PBPK models adequately described the pharmacokinetics in rats and may be useful in predicting human blood and tissue concentrations for zearalenone under different p,o, exposure conditions...
  28. ncbi request reprint Toxicokinetics of phthalic acid: the common final metabolite of phthalic acid esters in rats
    Duck Soo Lim
    Division of Toxicology, School of Pharmacy, Sungkyunkwan University, Suwon, Gyeonggi Do, Republic of Korea
    J Toxicol Environ Health A 70:1344-9. 2007
    ..o.) was recovered unchanged in urine within 24 h. Data concerning the toxicokinetic profiles of PA improve our understanding of the toxicological potential of PAE and may prove useful for risk assessments of multiple phthalates exposure...
  29. ncbi request reprint Study of mutagenicities of phthalic acid and terephthalic acid using in vitro and in vivo genotoxicity tests
    Kyung Hwan Lee
    Division of Toxicology, School of Pharmacy, Sungkyunkwan University, Suwon, Gyeonggi Do, Republic of Korea
    J Toxicol Environ Health A 70:1329-35. 2007
    ..These results indicate that PA and TPA produced no mutagenic effects using these in vitro and in vivo mutagenic test systems...
  30. ncbi request reprint Maternal-fetal disposition of bisphenol a in pregnant Sprague-Dawley rats
    Beom Soo Shin
    College of Pharmacy and Department of Biology, Sungkyunkwan University, Kyonggi Do, Korea
    J Toxicol Environ Health A 65:395-406. 2002
    ..0% [CLfoAUCfetus/(CLcoAUCmaternal serum + CLfoAUCfetus)]. The pharmacokinetic model used in this study provides insights into the routes of elimination of bisphenol A in the maternal-fetal rat upon maternal administration...
  31. ncbi request reprint Effect of estrogen receptor (ER) on benzo[a]pyrene-DNA adduct formation in human breast cancer cells
    Se Chan Kang
    Division of Toxicology, School of Pharmacy SungKyunKwan University, Jangan gu, Suwon, Kyonggi Do, South Korea
    J Toxicol Environ Health A 68:1833-40. 2005
    ..These observations suggest that the increased formation of BaP-DNA adducts may be mediated through the ERalpha expressed by E2...
  32. ncbi request reprint Effects of chemical carcinogens and physicochemical factors on the UV spectrophotometric determination of DNA
    Hyung Sik Kim
    Laboratory of Molecular Toxicology, College of Pharmacy, Pusan National University, Jangjun dong, Gumjung ku, Pusan, South Korea
    J Toxicol Environ Health A 68:2081-95. 2005
    ..These results suggest that the UV A260/A280 ratio is significantly affected by pH and the presence of contaminating species of macromolecules and chemicals...
  33. ncbi request reprint Genotoxic evaluation of the biocomponents of the cricket, Gryllus bimaculatus, using three mutagenicity tests
    Mi Young Ahn
    Department of Agricultural Biology, National Institute of Agricultural Science and Technology, RDA, Suwon, South Korea
    J Toxicol Environ Health A 68:2111-8. 2005
    ..bimaculatus extract at doses of 15, 150, or 1500 mg/kg. These results indicate that G. bimaculatus extract exerts no mutagenic effect in these in vitro and in vivo systems...
  34. ncbi request reprint Validation study of OECD rodent uterotrophic assay for the assessment of estrogenic activity in Sprague-Dawley immature female rats
    Hyung Sik Kim
    Laboratory of Molecular Toxicology, College of Pharmacy, Pusan National University, Jangjun dong, Gumjung ku, Korea
    J Toxicol Environ Health A 68:2249-62. 2005
    ..However, further combination studies using surrogate biomarkers may be needed to improve the sensitivity of this assay for the detection of weak estrogenic compounds, such as o,p-DDT...
  35. ncbi request reprint Toxicokinetic relationship between di(2-ethylhexyl) phthalate (DEHP) and mono(2-ethylhexyl) phthalate in rats
    Hyun Jung Koo
    Division of Toxicology, College of Pharmacy, Sungkyunkwan University, Suwon, Kyonggi Do, South Korea
    J Toxicol Environ Health A 70:383-7. 2007
    ..The toxicokinetic relationship between DEHP and MEHP in rats suggests that DEHP exposure assessment should be based on DEHP and MEHP in urine and serum for risk assessment applications...
  36. ncbi request reprint Effect of di(n-butyl) phthalate on testicular oxidative damage and antioxidant enzymes in hyperthyroid rats
    Ena Lee
    Laboratory of Molecular Toxicology, College of Pharmacy, Pusan National University, San 30, Jangjun dong, Gumjung ku, Busan, South Korea
    Environ Toxicol 22:245-55. 2007
    ..These results suggest that hyperthyroidism can cause a change in the expression level of PPAR-r in testes, and may increase the levels of oxidative damage induced by the metabolic activation of DBP...
  37. ncbi request reprint DNA methylation of estrogen receptor alpha gene by phthalates
    Se Chan Kang
    Division of Toxicology, School of Pharmacy, Sungkyunkwan University, Jangan gu, Suwon, Kyonggi Do, Korea
    J Toxicol Environ Health A 68:1995-2003. 2005
    ..These data suggest that an altered ER mRNA expression by BBP might be related to aberrant DNA methylation in the promoter region of ERalpha...
  38. ncbi request reprint No androgenic/anti-androgenic effects of bisphenol-A in Hershberger assay using immature castrated rats
    Hyung Sik Kim
    Reproductive and Developmental Toxicology Division, Department of Toxicology, National Institute of Toxicological Research, Korea Food and Drug Administration, 5 Nokbun dong, Eunpyung Ku, 122 704, Seoul, South Korea
    Toxicol Lett 135:111-23. 2002
    ..In summary, the Hershberger assay could be a sensitive method for detecting androgenic or anti-androgenic chemicals, but BPA did not exhibit any androgenic or anti-androgenic activities in Hershberger assay...
  39. ncbi request reprint Neurotoxic effects of alcohol and acetaldehyde during embryonic development
    Rhee Da Lee
    Department of Toxicology, National Institute of Toxicological Research, Korea Food and Drug Administration, Seoul
    J Toxicol Environ Health A 68:2147-62. 2005
    ..Data demonstrate that some antioxidants can partially protect against the alcohol-induced embryonic developmental toxicity...