Research Topics
| B M LeeSummaryAffiliation: Sungkyunkwan University Country: Korea Publications
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Detail Information
Publications
A proposed methodology of cancer risk assessment modeling using biomarkersByung Mu Lee
College of Pharmacy, Sungkyunkwan University, Suwon, Kyonggi Do, Korea
J Toxicol Environ Health A 65:341-54. 2002..Moreover, this methodology could be further applied to human cancer risk assessment after appropriate safety factors were employed...- Ras transgene expression in TG-AC mice treated with benzo[a]pyreneByung Mu Lee
Division of Toxicology, College of Pharmacy, Sungkyunkwan University, Chunchun dong, Suwon, Kyonggi Do, South Korea
Biol Pharm Bull 26:733-5. 2003..These data suggest that BP was tumorigenic in a dose-dependent manner in TG-AC mice and that TG-AC mice were dependent on transgene expression during BP carcinogenesis... - Inducible nitric oxide synthase mRNA is upregulated in skin tumors of v-ha-ras transgenic TG-AC mice treated with 12-o-tetradecanoylphorbol-13-acetateB M Lee
Division of Toxicology, College of Pharmacy, Sungkyunkwan University, Suwon, Kyunggi Do, South Korea
Biol Pharm Bull 23:826-9. 2000..However, the tissues surrounding the papillomas showed only a minor increase in the steady-state level of iNOS mRNA. These data suggest that iNOS gene expressions may underlie tumorigenesis during TPA promotion in TG-AC mice... - Beneficial and adverse effects of chemopreventive agentsByung Mu Lee
Division of Toxicology, College of Pharmacy, Sungkyunkwan University, Changan Ku, Chunchun dong, Kyunggi Do, Suwon 440 746, South Korea
Mutat Res 523:265-78. 2003..Therefore, definitive preventive guidelines should be carefully offered for various types of tumors, which properly consider ethnic variations, and the efficacies and the safety of chemopreventive agents... - Risk reduction of endocrine disruption by antioxidantsByung Mu Lee
Division of Toxicology, College of Pharmacy, Sungkyunkwan University, Suwon, South Korea
Forum Nutr 56:405-7. 2003 - Hershberger assay for antiandrogenic effects of phthalatesByung Mu Lee
Division of Toxicology, College of Pharmacy, Sungkyunkwan University, Suwon, Gyeonggi Do, Republic of Korea
J Toxicol Environ Health A 70:1365-70. 2007..These data suggest that some phthalates possess antiandrogenic activity, and that multiple cross-talk between androgen, estrogen, and steroid hormone receptors occurs... - Dietary exposure estimation of benzo[a]pyrene and cancer risk assessmentByung Mu Lee
Division of Toxicology, College of Pharmacy, Sungkyunkwan University, Suwon, Gyeonggi Do, Republic of Korea
J Toxicol Environ Health A 70:1391-4. 2007..52 x 10(-5). These data suggest that cancer risk due to dietary exposure to BaP is of concern in Koreans and needs to be reduced either by regulatory efforts or by modifying food manufacturing procedures... - Pharmacokinetic disposition and tissue distribution of bisphenol A in rats after intravenous administrationS D Yoo
College of Pharmacy, Sungkyunkwan University, Kyonggi Do, Korea
J Toxicol Environ Health A 61:131-9. 2000..0-5.8) except for brain (ratio 0.75). Given the high systemic clearance and short elimination half-life, bisphenol A is unlikely to accumulate significantly in the rat... - Benzo[a]pyrene diol-epoxide-I-DNA and oxidative DNA adducts associated with gastric adenocarcinomaB M Lee
Division of Toxicology, College of Pharmacy, Sung Kyun Kwan University, Suwon, South Korea
Cancer Lett 125:61-8. 1998.... - Inhibition of oxidative DNA damage, 8-OHdG, and carbonyl contents in smokers treated with antioxidants (vitamin E, vitamin C, beta-carotene and red ginseng)B M Lee
Division of Toxicology, School of Pharmacy, Sungkyunkwan University, Suwon, South Korea
Cancer Lett 132:219-27. 1998..3%). These preliminary data suggest that supplementation with antioxidants might protect smokers from oxidative damages and could reduce cancer risk or other diseases caused by free radicals associated with smoking... - Protective effects of antioxidant supplementation on plasma lipid peroxidation in smokersH S Kim
Division of Toxicology, School of Pharmacy, Sungkyunkwan University, Kyunggi-do, Suwon, Korea
J Toxicol Environ Health A 63:583-98. 2001..Our data suggest that smokers have insufficient concentrations of antioxidant vitamins in plasma and that supplementation with antioxidants might protect smokers from oxidative damage... - An alternative mode of action of endocrine-disrupting chemicals and chemopreventionSeul Min Choi
Division of Toxicology, College of Pharmacy, Sungkyunkwan University, Suwon, Kyonggi-do, South Korea
J Toxicol Environ Health B Crit Rev 7:451-63. 2004..Here, an alternative mode of action of EDCs and their possible chemoprevention are proposed... - Bioavailability and mammary excretion of bisphenol a in Sprague-Dawley ratsS D Yoo
College of Pharmacy, Sungkyunkwan University, Suwon, Kyonggi Do, Korea
J Toxicol Environ Health A 64:417-26. 2001..The systemic clearance (mean range, 119.2-154.1 ml/min/kg) remained unaltered over the dosing rate studied. The levels of bisphenol A in milk exceeded those in serum, with the steady-state milk to serum concentration ratio being 2.4-2.7... - Estimated exposure to phthaiates in cosmetics and risk assessmentHyun Jung Koo
College of Pharmacy, Sungkyunkwan University, Suwon, Kyonggi-do, South Korea
J Toxicol Environ Health A 67:1901-14. 2004..347 for DBP. These data suggest that estimated exposure to-phthalates in the cosmetics mentioned are relatively small. However, total exposure levels from several sources may be greater and require further investigation... - Age-related changes in oxidative DNA damage and benzo(a)pyrene diolepoxide-I (BPDE-I)-DNA adduct levels in human stomachByung Mu Lee
Division of Toxicology, College of Pharmacy, Sungkyunkwan University, Changan-Ku, Kyunggi-do, Suwon
J Toxicol Environ Health A 68:1599-610. 2005..It is possible that such damage contributes to the known increased incidence of gastric tumor with aging... - Human monitoring of phthalates and risk assessmentHyun Jung Koo
Division of Toxicology, College of Pharmacy, Sungkyunkwan University, Suwon, Kyonggi-do, South Korea
J Toxicol Environ Health A 68:1379-92. 2005..These data suggest that Koreans (women and children) were exposed to significant levels of phthalates, which should be reduced to as low a level as technologically feasible to protect Koreans from the exposure to toxic phthalates... - Risk assessment of bisphenol A migrated from canned foods in KoreaDuck Soo Lim
Division of Toxicology, College of Pharmacy, Sungkyunkwan University, Suwon, Gyeonggi Do, South Korea
J Toxicol Environ Health A 72:1327-35. 2009..03, which is the hazard index [HI = exposure level/(RfD or TDI)]. Evidence indicates that the levels of BPA levels in canned foods are not likely to constitute a safety concern for consumers in Korea... - Potential risk of bisphenol A migration from polycarbonate containers after heating, boiling, and microwavingDuck Soo Lim
Division of Toxicology, College of Pharmacy, Sungkyunkwan University, Suwon, Gyeonggi Do, South Korea
J Toxicol Environ Health A 72:1285-91. 2009..Data suggest that the use of PC plastic bottles in our daily life is considered safe in Korea... - Toxicological characteristics of endocrine-disrupting chemicals: developmental toxicity, carcinogenicity, and mutagenicitySeul Min Choi
Division of Toxicology/Pharmacokinetics, College of Pharmacy, Sungkyunkwan University, Suwon, Kyonggi-do, South Korea
J Toxicol Environ Health B Crit Rev 7:1-24. 2004.... - Pharmacokinetic scaling of bisphenol A by species-invariant time methodsChang Youn Cho
College of Pharmacy, Sungkyunkwan University, 300 Chonchon-dong, Changan-gu, Suwon, Kyonggi-do, 440-746, Korea
Xenobiotica 32:925-34. 2002..These preliminary parameter values may be useful in interpreting toxicity data in humans on environmental exposure to bisphenol A... - Comparative nephrotoxicitiy induced by melamine, cyanuric acid, or a mixture of both chemicals in either Sprague-Dawley rats or renal cell linesLan Choi
Division of Toxicology, School of Pharmacy, Sungkyunkwan University, Suwon, Gyeonggi Do, Korea
J Toxicol Environ Health A 73:1407-19. 2010..Furthermore, the 24-h IC(50) value for MC was found to be 208 ?g/ml in ACHN cells. Data suggest that NOAELs based upon acute nephrotoxic parameters for MC were low, which might require further reassessment of the current TDI... - Effects of pH and temperature on benzo[a]pyrene-DNA, -protein, and -lipid adducts in primary rat hepatocytesHyun Sun Park
Division of Toxicology, School of Pharmacy, Sungkyunkwan University, Kyunggi-do, Suwon, Korea
J Toxicol Environ Health A 65:205-14. 2002..These results suggest that the physicochemical properties of BaP-DNA, -protein, and -TG adducts might be important to consider when cells or humans who have been exposed to BaP are monitored for biomarkers... - Predicting the ideal serum creatinine of kidney transplant recipients by a simple formula based on the balance between metabolic demands of recipients and renal mass supply from donorsC K Oh
Department of Surgery, Ajou University School of Medicine, Yeongtong Gu, Suwon, Korea
Transplant Proc 40:2307-9. 2008..When recipient Scr is significantly higher than that predicted by the formula, a clinician should suspect an underlying graft injury... - Exposure assessment of polybrominated diphenyl ethers (PBDE) in umbilical cord blood of Korean infantsTae Hyung Kim
Laboratory of Molecular Toxicology, College of Pharmacy, Pusan National University, Pusan, South Korea
J Toxicol Environ Health A 72:1318-26. 2009..Therefore, further study on the relationship between the maternal and fetal blood concentrations of PBDE is recommended for a more comprehensive exposure assessment of PBDE in Koreans... - Physiologically based pharmacokinetics of zearalenoneBeom Soo Shin
College of Pharmacy, Catholic University of Daegu, Gyeongsan si, Gyeongbuk, Korea
J Toxicol Environ Health A 72:1395-405. 2009..0312 mg/kg/d). The developed PBPK models adequately described the pharmacokinetics in rats and may be useful in predicting human blood and tissue concentrations for zearalenone under different p,o, exposure conditions... - Hypothyroidism protects di(n-butyl) phthalate-induced reproductive organs damage in Sprague-Dawley male ratsEna Lee
College of Pharmacy, Pusan National University, Busan, Korea
J Toxicol Sci 33:299-306. 2008..This data suggests that the hypothyroid status might offer some protection from male reproductive organ toxicity caused by a disturbance in the metabolic activation of the parent compound, DBP... - Toxicokinetics of phthalic acid: the common final metabolite of phthalic acid esters in ratsDuck Soo Lim
Division of Toxicology, School of Pharmacy, Sungkyunkwan University, Suwon, Gyeonggi Do, Republic of Korea
J Toxicol Environ Health A 70:1344-9. 2007..o.) was recovered unchanged in urine within 24 h. Data concerning the toxicokinetic profiles of PA improve our understanding of the toxicological potential of PAE and may prove useful for risk assessments of multiple phthalates exposure... - Study of mutagenicities of phthalic acid and terephthalic acid using in vitro and in vivo genotoxicity testsKyung Hwan Lee
Division of Toxicology, School of Pharmacy, Sungkyunkwan University, Suwon, Gyeonggi Do, Republic of Korea
J Toxicol Environ Health A 70:1329-35. 2007..These results indicate that PA and TPA produced no mutagenic effects using these in vitro and in vivo mutagenic test systems... - Effect of di(n-butyl) phthalate on testicular oxidative damage and antioxidant enzymes in hyperthyroid ratsEna Lee
Laboratory of Molecular Toxicology, College of Pharmacy, Pusan National University, San 30, Jangjun dong, Gumjung ku, Busan, South Korea
Environ Toxicol 22:245-55. 2007..These results suggest that hyperthyroidism can cause a change in the expression level of PPAR-r in testes, and may increase the levels of oxidative damage induced by the metabolic activation of DBP... - Maternal-fetal disposition of bisphenol a in pregnant Sprague-Dawley ratsBeom Soo Shin
College of Pharmacy and Department of Biology, Sungkyunkwan University, Kyonggi-do, Korea
J Toxicol Environ Health A 65:395-406. 2002..0% [CLfoAUCfetus/(CLcoAUCmaternal serum + CLfoAUCfetus)]. The pharmacokinetic model used in this study provides insights into the routes of elimination of bisphenol A in the maternal-fetal rat upon maternal administration... - Effect of estrogen receptor (ER) on benzo[a]pyrene-DNA adduct formation in human breast cancer cellsSe Chan Kang
Division of Toxicology, School of Pharmacy SungKyunKwan University, Jangan-gu, Suwon, Kyonggi-do, South Korea
J Toxicol Environ Health A 68:1833-40. 2005..These observations suggest that the increased formation of BaP-DNA adducts may be mediated through the ERalpha expressed by E2... - DNA methylation of estrogen receptor alpha gene by phthalatesSe Chan Kang
Division of Toxicology, School of Pharmacy, Sungkyunkwan University, Jangan-gu, Suwon, Kyonggi-do, Korea
J Toxicol Environ Health A 68:1995-2003. 2005..These data suggest that an altered ER mRNA expression by BBP might be related to aberrant DNA methylation in the promoter region of ERalpha... - Effects of chemical carcinogens and physicochemical factors on the UV spectrophotometric determination of DNAHyung Sik Kim
Laboratory of Molecular Toxicology, College of Pharmacy, Pusan National University, Jangjun-dong, Gumjung-ku, Pusan, South Korea
J Toxicol Environ Health A 68:2081-95. 2005..These results suggest that the UV A260/A280 ratio is significantly affected by pH and the presence of contaminating species of macromolecules and chemicals... - Genotoxic evaluation of the biocomponents of the cricket, Gryllus bimaculatus, using three mutagenicity testsMi Young Ahn
Department of Agricultural Biology, National Institute of Agricultural Science and Technology, RDA, Suwon, South Korea
J Toxicol Environ Health A 68:2111-8. 2005..bimaculatus extract at doses of 15, 150, or 1500 mg/kg. These results indicate that G. bimaculatus extract exerts no mutagenic effect in these in vitro and in vivo systems... - Validation study of OECD rodent uterotrophic assay for the assessment of estrogenic activity in Sprague-Dawley immature female ratsHyung Sik Kim
Laboratory of Molecular Toxicology, College of Pharmacy, Pusan National University, Jangjun-dong, Gumjung-ku, Korea
J Toxicol Environ Health A 68:2249-62. 2005..However, further combination studies using surrogate biomarkers may be needed to improve the sensitivity of this assay for the detection of weak estrogenic compounds, such as o,p-DDT... - Toxicokinetic relationship between di(2-ethylhexyl) phthalate (DEHP) and mono(2-ethylhexyl) phthalate in ratsHyun Jung Koo
Division of Toxicology, College of Pharmacy, Sungkyunkwan University, Suwon, Kyonggi Do, South Korea
J Toxicol Environ Health A 70:383-7. 2007..The toxicokinetic relationship between DEHP and MEHP in rats suggests that DEHP exposure assessment should be based on DEHP and MEHP in urine and serum for risk assessment applications... - Functional role of phospholipase D (PLD) in di(2-ethylhexyl) phthalate-induced hepatotoxicity in Sprague-Dawley ratsNa Young Kim
Laboratory of Molecular Toxicology, College of Pharmacy, Pusan National University, Busan, South Korea
J Toxicol Environ Health A 73:1560-9. 2010..Our results suggest that DEHP significantly enhanced the expression of PLD, which may be correlated with PPAR?-induced hepatotoxicity through a complex interaction with nuclear receptors including CAR and PXR... - No androgenic/anti-androgenic effects of bisphenol-A in Hershberger assay using immature castrated ratsHyung Sik Kim
Reproductive and Developmental Toxicology Division, Department of Toxicology, National Institute of Toxicological Research, Korea Food and Drug Administration, 5 Nokbun-dong, Eunpyung-Ku, 122-704, Seoul, South Korea
Toxicol Lett 135:111-23. 2002..In summary, the Hershberger assay could be a sensitive method for detecting androgenic or anti-androgenic chemicals, but BPA did not exhibit any androgenic or anti-androgenic activities in Hershberger assay... - Neurotoxic effects of alcohol and acetaldehyde during embryonic developmentRhee Da Lee
Department of Toxicology, National Institute of Toxicological Research, Korea Food and Drug Administration, Seoul
J Toxicol Environ Health A 68:2147-62. 2005..Data demonstrate that some antioxidants can partially protect against the alcohol-induced embryonic developmental toxicity...